Stephen L. Glasior, Ph.D. University of New Orleans (Stephen Xootfly in SL) "Career and Seminal Contributions to Genetics of Barbara McClintock" Put on your "jumping jeans" (well in this case "jumping genes") and join us for the first talk of the Women in Science, Tech & Medicine. Stephen Xootfly will be lecturing on one of the few female Nobel laureates in the sciences, Barbara McClintock. TODAY, Friday, February 11, 2011 5 PM SLT, Space Destiny http://slurl.com/secondlife/Space%20Destiny/91/86/25

1. Barbara McClintockSeminal Contributions to Genetics

2. Barbara McClintock Timeline 1902—Born Eleanor McClintock in Hartford, Connecticut 1919—Graduates from Erasmus Hall High School, Brooklyn 1919—Enters undergraduate studies at Cornell fall of 1921—takes Genetics with C. B. Hutchison and cytology with Lester W. Sharp January of 1922—invited by Hutchison to take graduate Genetics course 1923, 1925—undergraduate and graduate degrees in botany 1927—Receives PhD (botany), Cornell University

3. Barbara McClintock Timeline 1927-31—Instructor and researcher in maize genetics, Cornell University 1931—Fellow, National Research Council; conducts research at Cornell, University of Missouri at Columbia, and California Institute of Technology 1933-34—Fellow, Guggenheim Memorial Foundation; conducts research at Kaiser Wilhelm Institute, Berlin, and Botanical Institute, Freiburg 1934-36—Researcher, Cornell 1936-40—Assistant Professor of Genetics, University of Missouri at Columbia 1941-67—Researcher in Genetics, Carnegie Institution of Washington Cold Spring Harbor, Long Island, New York

4. Barbara McClintock Timeline 1944—Elected to the National Academy of Sciences 1945—Elected President, Genetics Society of America 1967—Distinguished Service Award, Carnegie Institution of Washington 1971—Receives National Medal of Science 1981—Recipient, MacArthur Foundation Grant (inaugural recipient, lifetime award) 1981—Recipient, Albert and Mary Lasker Award 1983—Receives Nobel Prize in Physiology or Medicine 1992—Dies in Huntington, NY

5. Fig. 9-04 Dominant Dominant Recessive Recessive Flower color Pod shape Constricted Inflated White Purple Pod color Flower position Green Yellow Stem length Axial Terminal Seed color Green Yellow Tall Dwarf Seed shape Wrinkled Round

7. Fig. 9-08 1 1 1 1 2 2 2 2 1 1 1 1 1 1 1 1 4 4 4 4 4 4 4 4 9 16 3 16 3 16 1 16 (a) Hypothesis: Dependent assortment (b) Hypothesis: Independent assortment P Generation RRYY RRYY rryy rryy Gametes ry ry Gametes RY RY F1 Generation RrYy RrYy Sperm F2 Generation Ry ry rY RY Sperm ry RY RY RrYY RRYy RrYy RRYY RY rY Yellow round rrYY Eggs RrYy rrYy RrYY Eggs ry Green round Ry RRYy RrYy RRyy Rryy Yellow wrinkled ry rrYy RrYy Rryy rryy Green wrinkled Actual results (support hypothesis) Predicted results (not actually seen)

11. CHROMOSOME MORPHOLOGY IN ZEA MAYS Barbara Mcclintock Science 14 June 1929: 629.

30. Transposons in Genomes McClintock proposed they were “controlling elements” responsible for regulation of expression in response to stressful conditions. Which did not meet a lot of acceptance initially. Probably because genomes where not thought of as malleable. So the dynamic nature of transposons (and genomes) has since become widely supported

32. fruit fly 5%, Human 45%, maize 80%

33. Provide novel genetic variations when they insert. Some are still active!

34. Provide a site for recombination that leads to genomic rearrangements