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       1
SAMPLING TECHNIQUES

   Oyindamola B. YUSUF
       Biostatistician
        KAIMRC-WR
LECTURE OUTLINE
•   Introduction
•   Determining number of subjects
•   Total population Surveys
•   What is sampling?
•   Reasons for taking a sample
•   Principle of sampling
•   Types of sampling
DETERMINING NUMBER OF SUBJECTS
• Statistical considerations
• Practical Considerations
PRACTICAL CONSIDERATIONS


• AVAILABILITY OF SUBJECTS

• RESOURCES- TIME, MONEY,
  PERSONELL
STATISTICAL CONSIDERATIONS



• Purpose of study
• Primary outcome measure
• How small a difference is to be detected
• Type 1 error: To find treatments
  significantly different if treatments don’t
  really differ
• Drop out rate if study is prospective
• Power to detect an actual difference
TOTAL POPULATION SURVEY



• Every individual in the defined population
  is included and studied.

• It has Advantages and Disadvantages
ADVANTAGES OF STUDYING TOTAL
        POPULATION


• (a) The estimate is accurate and
  without error since no unit is left out
• (b) There is no need to worry about
  selection procedure
• (c) And there are no feelings of
  discrimination created in the
  population.
DISADVANTAGES OF TOTAL
           POPULATION STUDY


•   (a) It is expensive
•   (b) It takes time to complete
•   (c) Demands a lot of personnel
•   (d) It may not be feasible
•   (e) It may be less accurate.
WHAT IS A SAMPLE ?



• Part of a population selected for
  study
• May be able to infer the
  characteristics of the population
  from those of the sample.
ADVANTAGES OF TAKING A SAMPLE
•   Advantages
•   (a) Less expensive
•   (b) Quick results guaranteed
•   (c) Demands on personnel is less
•   (d) Possibility of obtaining more accurate data because of the smaller
    number of units involved
DISADVANTAGES OF TAKING A SAMPLE


• Estimate obtained from the sample is likely to be different from
  that would have been obtained if the total population have been
  studied.
    – - this discrepancy is called sampling error and it is always
       present.
• It is sometimes difficult to select a good sample i.e. a
  representative sample.
PRINCIPLE OF SAMPLING


• AVOIDANCE OF BIAS
GENERAL CAUSES OF BIAS


•   a.   Lack of proper knowledge of the population from
         which the sample is selected.
•   b.   Inadequacy of sampling frame.
•   c.   Personal prejudice - i.e. when personal feelings is
         allowed to influence sample selection-observer error.
HOW TO AVOID BIAS


• TAKE A PROBABILITY
  SAMPLE
• THIS IS KNOWN AS A
  RANDOM SAMPLE
• SAMPLE HAS A KNOWN
  CHANCE OF BEIGN
  SELECTED
DEFINITIONS OF TERMS NEEDED TO
   TAKE A PROBABILITY SAMPLE


•   (i) Sample Size
•   (ii) Sampling Fraction
•   (iii) Sampling Frame
•   (iv) Sampling Unit
•   (v) Unit of Enquiry
•   (vi) Sampling Error
•   (vii) Good or Representative Sample
EXAMPLES OF PROBABILITY SAMPLES


      • SIMPLE RANDOM SAMPLE
      • SYSTEMATIC SAMPLE
      • STRATIFIED RANDOM
        SAMPLE
      • CLUSTER RANDOM SAMPLE
      • MULTI-STAGE RANDOM
        SAMPLE
SIMPLE RANDOM SAMPLE
• Simple random sample: A sampling procedure in which each unit in the
  population has the same (equal) chance of being selected. However the
  population must be finite and a sampling frame must exist.

• Each unit must have an assigned number in the sampling frame. Without
  a proper sampling frame, it is impossible to take a simple random sample.
SELECTION PROCEDURE OF SIMPLE
           RANDOM SAMPLE


• 1. Lottery method
• 2. Use of table of Random numbers.
• 3. Use of computer facilities.
• Lottery
• 1. Construct a frame of all the sampling
  units.
• 2. Use ballots to select the required
  number of units.
SYSTEMATIC RANDOM SAMPLE



• Unit selected in any one sample
  occupied related position to each
  other in the sampling frame
• Determine sampling fraction and
  sampling interval-k
• The first unit to be selected is selected
  at random between 1 and k.
• Thereafter every kth unit is selected.
EXAMPLE ON SYSTEMATIC SAMPLE


• Suppose a sample of 50 patients is required
  from the register of 1,000 patients available in
  the records section of a teaching hospital. The
  sample fraction here will be 50/1000 = 1/20
  , thus k = 20.
• The first member in the register is selected
  randomly between 1 and 20.
• The first and every 20th member is
  subsequently selected as sample members.
STRATIFIED RANDOM SAMPLE


• Population is divided into homogenous strata according to some
  relevant characteristics of the population
• A random sample is selected from each stratum
• The sample size may be sub-divided in proportion to the
  population size in each stratum. This is called a proportional
  allocation.
• For example to select 200 units from a population of 6000 units of
  which 2000 units are females and 4000 units males. The number
  chosen in each sex stratum will be 68 and 132 respectively if there
  is a proportionate allocation of the sample numbers in the strata.
MULTISTAGE RANDOM SAMPLE
• Multistage Sample
• Sampling in stages
• Final sample obtained after more than one stage
• Ex. Selection sample of students from the university
• 1st Stage Selections: Select 50 depts at random out of the existing 160
  (for example).
• 2ND Stage: from each selected depts, list all the students then select
• students in each of these.
CLUSTER SAMPLE


• The sampling unit is a cluster of units
• Units could be households, streets, or villages.
• The approach is useful in rural areas where
  there are no sampling frames.
• Multi stage sample and cluster sample are the
  most popular method in a rural area.
• In cluster sample, selection takes place only
  once.
EXAMPLE OF CLUSTER SAMPLE



• Study of attitudes of medical students to
  HIV/AIDS pandemic.
• Define each department as a cluster of students
• May select a specified number of departments
  at random out of the total number of
  departments in the University of Ibadan
• Study all students in the departments selected.
EXAMPLES OF NON-PROBABILITY
               SAMPLES


   •   Volunteer
   •   Judgmental
   •   Quota
   •   Purposive
   •   Convenience
SUMMARY
• Feasibility of probability samples
• Endeavour to always take a probability sample
• Always report sampling procedures
THANK YOU.

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Sampling Techniques for Biostatisticians

  • 2. SAMPLING TECHNIQUES Oyindamola B. YUSUF Biostatistician KAIMRC-WR
  • 3. LECTURE OUTLINE • Introduction • Determining number of subjects • Total population Surveys • What is sampling? • Reasons for taking a sample • Principle of sampling • Types of sampling
  • 4. DETERMINING NUMBER OF SUBJECTS • Statistical considerations • Practical Considerations
  • 5. PRACTICAL CONSIDERATIONS • AVAILABILITY OF SUBJECTS • RESOURCES- TIME, MONEY, PERSONELL
  • 6. STATISTICAL CONSIDERATIONS • Purpose of study • Primary outcome measure • How small a difference is to be detected • Type 1 error: To find treatments significantly different if treatments don’t really differ • Drop out rate if study is prospective • Power to detect an actual difference
  • 7. TOTAL POPULATION SURVEY • Every individual in the defined population is included and studied. • It has Advantages and Disadvantages
  • 8. ADVANTAGES OF STUDYING TOTAL POPULATION • (a) The estimate is accurate and without error since no unit is left out • (b) There is no need to worry about selection procedure • (c) And there are no feelings of discrimination created in the population.
  • 9. DISADVANTAGES OF TOTAL POPULATION STUDY • (a) It is expensive • (b) It takes time to complete • (c) Demands a lot of personnel • (d) It may not be feasible • (e) It may be less accurate.
  • 10. WHAT IS A SAMPLE ? • Part of a population selected for study • May be able to infer the characteristics of the population from those of the sample.
  • 11. ADVANTAGES OF TAKING A SAMPLE • Advantages • (a) Less expensive • (b) Quick results guaranteed • (c) Demands on personnel is less • (d) Possibility of obtaining more accurate data because of the smaller number of units involved
  • 12. DISADVANTAGES OF TAKING A SAMPLE • Estimate obtained from the sample is likely to be different from that would have been obtained if the total population have been studied. – - this discrepancy is called sampling error and it is always present. • It is sometimes difficult to select a good sample i.e. a representative sample.
  • 13. PRINCIPLE OF SAMPLING • AVOIDANCE OF BIAS
  • 14. GENERAL CAUSES OF BIAS • a. Lack of proper knowledge of the population from which the sample is selected. • b. Inadequacy of sampling frame. • c. Personal prejudice - i.e. when personal feelings is allowed to influence sample selection-observer error.
  • 15. HOW TO AVOID BIAS • TAKE A PROBABILITY SAMPLE • THIS IS KNOWN AS A RANDOM SAMPLE • SAMPLE HAS A KNOWN CHANCE OF BEIGN SELECTED
  • 16. DEFINITIONS OF TERMS NEEDED TO TAKE A PROBABILITY SAMPLE • (i) Sample Size • (ii) Sampling Fraction • (iii) Sampling Frame • (iv) Sampling Unit • (v) Unit of Enquiry • (vi) Sampling Error • (vii) Good or Representative Sample
  • 17. EXAMPLES OF PROBABILITY SAMPLES • SIMPLE RANDOM SAMPLE • SYSTEMATIC SAMPLE • STRATIFIED RANDOM SAMPLE • CLUSTER RANDOM SAMPLE • MULTI-STAGE RANDOM SAMPLE
  • 18. SIMPLE RANDOM SAMPLE • Simple random sample: A sampling procedure in which each unit in the population has the same (equal) chance of being selected. However the population must be finite and a sampling frame must exist. • Each unit must have an assigned number in the sampling frame. Without a proper sampling frame, it is impossible to take a simple random sample.
  • 19. SELECTION PROCEDURE OF SIMPLE RANDOM SAMPLE • 1. Lottery method • 2. Use of table of Random numbers. • 3. Use of computer facilities. • Lottery • 1. Construct a frame of all the sampling units. • 2. Use ballots to select the required number of units.
  • 20. SYSTEMATIC RANDOM SAMPLE • Unit selected in any one sample occupied related position to each other in the sampling frame • Determine sampling fraction and sampling interval-k • The first unit to be selected is selected at random between 1 and k. • Thereafter every kth unit is selected.
  • 21. EXAMPLE ON SYSTEMATIC SAMPLE • Suppose a sample of 50 patients is required from the register of 1,000 patients available in the records section of a teaching hospital. The sample fraction here will be 50/1000 = 1/20 , thus k = 20. • The first member in the register is selected randomly between 1 and 20. • The first and every 20th member is subsequently selected as sample members.
  • 22. STRATIFIED RANDOM SAMPLE • Population is divided into homogenous strata according to some relevant characteristics of the population • A random sample is selected from each stratum • The sample size may be sub-divided in proportion to the population size in each stratum. This is called a proportional allocation. • For example to select 200 units from a population of 6000 units of which 2000 units are females and 4000 units males. The number chosen in each sex stratum will be 68 and 132 respectively if there is a proportionate allocation of the sample numbers in the strata.
  • 23. MULTISTAGE RANDOM SAMPLE • Multistage Sample • Sampling in stages • Final sample obtained after more than one stage • Ex. Selection sample of students from the university • 1st Stage Selections: Select 50 depts at random out of the existing 160 (for example). • 2ND Stage: from each selected depts, list all the students then select • students in each of these.
  • 24. CLUSTER SAMPLE • The sampling unit is a cluster of units • Units could be households, streets, or villages. • The approach is useful in rural areas where there are no sampling frames. • Multi stage sample and cluster sample are the most popular method in a rural area. • In cluster sample, selection takes place only once.
  • 25. EXAMPLE OF CLUSTER SAMPLE • Study of attitudes of medical students to HIV/AIDS pandemic. • Define each department as a cluster of students • May select a specified number of departments at random out of the total number of departments in the University of Ibadan • Study all students in the departments selected.
  • 26. EXAMPLES OF NON-PROBABILITY SAMPLES • Volunteer • Judgmental • Quota • Purposive • Convenience
  • 27. SUMMARY • Feasibility of probability samples • Endeavour to always take a probability sample • Always report sampling procedures