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Figure 29-1 Factors that influence the position of the oxygen-hemoglobin dissociation curve. Curve B is from a normal adult at 38°C, pH 7.40, and PCO 2 35.0 mm Hg. Curves A and Cillustrate the effect on the affinity for oxygen (P 50 ) of variations in temperature (°C), pH, PCO 2 , 2,3-diphosphoglycerate, adenosine triphosphate, methemoglobin, and carboxyhemoglobin. Curve A is of the newborn. (From Duc G: Assessment of hypoxia in the newborn: Suggestions for a practical approach. Pediatrics 48:469-481, 1971.)