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“The Role of Research Universities
for the Regional Economy
a case study

The Leuven Model

Dr Martin Hinoul
Moscow, december 10th , 2013
Business Development Manager KU Leuven R&D
World’s GDP and R&D Budgets !
500 Bi $ versus 360 Bi $ ?
1,74 tr $
16,5 tr $

18 tr $

3 % R&D 500 BI dollar

2% R&D360 Bi dollar

6,4 tr
$

5 tr $

1,5 tr $

2 tr $

Source : The World Bank-Reshaping Economic Geography, Hinoul
M.Hinoul
SIR* World Report 2012

INDICATORS
• Output
• International Collaboration
• Normalized Impact

• High Quality Publications
• Specialization Index (Gini
index)
• Excellence Rate

• 3290 Research Institutions (strong criteria)
• more than 80% of the world scientific output (2006-2010)
(Global Ranking KU Leuven 68 (universities 32) - European Ranking KU Leuven 5)
*Scimago Institutions Rankings
M.Hinoul
Barosso’s dream (or nightmare)
for 2020
 75% of the active population should be employed in 2020 –Today in

2013 it is only 66%- A long way to go.
 3% of the European GDP should be spent on R&D .


Today it is only 1,9%



One percent extra means an extra of 180 Bi€



One percent means also an extra 700.000 engineers and scientists.



R&D fine but how good is the valorization of the European research?

 20/20/20 in 2020:

Reducing green house gas emissions with 20% (level 1990)
Energy reduction minus 20%
Alternative Energy plus 20%
M.Hinoul
Economic growth and the
Knowledge Economy Regions

M.Hinoul
Globally there are more than 50 well
developed knowledge economy regions

M.Hinoul
Source : Harvard Business Review July-August2012 – p.26
M.Hinoul
M.Hinoul
“Third Generation Universities”
Some examples

Stanford University, Palo Alto

Cambridge

MIT

KU Leuven
Massachusetts Institute
of Technology - MIT
 February
•
•
•
•

2009:

25.800 companies founded by MIT alumni
3.3 mi employees
Annual sales : 2 trillion $
17th largest economy in the world

Estimated Number Of
Companies Founded
By “Foreign” MIT
Alumni

 Impact on ecosystem:
• < 10% MIT students are from Ma state
BUT: > 30% firms started in Ma by MIT

Location

Total

United States

2,340

alumni
> 50% firms started by foreign students
are located in the US

Europe

790

Latin America

495

Asia

342

•

Source: Bankboston Report (Kauffman Foundation)

Vannevar Bush

M.Hinoul
Stanford University at the basis of
Silicon Valley


Leland Stanford governor of California




1887 first stone of the university
1891 (March 22) opening – 559 students
David Starr Jordan – first rector


Frederick Emmon Terman








Start setting up companies such as Hewlett Packard, Varian, etc.
Build the first research parks
First Venture Capital which became later the famous Sand Hill
venture capital Road

27 Nobel Prizes, a lot of National Medals and other distinctions
Silicon Valley – more than 8000 high tech companies – hundred
thousands of new jobs
M.Hinoul
Regional Knowledge Economy
It all started with professor Fred Terman at the
Stanford University in 1939
Silicon Valley today

A State of Mind
Silicon Valley – A complex Network of Clusters
Clean Technology

Route 101 – Route 280 - State of mind

Silicon Valley Joint Venture Network

Stanford University – UCSF - Berkeley

VC – Kleiner Perkins Caulfield…NASDAQ

2005
2000

Nano-electronics-Bio Silicon
Internet – Google – e-Bay –YahooAmazon.com - Facebook
Networks – Cisco - Juniper
(Bosack,Lerner& Troiano -1984)
Software -Oracle

1980
Computers – Apple Computer - Sun
1975

Semiconductors – Shockley –-Intel
1955

1939

Electronics – Hewlett Packard Varian
Stanford – Fred Terman
M.Hinoul
The Power of
Silicon Valley Cies
2012
Rank

Company

Market Value
Bn $
March 31 2012

2012
Sales – Bn $

Net Profit – Bn$

164,7

42

416

2012

1

Apple

2

Hewlett-Packard

119

-12

46

3

Intel

53

11

108

4

Google

51

10

262

5

Cisco Systems

47

9

111

6

Oracle

37

10

152

7

eBay

14

3

70

8

Synnex

10,3

0,159

1,4

9

Gilead Sciences

10

2,6

75

10

Applied Materials

8,1

-

16

514

88

1258

Total

*GDP Be 444 Bn $
GDP Netherland 743 Bn $

Source: Silicon Valley 150
The Mercury News – May 2013
M.Hinoul
The “Echoes” of Silicon Valley are Everywhere
Cambridge

An Ancient yet Hi-Tech and Modern City
804 year old University
The Cambridge Phenomenon
50 years young


5,000 companies founded since 1960



1400 truly “HiTech”companies today. 2,500 Total Tech.



45,000 jobs



Ten $1 billion dollar companies



Two $10 billion dollar companies



Roads, airports, guided bus, rail transportation



Attracting up to 20% of European Early Stage VC
Key Components of the Entrepreneurial Eco-system
Cambridge
University

MRC
Laboratory
of Molecular
Biology

Cambridge
Interactive
System

Sinclair
Radionics

1960
CCL

CAD
Centre

Sinclair
Research Ltd

Barclays Bank
1970

Analysys

Cambridge
Science Park

Olivetti Research
Laboratory
(acquired by
AT&T in 1999)
Seiko Epson
Research
Lab

PA
Technology

1980

CHASE

Unilever Cambridge
Centre for Molecular
Informatics

Cambridge
Capital Group

Cambridge
Angels

EPSON

St. John
Innovation
Centre

CUE, Biology
in Business

Cambridge Research and
Innovation Ltd (CRIL)

Cambridge
Network

1990

CfEL (previously
CEC)

3i

Babraham
Bioincubator

Enterprise Link

Scientific
Generics
The Technology
Partnership
TTP

Hitachi
BP
Cambridge
Institute of Laboratory
The Wellcome
Biotechnolog
y
Trust Sanger
Cantab
Pharmaceuticals

GEIF

Institute of
Manufacturing

2000

Philip
s

Nickerson
Biotech
Laboratory

Eicon
Research Ltd

Acorn

Judge Business
School

Cambridge
Toshiba
Gateway
Cambridge
Research ET Capital
Laboratory

Glaxo

Cambridge
Enterprise

Glaxo Institute
of Applied
Pharmacology

ERBI
Avlar

Amadeus Capital
Partners
Library Granta Park
House
Cambridge
Create
Research
Partners
Park
CMI

Microsoft Research
(previously Entropic
Research)

TTP Ventures
The hi-tech start-ups and Networks associated with the Cambridge University

RealVNC
Virtual Network
Merged with
Andy Hopper
Level5Network
Computing
Globespan Andy Hopper
Steve Pope
Ubisense
Andy Hopper
Peter Warton
Andy Hopper
Cambridge
Andy Hopper
Andy Ward
Broadband
IPV (Telemedia Hermann Hauser Acquired by American
Pete
Acquired by AT &T Systems)
Andy Hopper
Microwave
Virata(ATML)
Steggles
Adaptive

Simon Elliott
David Cleevely
VBN
online
Splashpower

Acquired by
Western
Multiplex
Hermann Hauser Corp

Broadband

TerraPrise

Amadeus Capital Partners
Hermann Hauser
Tensails
nCipher
Mike Muller
Richard Green
Alex van Someren
Andy Hopper
Acquired by
Tudor Brown
Acquired by
Nicko van Someren
Broadcom
ARM Jamie Urquhart
Lily Chang
GE
ANT
Element 14
Icera
Acquired by
Richard Green Small
Alex van Someren
James Hay
Olivetti
Stan Boland
Stan Boland
Authur Chance World
Nicko van Someren
Simon Knowles Simon Knowles
Dick Newell
Cambridge Interactive Systems
Part of DAKO
DakoCytomation John Snyder
Dick Newell, Tom Sancha
Diagnostics
Merged with
Webtop
Acorn
Charles Lang
Hermann Hauser, Chris Keightley Cytomation Inc
Hermann
IQ Bio
Shape Data
Peter Duffett-Smith
Smartlogik
CAD Hauser
Netchannel
Acquired by
CPS
Hermann Hauser
Acquired by Dialog
Hermann Hauser NTL
Top
Jack Lang
Cambridge
Jack Lang Electronic Share Jack Lang
express
University
Information
Olivetti
Research Lab

Muscat
John Snyder
Martin Porter

Enterprise
Accelerator
John Snyder
Cambridge
Adam Twiss
Zeus
Semiconductor
David Reeves
Technology
Gehan Amaratunga
Pilgrim Beart
Florin Udrea
ActiveRF

Laser-Scan Analysys
R. O. Frisch
David Cleevely

Adam Twiss
Bryan Amesbury

Antenova
Pilgrim Beart

Richard Friend
Plastic Logic

1986-1990

ART

Polight
Technologies

Stephen Elliott
Pavel Krecmer
version (Sept 2005) – not to be used or copied without permission
Copyright – Y.M.Myint - y.myint@jims.cam.ac.uk, Dr. Shailendra Vyakarnam s.vyakarnam@jims.cam.ac.uk

David Cleevely
Cambridge
Hermann Hauser
Network
Alec Broers

1991-1995
Collin Ager
Garraint Davies
Innovia

1996-2000

Acquired by
E* Trade

Richard Friend

Until 1985

Daniel Hall
Saviso Group

CDT

Cambridge
3G
David Cleevely

M-Spatial
2001-2002 Adrian Cuthbert
Jon Billing
And a similar Network for Biosciences
Acquired by
Becker
Underwood

Merlin Biosciences
William Bains
Chris
Arakis
Greg Winter
John Caldwell Iain Cubitt
Evans
Changed its name
Merged with
Pestex
Diversys
Andy
Amedis
to MicroBio Group
Xenova
Cyclacel Richards
RiboTargets
pharmaceutic
Group Ltd
Microscience
Vernalis
al
Merlin Ventures
Simon Sturge
Ark Therapeutics
Chris Evans
Chris Evans
Iain Cubitt
Martin Davies
Acquired by
Vectura
Celsis
Axis Genetcs
Toad
Greg Winter
Chris Lowe
Prometic
ReNeuron Chris Evans
Cerebrus
BioRobotics
Daivd Chiswell
J. McCann
Biosciences
Biovex
ChiroTech
Chris Evans
CAT
Inc
Chris Evans
Cambridge
Chris Evans
Rapigene
Celltech
Alan Munro Sensors
Chris Lowe
Enviros
Smart
Enzymatix
Cantab
Merged by
Chris Evans
Chris Lowe
Holograms
Pharmaceuticals
Celltech
Chris Lowe
Ken Jones
Chiroscience
MRC LMB
Affinity chromatography
Group
Chris Evans
Genzyme
Chris Lowe
1960s
Purely
Daniel Roach
Alan Goodman
(UK) - AGC
David Bailey
LiDCO
Proteins
Alan Goodman
1985 1984
Philip Dean
Terry O’Brien
Alan
De Novo
Cambridge
CeNes
David Bailey
AdproTech
Alan Goodman Goodman
University
Alan
Peter Lachmann
CORE
ATM
Biotica Technology
Goodman
Until 1985
Alan
Peter Leadlay
Goodman
Kudos
Jim Staunton
Daniel Roach
Oxford
Pharmaceuticals
Alan
Alan Bimedica
. Mark Bodmer
Stephen Jackson
Hexagen
1986-1990
Goodman
Acquired by Incyte
Peptide
Goodman
Avlar
Therapeutics
Metris
Lorantis
BioVentures
Alan Goodman
Mark Bodmer
Now Acambis
Therapeutics
1991-1995
Daniel Roach
Amura
Paradigm
Stephen Smith
Salix
Alan
Therapeutics
Steve Charnock-Jones
pharmaceutical
Holometrica
Mark Carlton
Goodman
Astex
Abcam Roger Millington
Solexa
Alan
Sense
Technology
Jonathan Milner 1996-2000
Shankar
Goodman
Proteomics
Tom Blundell
David Cleevely
Balasubramanian
Jonathan Blackburn
Jonathan Milner
Chris Abell
David Klenerman
David Cleevely
Harren Jhoti
Paul Goldsmith
Akubio
Cambridge Theranostics
MC
Ivan Petyaev
Daniolabs
David Klenerman, Tony Minson

2001-2002
Leuven, a region for
innovation & high-tech
entrepreneurship
The Leuven Region
Close to Brussels
Leuven Region: 95.000 habitants

Airport

Brussels

Leuven
An old young city
The Leuven Case
Education

Research

Foundation
KU Leuven

Brewery Den Hoorn
Stella
AB Inbev

Famous researchers
• Mercator
• Vesalius
• Frisius
• Ortelius

Exploitation research

KU Leuven R&D
Transfer Office

Stanford University (1891)
Fred Terman-1939
Hewlett, Packard,Varian(s)

IPTEC Price

IMEC
• 137 spin offs
• 300 tech companies
• 7000 researchers
• 7000 high tech jobs
• Research Parks
• Incubators

M.Hinoul
University Leuven

IMEC

Knowledge Centers

664 mi€ R&D, 6400 Researchers

High Tech Industrie

300 Technology Cies, 135 spin offs

Life Sciences

Nanotechnology

Mechatronics

Cleantech

Clusters

Technology Platforms

Haasrode

Arenberg

Leuven Noord

Genk THOR

Tienen FFH

Research Parks

Networks

M.Hinoul
KU Leuven Research & Development
Technology Transfer Office
A Bridge between research and industry
K.U.Leuven Research & Development received the
2008 IPTEC Tech Transfer Award
Nominated:

•K.U.Leuven R&D (Winner 2008)
•Columbia University (USA)
•Imperial Innovations (UK)
•MIT (USA)
•Wisconsin Alumni Research Foundation (USA)
Received the award :
•2006 : Stanford University (USA)
•2007 : Tsinghua University (China)

© 2007 LRD
LRD: Mission
“Promoting and supporting knowledge and technology transfer between
university and industry”

Researchers

• Research collaboration
• Spin-offs and regional development
• IP protection and licenses

Companies
What is LRD?
• LRD consists of:
o

Central multidisciplinary staff
• Supports researchers in knowledge and technology transfer

o

Research divisions
• 1,422 researchers & 397 supporting
• Embedded in university via matrix structure
• Virtual organisations in which (groups of)
researchers (from different faculties
or departments) can group their
applied research, commercialindustrial and exploitation activities.
Intellectual property
• What do we do?
o
o

o
o
o
o

o

Creating awareness and transferring knowledge
Assessing the feasibility, patentability and market potential of
an invention
Determining a protection strategy
Drafting and filing a patent application
Following up on patent procedures and costs
Negotiating and drafting NDAs, MTAs
and license agreements
Finding industrial partners
LRD research divisions
Faculties, departments, research groups:
quality in research and educational activities

LRD divisions/projects:
Contract and budgetary
autonomy and flexibility
incentives
Organisation
Management (2)

Research
collaboration
(17)
• advice
• contract R&D
• projects with
government
support (IWT,
EC, etc.)

Intellectual
property rights
(12)
• intellectual
property rights
• licensing

Spin-off &
innovation
(9)
• spin-off creation
& growth
• networks &
regional
development
• KU Leuven
Association

Finance, HR &
logistics
(39)
• financial
administration
• HRM
administration

• Close interaction and collaboration between
different units
• Regional and international networking
Activities
•
•
•
•
•

Research collaboration
Protection and exploitation of intellectual property
Spin-off creation & innovation
Support of regional development
Stimulation of entrepreneurship through
network initiatives
Examples of technology transfer
Research collaboration
• Oldest activity of LRD
• Performing research & services for companies or
governments
• What do we do?
o
o
o
o

o
o
o

Creating awareness and transferring knowledge
Providing advice
Negotiating contracts
Following up on contracts
Managing research files financially
Offering administrative support
Preparing legal documents
Contract Research

thousands

€ 160.000

160.000

€ 140.000

144.802

126.807

€ 120.000

121.653

€ 100.000
97.844
87.908

€ 80.000
70.193
€ 60.000
54.332
€ 40.000

€ 20.000

€0
2004

2005

2006

2007

2008

2009

2010

2011
Intellectual property
• Internal specialised office: protection and exploitation of
intellectual property rights
• Network of formal collaborations with different European
patent attorneys
• Patent Fund: selective support of research groups to
help them cover their initial costs and expenses related
to patenting needs
Intellectual property
• 156 patent applications in 2011
o
o

496 active patent families
49 PCTs
In numbers

2011

Reported findings

154

Priority submissions

156

New patents

33

• 60 million euro license-income (71 million in 2012)
• Attributed patent is often the basis for setting up a
spin-off company
Spin-offs & innovation
• What do we do?
o

o
o
o
o

o
o
o
o

Developing business plans
Validating business models and the market
Offering legal support
Putting together a competent team
Finding investors
Finding infrastructure
Managing growth of spin-offs
Promoting valorisation and
entrepreneurship
Stimulating regional development,
networks and clusters
Definition of a Technology Cluster
Network relatedCies
(VC, Seed, IP, Legal..)

Mixed Innovative Cies

Knowledge
Centers

Attraction Innovative
Cies

Creation Innovative
Cies

M.Hinoul
Mechatronica
Kenniscentra

Stas
Ora Machines

Centers of
excellence

ACE Electronics
WTCM

Optidrive
Air Beraing Prec. Techn.

Barco Aarschot
Partec Eng

Alnaco

B.E.S.T.

Materialise

Electrical & Mech. Design
DV Consulting IPCOS
K.U.Leuven
Dept. Mechanics
Researh groups

Metris
Somatech

Krypton

Dynamotor
Decoster
Luyten Automation

KULeuven

SST
Food Mach Atos Engineering

Pure innovatieve
bedrijven

Camco
Techn
Flexlink
Systems

PEC EME
K.U.Leuven
Dept of Metall. & Mater. Eng
Lab Agric Mach & Proc

Entecom Systems
Tecmate
Intl.

D2S International
M&M Corporation
Data Analys Products
CSI

Scala Consultants

Mixed innovatieve
bedrijven

Donaldson

LMS
South Lancs
Belgium

Affilips

Robert Bosch
Life Science Cluster
Kenniscentra

E.S.R.I.
Deckers Div

Dermat

Centers of
excellence

Biotest Seralco
Benelux

Thrombogenics
Tigenix

Norgine

IDT(RNA-TEC)
Dakocytomation
BioTie Therapies Corp.
Univ hospitals
K.U.Leuven
Rega Institute
CEHA

Algonomics
PatientWeb
Medvision
Benelux

Puur innovatieve
bedrijven

Gemengd innovatieve
bedrijven

M-Elect
M4S

Materialise

K.U.Leuven
L-MTC

Autocyte
Europe

Neurogenetics
@Medical Techn.

MXS

VIB
VIGOUR

Custom8
Fugeia
Malaise&co

Terumo
Europe

Cochlear

Lab of Exp. Genetics & Transgenese

QMedit
IVIA

ReMynd

Medicim
CMPG

Centocor

Diatos

Onco
Methylome
Regenesys

New Standard Eng.

Formac
Pharmaceuticals

VWR International

Ortec

Conti BPC
A Top Technology Region
Much more
than the 3 % Lisbon target
HIGH TECH SYSTEMS & MATERIALEN
Specialisatie en pieken: Selectie en typologie belangrijkste actoren
TTR Nederland

Nederlandse
Vereniging
voor Precisietechnologie

Vereniging
van de
Nederlandse
Chemische
Industrie

DSP Valley
Sirris

DAF

nv Graco

Siemens VDO

Kenniscentra en
centers of excellence

Bosch
Packaging

FMTC
(mechatronica)

Vista nv
Philips

Chemelot

Alro Holdings

Ford Werke

Bosch Hydraulic

LAG
Trailers

Borealis Polymers
Akzo Nobel

Pure innovatieve
bedrijven

Netherlands
Aerospace
Group (NAG)
ATC
Eindhoven

Mixed innovatieve
bedrijven

Océ
Stork food
systems en
printing

Campus
Eindhoven

Cerobear
Verband der
Chemischen
industrie (VCI)

KUL

KUleuven
UImec
Hasselt

Philips (licht)/ Philips
Onderzoeksinstituut

Trützschler
FEV
Motorentechnik

Cluster Chemie/
Kunststoffe
Mitteldeutschland

INTRA e.V.

* Internationaal netwerk: Automotive.net

Tessenderlo
chemie

Forschungszentrum Jülich
RWTH
Hochschule
Aachen Niederrhein
Continental
Schumag AG

Spaas
Kaarsen

Prüfcentrum Siemens
transportation Systems

Agoria

Heraeus
Electro-Nite
International
Flanders
Drive

Oerlikon Textile

Scheidt & Bachmann

3M

Netwerken*

DOW Belgium

U Luik
U Hasselt
U
Fraunhofer Institut Luik

Siempelkamp

FLAMAC
(materialen
onderzoek)

Epiq
Imec

Philips

DSM
ASML

Nederlandse
vereniging
voor rubber
en
kunststoffen

Campus
Geleen

Nedcar
Vanderlande
Industries

TTR België

Walonie
Espace

Pierberg

Voith Paper
AUNDE

Verband der
Elektrotechnik
(VDE)

Munters Euroform
CAR e.V.
Verbundinitiative Automobil
Nordrhein-Westfalen (VIA NRW)

TTR Duitsland
49
K.U.Leuven Spin offs

100
90
80
70

Gemma Frisius-Seed Capital
2x 12,5 m€

60
50
40
30
20

10
0
1980

1982

1984

1986

1988

1990

1992

1994

1996

1998

2000

2002

2004

2006

2008

2010

2012
Spillovers and multipliers
• Spin-offs between 2006 - 2010:
– K.U.Leuven direct investments: 4,7 M€
– Gemma Frisius Fund investments: 12 M€
– Other third party investments: 476 M€
Perennial topics
Investment in spin-offs 2005 - 2012
700 000 000
631 426 634

Euro
600 000 000
500 000 000
400 000 000

300 000 000
200 000 000
100 000 000
7 453 606

14 591 843

KU Leuven

GFF

0
derden


Seed Capital – Venture Capital – 500 million €
Risicokapitaal Arr. Leuven (2002) : 200 miljoen euro

Servifund
12%

Gemma Frisius
Fonds 1
7%

Stonefund
19%

Beluga
12%
Softw are Holding
& Finance
8%

Gemma Frisius
Fonds 2
7%

IMEC
Incubatiefonds
3%

Capricorn Venture
Partners
12%

Quest
Management
20%
Spillovers and multipliers

• Patent portfolios:
– K.U.Leuven R&D, 454 active patent families of which 90%
economically exploited
– Multiplier effects of patent portfolios of spin-off companies
 sectoral multipliers of 3 to 4
Examples in Life Sciences KU Leuven
Spin-off companies: some examples
• Engineering

• Micro-electronics & ICT
Spin-off companies: examples
• Consultancy

• Biomedical
Incubation & seed financing
•

Gemma Frisius Fund KU Leuven (GFF)
o

o

Seed capital for spin-off companies
GFF founded in 1997 & GFF II in 2002
•

o

At the end of 2009 GFF and GFF II merged into one single fund

Partners:
•
•

o

KU Leuven (20% of capital)
Two banks: KBC Private Equity (40%) and BNP Paribas Fortis Private
Equity (40%)

Combination between:
•

•
o
o

Knowledge and technology transfer expertise
(university)

Financial expertise (financial partners)

Not restricted to one technology domain
25 million euro invested in 38 spin-off
companies
Regional and interregional development
• Partners:
o
o
o

o
o
o
o
o

City of Leuven
Province of Flemish Brabant
Vinnof
CREA - European Commission
KBC Private Equity
BNP Paribas Fortis Private Equity
imec
VIB

• ELAt: Eindhoven - Leuven - Aachen triangle
o
o

Cross-border and interregional network
Stimulation of knowledge economy

• HAE : Health Axis Europe (Heidelberg, Leuven, Cambridge)
Networks
• Stimulating knowledge exchange and partnering with
other high-tech businesses (both SMEs and large
companies) and innovation actors
• Horizontal networks:
o
o

Leuven.Inc
Flanders Smart Hub
Networks
• Vertical networks:
o
o

DSP Valley
LSEC

• Thematic centres:
o
o

o
o
o
o
o

CD3
L-MRC
L-MTC
LICT
PharmAbs
NERF
LFoRCe
Science parks, business centres
& incubators
•
•
•
•
•
•
•
•

Arenberg Science Park
Haasrode Science Park
Leuven Noord Science Park
Waterschei - Genk Science Park
Tienen Science Park
Ubicenter
Remy Campus
Leuven Business Centre
Science parks, business centres
& incubators
•
•
•
•

Leuven Bio-Incubators
Tienen Biogenerator
KU Leuven Innovation & Incubation Centre (I&I)
Kortrijk Innovation & Incubation Centre (IICK)
Multilevel interaction

KU LEUVEN

LRD
Financial
world

Science

GFF

Parks

Leuven.Inc

Industry

Region
12 Lessons from Leuven
1. Basis is a critical mass of high quality research

2. Create an appropriate entrepreneurial climate in a university
context
3. Create a legal framework with respect to exploitation of
academic research
4. Clear incentives and policies to encourage research groups and
departments to actively seek knowledge transfer opportunities
5. Create a professional Interface Unit – An Integrated approach on
research valorisation: multidisciplinary team & “high value” services

6. Create a Seed Capital and/or Venture Capital Fund
12 Lessons from Leuven
7. Foster spin-offs from your university research

8. Clear ownership of Intellectual Property
9. Improving awareness among federal, regional and local
shareholders

10. Supporting a forum for business, academia, government and
supporting organisations to build partnerships by sharing new
ideas and best practices. Importance of the networks.
11. Focus on Focus and Enthusiasm
12. Quality of life
Success factors
• A critical mass of high quality research
• Multidisciplinary team & high value support
• Clear incentives to encourage researchers and research
groups
• Favourable entrepreneurial climate within the university
• Legal context in Flanders
• Instruments and networks that further professionalise
technology transfer support
Towards an
Entrepreneurial Society






“The rise of the entrepreneur is not just about
economics.
It reflects profound changes from individual
careers to the social contract.
It signals the birth of an entrepreneurial society”
-The EconomistMarch 14, 2009
The Value Chain is the barometer
1. Knowledge Centers
2. Entrepreneurs
3. Role Models
4. Money
5. Capital Markets
6. Infrastructure
7. Cluster Policy
8. International Companies
9. Networks
10. Government
11. Quality of Life
Source : Hinoul, Gibbons, Saxenian
What makes a region attractive for talent?


Location – such as Silicon Valley, California – Sophia Antipolis, Mediteranée –
Heidelberg Old University



Universities or Research Centers - Magnets for talent
See Jiao Tong University League e.g. Stanford, Harvard, Princeton, IMEC
Leuven, LETI Grenoble, CERN Geneva.



Presence of top Succesful Companies Microsoft, Intel, Google, ASML, LMS…



Presence of Strong Individuals – Role Models
Bill Gates, Steve Jobs, Larry Page and even Nobel price winners.



Presence of Successful Clusters
San Diego Biotech-Golden Triangle – North Carolina Research triangle



Fiscal System – Salaries, tax incentives, research budgets



Quality of Life – Leisure, Housing, Medical care, International schools, culture…
Source: M. Hinoul – 7th Annual Conference – Technopolicy Network –
Heidelberg 2010
Towards a new Form of Culture
All things are
possible attitude

Risk Taking
We have not enough
spin-offs who fail

Co-competition
Stock options
Based on Meritocracy

Serial
Entrepreneurs

Time for the next big thing

CULTURE

Cross-pollination

Inflection Point
(Andy Grove)

Cross-investments
State of mind

Networking
Jumping on the Next Curve
(Oracle)

Failure

Badge of merit

Source : M. Hinoul

±
Flemish Entrepreneurs
The old generation

Leo Leander Bekaert
Lieven Gevaert
Leo H. Baekeland
75
Flemish Visionaries

Gaston Geens

John Cordier
Paul Janssen

Roger Van Overstraeten

Marc Van Montagu

Walter Fiers

76
Leuven Entrepreneurs
A new generation

.

A.OOSTERLINCK

J. DEJAEGER

D. COLLEN

P. STOFFELS

S. BIJNENS

U. VAN DEURZEN

J. CALLEWAERT

B. VAN COPPENOLLE

F. VAN CRAEN

T. DE PROFT
Speech recognition

Data screening

Micro electronics

Cloud computing

Components

Interplanetary
Space Flights

Ground Navigation

Suborbital
Space flights

Small satellites
Platform & pay load

Nuclear Medicine

Medical devices

Drug Delivery

Bio Informatics

Stemcells

Interdisciplinary Research
Clusters and Research Directions

Confidential-M.Hinoul
Clusters and Interdisciplinary Research
at Skolkovo
Director
TTO

 Research Collaboration
 IPR(Royalties,Licencing)
 Spin offs – Start ups
 Finance (Seed, VC, IPO)

5 Research Programs
(Clusters)
Research Centers
Interdisciplinary
approach
A close interaction
between different
research divisions
Technopark
(a state of the art
infrastructure)

Russian &
International Cies
Russian & International
Research Centers
Dual Incentive Mechanism
Russian & International
Universities

Russian & International
Cies

SIST

Technopark

 Striving for scientific excellence
 Gearing this excellence towards application and
technological innovation
Creation of the Knowledge Economy Region Skolkovo
Contact

KU Leuven Research & Development (LRD)
Waaistraat 6 – box 5105
3000 Leuven, Belgium
Tel.+32 16 32 65 00
lrd@kuleuven.be
lrd.kuleuven.be

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How universities drive regional economies

  • 1. “The Role of Research Universities for the Regional Economy a case study The Leuven Model Dr Martin Hinoul Moscow, december 10th , 2013 Business Development Manager KU Leuven R&D
  • 2. World’s GDP and R&D Budgets ! 500 Bi $ versus 360 Bi $ ? 1,74 tr $ 16,5 tr $ 18 tr $ 3 % R&D 500 BI dollar 2% R&D360 Bi dollar 6,4 tr $ 5 tr $ 1,5 tr $ 2 tr $ Source : The World Bank-Reshaping Economic Geography, Hinoul M.Hinoul
  • 3. SIR* World Report 2012 INDICATORS • Output • International Collaboration • Normalized Impact • High Quality Publications • Specialization Index (Gini index) • Excellence Rate • 3290 Research Institutions (strong criteria) • more than 80% of the world scientific output (2006-2010) (Global Ranking KU Leuven 68 (universities 32) - European Ranking KU Leuven 5) *Scimago Institutions Rankings M.Hinoul
  • 4. Barosso’s dream (or nightmare) for 2020  75% of the active population should be employed in 2020 –Today in 2013 it is only 66%- A long way to go.  3% of the European GDP should be spent on R&D .  Today it is only 1,9%  One percent extra means an extra of 180 Bi€  One percent means also an extra 700.000 engineers and scientists.  R&D fine but how good is the valorization of the European research?  20/20/20 in 2020: Reducing green house gas emissions with 20% (level 1990) Energy reduction minus 20% Alternative Energy plus 20% M.Hinoul
  • 5. Economic growth and the Knowledge Economy Regions M.Hinoul
  • 6. Globally there are more than 50 well developed knowledge economy regions M.Hinoul
  • 7. Source : Harvard Business Review July-August2012 – p.26 M.Hinoul
  • 9. “Third Generation Universities” Some examples Stanford University, Palo Alto Cambridge MIT KU Leuven
  • 10. Massachusetts Institute of Technology - MIT  February • • • • 2009: 25.800 companies founded by MIT alumni 3.3 mi employees Annual sales : 2 trillion $ 17th largest economy in the world Estimated Number Of Companies Founded By “Foreign” MIT Alumni  Impact on ecosystem: • < 10% MIT students are from Ma state BUT: > 30% firms started in Ma by MIT Location Total United States 2,340 alumni > 50% firms started by foreign students are located in the US Europe 790 Latin America 495 Asia 342 • Source: Bankboston Report (Kauffman Foundation) Vannevar Bush M.Hinoul
  • 11. Stanford University at the basis of Silicon Valley  Leland Stanford governor of California    1887 first stone of the university 1891 (March 22) opening – 559 students David Starr Jordan – first rector  Frederick Emmon Terman      Start setting up companies such as Hewlett Packard, Varian, etc. Build the first research parks First Venture Capital which became later the famous Sand Hill venture capital Road 27 Nobel Prizes, a lot of National Medals and other distinctions Silicon Valley – more than 8000 high tech companies – hundred thousands of new jobs M.Hinoul
  • 12. Regional Knowledge Economy It all started with professor Fred Terman at the Stanford University in 1939
  • 13. Silicon Valley today A State of Mind
  • 14. Silicon Valley – A complex Network of Clusters Clean Technology Route 101 – Route 280 - State of mind Silicon Valley Joint Venture Network Stanford University – UCSF - Berkeley VC – Kleiner Perkins Caulfield…NASDAQ 2005 2000 Nano-electronics-Bio Silicon Internet – Google – e-Bay –YahooAmazon.com - Facebook Networks – Cisco - Juniper (Bosack,Lerner& Troiano -1984) Software -Oracle 1980 Computers – Apple Computer - Sun 1975 Semiconductors – Shockley –-Intel 1955 1939 Electronics – Hewlett Packard Varian Stanford – Fred Terman M.Hinoul
  • 15. The Power of Silicon Valley Cies 2012 Rank Company Market Value Bn $ March 31 2012 2012 Sales – Bn $ Net Profit – Bn$ 164,7 42 416 2012 1 Apple 2 Hewlett-Packard 119 -12 46 3 Intel 53 11 108 4 Google 51 10 262 5 Cisco Systems 47 9 111 6 Oracle 37 10 152 7 eBay 14 3 70 8 Synnex 10,3 0,159 1,4 9 Gilead Sciences 10 2,6 75 10 Applied Materials 8,1 - 16 514 88 1258 Total *GDP Be 444 Bn $ GDP Netherland 743 Bn $ Source: Silicon Valley 150 The Mercury News – May 2013 M.Hinoul
  • 16.
  • 17.
  • 18.
  • 19. The “Echoes” of Silicon Valley are Everywhere
  • 20. Cambridge An Ancient yet Hi-Tech and Modern City 804 year old University
  • 21. The Cambridge Phenomenon 50 years young  5,000 companies founded since 1960  1400 truly “HiTech”companies today. 2,500 Total Tech.  45,000 jobs  Ten $1 billion dollar companies  Two $10 billion dollar companies  Roads, airports, guided bus, rail transportation  Attracting up to 20% of European Early Stage VC
  • 22. Key Components of the Entrepreneurial Eco-system Cambridge University MRC Laboratory of Molecular Biology Cambridge Interactive System Sinclair Radionics 1960 CCL CAD Centre Sinclair Research Ltd Barclays Bank 1970 Analysys Cambridge Science Park Olivetti Research Laboratory (acquired by AT&T in 1999) Seiko Epson Research Lab PA Technology 1980 CHASE Unilever Cambridge Centre for Molecular Informatics Cambridge Capital Group Cambridge Angels EPSON St. John Innovation Centre CUE, Biology in Business Cambridge Research and Innovation Ltd (CRIL) Cambridge Network 1990 CfEL (previously CEC) 3i Babraham Bioincubator Enterprise Link Scientific Generics The Technology Partnership TTP Hitachi BP Cambridge Institute of Laboratory The Wellcome Biotechnolog y Trust Sanger Cantab Pharmaceuticals GEIF Institute of Manufacturing 2000 Philip s Nickerson Biotech Laboratory Eicon Research Ltd Acorn Judge Business School Cambridge Toshiba Gateway Cambridge Research ET Capital Laboratory Glaxo Cambridge Enterprise Glaxo Institute of Applied Pharmacology ERBI Avlar Amadeus Capital Partners Library Granta Park House Cambridge Create Research Partners Park CMI Microsoft Research (previously Entropic Research) TTP Ventures
  • 23. The hi-tech start-ups and Networks associated with the Cambridge University RealVNC Virtual Network Merged with Andy Hopper Level5Network Computing Globespan Andy Hopper Steve Pope Ubisense Andy Hopper Peter Warton Andy Hopper Cambridge Andy Hopper Andy Ward Broadband IPV (Telemedia Hermann Hauser Acquired by American Pete Acquired by AT &T Systems) Andy Hopper Microwave Virata(ATML) Steggles Adaptive Simon Elliott David Cleevely VBN online Splashpower Acquired by Western Multiplex Hermann Hauser Corp Broadband TerraPrise Amadeus Capital Partners Hermann Hauser Tensails nCipher Mike Muller Richard Green Alex van Someren Andy Hopper Acquired by Tudor Brown Acquired by Nicko van Someren Broadcom ARM Jamie Urquhart Lily Chang GE ANT Element 14 Icera Acquired by Richard Green Small Alex van Someren James Hay Olivetti Stan Boland Stan Boland Authur Chance World Nicko van Someren Simon Knowles Simon Knowles Dick Newell Cambridge Interactive Systems Part of DAKO DakoCytomation John Snyder Dick Newell, Tom Sancha Diagnostics Merged with Webtop Acorn Charles Lang Hermann Hauser, Chris Keightley Cytomation Inc Hermann IQ Bio Shape Data Peter Duffett-Smith Smartlogik CAD Hauser Netchannel Acquired by CPS Hermann Hauser Acquired by Dialog Hermann Hauser NTL Top Jack Lang Cambridge Jack Lang Electronic Share Jack Lang express University Information Olivetti Research Lab Muscat John Snyder Martin Porter Enterprise Accelerator John Snyder Cambridge Adam Twiss Zeus Semiconductor David Reeves Technology Gehan Amaratunga Pilgrim Beart Florin Udrea ActiveRF Laser-Scan Analysys R. O. Frisch David Cleevely Adam Twiss Bryan Amesbury Antenova Pilgrim Beart Richard Friend Plastic Logic 1986-1990 ART Polight Technologies Stephen Elliott Pavel Krecmer version (Sept 2005) – not to be used or copied without permission Copyright – Y.M.Myint - y.myint@jims.cam.ac.uk, Dr. Shailendra Vyakarnam s.vyakarnam@jims.cam.ac.uk David Cleevely Cambridge Hermann Hauser Network Alec Broers 1991-1995 Collin Ager Garraint Davies Innovia 1996-2000 Acquired by E* Trade Richard Friend Until 1985 Daniel Hall Saviso Group CDT Cambridge 3G David Cleevely M-Spatial 2001-2002 Adrian Cuthbert Jon Billing
  • 24. And a similar Network for Biosciences Acquired by Becker Underwood Merlin Biosciences William Bains Chris Arakis Greg Winter John Caldwell Iain Cubitt Evans Changed its name Merged with Pestex Diversys Andy Amedis to MicroBio Group Xenova Cyclacel Richards RiboTargets pharmaceutic Group Ltd Microscience Vernalis al Merlin Ventures Simon Sturge Ark Therapeutics Chris Evans Chris Evans Iain Cubitt Martin Davies Acquired by Vectura Celsis Axis Genetcs Toad Greg Winter Chris Lowe Prometic ReNeuron Chris Evans Cerebrus BioRobotics Daivd Chiswell J. McCann Biosciences Biovex ChiroTech Chris Evans CAT Inc Chris Evans Cambridge Chris Evans Rapigene Celltech Alan Munro Sensors Chris Lowe Enviros Smart Enzymatix Cantab Merged by Chris Evans Chris Lowe Holograms Pharmaceuticals Celltech Chris Lowe Ken Jones Chiroscience MRC LMB Affinity chromatography Group Chris Evans Genzyme Chris Lowe 1960s Purely Daniel Roach Alan Goodman (UK) - AGC David Bailey LiDCO Proteins Alan Goodman 1985 1984 Philip Dean Terry O’Brien Alan De Novo Cambridge CeNes David Bailey AdproTech Alan Goodman Goodman University Alan Peter Lachmann CORE ATM Biotica Technology Goodman Until 1985 Alan Peter Leadlay Goodman Kudos Jim Staunton Daniel Roach Oxford Pharmaceuticals Alan Alan Bimedica . Mark Bodmer Stephen Jackson Hexagen 1986-1990 Goodman Acquired by Incyte Peptide Goodman Avlar Therapeutics Metris Lorantis BioVentures Alan Goodman Mark Bodmer Now Acambis Therapeutics 1991-1995 Daniel Roach Amura Paradigm Stephen Smith Salix Alan Therapeutics Steve Charnock-Jones pharmaceutical Holometrica Mark Carlton Goodman Astex Abcam Roger Millington Solexa Alan Sense Technology Jonathan Milner 1996-2000 Shankar Goodman Proteomics Tom Blundell David Cleevely Balasubramanian Jonathan Blackburn Jonathan Milner Chris Abell David Klenerman David Cleevely Harren Jhoti Paul Goldsmith Akubio Cambridge Theranostics MC Ivan Petyaev Daniolabs David Klenerman, Tony Minson 2001-2002
  • 25. Leuven, a region for innovation & high-tech entrepreneurship
  • 26. The Leuven Region Close to Brussels Leuven Region: 95.000 habitants Airport Brussels Leuven
  • 27. An old young city
  • 28. The Leuven Case Education Research Foundation KU Leuven Brewery Den Hoorn Stella AB Inbev Famous researchers • Mercator • Vesalius • Frisius • Ortelius Exploitation research KU Leuven R&D Transfer Office Stanford University (1891) Fred Terman-1939 Hewlett, Packard,Varian(s) IPTEC Price IMEC • 137 spin offs • 300 tech companies • 7000 researchers • 7000 high tech jobs • Research Parks • Incubators M.Hinoul
  • 29. University Leuven IMEC Knowledge Centers 664 mi€ R&D, 6400 Researchers High Tech Industrie 300 Technology Cies, 135 spin offs Life Sciences Nanotechnology Mechatronics Cleantech Clusters Technology Platforms Haasrode Arenberg Leuven Noord Genk THOR Tienen FFH Research Parks Networks M.Hinoul
  • 30. KU Leuven Research & Development Technology Transfer Office A Bridge between research and industry
  • 31. K.U.Leuven Research & Development received the 2008 IPTEC Tech Transfer Award Nominated: •K.U.Leuven R&D (Winner 2008) •Columbia University (USA) •Imperial Innovations (UK) •MIT (USA) •Wisconsin Alumni Research Foundation (USA) Received the award : •2006 : Stanford University (USA) •2007 : Tsinghua University (China) © 2007 LRD
  • 32. LRD: Mission “Promoting and supporting knowledge and technology transfer between university and industry” Researchers • Research collaboration • Spin-offs and regional development • IP protection and licenses Companies
  • 33. What is LRD? • LRD consists of: o Central multidisciplinary staff • Supports researchers in knowledge and technology transfer o Research divisions • 1,422 researchers & 397 supporting • Embedded in university via matrix structure • Virtual organisations in which (groups of) researchers (from different faculties or departments) can group their applied research, commercialindustrial and exploitation activities.
  • 34. Intellectual property • What do we do? o o o o o o o Creating awareness and transferring knowledge Assessing the feasibility, patentability and market potential of an invention Determining a protection strategy Drafting and filing a patent application Following up on patent procedures and costs Negotiating and drafting NDAs, MTAs and license agreements Finding industrial partners
  • 35. LRD research divisions Faculties, departments, research groups: quality in research and educational activities LRD divisions/projects: Contract and budgetary autonomy and flexibility incentives
  • 36. Organisation Management (2) Research collaboration (17) • advice • contract R&D • projects with government support (IWT, EC, etc.) Intellectual property rights (12) • intellectual property rights • licensing Spin-off & innovation (9) • spin-off creation & growth • networks & regional development • KU Leuven Association Finance, HR & logistics (39) • financial administration • HRM administration • Close interaction and collaboration between different units • Regional and international networking
  • 37. Activities • • • • • Research collaboration Protection and exploitation of intellectual property Spin-off creation & innovation Support of regional development Stimulation of entrepreneurship through network initiatives
  • 39. Research collaboration • Oldest activity of LRD • Performing research & services for companies or governments • What do we do? o o o o o o o Creating awareness and transferring knowledge Providing advice Negotiating contracts Following up on contracts Managing research files financially Offering administrative support Preparing legal documents
  • 40. Contract Research thousands € 160.000 160.000 € 140.000 144.802 126.807 € 120.000 121.653 € 100.000 97.844 87.908 € 80.000 70.193 € 60.000 54.332 € 40.000 € 20.000 €0 2004 2005 2006 2007 2008 2009 2010 2011
  • 41. Intellectual property • Internal specialised office: protection and exploitation of intellectual property rights • Network of formal collaborations with different European patent attorneys • Patent Fund: selective support of research groups to help them cover their initial costs and expenses related to patenting needs
  • 42. Intellectual property • 156 patent applications in 2011 o o 496 active patent families 49 PCTs In numbers 2011 Reported findings 154 Priority submissions 156 New patents 33 • 60 million euro license-income (71 million in 2012) • Attributed patent is often the basis for setting up a spin-off company
  • 43. Spin-offs & innovation • What do we do? o o o o o o o o o Developing business plans Validating business models and the market Offering legal support Putting together a competent team Finding investors Finding infrastructure Managing growth of spin-offs Promoting valorisation and entrepreneurship Stimulating regional development, networks and clusters
  • 44. Definition of a Technology Cluster Network relatedCies (VC, Seed, IP, Legal..) Mixed Innovative Cies Knowledge Centers Attraction Innovative Cies Creation Innovative Cies M.Hinoul
  • 45. Mechatronica Kenniscentra Stas Ora Machines Centers of excellence ACE Electronics WTCM Optidrive Air Beraing Prec. Techn. Barco Aarschot Partec Eng Alnaco B.E.S.T. Materialise Electrical & Mech. Design DV Consulting IPCOS K.U.Leuven Dept. Mechanics Researh groups Metris Somatech Krypton Dynamotor Decoster Luyten Automation KULeuven SST Food Mach Atos Engineering Pure innovatieve bedrijven Camco Techn Flexlink Systems PEC EME K.U.Leuven Dept of Metall. & Mater. Eng Lab Agric Mach & Proc Entecom Systems Tecmate Intl. D2S International M&M Corporation Data Analys Products CSI Scala Consultants Mixed innovatieve bedrijven Donaldson LMS South Lancs Belgium Affilips Robert Bosch
  • 46. Life Science Cluster Kenniscentra E.S.R.I. Deckers Div Dermat Centers of excellence Biotest Seralco Benelux Thrombogenics Tigenix Norgine IDT(RNA-TEC) Dakocytomation BioTie Therapies Corp. Univ hospitals K.U.Leuven Rega Institute CEHA Algonomics PatientWeb Medvision Benelux Puur innovatieve bedrijven Gemengd innovatieve bedrijven M-Elect M4S Materialise K.U.Leuven L-MTC Autocyte Europe Neurogenetics @Medical Techn. MXS VIB VIGOUR Custom8 Fugeia Malaise&co Terumo Europe Cochlear Lab of Exp. Genetics & Transgenese QMedit IVIA ReMynd Medicim CMPG Centocor Diatos Onco Methylome Regenesys New Standard Eng. Formac Pharmaceuticals VWR International Ortec Conti BPC
  • 48. Much more than the 3 % Lisbon target
  • 49. HIGH TECH SYSTEMS & MATERIALEN Specialisatie en pieken: Selectie en typologie belangrijkste actoren TTR Nederland Nederlandse Vereniging voor Precisietechnologie Vereniging van de Nederlandse Chemische Industrie DSP Valley Sirris DAF nv Graco Siemens VDO Kenniscentra en centers of excellence Bosch Packaging FMTC (mechatronica) Vista nv Philips Chemelot Alro Holdings Ford Werke Bosch Hydraulic LAG Trailers Borealis Polymers Akzo Nobel Pure innovatieve bedrijven Netherlands Aerospace Group (NAG) ATC Eindhoven Mixed innovatieve bedrijven Océ Stork food systems en printing Campus Eindhoven Cerobear Verband der Chemischen industrie (VCI) KUL KUleuven UImec Hasselt Philips (licht)/ Philips Onderzoeksinstituut Trützschler FEV Motorentechnik Cluster Chemie/ Kunststoffe Mitteldeutschland INTRA e.V. * Internationaal netwerk: Automotive.net Tessenderlo chemie Forschungszentrum Jülich RWTH Hochschule Aachen Niederrhein Continental Schumag AG Spaas Kaarsen Prüfcentrum Siemens transportation Systems Agoria Heraeus Electro-Nite International Flanders Drive Oerlikon Textile Scheidt & Bachmann 3M Netwerken* DOW Belgium U Luik U Hasselt U Fraunhofer Institut Luik Siempelkamp FLAMAC (materialen onderzoek) Epiq Imec Philips DSM ASML Nederlandse vereniging voor rubber en kunststoffen Campus Geleen Nedcar Vanderlande Industries TTR België Walonie Espace Pierberg Voith Paper AUNDE Verband der Elektrotechnik (VDE) Munters Euroform CAR e.V. Verbundinitiative Automobil Nordrhein-Westfalen (VIA NRW) TTR Duitsland 49
  • 50. K.U.Leuven Spin offs 100 90 80 70 Gemma Frisius-Seed Capital 2x 12,5 m€ 60 50 40 30 20 10 0 1980 1982 1984 1986 1988 1990 1992 1994 1996 1998 2000 2002 2004 2006 2008 2010 2012
  • 51. Spillovers and multipliers • Spin-offs between 2006 - 2010: – K.U.Leuven direct investments: 4,7 M€ – Gemma Frisius Fund investments: 12 M€ – Other third party investments: 476 M€
  • 52. Perennial topics Investment in spin-offs 2005 - 2012 700 000 000 631 426 634 Euro 600 000 000 500 000 000 400 000 000 300 000 000 200 000 000 100 000 000 7 453 606 14 591 843 KU Leuven GFF 0 derden
  • 53.  Seed Capital – Venture Capital – 500 million € Risicokapitaal Arr. Leuven (2002) : 200 miljoen euro Servifund 12% Gemma Frisius Fonds 1 7% Stonefund 19% Beluga 12% Softw are Holding & Finance 8% Gemma Frisius Fonds 2 7% IMEC Incubatiefonds 3% Capricorn Venture Partners 12% Quest Management 20%
  • 54. Spillovers and multipliers • Patent portfolios: – K.U.Leuven R&D, 454 active patent families of which 90% economically exploited – Multiplier effects of patent portfolios of spin-off companies  sectoral multipliers of 3 to 4
  • 55. Examples in Life Sciences KU Leuven
  • 56. Spin-off companies: some examples • Engineering • Micro-electronics & ICT
  • 57. Spin-off companies: examples • Consultancy • Biomedical
  • 58. Incubation & seed financing • Gemma Frisius Fund KU Leuven (GFF) o o Seed capital for spin-off companies GFF founded in 1997 & GFF II in 2002 • o At the end of 2009 GFF and GFF II merged into one single fund Partners: • • o KU Leuven (20% of capital) Two banks: KBC Private Equity (40%) and BNP Paribas Fortis Private Equity (40%) Combination between: • • o o Knowledge and technology transfer expertise (university) Financial expertise (financial partners) Not restricted to one technology domain 25 million euro invested in 38 spin-off companies
  • 59. Regional and interregional development • Partners: o o o o o o o o City of Leuven Province of Flemish Brabant Vinnof CREA - European Commission KBC Private Equity BNP Paribas Fortis Private Equity imec VIB • ELAt: Eindhoven - Leuven - Aachen triangle o o Cross-border and interregional network Stimulation of knowledge economy • HAE : Health Axis Europe (Heidelberg, Leuven, Cambridge)
  • 60. Networks • Stimulating knowledge exchange and partnering with other high-tech businesses (both SMEs and large companies) and innovation actors • Horizontal networks: o o Leuven.Inc Flanders Smart Hub
  • 61. Networks • Vertical networks: o o DSP Valley LSEC • Thematic centres: o o o o o o o CD3 L-MRC L-MTC LICT PharmAbs NERF LFoRCe
  • 62. Science parks, business centres & incubators • • • • • • • • Arenberg Science Park Haasrode Science Park Leuven Noord Science Park Waterschei - Genk Science Park Tienen Science Park Ubicenter Remy Campus Leuven Business Centre
  • 63. Science parks, business centres & incubators • • • • Leuven Bio-Incubators Tienen Biogenerator KU Leuven Innovation & Incubation Centre (I&I) Kortrijk Innovation & Incubation Centre (IICK)
  • 65. 12 Lessons from Leuven 1. Basis is a critical mass of high quality research 2. Create an appropriate entrepreneurial climate in a university context 3. Create a legal framework with respect to exploitation of academic research 4. Clear incentives and policies to encourage research groups and departments to actively seek knowledge transfer opportunities 5. Create a professional Interface Unit – An Integrated approach on research valorisation: multidisciplinary team & “high value” services 6. Create a Seed Capital and/or Venture Capital Fund
  • 66. 12 Lessons from Leuven 7. Foster spin-offs from your university research 8. Clear ownership of Intellectual Property 9. Improving awareness among federal, regional and local shareholders 10. Supporting a forum for business, academia, government and supporting organisations to build partnerships by sharing new ideas and best practices. Importance of the networks. 11. Focus on Focus and Enthusiasm 12. Quality of life
  • 67. Success factors • A critical mass of high quality research • Multidisciplinary team & high value support • Clear incentives to encourage researchers and research groups • Favourable entrepreneurial climate within the university • Legal context in Flanders • Instruments and networks that further professionalise technology transfer support
  • 68. Towards an Entrepreneurial Society    “The rise of the entrepreneur is not just about economics. It reflects profound changes from individual careers to the social contract. It signals the birth of an entrepreneurial society” -The EconomistMarch 14, 2009
  • 69. The Value Chain is the barometer 1. Knowledge Centers 2. Entrepreneurs 3. Role Models 4. Money 5. Capital Markets 6. Infrastructure 7. Cluster Policy 8. International Companies 9. Networks 10. Government 11. Quality of Life Source : Hinoul, Gibbons, Saxenian
  • 70. What makes a region attractive for talent?  Location – such as Silicon Valley, California – Sophia Antipolis, Mediteranée – Heidelberg Old University  Universities or Research Centers - Magnets for talent See Jiao Tong University League e.g. Stanford, Harvard, Princeton, IMEC Leuven, LETI Grenoble, CERN Geneva.  Presence of top Succesful Companies Microsoft, Intel, Google, ASML, LMS…  Presence of Strong Individuals – Role Models Bill Gates, Steve Jobs, Larry Page and even Nobel price winners.  Presence of Successful Clusters San Diego Biotech-Golden Triangle – North Carolina Research triangle  Fiscal System – Salaries, tax incentives, research budgets  Quality of Life – Leisure, Housing, Medical care, International schools, culture… Source: M. Hinoul – 7th Annual Conference – Technopolicy Network – Heidelberg 2010
  • 71. Towards a new Form of Culture All things are possible attitude Risk Taking We have not enough spin-offs who fail Co-competition Stock options Based on Meritocracy Serial Entrepreneurs Time for the next big thing CULTURE Cross-pollination Inflection Point (Andy Grove) Cross-investments State of mind Networking Jumping on the Next Curve (Oracle) Failure Badge of merit Source : M. Hinoul ±
  • 72. Flemish Entrepreneurs The old generation Leo Leander Bekaert Lieven Gevaert Leo H. Baekeland 75
  • 73. Flemish Visionaries Gaston Geens John Cordier Paul Janssen Roger Van Overstraeten Marc Van Montagu Walter Fiers 76
  • 74. Leuven Entrepreneurs A new generation . A.OOSTERLINCK J. DEJAEGER D. COLLEN P. STOFFELS S. BIJNENS U. VAN DEURZEN J. CALLEWAERT B. VAN COPPENOLLE F. VAN CRAEN T. DE PROFT
  • 75.
  • 76.
  • 77. Speech recognition Data screening Micro electronics Cloud computing Components Interplanetary Space Flights Ground Navigation Suborbital Space flights Small satellites Platform & pay load Nuclear Medicine Medical devices Drug Delivery Bio Informatics Stemcells Interdisciplinary Research Clusters and Research Directions Confidential-M.Hinoul
  • 78. Clusters and Interdisciplinary Research at Skolkovo Director TTO  Research Collaboration  IPR(Royalties,Licencing)  Spin offs – Start ups  Finance (Seed, VC, IPO) 5 Research Programs (Clusters) Research Centers Interdisciplinary approach A close interaction between different research divisions Technopark (a state of the art infrastructure) Russian & International Cies Russian & International Research Centers
  • 79. Dual Incentive Mechanism Russian & International Universities Russian & International Cies SIST Technopark  Striving for scientific excellence  Gearing this excellence towards application and technological innovation Creation of the Knowledge Economy Region Skolkovo
  • 80. Contact KU Leuven Research & Development (LRD) Waaistraat 6 – box 5105 3000 Leuven, Belgium Tel.+32 16 32 65 00 lrd@kuleuven.be lrd.kuleuven.be