Dur­ing Expo Day selected Sum­mit Spon­sors show­cased their lat­est ini­tia­tives and solutions: -- Bay­crest: Meet the new $100m+ Cana­dian Cen­tre for Aging and Brain Health Inno­va­tion, with Dr. Randy McIn­tosh, Vice-president of Research and Direc­tor of Baycrest’s Rot­man Research Institute. -- Lumos­ity: Dis­cuss emerg­ing stan­dards for cog­ni­tive research with Dr. Glenn Mor­ri­son, Direc­tor of Clin­i­cal Trials. -- Brain­Base­line: Explore the lat­est in mobile cog­ni­tive assess­ments with Joan Sev­er­son, Pres­i­dent of Dig­i­tal Artefacts. -- Help improve and expand The Sharp­Brains Guide to Brain Fit­ness with co-author Alvaro Fernandez. Presentations @ The 2015 SharpBrains Virtual Summit http://sharpbrains.com/summit-2015/agenda

1. Expo Day

2. 2CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
PRESENTED TO
SharpBrains
November 19, 2015
Dr. Randy McIntosh
Vice President, Research

3. 3CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
THE GLOBAL CHALLENGE
• 47.5M people with dementia now
• 1.1 billion more seniors globally by
2050; 135.5M of them will have
dementia
• Dementia leading cause of disability
among Canadian seniors

4. 4CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
NO CURE, BUT HOPE
• Research
• Lifestyle strategies
• Early diagnosis/intervention
• Quality of life

5. 5CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
OPPORTUNITY
• Senior care and brain health markets
• Senior care projected worth $319 billion in US
by 2016
• Brain health applications, software, biometrics
projected growth to between $4 and 10 billion by
2020

6. 6CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
BARRIERS TO INNOVATION
Lack of:
• Focus
• Test environment
• Evidence
• Supporting resources
• Lead customer

7. 7CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
OPPORTUNITY
Senior care and brain health markets
• Senior care projected worth $319
billion in US by 2016
• Brain health applications, software,
biometrics projected growth to
between $4 and 10 billion by 2020

8. 8CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
Canadian Centre for Aging and Brain Health
Innovation (CC-ABHI)
VISION
A world in which people can age in the setting of their choice,
maintaining their cognitive, emotional and physical well-being, and
independence as long as possible
MISSION
To accelerate: development, validation, commercialization,
dissemination and adoption of innovative products, services and
best practices to support brain health and aging

9. 9CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
FUNDING
Over next 5 years
• $42M Government of Canada
• $23.5M Government of Ontario
• $33.1M Industry & Public Sector
• $25M Donors

10. 10CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
PROGRAM AREAS
DEVELOP
Innovative
Solutions
DISSEMINATE
Knowledge &
Best Practices
TEST
Products in
Real-World
Settings
CC-ABHI

11. 11CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
DEVELOP
Solutions to enhance aging
• Translate basic research into real-world
technologies, solutions and applications
• Become a catalyst for commercialization of
technologies and solutions in this sector

12. 12CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
TEST
Support companies and other innovators to
demonstrate, test and improve products and
processes targeting aging adults and the mental
or cognitive health of seniors
• Healthcare organizations, governments,
physicians won’t invest without evidence.
• CC-ABHI offers a population of elders and
expertise in testing methodologies and
generating evidence

13. 13CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
DISSEMINATE
Disseminate solutions by providing
services to drive adoption and scalability
• Innovations and knowledge offered to
all partners within CC-ABHI’s network
• Experiential training, telemedicine, e-
learning modules ensure wide
adoption of validated solutions

14. 14CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
COLLABORATION MODEL

15. 15CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
INNOVATION PIPELINE
INNOVATION

16. 16CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
PARTNERS TO DATE

17. 17CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
Seniors Quality LEAP Initiative (SQLI)

18. 18CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
Thank you
Dr. Randy McIntosh
Vice President, Research
rmcintosh@research.baycrest.org

19. 19CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
Summit is on break.
(we will resume at 11:15am Pacific Time)

20. Privileged & Confidential
Lumos Labs, Inc.
Lumos Labs
SharpBrains Summit
19 November 2015
Glenn Morrison, PhD

21. LUMOS LABS, INC.
Our Mission
• Create and validate training tools that aim to improve cognitive
abilities
• Create and validate assessment tools to measure cognitive
performance
• Advance the pace of cognitive science research
• Expand the understanding of the human brain

22. LUMOS LABS, INC.
HCP Researcher Ecosystem
• Includes university-based researchers, industry partners,
educators, clinicians, and study volunteers
• Research areas include:
• brain injuries and rehabilitation
• chronic conditions
• diseases and disorders
• data science projects
• education and learning
• exercise and athletics
• cognitive change in healthy adults

23. LUMOS LABS, INC.
Problem Statement for
Brain Training Industry
➡ No clear agreement on the core elements that need to be included
in any study of CCT in order to demonstrate clear evidence of
efficacy (statistical improvement) and effectiveness (real-world
relevance)
• ‘Stanford’ Statement
• Statement released by The Stanford Center on
Longevity and the Berlin Max Planck Institute for
Human Development
• Signed by 70 largely academic researchers
• Finds that claims promoting brain games are
frequently exaggerated and at times misleading
• Encourages continued careful research and
validation in this field
• Open Response Letter
• Open Letter published and signed by 127
neuroscientists, psychologists, and other experts in
the field of neural plasticity
• Disagrees with the consensus
• Does not agree that “there is no compelling
scientific evidence” that brain exercises “offer
consumers a scientifically grounded avenue to
reduce or reverse cognitive decline.”
• Expressed concern that many readers of the
Stanford statement might wrongly conclude that
there is no evidence that any cognitive training
regimen can improve cognitive function

24. LUMOS LABS, INC.
Call to Action
• Bring together CCT industry leaders, academics, and experts in
the field
• Review and discuss current state of computerized cognitive
training research
• Reach consensus on the standards for conducting adequate and
well-controlled studies to support efficacy and effectiveness
• Publish consensus paper that those in the field can turn to for
guidance

25. LUMOS LABS, INC.
Open Questions for Consideration
• What is the best control condition?
• Active control?
• Passive/no-contact control?
• What is the optimal training regimen?
• How many times/week?
• How many weeks?
• Requirement for booster?
• Requirement for maintenance of effect?
• What are the best outcomes
• Measuring cognition
• Computerized assessments vs pencil/paper
• Remote vs in-clinic
• Measuring function
• Self-reported outcomes
• Performance based outcomes
• Other

26. LUMOS LABS, INC.
How to Get Involved
• An Industry effort and not a Lumos/Lumosity effort
• Currently generating list of experts to reach out to and plan for an
initial meeting in early 2016
• Small group first in an effort to identify key principles and agree on
major themes
• Plan for larger meeting in Q1 2016
• Interested? Contact glenn@lumoslabs.com

27. LUMOS LABS, INC.
Privileged & Confidential
Lumos Labs, Inc.
70 Million Bright Minds

28. LUMOS LABS, INC.
Summit is on break.
(we will resume at 12pm Pacific Time)

29. Joan Severson,
President of Digital Artefacts

61. Summit is on break.
(we will resume at 12:45pm Pacific Time)

62. Alvaro Fernandez
@alvarof

64. Remember the opportunity…
Improve
performance Delay
decline

65. …but, no one shoe fits all
AGE
PERFORMANCE
25 50 75 100
PERFORMANCE
AGE

68. Japanese edition in 1-2 months
(Hankyu Communications)

69. Source: The SharpBrains Guide to Brain Fitness (second edition)

70. Example: Cells that fire together
wire together

71. Example: Don’t need to be a
car mechanic, but…

72. Example: Mental activity
vs. mental exercise
Source: Maguire, Woollett, & Spiers, 2006

73. We better start educating
users and professionals

74. "A stimulating, challenging resource, full of solid
information and practical tips for
improving brain health." –Kirkus Reviews
"On a personal note, I have to say I wish I had
read this awesome guide when I was much
younger.” –Scientific American
"...nice to see the new book…where all of the
relevant information is in one place." –Greater
Good Science Center at UC-Berkeley
à Amazon + Libraries

75. • Getting to more readers
• Book or another format
• “Brain Fitness” or “Invest in your Brain”
• Science-help vs divulgation vs self-help
• Start or end with Jigsaw
• Role of interviews
• Questionnaire/ quiz?
Brainstorming

76. Sponsors
Thank you

77. To learn more, visit sharpbrains.com