1. SEPSIS Sepsis is generalized infection, which forwards by bacteremia on lowering of protective forces of organism. This problem is not only surgical, but also generally biological, because during the last years the new approaches appeared to understanding of its pathogenesis. They are in the new interpretation of general mechanisms of violation of homeostasis and inflammation. The frequency of sepsis does not fall down though the huge antibacterial therapy is used. 75000 patients die yearly in Germany. 50000 cases registered in the USA every year. Mortality consist 30-80%. Home statistics is absent to great regret.

5. The phases of the development of the generalized infection Local inflectional focus Purulent resorptive fever Recovery Syndrome of the systematic inflammatory answer Septicemia Lethal result Chronic sepsis Septicopyemia 1. 2. 3. 4. 5.

6. In according to coordinate conference on sepsis (Chicago, 1992) the development of sepsis is interpreted something otherwise: Local focus of infection Syndrome on the systematic inflammatory answer Sepsis Difficult (heavy) sepsis Septic shock Poly-organ insufficiency Lethal result (fatal termination)