1. Questions asked in previous years
• (1)What are application of solubilization technequies & how will you
compare the effeciency of each technequies with respect to its
application(2008)
• (2)Cyclodextrin(2008)
• (3)What do you mean by fast dissolving product?Write mechanism for
obtaining these product(2008)
• (4)Advantages & disadvantages of different technequies to improves
solubility of API(2005;08)
• (5)factors affecting solubility & dissolution rate(2006;LM-06)
• (6)How will you carried out solubilization study in preformulation(06; LM-06)
• (7)Explain Dankert’s models of soubility(2006; LM-06)
• (8)Elimination rate differ in various condition –Justify the statement using
Michales Menton equation(2006; LM-06)
• (9)With respect to drug-cyclodextrin complexation Explain the calculation of
USD with suitable example(2005;LM-04)
• (10)Describe the different method of preparation of beta-cyclo dextrin
inclusion complex(2004)
1

2. (1)Michaelis Mentons equation(LM-08)
(2)How vitamin use as solubilizer(LM-04;07)
(3)Discuss use of salt formation ,surfactant,adducts,clathrates in
solubilization of poorly soluble drug(LM-07)
(4)What make drug insoluble & why we want to solubilized them?(LM 06)
(5)How can you express solubility in different term?(LM-06)
(6)What do you mean by combined technequies of solubilization Explain
one of them in detail(LM-06)
(7)Give conventional & patent technequies of getting fast dissolving
product(LM-06)
(8)Discuss factor to be considered in selecting PH for adequate solubility of
API(LM-06)
1. Micronization as a solubilization technequies(LM-04)
(9)Which are newer approaches in micellar system(LM-04)
(10)Bioavailability of poorly soluble API is challeng to formulation scientist-
Discuss physical & chemical modification to solve this (LM-04)

3. (11)SHORT QUESTIONS:-
1. Explain complexation constant(LM-04)
2. Fast dissolving product (LM-04)
3. Quick dissolving films(LM-04)
4. Combined effect of PH & polysorbate with cyclodextrin on solubilization
with suiable example(LM-04)