Presentation held by Dr. Hermann Stuebler, Head of Weed Control Research and Dr. Harry Strek, Head of Profiling and Market Support – Weed Control Biology at a workshop dedicated to Weed Resistance at the Bayer CropScience Annual Press Conference 2013 in Monheim, Germany.

1. Weed Resistance Management
Dr. Hermann Stuebler – Head of Weed Control Research
Monheim, Germany │September 5, 2013

2. Effective weed control:
Essential for global production of food and feed
• Annual Press Conference 2013 • Weed Resistance Management • September 5, 2013Page 2

3. But current agricultural practices are resulting
in weed resistance
Page 3
Growing exponentially at a global scale –
in all crops and all continents
Both broadleaf weeds and grass weeds
Increasing resistance to multiple herbicide classes
Effectiveness of numerous herbicide classes endangered
Continued decline in herbicide diversity
A paradigm shift in weed control is urgently required
• Annual Press Conference 2013 • Weed Resistance Management • September 5, 2013

4. Glyphosate resistance today threatens
US crop production
Page 4
… caused massive development
of weed shifts and resistance
Dose rate x 2 x 16x 4 x 8
The exclusive reliance
on Glyphosate for weed control…
Soybeans 1996 Soybeans 2008
Source: Bayer CropScience
• Annual Press Conference 2013 • Weed Resistance Management • September 5, 2013

5. • Annual Press Conference 2013 • Weed Resistance Management • September 5, 2013Page 5

6. • Annual Press Conference 2013 • Weed Resistance Management • September 5, 2013Page 6

7. • Annual Press Conference 2013 • Weed Resistance Management • September 5, 2013Page 7

8. Fewer new herbicides are coming to market,
while those that remain are becoming less effective
Page 8
Source: Bayer CropScience
Source: Bayer CropScience
• Annual Press Conference 2013 • Weed Resistance Management • September 5, 2013

9. Numerous herbicide target sites discovered,
but more than half did not make it to the market
Page 9
FPPS
ADSS
IMDH
ZDS
IGPD
TrpS
AMPDA
DXR
7StC5Des
24StRed
OSCyc
GPAT CLObtI
C24SMT
KARI
GibB ObtDM
GSAT PyrDeh
LyCyc CBL
CGS
EPSP
ACCase
GS
Cytokinin Ox
PS II
Auxin
PS I
Uncoupling
HPPD
PPO
ALS
PDS
Microtubuli
Cell Division
Cellulose
DHPS
VLCFA DXS
1950 1960 1970 1980 20101990 2000
Discovery of new
development candidates
Source: Bayer CropScience
• Annual Press Conference 2013 • Weed Resistance Management • September 5, 2013

10. And the pipeline for new herbicides is limited
Page 10
20122010 2013 2014
indaziflamthiencarbazone-
methyl and
cyprosulfamide
tefuryltrione triafamone
bicyclopyrone
aminocyclopyrachlor
pyroxsulam
saflufenacil
HPPD PPO Auxin ALS Safener CBI
2009 2011 2015 2016 2017 2018 2019
Halauxifen
Source: Bayer CropScience
• Annual Press Conference 2013 • Weed Resistance Management • September 5, 2013

11. Sharp decrease in weed control research
Page 11
0
50
100
150
200
250
1990 1995 2000 2005 2010
Numberofnewa.i.applications
Dow
DuPont
BASF
Syngenta
Bayer CropScience
Number of new a.i. patent applications published in 2012
0 5 10 15 20
… but Bayer CropScience remains committed
to discovering new herbicides
Industry-wide, a sharp decrease in herbicide
a.i. patent applications…
Source: Bayer CropScience Source: Bayer CropScience
• Annual Press Conference 2013 • Weed Resistance Management • September 5, 2013

12. The next decade to benefit from Bayer CropScience’s
unique and diverse herbicide portfolio…
... and beyond 2020, Bayer CropScience committed to
developing the next generation in weed control technology
Bayer CropScience
All tools to manage challenges

13. Dr. Harry Strek – Head of Profiling and Market Support –
Weed Control Biology
Weed Resistance Management
Monheim, Germany │September 5, 2013

14. How weed resistance develops
Page 14
Normal population
After continued
selection pressure
Resistant population
Development of herbicide resistance in a weed population
Resistance can be delayed through a reduction in the selection pressure
Resistance development is a natural evolutionary process
• Annual Press Conference 2013 • Weed Resistance Management • September 5, 2013

15. • Annual Press Conference 2013 • Weed Resistance Management • September 5, 2013
markets
Understanding key herbicide resistance mechanisms
Page 15

16. Bayer: Global expertise in weed resistance
Monitoring Diagnostics Outreach &
Education
Research &
Development
Molecular diagnostics
Analytics diagnostics
Greenhouse bioassays
In-field investigation &
detection
Extensive expertise &
knowledge base
Global oversight & local
know-how
Breeding & trait
development
Resistance management
New modes of actionMode of Action rotation
Crop rotation
Cultivation methods
Page 16 • Annual Press Conference 2013 • Weed Resistance Management • September 5, 2013

17. Monitoring weed resistance globally
Page 17
Monitoring Diagnostics Research Outreach
 Global Oversight and local know-how
 Extensive expertise and knowledge base
 In-field investigation for detailed understanding
of local situations
• Annual Press Conference 2013 • Weed Resistance Management • September 5, 2013

18. Offering the most extensive diagnostics tests
Page 18
• Facilities for Greenhouse Bioassays and resistance analyses
• Only major company using Pyrosequencing for high quality
and more accurate monitoring data
• Tests in Greenhouse to more accurately mimic field conditions
• More than 3,000 samples analyzed in 2012
• Delivering best possible recommendations to farmers
State-of-the-art facilities from resistance research to diagnostics
Monitoring Diagnostics Research Outreach
• Annual Press Conference 2013 • Weed Resistance Management • September 5, 2013

19. Page 19
Groundbreaking research in weed resistance
At the forefront of weed resistance research
• Development of novel diagnostics technologies
• Genetic control of metabolic resistance
• Global oversight of weed resistance development
~20 cooperations with leading international experts on weed
resistance
• Generating mathematical models to predict resistance development
• Discovering key factors inducing weed resistance to herbicides
Monitoring Diagnostics Research Outreach
• Annual Press Conference 2013 • Weed Resistance Management • September 5, 2013

20. Page 20
Satisfying grower needs beyond 2020
Monitoring Diagnostics Research Outreach
We are developing a new
herbicide class for weed control
and resistance management
• Novel and promising chemical class
of HPPD inhibitors
• Resistance-breaking properties
• Excellent activity @ low doses
• Applicability in all major crops
• Herbicide tolerance traits
in development
• Annual Press Conference 2013 • Weed Resistance Management • September 5, 2013

21. Page 21
Outreach and Education
• Extensive outreach and education programs
in US, Canada and internationally
• Information sharing include
field reports, firsthand evidence of effects
of weed resistance, and advice on action plans
to address the issue
Monitoring Diagnostics Research Outreach
• Annual Press Conference 2013 • Weed Resistance Management • September 5, 2013

22. Protecting farmers’ seed investment and
safeguarding yield with Liberty and Liberty Link
• Liberty herbicide and Liberty Link offer the only non-selective alternative
to glyphosate-tolerant system
• Sustainable weed control:
• Kills weeds in a short timeframe
• A nonselective, contact herbicide with an unique mode of action
that provides post-emergent control of more than 120 broadleaf
weeds and grasses
• Control of ALS- and glyphosate-resistant weeds, including
resistant waterhemp, pigweed, ragweed, and marestail
• So far no weed resistance after > 15 years
in crop use in herbicide-tolerant canola
Fundamental tool for solving existing – and preventing future – resistance problems
Page 22
Monitoring Diagnostics Research Outreach
• Annual Press Conference 2013 • Weed Resistance Management • September 5, 2013

23. Page 23
Diversity is the Future
THE BAYER INITIATIVE
AGAINST WEED RESISTANCE
Monitoring Diagnostics Research Outreach
• Annual Press Conference 2013 • Weed Resistance Management • September 5, 2013

24. Q & A