The document discusses several key topics regarding the chromosomal basis of inheritance: 1) Early experiments transformed views on inheritance by showing bacterial cells could be transformed with DNA from other bacteria, and DNA was found to be the genetic material in viruses. 2) The structure of DNA was determined in the 1950s, with Rosalind Franklin's X-ray crystallography work revealing the double helix structure of DNA, which Watson and Crick modeled based on her data. 3) DNA replication involves separation of the DNA strands and synthesis of new complementary strands, with specific proteins involved in starting replication at the origin of replication site.

1. Chapter 16 The chromosomal basis of inheritance

11. 4: Hershey-Chase experiment ‘Is protein or DNA the genetic material?’

12. 4: Hershey-Chase experiment ‘Is protein or DNA the genetic material?’

13. 4: Hershey-Chase experiment ‘Is protein or DNA the genetic material?’

14. 4: Hershey-Chase experiment ‘Is protein or DNA the genetic material?’

15. 4: Hershey-Chase experiment ‘Is protein or DNA the genetic material?’  DNA is genetic material, not protein

18. 6: Rosalind Franklin X-ray diffraction

19. 5.25: Röntgendiffraction or X-ray crystallography

20. 5.25: Röntgendiffraction or X-ray crystallography

21. 5.25: Röntgendiffraction or X-ray crystallography

22. 5.25: Röntgendiffraction or X-ray crystallography

23. Nobel prize for Watson and Crick Stockholm 1962 Francis Crick Maurice Wilkins John Steinbeck James Watson Max Perutz John Kendrew

24. 7: DNA structure: the double helix

25. 7: DNA structure: the double helix

26. 7: DNA structure: the double helix

29. 9 The basics of DNA replication (a) Parent molecule (c) “Daughter” DNA molecules, each consisting of one parental strand and one new strand (b) Separation of strands

30. 10 Three alternative models for DNA replication

31. 10 Three alternative models for DNA replication Study Figure 16.11 The Meselson-Stahl experiment

34. 14: Incorporation of a new nucleotide

35. 14: Incorporation of a new nucleotide

36. 14: Incorporation of a new nucleotide Energy from triphosphates