The document discusses the 2012 annual retreat of the Clinical and Translational Science Institute (CTSI) at the University of California, San Francisco. It notes that over 260 people attended the retreat, including many campus leaders and panelists. The retreat had a fun agenda aimed at helping CTSI continue its trajectory. It also discusses key questions around how CTSI knows it is meeting its mission and how it can better serve its "customers". CTSI faces drivers for change like reduced funding but aims to preserve its core mission overseen by NCATS.