The Clinical and Translational Science Awards (CTSA) Program aims to transform clinical and translational research. It establishes a national consortium of academic health centers to break down barriers between disciplines. The program's goals are to build research capabilities, train scientists, enhance collaboration, improve community health, and advance translational research. Each CTSA institution provides resources like training, mentoring, informatics tools, and community partnerships to researchers to improve efficiency and quality of clinical research.

1. The Clinical and Translational Science Awards (CTSA) Program: What can it do for you? Lisa M. Guay-Woodford, MD Professor and Vice Chair Department of GeneticsDirector, Center for Clinical and Translational Science University of Alabama at Birmingham Physician-Scientist Career Development Meeting New York Academy of Sciences November 04-05, 2010

2. Translational Research Phase 1 translation (T1) research:move a basic discovery into a candidate health application. Phase 2 translation (T2) research: assess the value of T1 application for health practice leading to the development of evidence-based guidelines. Phase 3 translation (T3) research: move evidence-based guidelines into health practice, through delivery, dissemination, and diffusion research. Phase 4 translation (T4) research: evaluate the "real world" health outcomes of a T1 application in practice. Pre-clinical T1 T2 T3 T4

3. Translational Research: Lessons from Goldilocks

5. This investment has fueled huge strides in understanding human disease mechanisms.

6. BUT the commensurate gains in new treatments, diagnostics and prevention have been limited.Butler (2008) Nature 453:840-842

8. $9.1 billion for applied and developmental research

9. $787 million for health services research Woolf (2008) JAMA 299:211-213

10. Impetus for the CTSA Program The Clinical and Translational Science Award Consortium To ensure new discoveries lead to improved public health, clinical science must evolve to better: Implement biomedical discoveries. Develop, test, and bring new prevention strategies into medical practice more rapidly. Catalyze change - lower barriers between disciplines. Encourage creative and innovative approaches.

11. Building a National CTSA Consortium Building a National CTSA Consortium WA ME MT ND VT MN OR NH ID WI NY SD MA MI RI WY CT IA PA NJ NE NV OH IN DE IL UT MD CO WV VA KS MO CA KY NC TN AR AZ OK SC NM GA AL MS TX LA AK FL HI PR Participating Institutions New members 2010 Members CTSA States

12. The CTSA Philosophy Team Science Working together as a national consortium, CTSA institutions share a common vision to improve human health by transforming the research and training environment to enhance the efficiency and quality of clinical and translational research. Connectivity Partnerships Collaboration Breaking Down Institutional Barriers

13. Cultivating Networks: The National Consortium The NIH and CTSA Institutions have established a committee structure to execute the vision and goals of the CTSA Consortium. The consortium will reach 60 member institutions by 2011.

14. CTSA Strategic Goals To set a national research agenda, CTSA consortium leaders have identified five overarching strategic goals that guide consortium-wide activities: Goal 1: Build national clinical and translational research capability. Goal 2: Provide training and improve career development of clinical and translational scientists. Goal 3: Enhance consortium-wide collaborations. Goal 4: Improve the health of our communities and the nation. Goal 5: Advance T1 translational research to move basic laboratory discoveries and knowledge into clinical testing.

16. http://www.ctsaweb.org

17. Institutional Structure Each CTSA institution has created a home for clinical and translational science that supports areas of research expertise such as biostatistics, clinical trial design and community engagement. Input from the NIH and other federal agencies, industry, and private and community organizations helps guide the work of every CTSA institution.

19. Equipping diverse research teams to solve complex problems in medical research, e.g., supplying cost-effective, centralized biostatistical and informatics support.

20. Working collaboratively to improve clinical research management efficiency, and to develop best practices, policies and procedures.

21. Maximizing results by working with private companies and other partners to advance medical discoveries.

22. Enhancing public trust by reaching out to underserved populations, including racially and ethnically diverse groups as well as those living in rural and inner-city areas.

24. Maximizing investments in core and other resources increases efficiency and helps NIH support a wide range of researchers and projects.

25. Creating new fields of study or new uses for technologies.

26. Engaging community partners to ensure that research moves successfully into clinical practice.

28. CTSA-IP is a web-based intellectual property search engine that aggregates and promotes technologies from CTSA institutions and the NIH to enhance research activity and encourage private partnerships across the consortium. www.ctsaip.org.

31. Guidance with project development, grant applications, manuscript preparation.

32. Bioinformatics resources and consultation; access to biostatistical support.

33. Specialized resources (e.g., nursing and bionutrition) for human studies with support in new technologies, regulatory compliance, and the responsible conduct of research.

34. Access to community networks for community-based participatory research; creation of public and private partnerships to speed innovation.