This document discusses the challenges facing cities in the 21st century, focusing on smart and human-centered approaches to mobility. It notes that cities are facing issues related to ecology, society, culture, economy and resilience as urban populations grow and mobility needs change. The document argues that new digital technologies can enable innovative mobility solutions to address these challenges, but they must be developed and applied in a way that enhances social inclusion and does not disrupt existing urban models. An approach focused on collaboration, sharing and reinvention is proposed to build truly smart and human-centered cities.