Weekly presentation of new products with structures/diagrams, references and links to the product pages.

1. New Products

2. Our presentation contains information on each
item, including structures or diagrams.
To learn more, follow the link in the Product Name
to visit our website.

3. August 9 – August 15, 2016

4. 11685 Bavachin
• Flavonoid that activates the estrogen receptors
ERα and ERβ (EC50s = 320 and 680 nM,
respectively)
• Stimulates osteoblast proliferation and
differentiation and prevents bone loss following
ovariectomy in rats
• Less potently inhibits acyl-coenzyme A:cholesterol
acyltransferase (IC50 = 86 µM)
Phytoestrogen

5. 11844 α-Glycyrrhetinic Acid
• One of two epimers produced by removal of glucose from the
triterpenoid saponin glycyrrhizic acid (Item No. 11847), the
other being β-glycyrrhetinic acid (Item No. 11845)
• Inhibits intercellular communication through gap junctions
• Blocks gap junctions involving connexin-43 (also known as gap
junction α-1 protein) and connexin-26 (gap junction β-2 protein)
Gap junction blocker

6. 19286 Esculetin
• A natural plant phenolic that shares features of
coumarins and catechols
• Inhibits 5-LO and 12-LO (ID50s = 4 and 2.5 µM,
respectively)
• Binds iron and also inhibits other iron-containing
enzymes, including the lysine-specific
demethylase KDM5B
• Promotes TRAIL-induced apoptosis in cancer cells
• Used as an antioxidant to reduce ROS and
modulate oxidant-sensitive enzymes
• Anti-fungal activities
Lipoxygenase inhibitor

7. 19588 D-Fructose-6-phosphate (sodium salt)
• A sugar intermediate of the glycolytic pathway formed by the
isomerization of glucose-6-phosphate
• Further phosphorylated to fructose-1,6-bisphosphate, which is
one of the rate-limiting steps in glycolysis
• Because cancer cells adopt glycolysis as a major source of
metabolic energy production, this pathway has become a new
target for cancer chemotherapy
• Used to help identify, differentiate, and characterize the enzymes
in glycolysis
Glycolytic pathway intermediate

8. 19716 NCT-502
• Inhibits PHGDH, inhibiting serine synthesis from 3-
phosphoglycerate in cells (IC50 = 3.7 µM)
• Reversibly blocks the production of glucose-derived
serine in cells
19718 NCT-503
• Inhibits PHGDH, inhibiting serine synthesis from 3-
phosphoglycerate in cells (IC50 = 2.5 µM)
• Reduces the production of glucose-derived serine in cells
• Suppresses the growth of PHGDH-dependent MDA-MB-
468 cancer cells both in vitro and in mice bearing
orthotopic xenograft tumors
3-phosphoglycerate dehydrogenase inhibitors

9. 19847 Diosgenin
• A natural steroid sapogenin with antioxidant and anti-
inflammatory activities
• Protective against metabolic and cardiovascular diseases
and can have immunomodulatory and estrogenic effects
19849 Deoxyschizandrin
• A lignan with liver-protective, antitumor, and antioxidant
activities
• Adiponectin receptor 2 agonist (IC50 = 3.5 µM)
• Protective role in a rat model of myocardial ischemia-
reperfusion injury
• Down-regulates the increased production of nitric oxide,
TNF-α and IL-6 induced by LPSboth in BV-2 cells and
primary microglia cells
Natural antioxidants

10. 19865 Procyanidin B2
• Flavanol with potent antioxidant activity
• A dimer of epicatechin (Item No. 11807) that scavenges hydroxyl
radical and superoxide anion more potently than epicatechin and
procyanidin B4
19867 Rhapontin
• A stilbenoid glycoside first isolated from rhubarb rhizomes
• Converted by glucosidases to rhapontigenin (Item No. 13293), a
resveratrol analog with antioxidant and anti-cancer activity
19868 Rutin (hydrate)
• A flavonol glycoside with iron chelating and antioxidant properties
• Anti-inflammatory, anti-cancer, and anti-fibrosis effects and displays
hepato- and neuroprotective actions
Natural antioxidants

11. 19861 Paeoniflorin
• Monoterpene glycoside that modulates NMDA and TRPV1
receptors
• Inhibits testosterone synthesis and stimulates aromatase
activity
• Reduces inflammatory signaling by inhibiting p38 MAP
kinase
• Blocks pancreatic cancer cell apoptosis by suppressing
MMP-9 and ERK signaling
• Analgesic and anti-inflammatory actions
19862 Paeonol
• Phenolic compound with anti-oxidative actions
• Analgesic, anti-inflammatory, and hepatoprotective effects
Analgesics

12. 19870 Chrysophanol
• An anthraquinone with antibacterial, antiviral, anti-inflammatory, and anticancer activities
• Inhibits hepatitis B viral DNA production and HBsAg secretion in HepG2 2.2.15 cells.
• Reduces the level of nitric oxide and PGE2 production by diminishing the expression of
inducible nitric oxide synthase and COX-2 in BV2 microglia
• Induces necrosis through the production of ROS in J5 human liver cancer cells
19873 Isobavachalcone
• Chalcone with antibacterial, antifungal, anticancer, anti-reverse transcriptase, antitubercular,
and antioxidant activities
• Inhibits the growth of MGC803 gastric cancer cells by regulating the protein expression of
caspase-3, Bcl-2, and Bax and by inhibiting Akt and ERK signaling pathways
• Inhibits oligomerization and fibrillization of Aβ42 in an SH-SY5Y cell model of Aβ42 aggregation
Antibacterial/ Antiviral

13. 19872 Ginkgolide C
• Flavone with a selective platelet activating factor
receptor antagonist (IC50 = 37.6 μM)
• Increases lipolysis and inhibits adipogenesis in
adipocytes via the activated AMPK pathway
PAF receptor antagonist

14. 20184 Oligomycin D
• Inhibits the mitochondrial F1FO-ATPase
• Used to uncouple oxidative phosphorylation from
electron transport
• Inhibits K-Ras plasma membrane localization in MDCK
cells (IC50 = 3.49 nM) and is cytotoxic to SW620 colon
cancer cells (IC50 = 36 µM)
20185 Oligomycin E
• Exhibits relatively weak antifungal activity compared to
other oligomycins, yet is active against Gram-positive
bacteria
• Demonstrates strong antitumor activity against HeLa
cells (IC50 = 14 ng/ml)
Antibiotics

15. 20188 Teicoplanin A2-3
• Major component of the teicoplanin complex that is
broadly effective against Gram-positive bacteria
20189 Teicoplanin A2-4
• Component of the teicoplanin complex that is broadly
effective against Gram-positive bacteria
20192 Teicoplanin A2-5
• The most non-polar metabolite in the family of
teicoplanins
20193 Teicoplanin A3-1
• Degradation product of teicoplanins A2-1 to 5
Antibiotics

16. 9002780 1-(4-Fluorophenyl)-2-methyl-2-propylamine
• A fluorinated building block used for the synthesis of various
pharmaceutical amides
Building block

17. 20061 MDMB-FUBINACA metabolite M1
• An expected metabolite of MDMB-FUBINACA and ADB-FUBINACA
17761 AB-FUBINACA metabolite 3
• An expected metabolite of AB-FUBINACA
19730 5-fluoro BEPIRAPIM (hydrochloride)
• A synthetic cannabinoid whose physiological and toxicological
properties are not known
Forensic Science

18. 19567 ortho-Fluorobutyryl fentanyl (hydrochloride)
• An opioid whose physiological and toxicological properties are not known
19735 para-Fluorofentanyl (hydrochloride) (CRM)
• Activates the human μ opioid receptor with greater potency than fentanyl
(EC50s = 4.2 and 28.8 nM for para-fluorofentanyl and fentanyl, respectively)
19736 β-Hydroxythiofentanyl (hydrochloride) (CRM)
• An opioid regulated as a Schedule I controlled substance in the United States
19883 Benzyl fentanyl (hydrochloride)
• An opioid that is reported to have low opioid activity in a mouse analgesia hot
plate assay
Forensic Science

19. 19737 MT-45 (hydrochloride) (CRM)
• A piperazine that displays potent analgesic activity
comparable to morphine despite being structurally
unrelated to most other opioids
19794 Tiletamine (hydrochloride)
• A non-competitive NMDA receptor antagonist used in
veterinary medicine for its anesthetic and sedative
properties, which are comparable to ketamine
19745 2,6-DMA (hydrochloride)
• An amphetamine that acts as a serotonin 5-HT2 receptor
agonist (apparent pA2 = 5.09)
Forensic Science

20. 19275 4’-methoxy-α-Ethylaminovalerophenone (hydrochloride)
• A cathinone whose physiological and toxicological properties are not known
20132 Benzocaine
• A topical anesthetic commonly found as an adulterant in cocaine
20200 5α-dihydro-11-keto Testosterone
• A metabolite of 11β-hydroxyandrostenedione and 11β-hydroxytestosterone that has
been shown to act as a full androgen receptor agonist with equal potency as that of
dihydrotestosterone
Forensic Science

21. 19222 AH 7921-d3 (CRM)
• An internal standard for the quantification of AH7921 by GC- or LC-MS
19507 MT-45-d11 (hydrochloride) (CRM)
• An internal standard for the quantification of MT-45 by GC- or LC-MS
19928 Fentanyl-d5 (hydrochloride) (CRM)
• An internal standard for the quantification of fentanyl by GC- or LC-MS
19947 β-Hydroxythiofentanyl-d5 (hydrochloride) (CRM)
• An internal standard for the quantification of β-hydroxythiofentanyl
(hydrochloride) by GC- or LC-MS
Forensic Science