CRAIS Board is a virtual white board for collaborative discussions with chemical structures. It allows multiple users to edit one diagram simultaneously in real-time. CRAIS Board can be integrated with the corporate compound database, assay database or web services. Therefore, you can easily insert items such as chemical structures, activity, ADMET data and physicochemical properties to your discussion diagram. You can also create parent-child relationships between two compounds and visualize the difference in their activity and properties or for comparative search. Today, many non-chemistry projects are conducted online in other industries including Web design, graphic design, programming etc, but not really for medchems or other chemistry related projects yet. We believe CRAIS Board definitely can help to have intense brainstorming sessions in the facility and also outside, as many pharmaceutical companies use CROs outside of their home countries, the online system like CRAIS Board will increase their research efficiency and also may cut travel cost & time.

1. ■ Proprietary and Confidential ■ © 2013 Patcore Inc. all rights reserved.
CRAIS Board
The virtual white board for scientific discussions
Yoshiko Matsumoto
International Sales Manager
Patcore Inc.
info@patcore.com
http://patcore.com/en/

2. ■ Proprietary and Confidential ■ © 2013 Patcore Inc. all rights reserved.
Motivation of development
Many projects are conducted online.
– Web design
– Graphic design
– Programming
– CAD
– …..
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Why not for scientific discussions?

3. ■ Proprietary and Confidential ■ © 2013 Patcore Inc. all rights reserved.
Aim of development
1. Provide virtual white board environment which enables
scientific discussion.
- Share/edit one diagram simultaneously by multiple users.
- Drawing chemical structures.
2. Retrieve information from databases or web services to support
discussion.
- Assay results
- Physicochemical properties
3. Store discussion history to understand how the project has
progressed so far.
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4. ■ Proprietary and Confidential ■ © 2013 Patcore Inc. all rights reserved.
Application structure
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Collaborative Drawing Tool +
 Simultaneous access/edit of one diagram
 Basic drawing functionalities
- A wide variety of stencils - Auto alignment
- Rotate/Re-arrange - Enlarge/Down size
- Flexible connectors - Freehand option
- History logging etc…
Chemistry Engine
http://vimeo.com/7502521
http://www.youtube.com/watch?v=-l5FA54lT2U
 JChemBase (.NET)
 Marvin

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Edit one diagram simultaneously
• One diagram can be shared, modified and updated by multiple
users in real time.
• Changes are displayed on the sharers screen in real time.
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Edit by other users
In Budapest In TOKYO

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Insert Chemical Structures
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Direct drawing Search by ID Search by structure
JChem DB

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Integration with corporate databases
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Assay
DB
Compound
DB
Related information
can be retrieved from
corporate databases

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Parent-Child Relationship and Calculation
Arrow connector
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A B
Calc results

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Search function
• Structure search for structures in diagrams
• Full text search
• Comparative value search
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10. ■ Proprietary and Confidential ■ © 2013 Patcore Inc. all rights reserved.
History Logging
• Able to review how the project has progressed so far.
• Modified parts can be highlighted.
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Demo Movie
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12. ■ Proprietary and Confidential ■ © 2013 Patcore Inc. all rights reserved.
Current status of CRAIS Board
 Completed the prototype development.
 Looking for tools / partners for further enhancement.
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Functions under consideration
• Property calculation via web service
• Duplicate check to corporate databases
• HTML5 to support touch panel operation
• Anything else?

13. ■ Proprietary and Confidential ■ © 2013 Patcore Inc. all rights reserved.
Summary
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External collaboratorRemote sites
A virtual white board for
scientific discussions
Real-time collaboration
Chemistry intelligent
Integrating with corporate DBs
Parent-Child relationship and
calculation
Search function
History logging