To effectively negotiate the aging process it is important to have a unifying theory of disease and treatment. In this brief presentation we at Integrative Psychiatry review overarching principles of age-related disease and offer our version of such a theory. • Aging is a disease which can be delayed, prevented, or even reversed; • You are not a victim of your genetic endowment; and • Chronic inflammation is a major cause and effect of aging and age related diseases of civilization. Life stressors superimposed upon your unique genetic and biochemical makeup trigger, aggravate, and/or perpetuate the diseases of civilization that you are at risk for. The biological imbalances that drive your particular diseases can be measured and so they should be measured. These imbalances include but are not limited to the following: • Adrenal hormones (cortisol, DHEA); • Neurotransmitters (norephinephrine, serotonin, dopamine, GABA, glutamate, etc.); • Immune factors (hs-CRP, homocysteine, fibrinogen, cytokines, interleukins); • Thyroid Hormones; • Sex Hormones; • Vitamins/Minerals/Fatty Acids; • Growth Factors (BDNF); and • Genetic Polymorphisms. In order to help you craft and implement an integrated anti-aging strategy we strongly recommend testing of these mediators.

1. Anti-Aging Medicine:
Toward A Unifying
Theory
Integrative Psychiatry, Inc.
info@integrativepsychiatry
Integrativepsychiatry.net
(800) 385-7863

2. What We Believe
• Aging is a dis-ease which can be
delayed, prevented, or even reversed.
• We are not mere victims of our
genetic endowments.
• Chronic inflammation is the major
cause and the principle effect of the
diseases of civilization.

3. Not a haphazard, trial and error,
supplement/recipe/food du jour, jump on the
bandwagon approach.

4. The Big Picture

5. Let’s Break It Down and
Bring It Into Sharper Focus
Antecedents
T
r
i
g
g
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r
s
DOCs*
*DOCs=Diseases of Civilization
M
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i
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t
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r
s

6. Antecedents
Antecedents are
predisposing factors that
determine which diseases
you are vulnerable to as
you age. We have put
them into 5 categories:
“GULCH.”
G – Genes
U – Uterine Environment
L – Life Experiences
C – Choices
H – Habits
Genes
Uterine
Environment
Life
Experiences
Choices
Habits

7. Triggers
WORK-RELATED
URBANICITY
POOR NUTRITION
LACK OF SLEEP
TOXINS
EMOTIONAL
STRESS
HORMONAL
IMBALANCE
INFECTION
PACE
DRUGS
Triggers comprise acute
and chronic stressors
(life’s “slings & arrows”)
that precipitate or
“trigger” the DOCs you
are vulnerable to based
on your “GULCH”
antecedents.

8. Mediators
Hormones
Metabolic
Parameters
Growth
Factors
Neurotransmitters
Immune
Cells
The term mediators refers collectively to the specific biological
imbalances, brought about by your unique antecedents and
triggers, that drive your particular symptoms and diseases.
Because they can be measured, they should be measured.

9. Mediators In General
Estrogens
Androgens
Insulin
Thyroid
(-)
(+)
SNS
CRH, Cortisol, Prolactin,
Vasopressin, Glucagon,
Beta-endorphin
(+)
Serotonin
PNS
(+)
Cytokines
(-)
(-)
BDNF
Somatomedins

10. Frequently Measured
Mediators
Salivary Cortisol
Urinary Neurotransmitters
Markers of Inflammation (hs-CRP,
homocysteine, cytokines)
Thyroid and Adrenal Function
Sex Hormones (estrogens, testosterone,
progesterone)
Vitamin D
Genetic Testing

11. Find Out More
C
l
i
c
k
H
e
r
e
Salivary Cortisol
Urinary Neurotransmitters
Markers of Inflammation (hs-CRP,
homocysteine, cytokines)
Thyroid and Adrenal Function
Sex Hormones (estrogens, testosterone,
progesterone)
Vitamin D
Genetic Testing
Click here to learn about
some of our
neurotransmitter tests.

12. Ok. So You’ve Measured
Your Mediators. Now what?

13. Putting It All Together
Antecendents
“GULCH”
Triggers
Diseases of
Civization
Mediators
WORKRELATED
Genes
Cancer
CHD
URBANICITY
DM
POOR
NUTRITION
Uterine
Environment
Life
Experiences
GERD
Hormones
LACK OF
SLEEP
TOXINS
Depression
Metabolic
Parameters
Neurotransmitters
Alzheimer’s
EMOTIONAL
STRESS
Choices
HORMONAL
IMBALANCE
INFECTION
Habits
MS
IBD
Growth
Factors
Immune
Cells
Psoriasis
Arthritis
Pain
PACE
Obesity
DRUGS
Asthma

14. The ToCaToAct (Token Call
To Action) Slide
1) Visit us online at Integrativepsychiatry.net
2) Arrange for an individual consultation:
(800) 385-7863
info@integrativepsychiatry.net