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NON-ST ELEVATION MI BBH, Bangalore Ahmad Hafiz Nov 2011
ACUTE CORONARY SYNDROME SPECTRUM ACS >  NSTEMI > Pathophysiology > Clinical > Physical > ECG > Cardiac Markers  > Emergency > Thrombolysis > PCI > CABG > Hospital  > Late MGMT > Secondary Prevention
WHAT IS NSTEMI? ,[object Object],[object Object],[object Object],[object Object],[object Object],ACS  > NSTEMI >  Pathophysiology > Clinical > Physical > ECG > Cardiac Markers  > Emergency > Thrombolysis > PCI > CABG > Hospital > Late MGMT > Secondary Prevention
Davidson pg. 589
PATHOPHYSIOLOGY ,[object Object],ACS > NSTEMI  > Pathophysiology >  Clinical > Physical > ECG > Cardiac Markers  > Emergency > Thrombolysis > PCI > CABG > Hospital > Late MGMT > Secondary Prevention
[object Object],[object Object],[object Object],[object Object]
 
 
 
CLINICAL PRESENTATION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],ACS > NSTEMI > Pathophysiology  > Clinical >  Physical > ECG > Cardiac Markers  > Emergency > Thrombolysis > PCI > CABG > Hospital  > Late MGMT > Secondary Prevention
PHYSICAL EXAMINATION ,[object Object],[object Object],[object Object],[object Object],[object Object],ACS > NSTEMI > Pathophysiology > Clinical  > Physical >  ECG > Cardiac Markers  > Emergency > Thrombolysis > PCI > CABG > Hospital  > Late MGMT > Secondary Prevention
ECG CHANGES ,[object Object],[object Object],[object Object],[object Object],[object Object],ACS > NSTEMI > Pathophysiology > Clinical > Physical  > ECG >  Cardiac Markers  > Emergency > Thrombolysis > PCI > CABG > Hospital  > Late MGMT > Secondary Prevention
 
 
CARDIAC MARKERS ACS > NSTEMI > Pathophysiology > Clinical > Physical > ECG  > Cardiac Markers  >  Emergency > Thrombolysis > PCI > CABG > Hospital  > Late MGMT > Secondary Prevention
TROPONIN-T ,[object Object],[object Object],[object Object],[object Object],[object Object]
BNP ,[object Object]
GLYCOGEN PHOSPHORYLASE  ISOENZYME BB ,[object Object],[object Object],[object Object],[object Object]
MYOGLOBIN (MB) ,[object Object],[object Object],[object Object]
CK-MB ,[object Object],[object Object],[object Object],[object Object],[object Object]
MANAGEMENT GUIDELINE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
ALGORITHM FOR EVALUATION AND MANAGEMENT OF PATIENTS SUSPECTED  OF HAVING ACS
EMERGENCY MANAGEMENT ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],ACS > NSTEMI > Pathophysiology > Clinical > Physical > ECG > Cardiac Markers  > Emergency >  Thrombolysis > PCI > CABG > Hospital  > Late MGMT > Secondary Prevention
ACUTE REPERFUSION THERAPY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
THROMBOLYSIS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],ACS > NSTEMI > Pathophysiology > Clinical > Physical > ECG > Cardiac Markers  > Emergency >  Thrombolysis >  PCI > CABG > Hospital  > Late MGMT > Secondary Prevention
 
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],First 30 mins Bolus dose 15mg Followed by 0.75mg/kg Next 60 mins 0.5mg/kg (not > 35mg)
FULL THERAPEUTIC ANTICOAGULATION ,[object Object],[object Object]
ADJUNCTIVE THERAPY ,[object Object],[object Object],[object Object],[object Object]
CONTRAINDICATIONS TO THROMBOLYTIC THERAPY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PRIMARY PERCUTANEOUS CORONARY INTERVENTION ,[object Object],[object Object],[object Object],ACS > NSTEMI > Pathophysiology > Clinical > Physical > ECG > Cardiac Markers  > Emergency > Thrombolysis  > PCI >  CABG > Hospital  > Late MGMT > Secondary Prevention
 
[object Object],[object Object],[object Object],[object Object],[object Object]
CORONARY ARTERY BYPASS GRAFTING (CABG) ,[object Object],[object Object],[object Object],ACS > NSTEMI > Pathophysiology > Clinical > Physical > ECG > Cardiac Markers  > Emergency > Thrombolysis > PCI  > CABG >  Hospital  > Late MGMT > Secondary Prevention
HOSPITAL PHASE MANAGEMENT ,[object Object],[object Object],[object Object],[object Object],[object Object],ACS > NSTEMI > Pathophysiology > Clinical > Physical > ECG > Cardiac Markers  > Emergency > Thrombolysis > PCI > CABG  > Hospital >  Late MGMT > Secondary Prevention
LATE MANAGEMENT ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],ACS > NSTEMI > Pathophysiology > Clinical > Physical > ECG > Cardiac Markers  > Emergency > Thrombolysis > PCI > CABG > Hospital  > Late MGMT >  Secondary Prevention
[object Object],[object Object],[object Object],[object Object],[object Object]
SECONDARY PREVENTION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],ACS > NSTEMI > Pathophysiology > Clinical > Physical > ECG > Cardiac Markers  > Emergency > Thrombolysis > PCI > CABG > Hospital  > Late MGMT  > Secondary Prevention
REFERENCE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object]
 

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NSTEMI DrHafiz

  • 1. NON-ST ELEVATION MI BBH, Bangalore Ahmad Hafiz Nov 2011
  • 2. ACUTE CORONARY SYNDROME SPECTRUM ACS > NSTEMI > Pathophysiology > Clinical > Physical > ECG > Cardiac Markers > Emergency > Thrombolysis > PCI > CABG > Hospital > Late MGMT > Secondary Prevention
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  • 15. CARDIAC MARKERS ACS > NSTEMI > Pathophysiology > Clinical > Physical > ECG > Cardiac Markers > Emergency > Thrombolysis > PCI > CABG > Hospital > Late MGMT > Secondary Prevention
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  • 22. ALGORITHM FOR EVALUATION AND MANAGEMENT OF PATIENTS SUSPECTED OF HAVING ACS
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Editor's Notes

  1. NSTEMI is part of a wide spectrum ranging from unstable angina to stemi. I am going to focus on how to identify the patient and to manage them
  2. Spectrum of ACS with its features
  3. ACC - 99th percentile cutoff for a healthy patient population WHO – Coefficient variance 10% 
  4. U&E = urea & electrolytes Clopidogrel? GTN 600mg as needed
  5. The heart rhythm must be supraventricular in origin The QRS duration must be ≥ 120 ms [2] There should be a QS or rS complex in lead V1 There should be a RsR' wave in lead V6.
  6. The T wave should be deflected opposite the terminal deflection of the QRS complex. This is known as appropriate T wave discordance with bundle branch block. A concordant T wave may suggest ischemia or myocardial infarction.
  7. Inflation of balloon or stent into coronary artery, which crushed the plaque into the wall and dilate the lumen Normal flow is restored
  8. Silent ischemia : ST changes at rest without angina. Exercise testing:12 lead ECG recorded during exercise on a treadmill or bicycle ergometer. Limb leads are placed on shoulders and hips instead of wrist and ankle. Low bp, exercise induced arrhythmia ,prolonged ischemic ECG changes suggestive of high risk findings Follow BRUCE protocols that have 5 stages to classified ischemia and it depends on speed and % of inclination of the treadmill.