5. Q14 - Drug dose adjust for
Hemodialysis for Low Molecular
Weight Heparin
For Lovenox, no dose adjustment for H.D.
For CrCl < 30 DVT proph. 30 mg SQ
daily not 40.
Normal halflife 4.5-7 hrs.
Nir Hus
6. Q15 - Staphylococcus epidermis
Eradication of Staphylococcus epidermis
is difficult to achieve due to:
A. Secretion of exotosins
B. Production of exoslime
C. Release of endotoxin
D. Rapid growth rate
Nir Hus
7. Staphylococcus epidermis
Staphylococcus epidermis exoslime is a polysaccharide
composed of glycosaminoglycans which allows for
strong intercellular adhesion between bacterial cells and
the formation of biofilms.
The ability to form biofilms allows S. epidermidis to
cause resistant infections particularly when foreign object
are present.
This is due to inability of antibiotics to penetrate the
mucopolysaccharide of the biofilm.
The ica operon has been shown to control the production
of slime . The ica genes can be tested for as a
virulence marker.
Nir Hus
8. Q - Respirator Quotient in sepsis
& vent support
Respirator Quotient (RQ) is the ratio of VCO2
(production) to VO2 (consumption).
A characteristic RQ exists for each fuel being
metabolized.
Fat: 0.7
Protein: 0.8
Glucose : 1.0
If RQ is greater than 1, strong indicator of
overfeeding.
Nir Hus