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The antimicrobial
resistance
   {   Growing threat and the options for action
       V. Harutyunyan M.D.
Antimicrobial Resistance: a global issue



   Cause of considerable mortality
   Greatly increases care costs and productivity losses
   Impediment to control of infectious diseases
   Jeopardizes healthcare gains for individuals and society
   Treat to international travel and trade
   Dwindling options for treatment of the infectious diseases
Mortality & Cost

   25,000 deaths/year in hospitals Europe
   63,000 year in USA in outpatients
   Mortality due to AMR in community settings
   Mortality in developing countries

   1.5 billion € for the EU region
   25-35 billion USD: total additional costs of the US hospitals
   Costs for the individuals, families and societies hard to quantify
Cost of AMR




Containing antimicrobial resistance. Geneva, World Health Organization, 2005, WHO Policy Perspectives on Medicines, No.
10 (http://whqlibdoc.who.int/hq/2005/WHO_PSM_ 2005.1.pdf, accessed 9 January 2012).
Treat to global health


   290,000 new multidrug resistance (MDR) TB cases in 2010
   Malaria: Emergence of Artemisinin resistance
   HIV: 10%-20% of the resistance rates to anti HIV regimens in the US
    and Europe
   Increasing spread of common bacterial infections resistant to
    antibiotics in health care settings, communities and across borders
Dwindling treatment options




The evolving threat of antimicrobial resistance: options for action. WHO 2012
WHO global response


   WHO Global Strategy for Containment of
    AMR (2001)
   WHO Regional Committee Resolutions
    (e.g. AFRO, PAHO, SEARO)
   World Health Assembly Resolutions
   WHD 2011 Six Point Policy Package
WHO actions

   Promote the sharing of information about, understanding of
    resistance and coordination of actions to control the spread of AMR
   Raise awareness of the problems posed by antimicrobial resistance
   Build consensus on the methods of AMR surveillance and control
   Provide strategic and technical guidance on interventions to contain
    resistance
   Assist Member States to implement these interventions
   Stimulate innovation and research to improve understanding of
    antimicrobial resistance and to encourage research and development
    of new drugs, vaccines and diagnostics

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Antimicrobal Resistance

  • 1. The antimicrobial resistance { Growing threat and the options for action V. Harutyunyan M.D.
  • 2. Antimicrobial Resistance: a global issue  Cause of considerable mortality  Greatly increases care costs and productivity losses  Impediment to control of infectious diseases  Jeopardizes healthcare gains for individuals and society  Treat to international travel and trade  Dwindling options for treatment of the infectious diseases
  • 3. Mortality & Cost  25,000 deaths/year in hospitals Europe  63,000 year in USA in outpatients  Mortality due to AMR in community settings  Mortality in developing countries  1.5 billion € for the EU region  25-35 billion USD: total additional costs of the US hospitals  Costs for the individuals, families and societies hard to quantify
  • 4. Cost of AMR Containing antimicrobial resistance. Geneva, World Health Organization, 2005, WHO Policy Perspectives on Medicines, No. 10 (http://whqlibdoc.who.int/hq/2005/WHO_PSM_ 2005.1.pdf, accessed 9 January 2012).
  • 5. Treat to global health  290,000 new multidrug resistance (MDR) TB cases in 2010  Malaria: Emergence of Artemisinin resistance  HIV: 10%-20% of the resistance rates to anti HIV regimens in the US and Europe  Increasing spread of common bacterial infections resistant to antibiotics in health care settings, communities and across borders
  • 6. Dwindling treatment options The evolving threat of antimicrobial resistance: options for action. WHO 2012
  • 7. WHO global response  WHO Global Strategy for Containment of AMR (2001)  WHO Regional Committee Resolutions (e.g. AFRO, PAHO, SEARO)  World Health Assembly Resolutions  WHD 2011 Six Point Policy Package
  • 8. WHO actions  Promote the sharing of information about, understanding of resistance and coordination of actions to control the spread of AMR  Raise awareness of the problems posed by antimicrobial resistance  Build consensus on the methods of AMR surveillance and control  Provide strategic and technical guidance on interventions to contain resistance  Assist Member States to implement these interventions  Stimulate innovation and research to improve understanding of antimicrobial resistance and to encourage research and development of new drugs, vaccines and diagnostics