MCC 2011 - Slide 22

Follow-up: Evidence and optimalisation Klaas Havenga University Medical Center Groningen The Netherlands

This talk: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale to FU  Approaches  Trials  Framing  CEAwatch  Summary

Results of hepatic resection for colorectal cancer Source: Uptodate Rationale to FU  Approaches  Trials  Framing  CEAwatch  Summary Author and year Number of patients 5 yr OS, percent Hughes, KS; 1986 607 33 Scheele, J; 1995 434 33 Nordlinger, B; 1996 1568 28 Jamison, RL; 1997 280 27 Fong, Y; 1999 1001 37 Iwatsuki, S; 1999 305 32 Choti, M; 2002 133 58 Abdalla, E; 2004 190 58 Fernandez, FG; 2004 100 58 Wei, AC; 2006 423 47 Rees, M; 2008 929 36 De Jong, M; 2009 1669 47 Morris, EJ; 2010 3116 44

Developments in treatment of metastatic disease ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale to FU  Approaches  Trials  Framing  CEAwatch  Summary

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

Office Visits ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

Office Visits ,[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Guidelines  CEAwatch  Summary

Office Visits ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

Endoscopy: colonoscopy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

Endoscopy: sigmoidoscopy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

Carcino Embryonic Antigen ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Guidelines  CEAwatch  Summary

Carcino Embryonic Antigen ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

Grossmann et al. CEA measurement during follow-up for rectal carcinoma is useful even if normal levels exist before surgery ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

Carcino Embryonic Antigen ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

Carcino Embryonic Antigen ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

Imaging ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

Imaging ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

Not supported ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

Figueredo - BioMed Central 2003 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

Jeffery 2007 (Cochrane) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Guidelines  CEAwatch  Summary ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Wattchow 2006 (Australia) General practice vs surgical-based follow-up for patients with colon cancer: randomised controlled trial. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Guidelines  CEAwatch  Summary

Discussing Wattchow trial ,[object Object],[object Object],Rationale  Approaches to FU  Trials  Guidelines  CEAwatch  Summary

Rodriguez (2006, Barcelona) . ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

Rodriguez (2006, Barcelona) . ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

Evidence for CT? Confused? ,[object Object],[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

General considerations ,[object Object],[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

General considerations ,[object Object],Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

General considerations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

CEAwatch ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

APR 02-07-2010 female pt 10-06-1960 T3N0 Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

CEAwatch - study ,[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

CEAwatch - study ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

Stepped wedge design Patients in control group Time Patients in intervention group 1st Hospital randomization Rationale  Approaches to FU  Trials  Framing  CEAwatch  Summary

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rationale to FU  Approaches  Trials  Guidelines  CEAwatch  Summary

MCC 2011 - Slide 22

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MCC 2011 - Slide 22