Josef Haik MD MPH, Eyal Winkler MD, Nimrod Farber MD, Moti Harats MD, Oren Weissman MD Department of Plastic and Reconstructive Surgery and The Burn Unit, Sheba Medical Center ISRAEL

1. Negatively Charged Microspheres
Technology for the Treatment of Post
Aesthetic Surgery Complications
Josef Haik MD MPH, Eyal Winkler MD, Nimrod Farber
MD, Moti Harats MD, Oren Weissman MD
Department of Plastic and Reconstructive Surgery
and The Burn Unit, Sheba Medical Center
ISRAEL

2. Background
• Complications following aesthetic procedures such as
lower T-junction wound dehiscence following breast
reduction surgery, or flap necrosis following a facelift
procedure are vexing and grievous complications both to
the patient and the surgeon.
• Treatment modalities that can actively expedite wound
healing and re-epithelialization rates are highly craved.
• Objectives - To assess wound healing and re-
epithelialization rates of open wounds due to dehiscence
following breast reduction surgery or flap necrosis
following a facelift procedure.

3. Methods
• Eight patients with wounds of the aforementioned
types (5 breast reduction patients and 3 facelift
patients) were treated with daily dressing with NCM
soaked dressings.
• Wound closure rates were documented daily.

4. Results
• Treatment duration averaged 10 days in the facelift
cases and 33 days for breast cases.
• Wounds showed both accelerated granulation
tissue formation, and re-epithelialization rates.
• Average wound epithelialization rate was 1.9
millimeters per day for breast cases and 1
millimeters per day for the facelift cases.
• In these cases, NCM treatment helped patients
avoid additional surgery such as skin grafting. No
complications or side effects were encountered.

5. Patient’s Results
• Female, 29 year old
• Wound etiology: Post bilateral breast reduction, postoperative wound dehiscence
• Wound duration: 29 days
• Previous treatment: Povidone iodine soaked dressings, AG hydrofiber dressings
Prior to treatment Day 5 of treatment Day 12 of treatment Day 24 of treatment

6. Patient’s Results
• Female, 52 year old
• Wound etiology: Post bilateral breast reduction, postoperative wound dehiscense
• Wound duration: 19 days
• Previous treatment: Silver sulfadiazine, AG hydrofiber dressings
Prior to treatment Day 5 of treatment Day 10 of treatment Day 17 of treatment

7. Patient’s Results• Female, 31 year old
• Wound etiology: Post unilateral facelift due to regressed hemangioma,
postoperative flap necrosis
• Wound duration: 32 days
• Previous treatment: Silver sulfadiazine, surgical debridement, AG hydrofiber
dressings
Prior to treatment 1 Week of treatment 2 Weeks of treatment

8. Discussion
• CPM may offer a new and efficacious way to expedite
the healing of open wounds of various etiologies,
including resistant wounds that failed to heal despite
deploying a multitude of treatment modalities including
surgery.
• CPM seems to expedite both the formation of
granulation tissue (including over bones, cartilages
and tendons) as well as epithelialization rates.
• Further research with larger patient volumes are still
needed to verify these findings.