1. SPOT-ON SKIN LIPID COMPLEX
AS AN ADJUNCT THERAPY IN
DOGS WITH ATOPIC DERMATITIS
AN OPEN PILOT STUDY
Elin Põldemaa
2011

2. OUTLINE
 Introduction
 Methods
 Results
 Conclusions
 Refrences

3. INTRODUCTION
 Atopic dermatitis (AD) is a common allergic skin
disease in both people and dogs
 The treatment of dogs with AD is complex and lifelong
 The aim of this study was to evaluate the clinical
benefits of topical Spot-On Skin Lipid Complex (SLC)
in the treatment of dogs with chronic AD
 The study took place in Fujimura Animal Allergy
Hospital, Japan, from September 2009 to December
2009

4. METHODS
 The investigators recruited 8 dogs from their hospital
with a diagnosis of chronic AD and persistent pruritus
despite therapy.
 The dogs were treated with SLC topically as adjunct
therapy for 12 weeks.
 A topical SLC product containing ceramides,
cholesterol and free fatty acids was applied at a dose
of 2 mL twice weekly, by applying several drops on the
head, inter scapular area, and directly on lesion sites

5. RESULTS
 After 6 weeks of SLC treatment, a substantial
improvment in the dogs condition occured
 It was caused by the reduction in the erythema
(36.2%, p<0,005), excoriation (39,9%, p<0,05) and
alopecia subscores (19.9%, p<0,05).
 There were no markable advances in the treatment
of lichenification as the decrease rate was
statistically unimportant.
 For the evaluation of the efficency of SLC therapy, the third version of
the Canine Atopic Dermatitis Extent and Severity Index (CADESI-03)
modification was used

6. Clinical
characteristics
of Dog 5 at
start of the
treatment (D0)

7. 6 weeks
after D0

8. 12 weeks
after
treatment

9. The dog was
treated
continuously after
the completion of
the trial. Clinical
symptoms
improved 18
weeks after D0.

10. CONCLUSIONS
The results of this study suggest that topical SLC
application is beneficial when used in the management of
canine AD.
 Topical lipid applications are not effective as
monotherapy but as an adjunct therapy they may bring
new hope in the treatment of canine AD
 Although the findings are encouraging, double-blinded
placebo-controlled or cross-over studies are needed to
confirm the results.
 The drug-sparing effects of SLC applications also
deserve further investigation

11. REFRENCES
“Spot-On Skin Lipid Complex as an Adjunct Therapy
in Dogs with Atopic Dermatitis: An Open Pilot Study“
Masato Fujimura, Yoshinobu Nakatsuji, Subaru
Fujiwara, Christophe Rème and Hugues Gatto
Veterinary Medicine International, Volume 2011
http://www.hindawi.com/journals/vmi/2011/281846/

12. THANK YOU FOR YOUR ATTENTION!