Music Therapy's Impact in Palliative Care| IAPCON2024| Dr. Tara Rajendran
Women's cancers navs 2011
1. A Presentation at North
American Vegetarian
Summerfest 7/2011
Stephan Esser MD
www.esserhealth.com
2. Women’s Cancers
a
Primer and Review
Stephan Esser USPTA, MD
www.esserhealth.com
3. Goals
• Review definitions and tenets
• Overview of the Statistics
• Visit the classroom: anatomy,
physiology
• Brief review of each common cancer
• Propose some models for cause
• Discuss opportunities for prevention
4. NOT Goals
• Personal recommendations for
screening or treatment
• Updates on surgical techniques
• Intro to alternative treatments
5. What this is!
• The beginning…….not the end
• Incomplete…..
• More questions than answers
6. Definition
– Etymology: Middle English, from Latin, literally,
crab; akin to Greek karkinos crab
– a northern zodiacal constellation between Gemini and Leo b (1) :
the fourth sign of the zodiac in astrology
– A malignant tumor of potentially
unlimited growth that expands locally
by invasion and systematically by
metastasis
– Something evil or malignant that spreads destructively
7. “Cancer is a term used for diseases in
which abnormal cells divide
without control and are able to
invade other tissues.”
8. Levels of the Organism
• Atomic: Oxygen
• Molecular: DNA
• Organelle: Nucleus of the cell
• Cellular: Cell
• Tissue: Cells function together
• Organ: multiple Tissues work together
• Organ System: respiratory, circulatory etc.
• Organism: Human Being
9.
10. Cell Cycle
G1: Growth and
function
S: DNA Replication
G2: Preparation
M: Mitosis
12. Cell Cycle
G1: Growth and
function
S: DNA Replication
G2: Preparation
M: Mitosis
13. Cancer Operatives
• 1: Failure to slow/block abnormal growth
• 2: Acceleration of growth (ie: to an abnormal
level)
14.
15. Cancer Subtypes
• Carcinoma: skin or tissues that line/cover
internal organs
• Sarcoma: begin in bone, cartilage, fat, muscle
blood vessels or other connective tissues
• Leukemia: blood forming tissue. Eg: bone
marrow
• Lymphoma/Myeloma: cells of the immune
system
• Central Nervous System: in the brain and spinal
cord
16. Valuable Terminology
• Staging: evaluates the extent of a
persons cancer
• Grading: how abnormal a tumor
looks under a microscope
17. What we know!
• Cancer is an abnormal state of the cell
• It is often caused by dysfunction in the cell
cycle
• Overgrowth/inappropriate growth at the
cellular level = dysfunction at the
tissue/organ = dysfunction at the organism
level
24. In Review
• Cancer is the 2nd leading cause of death
• Breast Cancer is the leading female cancer
• Cancer mortality:
– Breast Cancer ≈ unchanged
– Uterine Cancer < 1930
– Ovarian Cancer ≈ unchanged
– Cervical Cancer < 1930
• Cancer risk is quite significant
27. 90
77.3
80 70.8
65.4 64.6
Percent of Population
70
60 53.2 54.1
50 38.8 38.4
40
30 24.4
16.2
20 12.2
6.6
10
0
20-34 35-44 45-54 55-64 65-74 75+
Men Women
Prevalence of high blood pressure in Adults age 20 and
older, by age and sex (NHANES: 2003-2006). Source: NCHS
and NHLBI.
28. Per 100,000 Population 200
150 130.0
101.5
100
57.0
41.1 41.1 39.0
50 31.6
22.9
0
Coronary Heart Stroke Lung Cancer Breast Cancer
Disease
White Females Black Females
Age-adjusted death rates for CHD, stroke, lung and breast
for white and black females (United States: 2006).
Source: NCHS.
35. Lum Skin Dimpling Change in color
p or texture
Change in how the Clear or bloody fluid
nipple looks: like that leaks out of the
nipple pulling in nipple
42. The Power of Hormones
• Glands and hormonal response
Organ or gland: adrenals,
thyroid, pituitary etc.
Gland: Breast Ducts, ovarian
tissue, endometrium etc.
43. In Review
• Cancer is more common in hormonally
responsive tissues
• The relationship is a complex, multi-factorial
one
• Breast Cancer and Uterine/Cervical Cancer are
easier to diagnose
• Ovarian Cancer may be a silent killer
60. “Inflammation is a critical component of tumor
progression. It is now becoming clear that the tumor
microenvironment, which is largely orchestrated by
inflammatory cells, is an indispensable part of the
neoplastic process.”
65. Cervical Cancer
• Modifiable Risks:
– Sexual Habits
– Human Papilloma Virus
– Tobacco
– Impaired Immunity: HIV
– Diet
– OCPs
– Toxins: DES, etc.
66. Cardiovascular
Disease
Atherosclerosis, Heart Failure,.
CVD, Cardiomyopathy, Stroke
Neurologic Auto-
Disorders Immune etc.
Alzheimers, RA, Psoriasis,
Parkinsons, ALS, IBD, Chronic
Dementia, Panx., CIDP
Chronic
Inflammation
Bone and
Metabolic Muscle
Disorders Osteoporosis,
Fatty Liver Osteoarthritis,
Type 2 Diabetes DDD, MD
Heart Disease
CKD, HLD
Cancer
Lung, Breast, Uterine, Colon,
Gastric, Pancreatic etc.
67. Conclusions
• Cancer is a significant cause of death and
disability in America today
• Cancer is directly related to inappropriate cell
division and development
68. Conclusions
• An environment of inflammation appears to
foster cancer growth and proliferation
• Reducing systemic and local inflammation can
– Reduce the risk of cancer
– Slow progression
– Reduce recurrence rates
70. T
his is such a great thing, it should spread like wildfire. It offers
great hope for people, and a wide variety of conditions
respond well ……………….But it requires discipline. It is not
something to be bought or to be sold as a quick fix. Those
who are not disciplined are accustomed to their addictions,
and it is very difficult for them to get away from that.………..I
tell people to value health and the pleasure of being well.
Cherish the wonderful knowledge and enjoyment that you
gain from living in a healthy way. That is the reward of it all!
William Esser ND. D.C
http://www.merriam-webster.com/dictionary/cancer I put the word cancer into google as a search and received 229,000,000 results.
http://www.cancer.gov/cancertopics/what-is-cancer
Tissue --> a bunch of cells working together on one job Organ --> lots of tissues working together Organ system --> a group of organs working together for a particular function Organism --> many organ systems working together
So here is our prototipical cell……..this illustration shows well the basic structural components of a cell. And it is at this level that I want to briefly discuss cancer. Trillions of cells = the body
G1: cell is synthesizing its structural proteins and enzymes to perform its functions. Notice the checkpoints on the cell and it’s function. These are moments when the cell is evaluated by RNA/DNA Check points: are proteins in the cytoplasm which making the key decision of whether the cell should divide, delay division, or enter a resting stage
Road Rage example…one hit…late for work…..two hits someone cuts us off….someone stressing us from home…etc….then we snap
G1: cell is synthesizing its structural proteins and enzymes to perform its functions. Notice the checkpoints on the cell and it’s function. These are moments when the cell is evaluated by RNA/DNA Check points: are proteins in the cytoplasm which making the key decision of whether the cell should divide, delay division, or enter a resting stage
The real cell cycle……likely even more complex than this….this is where the influence of a multitude of outside and internal factors can influence the health of the cell cycle. Alter any of these cell processes…those that limit the rate of cell multiplication or alter the self-checking potential or potential for apoptosis and the result will be abnormal growth
What is staging? Staging describes the extent or severity of an individual’s cancer based on the extent of the original (primary) tumor and the extent of spread in the body. Staging is important:Staging helps the doctor plan a person’s treatment.The stage can be used to estimate the person’s prognosis (likely outcome or course of the disease). Cancer cells divide and grow without control or order to form a mass of tissue, called a growth or tumor. As the tumor grows, it can invade nearby organs and tissues. Cancer cells can also break away from the tumor and enter the bloodstream or lymphatic system. By moving through the bloodstream or lymphatic system, cancer can spread from the primary site to form new tumors in other organs. The spread of cancer is called metastasis Tumor (T) TX Primary tumor cannot be evaluated T0 No evidence of primary tumor Tis Carcinoma in situ (early cancer that has not spread to neighboring tissue) T1, T2, T3, T4 Size and/or extent of the primary tumor Regional Lymph Nodes (N) NX Regional lymph nodes cannot be evaluated N0 No regional lymph node involvement (no cancer found in the lymph nodes) N1, N2, N3 Involvement of regional lymph nodes (number and/or extent of spread) Distant Metastasis (M) MX Distant metastasis cannot be evaluated M0 No distant metastasis (cancer has not spread to other parts of the body) M1 Distant metastasis (cancer has spread to distant parts of the body)
Dysfunction may be excess stimulus of growth, failure to slow growth or the like.
Approx. 1,300,000 new cases per year www.cdc.gov/.../mmwrhtml/ figures/m846qsf.gif www.ncbi.nlm.nih.gov/ bookshelf/picrender.fcgi.. http://www.ctahr.hawaii.edu/CS/blogs/sustainable_agriculture/cdc_logo(2).jpg
Unfortunately 1 million plus American’s die from cancer every year as well. And of these you can see the break down on the side. Notice the distribution. Although breast cancer was far more common than Lung cancer, lung cancer tends to be much more aggressive cancer and causes greater mortality as a result.
Blue =breast Green = Uterus Purple= Ovary Age Adjusted Cancer death rates for females per cancer type. You can appreciate that since 1930 we have noticed a decline in several cancers including Uterine and Stomach cancer for a variety of reasons but regrettably most cancer death has remained stable or in the case of Lung cancer has significantly increased
Probability of Developing Invasive Cancers Within Selected Age Intervals by Gender, United States, 1996-1998 a
A gland is an organ in an animal's body that synthesizes a substance for release such as hormones or breast milk, often into the bloodstream (endocrine gland) or into cavities inside the body or its outer surface (exocrine gland).
Caucasian women more likely to ……. http://www.cancer.org/Cancer/BreastCancer/DetailedGuide/breast-cancer-risk-factors
The Health Consequences of Involuntary Exposure to Tobacco Smoke, concluded that there is &quot;suggestive but not sufficient&quot; evidence of a link at this point. In any case, this possible link to breast cancer is yet another reason to avoid secondhand smoke. Higher red meat intake in adolescence may increase the risk of premenopausal breast cancer. (Cancer Epidemiol Biomarkers Prev 2008;17(8):2146–51) The approximate 50% reduction in risk( of recurrence) associated with these healthy lifestyle behaviors was observed in both obese and nonobese women, although fewer obese women were physically active with a healthy dietary pattern (16% v 30%). Among those who adhered to this healthy lifestyle, there was no apparent effect of obesity on survival. The effect was stronger in women who had hormone receptor–positive cancers. http://www.mayoclinic.com/health/breast-cancer/DS00328/DSECTION=risk-factors
http://www.mayoclinic.com/health/endometrial-cancer/DS00306/DSECTION=risk-factors Caucasian women are 70% more likely to get Endometrial CA than Blacks http://www.mskcc.org/mskcc/html/13172.cfm
OCPs reduce uterine cancer risk increase breast, cervical cancer risk http://www.cdc.gov/cancer/uterine/basic_info/risk_factors.htm
Up to 80% of sexually active Americans may be infected Sexual Habits= early exposure, # of partners, Plasma beta-carotene reduced risk from top to bottom quartile by 80%, vitamin C by 60%, and fruit juices by 50%., Consumption of a diet rich in anti-oxidents reduces progression, Those patients in the highest quartiles of dietary vitamin A, β -carotene, and vitamin C intakes had statistically significantly lower cervical cancer risks than those in the lowest quartiles for vitamin A, β -carotene, and vitamin C Vitamin A and vegetable intake were unrelated to risk. Dark yellow-orange vegetable consumption and duration of multivitamin use were each strongly related to reduced risk of in situ disease (P for trend = 0.02 and 0.002, respectively) and need to be evaluated in other studies. http://www.cdc.gov/cancer/cervical/basic_info/risk_factors.htm http://www.healthyhints.co.uk/wp-content/uploads/cache/2921_NpAdvHover.jpg http://www.ehealthmd.com/library/cervicalcancer/cc_causes.html http://www.webmd.com/sex/birth-control/news/20071108/pill-raises-cervical-cancer-risk ( 5 years of use =‘s double the risk) http://aje.oxfordjournals.org/cgi/content/short/132/3/432 http://jnci.oxfordjournals.org/cgi/content/abstract/80/8/580 http://www.springerlink.com/content/mqu69081w6084672/ http://www.smw.ch/docs/pdf200x/2001/37/smw-09779.pdf http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WG6-50BBSS4-1&_user=10&_coverDate=06%2F18%2F2010&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1411187379&_rerunOrigin=scholar.google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d742dd9fa8f7c7f0e6aab798fc344cf1 http://www.informaworld.com/smpp/content~db=all~content=a918786268 http://www.nature.com/bjc/journal/v101/n1/full/6605098a.html
The real cell cycle……likely even more complex than this….this is where the influence of a multitude of outside and internal factors can influence the health of the cell cycle. Alter any of these cell processes…those that limit the rate of cell multiplication or alter the self-checking potential or potential for apoptosis and the result will be abnormal growth
Chronic Inflammation creates a micro-environment that encourages, cancer development, proliferation and growth The body is in a constant state striving for balance……you see there are pro-inflammatory cells and anti-inflammatory cells which work in concert together to balance the body. For example….the immune cells which help protect us from bacterial and viral infections also have the potential when they become overactive or mis-infirmed to cause Rheumatoid arthritis etc……so when inflammation becomes a primary force….then dysfunction increases
Caucasian women more likely to ……. http://www.cancer.org/Cancer/BreastCancer/DetailedGuide/breast-cancer-risk-factors
The Health Consequences of Involuntary Exposure to Tobacco Smoke, concluded that there is &quot;suggestive but not sufficient&quot; evidence of a link at this point. In any case, this possible link to breast cancer is yet another reason to avoid secondhand smoke. Higher red meat intake in adolescence may increase the risk of premenopausal breast cancer. (Cancer Epidemiol Biomarkers Prev 2008;17(8):2146–51) The approximate 50% reduction in risk( of recurrence) associated with these healthy lifestyle behaviors was observed in both obese and nonobese women, although fewer obese women were physically active with a healthy dietary pattern (16% v 30%). Among those who adhered to this healthy lifestyle, there was no apparent effect of obesity on survival. The effect was stronger in women who had hormone receptor–positive cancers. http://www.mayoclinic.com/health/breast-cancer/DS00328/DSECTION=risk-factors
http://www.mayoclinic.com/health/endometrial-cancer/DS00306/DSECTION=risk-factors Caucasian women are 70% more likely to get Endometrial CA than Blacks http://www.mskcc.org/mskcc/html/13172.cfm
OCPs reduce uterine cancer risk increase breast, cervical cancer risk http://www.cdc.gov/cancer/uterine/basic_info/risk_factors.htm
Up to 80% of sexually active Americans may be infected Sexual Habits= early exposure, # of partners, Plasma beta-carotene reduced risk from top to bottom quartile by 80%, vitamin C by 60%, and fruit juices by 50%., Consumption of a diet rich in anti-oxidents reduces progression, Those patients in the highest quartiles of dietary vitamin A, β -carotene, and vitamin C intakes had statistically significantly lower cervical cancer risks than those in the lowest quartiles for vitamin A, β -carotene, and vitamin C Vitamin A and vegetable intake were unrelated to risk. Dark yellow-orange vegetable consumption and duration of multivitamin use were cach strongly related to reduced risk of in situ disease (P for trend = 0.02 and 0.002, respectively) and need to be evaluated in other studies. http://www.cdc.gov/cancer/cervical/basic_info/risk_factors.htm http://www.healthyhints.co.uk/wp-content/uploads/cache/2921_NpAdvHover.jpg http://www.ehealthmd.com/library/cervicalcancer/cc_causes.html http://www.webmd.com/sex/birth-control/news/20071108/pill-raises-cervical-cancer-risk ( 5 years of use =‘s double the risk) http://aje.oxfordjournals.org/cgi/content/short/132/3/432 http://jnci.oxfordjournals.org/cgi/content/abstract/80/8/580 http://www.springerlink.com/content/mqu69081w6084672/ http://www.smw.ch/docs/pdf200x/2001/37/smw-09779.pdf http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WG6-50BBSS4-1&_user=10&_coverDate=06%2F18%2F2010&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1411187379&_rerunOrigin=scholar.google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d742dd9fa8f7c7f0e6aab798fc344cf1 http://www.informaworld.com/smpp/content~db=all~content=a918786268 http://www.nature.com/bjc/journal/v101/n1/full/6605098a.html