SlideShare una empresa de Scribd logo
1 de 21
Post-Transcriptional Modification The mRNA transcript synthesized by RNA polymerase II is modified in eukaryotes.
Steps of mRNA Processing ,[object Object],[object Object],[object Object]
Nascent RNA transcripts from protein-coding genes are called pre-mRNA . They  are associated with proteins until they are exported into the cytosol.  These proteins and the mRNA are collectively called heterogenous ribonucleoprotein particles (hnRNP).
Functions of hnRNP ,[object Object],[object Object],[object Object]
5’ CAPPING ,[object Object],[object Object],[object Object]
3’POLYADENYLATION ,[object Object],[object Object],[object Object],[object Object]
RNA SPLICING ,[object Object],[object Object],[object Object],[object Object]
Splicing Mechanism – PART 1 ,[object Object],[object Object],[object Object]
SPLICING MECHANISM – PART 2 ,[object Object],[object Object],[object Object]
SPLICING MECHANISM – PART 3 ,[object Object],[object Object],[object Object],[object Object],[object Object]
Trans-Splicing ,[object Object],[object Object],[object Object]
Ribozymes ,[object Object],[object Object],[object Object],[object Object],[object Object]
Alternative Splicing ,[object Object],[object Object],[object Object]
RNA Editing ,[object Object],[object Object]
Transport Across the Nuclear Membrane ,[object Object],[object Object],[object Object]
Nuclear Pore Complex
Molecular trafficking between the nucleus and the cytoplasm occurs via nuclear pore complexes (NPCs). The NPCs allow passive diffusion of ions and small molecules. Nuclear proteins, RNAs, and ribonucleoprotein (RNP) particles larger than ~9 nm are selectively and actively transported through NPCs by a signal-mediated and energy-dependent mechanism.
Import into the Nucleus ,[object Object],[object Object],[object Object]
 
[object Object]
MRNA Export through the NPC ,[object Object]

Más contenido relacionado

La actualidad más candente

La actualidad más candente (20)

Translation and post translational modifications
Translation and post translational modificationsTranslation and post translational modifications
Translation and post translational modifications
 
post transcriptional modifications
post transcriptional modificationspost transcriptional modifications
post transcriptional modifications
 
Tryptophan operon
Tryptophan operonTryptophan operon
Tryptophan operon
 
post-translational modification
post-translational modificationpost-translational modification
post-translational modification
 
Transcription
TranscriptionTranscription
Transcription
 
Transcription and post-transcriptional modification.
Transcription and post-transcriptional modification.Transcription and post-transcriptional modification.
Transcription and post-transcriptional modification.
 
Arabinose Operon
Arabinose OperonArabinose Operon
Arabinose Operon
 
Rna polymerase & transcription in prokaryotes
Rna polymerase & transcription in prokaryotesRna polymerase & transcription in prokaryotes
Rna polymerase & transcription in prokaryotes
 
Post transcriptional modification ( splicing mechanisms)
Post transcriptional modification ( splicing mechanisms)Post transcriptional modification ( splicing mechanisms)
Post transcriptional modification ( splicing mechanisms)
 
PLASMID - TYPES & ITS PROPERTIES.pptx
PLASMID - TYPES & ITS PROPERTIES.pptxPLASMID - TYPES & ITS PROPERTIES.pptx
PLASMID - TYPES & ITS PROPERTIES.pptx
 
EUKARYOTIC TRANSCRIPTION.pptx
EUKARYOTIC TRANSCRIPTION.pptxEUKARYOTIC TRANSCRIPTION.pptx
EUKARYOTIC TRANSCRIPTION.pptx
 
Transcription
TranscriptionTranscription
Transcription
 
RNA processing final eukaryotes.
RNA processing final eukaryotes.RNA processing final eukaryotes.
RNA processing final eukaryotes.
 
Eukaryotic transcription
Eukaryotic transcription Eukaryotic transcription
Eukaryotic transcription
 
Post translational modification
Post translational modificationPost translational modification
Post translational modification
 
Dna replication in eukaryotes
Dna replication in eukaryotesDna replication in eukaryotes
Dna replication in eukaryotes
 
Rna splicing
Rna splicingRna splicing
Rna splicing
 
Translation in eukaryotes
Translation in eukaryotesTranslation in eukaryotes
Translation in eukaryotes
 
Translation
TranslationTranslation
Translation
 
Translation in Prokaryotes and Eukaryotes
Translation in Prokaryotes and EukaryotesTranslation in Prokaryotes and Eukaryotes
Translation in Prokaryotes and Eukaryotes
 

Destacado (7)

Post translational modifications
Post translational modificationsPost translational modifications
Post translational modifications
 
Polygenic Inheritance
Polygenic InheritancePolygenic Inheritance
Polygenic Inheritance
 
Post-Translational Modifications
Post-Translational ModificationsPost-Translational Modifications
Post-Translational Modifications
 
Post transcriptional modification
Post transcriptional modificationPost transcriptional modification
Post transcriptional modification
 
Polygenic inheritance
Polygenic inheritancePolygenic inheritance
Polygenic inheritance
 
Polygenic Inheritance (AHL)
Polygenic Inheritance (AHL)Polygenic Inheritance (AHL)
Polygenic Inheritance (AHL)
 
Genetic disorders
Genetic disordersGenetic disorders
Genetic disorders
 

Similar a Post-Transcriptional Modification

5 cap and polyadenylationPost-transcriptional mRNA modification.pdf
5 cap and polyadenylationPost-transcriptional mRNA modification.pdf5 cap and polyadenylationPost-transcriptional mRNA modification.pdf
5 cap and polyadenylationPost-transcriptional mRNA modification.pdf
krram1989
 
Group 6 - Post Transcriptional Modifications (RNA Splicng and ALternative Spl...
Group 6 - Post Transcriptional Modifications (RNA Splicng and ALternative Spl...Group 6 - Post Transcriptional Modifications (RNA Splicng and ALternative Spl...
Group 6 - Post Transcriptional Modifications (RNA Splicng and ALternative Spl...
NafeesaHanif1
 
Biochem synthesis of rna(june.23.2010)
Biochem   synthesis of rna(june.23.2010)Biochem   synthesis of rna(june.23.2010)
Biochem synthesis of rna(june.23.2010)
MBBS IMS MSU
 

Similar a Post-Transcriptional Modification (20)

Structure and function of Messenger RNA (mRNA )
Structure and function of Messenger RNA (mRNA )Structure and function of Messenger RNA (mRNA )
Structure and function of Messenger RNA (mRNA )
 
POST TRANSCRIPTIONAL MODIFICATIONS IN EUKARYOTES
POST TRANSCRIPTIONAL MODIFICATIONS IN EUKARYOTESPOST TRANSCRIPTIONAL MODIFICATIONS IN EUKARYOTES
POST TRANSCRIPTIONAL MODIFICATIONS IN EUKARYOTES
 
Post transcriptional modifications
Post transcriptional modificationsPost transcriptional modifications
Post transcriptional modifications
 
RNA_splicing_ppt.ppt
RNA_splicing_ppt.pptRNA_splicing_ppt.ppt
RNA_splicing_ppt.ppt
 
13-miller-chap-8-lecture (1).ppt
13-miller-chap-8-lecture (1).ppt13-miller-chap-8-lecture (1).ppt
13-miller-chap-8-lecture (1).ppt
 
transcription activators, repressors, & control RNA splicing, procesing and e...
transcription activators, repressors, & control RNA splicing, procesing and e...transcription activators, repressors, & control RNA splicing, procesing and e...
transcription activators, repressors, & control RNA splicing, procesing and e...
 
Rna splicing
Rna splicingRna splicing
Rna splicing
 
Mol genet-8. transkripsi2
Mol genet-8. transkripsi2Mol genet-8. transkripsi2
Mol genet-8. transkripsi2
 
POST TRANSCRIPTIONAL MODOFICATION.pptx
POST TRANSCRIPTIONAL MODOFICATION.pptxPOST TRANSCRIPTIONAL MODOFICATION.pptx
POST TRANSCRIPTIONAL MODOFICATION.pptx
 
Post transcriptional modification
Post transcriptional modificationPost transcriptional modification
Post transcriptional modification
 
Small nuclear rna
Small nuclear rnaSmall nuclear rna
Small nuclear rna
 
5 cap and polyadenylationPost-transcriptional mRNA modification.pdf
5 cap and polyadenylationPost-transcriptional mRNA modification.pdf5 cap and polyadenylationPost-transcriptional mRNA modification.pdf
5 cap and polyadenylationPost-transcriptional mRNA modification.pdf
 
post transcriptional modifications
post transcriptional modifications post transcriptional modifications
post transcriptional modifications
 
Group 6 - Post Transcriptional Modifications (RNA Splicng and ALternative Spl...
Group 6 - Post Transcriptional Modifications (RNA Splicng and ALternative Spl...Group 6 - Post Transcriptional Modifications (RNA Splicng and ALternative Spl...
Group 6 - Post Transcriptional Modifications (RNA Splicng and ALternative Spl...
 
Post transcriptional modification of proteins
Post transcriptional modification of proteinsPost transcriptional modification of proteins
Post transcriptional modification of proteins
 
Non coding RNA,s
Non coding RNA,sNon coding RNA,s
Non coding RNA,s
 
Molecular biology of the gene ch 13 rna splicing part1
Molecular biology of the gene ch 13 rna splicing part1Molecular biology of the gene ch 13 rna splicing part1
Molecular biology of the gene ch 13 rna splicing part1
 
RNA Splicing
RNA SplicingRNA Splicing
RNA Splicing
 
Biochem synthesis of rna(june.23.2010)
Biochem   synthesis of rna(june.23.2010)Biochem   synthesis of rna(june.23.2010)
Biochem synthesis of rna(june.23.2010)
 
hn RNA processing
hn RNA processinghn RNA processing
hn RNA processing
 

Último

Architecting Cloud Native Applications
Architecting Cloud Native ApplicationsArchitecting Cloud Native Applications
Architecting Cloud Native Applications
WSO2
 
Cloud Frontiers: A Deep Dive into Serverless Spatial Data and FME
Cloud Frontiers:  A Deep Dive into Serverless Spatial Data and FMECloud Frontiers:  A Deep Dive into Serverless Spatial Data and FME
Cloud Frontiers: A Deep Dive into Serverless Spatial Data and FME
Safe Software
 
+971581248768>> SAFE AND ORIGINAL ABORTION PILLS FOR SALE IN DUBAI AND ABUDHA...
+971581248768>> SAFE AND ORIGINAL ABORTION PILLS FOR SALE IN DUBAI AND ABUDHA...+971581248768>> SAFE AND ORIGINAL ABORTION PILLS FOR SALE IN DUBAI AND ABUDHA...
+971581248768>> SAFE AND ORIGINAL ABORTION PILLS FOR SALE IN DUBAI AND ABUDHA...
?#DUbAI#??##{{(☎️+971_581248768%)**%*]'#abortion pills for sale in dubai@
 

Último (20)

Apidays New York 2024 - Passkeys: Developing APIs to enable passwordless auth...
Apidays New York 2024 - Passkeys: Developing APIs to enable passwordless auth...Apidays New York 2024 - Passkeys: Developing APIs to enable passwordless auth...
Apidays New York 2024 - Passkeys: Developing APIs to enable passwordless auth...
 
ProductAnonymous-April2024-WinProductDiscovery-MelissaKlemke
ProductAnonymous-April2024-WinProductDiscovery-MelissaKlemkeProductAnonymous-April2024-WinProductDiscovery-MelissaKlemke
ProductAnonymous-April2024-WinProductDiscovery-MelissaKlemke
 
Biography Of Angeliki Cooney | Senior Vice President Life Sciences | Albany, ...
Biography Of Angeliki Cooney | Senior Vice President Life Sciences | Albany, ...Biography Of Angeliki Cooney | Senior Vice President Life Sciences | Albany, ...
Biography Of Angeliki Cooney | Senior Vice President Life Sciences | Albany, ...
 
WSO2's API Vision: Unifying Control, Empowering Developers
WSO2's API Vision: Unifying Control, Empowering DevelopersWSO2's API Vision: Unifying Control, Empowering Developers
WSO2's API Vision: Unifying Control, Empowering Developers
 
Architecting Cloud Native Applications
Architecting Cloud Native ApplicationsArchitecting Cloud Native Applications
Architecting Cloud Native Applications
 
Apidays New York 2024 - The value of a flexible API Management solution for O...
Apidays New York 2024 - The value of a flexible API Management solution for O...Apidays New York 2024 - The value of a flexible API Management solution for O...
Apidays New York 2024 - The value of a flexible API Management solution for O...
 
How to Troubleshoot Apps for the Modern Connected Worker
How to Troubleshoot Apps for the Modern Connected WorkerHow to Troubleshoot Apps for the Modern Connected Worker
How to Troubleshoot Apps for the Modern Connected Worker
 
MS Copilot expands with MS Graph connectors
MS Copilot expands with MS Graph connectorsMS Copilot expands with MS Graph connectors
MS Copilot expands with MS Graph connectors
 
Polkadot JAM Slides - Token2049 - By Dr. Gavin Wood
Polkadot JAM Slides - Token2049 - By Dr. Gavin WoodPolkadot JAM Slides - Token2049 - By Dr. Gavin Wood
Polkadot JAM Slides - Token2049 - By Dr. Gavin Wood
 
MINDCTI Revenue Release Quarter One 2024
MINDCTI Revenue Release Quarter One 2024MINDCTI Revenue Release Quarter One 2024
MINDCTI Revenue Release Quarter One 2024
 
Exploring Multimodal Embeddings with Milvus
Exploring Multimodal Embeddings with MilvusExploring Multimodal Embeddings with Milvus
Exploring Multimodal Embeddings with Milvus
 
[BuildWithAI] Introduction to Gemini.pdf
[BuildWithAI] Introduction to Gemini.pdf[BuildWithAI] Introduction to Gemini.pdf
[BuildWithAI] Introduction to Gemini.pdf
 
Cloud Frontiers: A Deep Dive into Serverless Spatial Data and FME
Cloud Frontiers:  A Deep Dive into Serverless Spatial Data and FMECloud Frontiers:  A Deep Dive into Serverless Spatial Data and FME
Cloud Frontiers: A Deep Dive into Serverless Spatial Data and FME
 
Apidays New York 2024 - The Good, the Bad and the Governed by David O'Neill, ...
Apidays New York 2024 - The Good, the Bad and the Governed by David O'Neill, ...Apidays New York 2024 - The Good, the Bad and the Governed by David O'Neill, ...
Apidays New York 2024 - The Good, the Bad and the Governed by David O'Neill, ...
 
Mcleodganj Call Girls 🥰 8617370543 Service Offer VIP Hot Model
Mcleodganj Call Girls 🥰 8617370543 Service Offer VIP Hot ModelMcleodganj Call Girls 🥰 8617370543 Service Offer VIP Hot Model
Mcleodganj Call Girls 🥰 8617370543 Service Offer VIP Hot Model
 
+971581248768>> SAFE AND ORIGINAL ABORTION PILLS FOR SALE IN DUBAI AND ABUDHA...
+971581248768>> SAFE AND ORIGINAL ABORTION PILLS FOR SALE IN DUBAI AND ABUDHA...+971581248768>> SAFE AND ORIGINAL ABORTION PILLS FOR SALE IN DUBAI AND ABUDHA...
+971581248768>> SAFE AND ORIGINAL ABORTION PILLS FOR SALE IN DUBAI AND ABUDHA...
 
"I see eyes in my soup": How Delivery Hero implemented the safety system for ...
"I see eyes in my soup": How Delivery Hero implemented the safety system for ..."I see eyes in my soup": How Delivery Hero implemented the safety system for ...
"I see eyes in my soup": How Delivery Hero implemented the safety system for ...
 
Understanding the FAA Part 107 License ..
Understanding the FAA Part 107 License ..Understanding the FAA Part 107 License ..
Understanding the FAA Part 107 License ..
 
Apidays New York 2024 - APIs in 2030: The Risk of Technological Sleepwalk by ...
Apidays New York 2024 - APIs in 2030: The Risk of Technological Sleepwalk by ...Apidays New York 2024 - APIs in 2030: The Risk of Technological Sleepwalk by ...
Apidays New York 2024 - APIs in 2030: The Risk of Technological Sleepwalk by ...
 
Introduction to Multilingual Retrieval Augmented Generation (RAG)
Introduction to Multilingual Retrieval Augmented Generation (RAG)Introduction to Multilingual Retrieval Augmented Generation (RAG)
Introduction to Multilingual Retrieval Augmented Generation (RAG)
 

Post-Transcriptional Modification

  • 1. Post-Transcriptional Modification The mRNA transcript synthesized by RNA polymerase II is modified in eukaryotes.
  • 2.
  • 3. Nascent RNA transcripts from protein-coding genes are called pre-mRNA . They are associated with proteins until they are exported into the cytosol. These proteins and the mRNA are collectively called heterogenous ribonucleoprotein particles (hnRNP).
  • 4.
  • 5.
  • 6.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15.
  • 17. Molecular trafficking between the nucleus and the cytoplasm occurs via nuclear pore complexes (NPCs). The NPCs allow passive diffusion of ions and small molecules. Nuclear proteins, RNAs, and ribonucleoprotein (RNP) particles larger than ~9 nm are selectively and actively transported through NPCs by a signal-mediated and energy-dependent mechanism.
  • 18.
  • 19.  
  • 20.
  • 21.