Six sigma is a business strategy that seeks to improve quality by identifying and removing causes of defects. It aims for 3 defects per million opportunities by using a DMAIC model for process improvement. The DMAIC model involves designing processes around customer demands, measuring current performance, analyzing data for variation, improving processes with variation, and controlling deviations to prevent defects. Sigma indicates how often defects occur, with higher sigma representing lower defect rates and higher quality.