GRF One Health Summit 2012, Davos: Presentation by Prof. Cezmi A. Akdis - Director - Swiss Institute of Allergy and Asthma Research SIAF / President - European Academy of Allergy Clinical Immunology EAACI

1. World’s leader in allergy and clinical immunology

2. The Leader … 42 National Societies, more than 7000 academicians, researchers and clinicians

3. National societies GARD WHO EFA EAACI Patient Organizations committee EU Research Networks Predicta Medall EuroPrevall AllFUN Cohorts The Umbrella EAACI Dieticians EAACI GPs Allergy Nurses and other allied health JMA EAACI Mentorship Programme

4. Matrix Organization of Sections & IGs: The Matrix Allied health Epidemiology Junior Members Ocular allergy Allergy Diagnosis Functional genomics&proteomics Infection and allergy

5. Congresses The Quality

8. Allergy Impact factor: 6.2 PAI Impact factor: 2.7 EAACI newsletter EAACI monographs New EAACI E-Journal Clinical and Translational Allergy www.ctajournal.com

10. Food Quality & Safety Quality & Safety of Skin Care Products

11. EAACI Congress 2012, Geneva

12. The School

13. Bern-Interlaken Davos Dubrovnik Prague Rotterdam Davos Chalkidiki Antalya Oxford Bischenberg– Bischoffsheim Helsinki London Davos Venice Madeira Davos Norwich Fischbachau, Germany Mykonos, Greece Ancona, Italy EAACI Schools 2003-12 Berlin Sardinia Kusadasi Verona Saariselkä Krakow Athens Grainau Pickl Hannover Grainau äre Edinburgh Porto Heli, Greecei

14. Body surfaces: Skin 0.5% Mucosas 99.5% Lung: 100 m 2 Gut: 300 m 2 1 Ton food mixed with water per year 10 14 bacteria 1 kg 2000 species =12*0.6*60*24*365*80 3‘027‘456‘000 liters 10 billion particles (3 perLiter) 1 kg 1 1/2 Tennis court

15. Immune system is a highly interactive networking, which makes ist decisions on the basis of input from all organs and tissues, infections, normal flora bacteria, and many or even any environmental agents

16. Allergens Sensitization Phase IgE eosinophil mucosal epithelium Th2/Th0 apoptosis Effector Phase x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x

18. Las Meninas , 318x276 cm Prado Museum- Madrid 1656 , Diego Velàsquez

19. Pablo Picasso Las Meninas 161x129 cm Musée Picasso - Barcelone

23. Framework programmes – budget (in billion Euro)

24. CK-CARE Global Allergy Forum GAF-Davos Immunobiology of allergic inflammation WG4 C. Akdis, M. Akdis, K. Blaser, B. Bochner, E-M. de Villiers, A. Fire, S.Galli, G. Marone, M. Mempel, H. zur Hausen,

29. GA²LEN Network of Excellence Collaboration centres Partners 26 partners 60 collaborating cente rs

31. 2010 -2015 WP no. Work package WP 1 Longitudinal cohort WP 2 Mouse models WP 3 Epithelial models WP 4 Virus-bacteria interactions WP 5 Immune regulation WP 6 Resolution of inflammation WP 7 Diagnostics WP 8 Interventions WP 9 Management

32. Ted’s friends are laughing at him… He is the only one in the class without allergy !

33. Solution Networking & incentives for efficient collaborative research among clinicians, biologists/immunologists, epidemiologists and bioinformaticians, in collaborating groups elsewhere, to solve all of the unresolved questions Research, Research, Research Meet to discuss results

34. Solution Increase worldwide awareness and embrace all parties

35. Solution Develop evidence based One Health and (The Science of One Health)

37. Thank you

39. CK-CARE Action-I Induction of immune tolerance to allergens - Establish an immune tolerance subgroup Use direct approaches (tonsil, lymph node) Start clinical trials Detailed analyses of patients (e.g., deep sequencing of mRNAs and DNAs) Meet again to evaluate the data

40. CK-CARE Action-II A CK-CARE patient cohort should be established and a continuous flow of specimens should be provided (e.g., to CK-CARE network and collaborating outside laboratories) for broad „discovery“ research For endotypes/subtypes of asthma Identify endotypes (define biomarkers) Identify causative molecular mechanisms Clone and express biologicals Start clinical trials

44. BUT there are Geographic Differences There is v little allergy in Athens and NO reported allergy to peanut There is a lot of food allergy in Amsterdam to all the foods