Dr. harman vasopeptidase inhibition

Vasopeptidase Inhibition: A New Direction in Cardiovascular Treatment . By: Dr. HARMANJIT SINGH MD STUDENT , GMC , PATIALA

INTRODUCTION ,[object Object],[object Object],[object Object]

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Risk stratification in patients with hypertension Risk Group A Risk Group B Risk Group C ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Treatment strategies by risk stratification and risk group categories in patients with hypertension BP stages (mm Hg) Treatment Strategy Risk Group A Risk Group B Risk Group C High-Normal (130-139 / 85-89) Lifestyle modification Lifestyle modification Drug therapy, Lifestyle modification Stage 1 (140-159 / 90-99) Lifestyle modification upto 12 months Lifestyle modification upto 6 months (patients with multiple factors should receive drug therapy + lifestyle modification) Drug therapy, lifestyle modification Stage 2 & 3 (> 160 / > 100) Drug therapy, lifestyle modification Drug therapy + lifestyle modification Drug therapy + lifestyle modification

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Renin-Angiotensin System ,[object Object],[object Object],[object Object]

Figure 1 showing role of RAS system in cardiovascular disease

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[object Object],[object Object],[object Object],Natriuretic Pep Ctnd……

[object Object],[object Object],[object Object],[object Object],[object Object],There is also a forth natriuretic peptide known as dendroaspis natriuretic peptide (DNP), isolated from the venom of the green Mamba snake but little is known about it.

Figure 2 showing the benefits of inhibiting NEP

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Figure 3 showing combined pathways involved in vasopeptidase inhibition

Other Trials ,[object Object]

Adverse effects of VPIs ,[object Object],[object Object],[object Object]

Conclusion ,[object Object],[object Object],[object Object]

Dr. harman vasopeptidase inhibition

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