Health in Gum is the best option to your new medicated chewing gum against Xerostomia

2. What is Xerostomia?
Xerostomia is the medical term for a dry mouth due to the
lack of saliva
Xerostomia can lead to a bad breath, a dramatic rise in the
number of cavities as the protective effect of saliva is no
longer present, and can make the mouth more vulnerable
to infection and ulceration

3. Types of Xerostomia
Salivary glands
1
IRREVERSIBLE
Salivary glands produce NO
saliva (Sjögren’s Syndrome,
radiotherapy treatment)
2
REVERSIBLE
Reduction in salivary gland
function

4. How to relief Xerostomia?
Chewing
Xylitol
+
Chewing sugarfree
gum, increases
salivary flow in patients
with xerostomia by up
to 7 times
Xylitol is proven to
prevent harmful bacteria
from growing and harmful
plaque from building up
on teeth

5. Which active ingredients can help with
Xerostomia?
1
ACIDS
Like malic acid or ascorbic
acid
2
ENZYMES
Like lactoperoxidase,
lysozyme or lactoferrin

6. Is chewing gum effective in stimulating
salivary flow?
Mastication is agreed to be the main reason for saliva stimulation
during gum chewing
Furthermore intensity of mastication is positively related to salivary flow

7. Studies: chewing gum and salivary flow rate
A study into the effects of chewing duration and frequency
on the flow rate of whole saliva, by the International and
American Association for Dental Research, revealed that
salivary flow rate peaked during the first minute of
chewing

8. Studies: chewing gum and salivary flow rate
The flow rate was independent of chewing frequency within
a range of 35 to 130 chewing maneuvers per minute
The influence of sample size (weight) of chewing gum on
saliva flow was assessed by means of gums weighing from
1 to 9 g
The 1-g piece led to a four-fold, the 9-g piece to a 13-fold
increase in salivary flow
The size of a piece of chewing gum can have a
significant influence on salivary flow rate

9. Conclusion
Chewing gum is a potent and fast stimulant of salivary flow
rate, being a very effective way to relief Xerostomia
The addition of specific active ingredients- acids or
enzymes- in the gum can also improve such positive effects
Cafosa presents Health in Gum®, the ideal excipient to
formulate and produce medicated chewing gum by direct
compression, using standard pharmaceutical equipment
The best option to your new medicated chewing
gum against Xerostomia

10. Sources:
EFSA Journal
Cro.sagepub.com
Dentaid.com
Medicalnewstoday.com
Wrigley