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One Health approaches
Genesis, implementation and best practices
National One Health Symposium
November 26, 2013
Hotel Royal Plaza, New Delhi

Organised by Massey and PHFI

Delia Grace
International Livestock Research Institute
CGIAR Research Program on Agriculture for Nutrition and Health (A4NH)
Overview
• Human and animal health in the 21st century
• One Health: its genesis and kindred

• One Health in practice
– Mapping multiple burdens of disease
– Making safe food fair
– Understanding barriers and bridges to One Health

• Building a business case for One Health
Human health in the 21st century
• 7 billion people 2011
30
25

Deaths (millions)

– 1 billion hungry;
– 2 billion with hidden hunger;
– 1.5 billion overweight / obese

20

15

• In 2011 55 million died
– 18 million from infection
– 7 million deaths in under
fives (2/3 infectious)
– One in four of the deaths in under five
children occur in India

10
5
0

04

15

30

High-income

04

15

30

04

15

30

Middle-income Low-income
Animal health in the 21st century
• 24 billion livestock
– 19 billion in developing countries
– 1 billion poor people depend on livestock
• 600,000 in south Asia

• 5 billion die each year (~25%)
Young

Adult

Annual mortality of African
livestock

Cattle

22%

6%

(About half due to preventable or
curable diseases)

Shoat

28%

11%

Poultry

70%

30%
Otte & Chilonda,
Animal endemic disease costs billions annually
8
7

Billion $ lost yearly

6

Africa
South Asia

5
4
South Asia
3

Africa

2
1
0

Estimates from BMGF
One Health approach
Humans

...encourages the collaborative efforts of
multiple disciplines working locally,
nationally, and globally, to attain optimal
health for people, animals, and our
environment

Wildlife

Domestic
animals
“One Health”– Addresses Zoonotic Dieases
19th century

Robert Virchow (18211902) : “…between animal
and human medicine there
is no dividing line” (Kahn et
al., 2007).

20th century   

Calvin Schwabe (1927-2006): veterinary
epidemiologist and parasitologist,
described and promoted One Medicine
and proposed a unified human and
veterinary approach to zoonoses in his
1964 book Veterinary Medicine and
Human Health.

The American Veterinary
Medicine Association defines
One Health as “the
collaborative effort of
multiple disciplines-working
locally, nationally, and
globally – to attain optimal
health for people, animals
and our environment.”
Integrative approaches
ONE HEALTH

EcoHealth

Animal Health health
Human

Human health

VP
H.
One Medicine

.livestock

.CA
.wildlife

Agro-ecosystem health

Societies, cultures,
Economies, institutions,
Policies

Incentives
Values
Preferences
Culture
Ignorance
Governance
Rule-breaking

Modified from Schelling

8
The unfinished agenda - challenges
• Good experience in linking human and animal
health and sometimes environmental but:
– in specific communities or locations;
– around specific events / outbreaks; and

– at pilot intervention scale

• Capacity is more responsive than preventive

• Systems change faster than paradigms
Overview
• Human and animal health in the 21st century
• One Health: its genesis and kindred

• One Health in practice
– Mapping multiple burdens of disease
– Making safe food fair
– Understanding barriers and bridges to One Health

• Building a business case for One Health
One Health as added value
“One Health” can be defined as the added value in
terms of lives of animals and humans saved, financial
savings and improved ecosystem services from a
closer cooperation of human and animal health as
compared to single sector approaches.

Zinsstag et al. (2012) Onderstepoort J Vet Res. 2012 Jun 20;79(2):E1-5. doi:
10.4102/ojvr.v79i2.492.
Top Zoonoses (multiple burdens)
• Assessed 56 zoonoses from Deaths - annual
6 listings:
responsible 2.7 billion cases, 2.5 million deaths
• “Unlucky 13” responsible for 2.2 billion
illnesses and 2.4 million deaths

2000000
1800000

140000

1600000

120000

1400000

100000

1200000

80000

1000000
800000
600000

– All 13 have a wildlife interface
– 9 have a major impact on livestock
– All 13 amenable to on-farm intervention
60000

40000

400000
200000

20000

0

0

Top 13
zoonoses

Next 43
Official reporting systems
Reporting Zoonoses Scope
system
WAHID

33

Animal

TAD Info

2

Animal

Pro Med

All

All

GLEWS

19

All

Health
Map

All

All

Source: HealthMap

Africa
•
•
•
•

253 million SLU
25 million lost annually
12-13 million from notifiable disease
80,000 reported == 99.8% un-reported
PRIORITY DISEASES
1: Avian influenza
2: Rabies
3: Leptospirosis

Priority diseases don’t reflect importance
OR ability to control
Driven by media, donors, misperceptions
•

One billion PLK depend on 19 billion livestock

•

4 countries have 44% of PLK

•

75% rural, 25% urban poor depend on livestock

•

Livestock contribute typically 2-33% income

•

Livestock contribute typically 6-36% protein
Greatest burden of endemic zoonoses falls on on
billion poor livestock keepers

• Unlucky 13 zoonoses sicken 2.4 billion
people, kill 2.2 million people and
affect more than 1 in 7 livestock each
year
Hotspots
• Poor livestock keepers: South Asia 600 m,
sub-saharan Africa 300 m
• Zoonoses burden: India, Myanmar, Bangladesh,
Pakistan
• Emerging disease risk: West Europe, West USA
• BIG SIX Countries for all risk factors
– S Asia: India, Bangladesh, Pakistan
– Africa: Ethiopia, Nigeria, Congo
SAFE FOOD FAIR FOOD
19
20
Zoonoses:

Milk

Bacterial

Xenobiotics

Viral

Chemicals

Parasitic

Pathogens

Prion

Allergens

Every study finds
hazards

Manure
Social conflict

Xenobiotics

Traffic accidents

Chemicals

Injuries

Pathogens

Environmental degradation

Aesthetic

21
100%

Fail to meet standards

In many cases the
formal sector is no
better or worse at
meeting standards
0%

The high hazards of
the informal sector
often do not translate
to risks
Every study finds
massive nutrition &
livelihood benefits for
the informal sector

Raw milk

Pasteurised

• Generates million of jobs
• Raw milk earns more for the
farmer and costs less for the
household
• Consumers prefer taste and
provenance of local products
22
Framework for understanding the barriers & bridges to
OH as well as the costs and benefits
New mechanisms for developing
policies & implementing programs
•Clear shared goals
•Agreed structures, processes, roles
•Buy-in at senior level
•Sufficient human resources
•Sufficient financial resources

Changes in organisational culture
& philosophy
•Strong culture
•Fosters cooperation & collegiality
•Welcomes different perspectives
•Focus on outcome, not output
•Innovation

New Incentives & accountabilities
•360 degree accountability

•Performance measures that reflect One Health principles
•Reward and recognition for this
•Shared outcome targets
•Benefits for all

23
Overview
• Human and animal health in the 21st century
• One Health: its genesis and kindred

• One Health in practice
– Mapping multiple burdens of disease
– Making safe food fair
– Understanding barriers and bridges to One Health

• Building a business case for One Health
The business case for One Health
1. Sharing resources: efficiency & effectiveness
savings
2. Controlling diseases in the animal reservoir
rather than human victim
3. Early detection and management of
emerging threats
4. Pandemic prevention
5. Generating insights and adding value
25
Costs & benefits of controlling zoonoses
Annual benefit

Annual cost

Confidence

Sharing resources

4 billion

1 billion

++

Controlling zoonoses

90 billion

15 billion*

+++

Ensuring timely response

6 billion

++
3.4 billion

Averting pandemics

37 billion

+

Improving research and
development

?

?

+++

Bottom line

137 billion

20 billion

++
26
20 billion investment for 140 billion benefits

Extraordinary return to investments
Need to generate more evidence where
lacking, and ramp up lobbying where strong
Payoff: Avert 2.2 human million deaths, 2.4
million human illnesses, 2 billion animal
deaths, 6.7 billion $ outbreak losses

27
Conclusions: One Health
• Benefits
– Provides important and non-obvious insights
– Helps attain multiple societal objectives
– Improves effectiveness and efficiency

• Challenges
– Up-scaling and out-scaling
– Demonstrating added value

• Opportunities
– Building a business case
– Overcoming barriers, opening bridges
Agriculture Associated Diseases
http://aghealth.wordpress.com/

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One Health approaches: Genesis, implementation and best practices

  • 1. One Health approaches Genesis, implementation and best practices National One Health Symposium November 26, 2013 Hotel Royal Plaza, New Delhi Organised by Massey and PHFI Delia Grace International Livestock Research Institute CGIAR Research Program on Agriculture for Nutrition and Health (A4NH)
  • 2. Overview • Human and animal health in the 21st century • One Health: its genesis and kindred • One Health in practice – Mapping multiple burdens of disease – Making safe food fair – Understanding barriers and bridges to One Health • Building a business case for One Health
  • 3. Human health in the 21st century • 7 billion people 2011 30 25 Deaths (millions) – 1 billion hungry; – 2 billion with hidden hunger; – 1.5 billion overweight / obese 20 15 • In 2011 55 million died – 18 million from infection – 7 million deaths in under fives (2/3 infectious) – One in four of the deaths in under five children occur in India 10 5 0 04 15 30 High-income 04 15 30 04 15 30 Middle-income Low-income
  • 4. Animal health in the 21st century • 24 billion livestock – 19 billion in developing countries – 1 billion poor people depend on livestock • 600,000 in south Asia • 5 billion die each year (~25%) Young Adult Annual mortality of African livestock Cattle 22% 6% (About half due to preventable or curable diseases) Shoat 28% 11% Poultry 70% 30% Otte & Chilonda,
  • 5. Animal endemic disease costs billions annually 8 7 Billion $ lost yearly 6 Africa South Asia 5 4 South Asia 3 Africa 2 1 0 Estimates from BMGF
  • 6. One Health approach Humans ...encourages the collaborative efforts of multiple disciplines working locally, nationally, and globally, to attain optimal health for people, animals, and our environment Wildlife Domestic animals
  • 7. “One Health”– Addresses Zoonotic Dieases 19th century Robert Virchow (18211902) : “…between animal and human medicine there is no dividing line” (Kahn et al., 2007). 20th century    Calvin Schwabe (1927-2006): veterinary epidemiologist and parasitologist, described and promoted One Medicine and proposed a unified human and veterinary approach to zoonoses in his 1964 book Veterinary Medicine and Human Health. The American Veterinary Medicine Association defines One Health as “the collaborative effort of multiple disciplines-working locally, nationally, and globally – to attain optimal health for people, animals and our environment.”
  • 8. Integrative approaches ONE HEALTH EcoHealth Animal Health health Human Human health VP H. One Medicine .livestock .CA .wildlife Agro-ecosystem health Societies, cultures, Economies, institutions, Policies Incentives Values Preferences Culture Ignorance Governance Rule-breaking Modified from Schelling 8
  • 9. The unfinished agenda - challenges • Good experience in linking human and animal health and sometimes environmental but: – in specific communities or locations; – around specific events / outbreaks; and – at pilot intervention scale • Capacity is more responsive than preventive • Systems change faster than paradigms
  • 10. Overview • Human and animal health in the 21st century • One Health: its genesis and kindred • One Health in practice – Mapping multiple burdens of disease – Making safe food fair – Understanding barriers and bridges to One Health • Building a business case for One Health
  • 11. One Health as added value “One Health” can be defined as the added value in terms of lives of animals and humans saved, financial savings and improved ecosystem services from a closer cooperation of human and animal health as compared to single sector approaches. Zinsstag et al. (2012) Onderstepoort J Vet Res. 2012 Jun 20;79(2):E1-5. doi: 10.4102/ojvr.v79i2.492.
  • 12. Top Zoonoses (multiple burdens) • Assessed 56 zoonoses from Deaths - annual 6 listings: responsible 2.7 billion cases, 2.5 million deaths • “Unlucky 13” responsible for 2.2 billion illnesses and 2.4 million deaths 2000000 1800000 140000 1600000 120000 1400000 100000 1200000 80000 1000000 800000 600000 – All 13 have a wildlife interface – 9 have a major impact on livestock – All 13 amenable to on-farm intervention 60000 40000 400000 200000 20000 0 0 Top 13 zoonoses Next 43
  • 13. Official reporting systems Reporting Zoonoses Scope system WAHID 33 Animal TAD Info 2 Animal Pro Med All All GLEWS 19 All Health Map All All Source: HealthMap Africa • • • • 253 million SLU 25 million lost annually 12-13 million from notifiable disease 80,000 reported == 99.8% un-reported
  • 14. PRIORITY DISEASES 1: Avian influenza 2: Rabies 3: Leptospirosis Priority diseases don’t reflect importance OR ability to control Driven by media, donors, misperceptions
  • 15. • One billion PLK depend on 19 billion livestock • 4 countries have 44% of PLK • 75% rural, 25% urban poor depend on livestock • Livestock contribute typically 2-33% income • Livestock contribute typically 6-36% protein
  • 16. Greatest burden of endemic zoonoses falls on on billion poor livestock keepers • Unlucky 13 zoonoses sicken 2.4 billion people, kill 2.2 million people and affect more than 1 in 7 livestock each year
  • 17. Hotspots • Poor livestock keepers: South Asia 600 m, sub-saharan Africa 300 m • Zoonoses burden: India, Myanmar, Bangladesh, Pakistan • Emerging disease risk: West Europe, West USA • BIG SIX Countries for all risk factors – S Asia: India, Bangladesh, Pakistan – Africa: Ethiopia, Nigeria, Congo
  • 19. 19
  • 20. 20
  • 21. Zoonoses: Milk Bacterial Xenobiotics Viral Chemicals Parasitic Pathogens Prion Allergens Every study finds hazards Manure Social conflict Xenobiotics Traffic accidents Chemicals Injuries Pathogens Environmental degradation Aesthetic 21
  • 22. 100% Fail to meet standards In many cases the formal sector is no better or worse at meeting standards 0% The high hazards of the informal sector often do not translate to risks Every study finds massive nutrition & livelihood benefits for the informal sector Raw milk Pasteurised • Generates million of jobs • Raw milk earns more for the farmer and costs less for the household • Consumers prefer taste and provenance of local products 22
  • 23. Framework for understanding the barriers & bridges to OH as well as the costs and benefits New mechanisms for developing policies & implementing programs •Clear shared goals •Agreed structures, processes, roles •Buy-in at senior level •Sufficient human resources •Sufficient financial resources Changes in organisational culture & philosophy •Strong culture •Fosters cooperation & collegiality •Welcomes different perspectives •Focus on outcome, not output •Innovation New Incentives & accountabilities •360 degree accountability •Performance measures that reflect One Health principles •Reward and recognition for this •Shared outcome targets •Benefits for all 23
  • 24. Overview • Human and animal health in the 21st century • One Health: its genesis and kindred • One Health in practice – Mapping multiple burdens of disease – Making safe food fair – Understanding barriers and bridges to One Health • Building a business case for One Health
  • 25. The business case for One Health 1. Sharing resources: efficiency & effectiveness savings 2. Controlling diseases in the animal reservoir rather than human victim 3. Early detection and management of emerging threats 4. Pandemic prevention 5. Generating insights and adding value 25
  • 26. Costs & benefits of controlling zoonoses Annual benefit Annual cost Confidence Sharing resources 4 billion 1 billion ++ Controlling zoonoses 90 billion 15 billion* +++ Ensuring timely response 6 billion ++ 3.4 billion Averting pandemics 37 billion + Improving research and development ? ? +++ Bottom line 137 billion 20 billion ++ 26
  • 27. 20 billion investment for 140 billion benefits Extraordinary return to investments Need to generate more evidence where lacking, and ramp up lobbying where strong Payoff: Avert 2.2 human million deaths, 2.4 million human illnesses, 2 billion animal deaths, 6.7 billion $ outbreak losses 27
  • 28. Conclusions: One Health • Benefits – Provides important and non-obvious insights – Helps attain multiple societal objectives – Improves effectiveness and efficiency • Challenges – Up-scaling and out-scaling – Demonstrating added value • Opportunities – Building a business case – Overcoming barriers, opening bridges