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Lung cancer is an epidemical disease, annually there are 1.4 million deaths and about 1.6 million new cases. More people die of lung cancer than of colon, breast, and prostate cancers combined. Lung cancer mainly occurs in older people. About 2 out of 3 people diagnosed with lung cancer are older than 65. Fewer than 3% of all cases are found in people under the age of 45. The average age at the time of diagnosis is about 71. The chance that a man will develop lung cancer is about 1 in 13, for a woman, the risk is about 1 in 16, These numbers include both smokers and non-smokers. For smokers the risk is much higher, while for non-smokers the risk is lower. Lung cancer incidence rates were around twice as high in more developed countries compared with less developed countries
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Alzheimer is the most neurodegenerative disorder in the aged people. It is characterized by senile, accumulation of amyloid plaque, neurofibrillary tangle and progressive decline in brain memory cells. Alzheimer disease is associated with inflammatory response, synaptic damage and mitochondrial dysfunctions which are a prominent and early feature of Alzheimer disease.
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XCI is a dosage-compensation mechanism that evolved to equalize expression levels of x-linked genes in female (2x) and male (1x) by transcriptional silencing of one x-chromosome in female mammalian cells. XIC It is responsible for initiating X inactivation in cis: an X-chromosome fragment that carries a Xic can become inactivated, whereas one in which the Xic is missing cannot. The Xic is also involved in ‘counting’, whereby only a single X is kept active per two sets of autosomes in a cell, and all other Xic-carrying chromosomes are inactivated.
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