Dr. Michael Vander Kooy and Dr. Michael Jones present the latest news and information from the Agnesian Cancer Center about technology and the team.

2. What’s New In
Cancer Care
Michael Vander Kooy, MD
Radiation Oncologist
Agnesian Cancer Center
Know & Go Friday. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Michael Jones, MD
Medical Oncologist
Agnesian Cancer Center

3. Advances In Radiation Oncology
Michael Vander Kooy, MD
Radiation Oncologist
Agnesian Cancer Center

4. Radiation Oncology
Michael Vander Kooy, MD Filip Troicki, MD Timothy Korytko, MD

5. Radiation Therapy
Noelle B., RTT Ellie B., RTT Bonnie D., RTT

6. Radiation Therapy
Brian S., RTT Angie H., RN

7. Radiation Nursing
Tammie L., RN Mary L., RNStacy S., RN

8. Ancillary Associates
Tim L.
Physicist
Phil B.
Dosimetrist
Heather B.,
Oncology Supervisor

9. Ancillary Associates
Chris B.
Oncology Navigator
Liz H., RD
Dietitian
Kristie M., MSW
Social Worker

10. Agnesian Cancer Center

11. Linear Accelerator

41. THANK YOU!

42. Advances In Medical Oncology
Michael Jones, MD
Medical Oncologist
Agnesian Cancer Center

43. Medical Oncology
Joel Lundberg, MD Michael Jones, MD

44. Sara S., LPN Betsy M., LPN Rachel S., RN
Medical Oncology

45. Nicki W., RN Margot B., RN Terri B., RN
Medical Oncology

46. Kristin M., RN Cindy K., RN
Medical Oncology

47. Patty S.
Pharmacy Technician
Travis D., PharmD, RPh
Medical Oncology

48. General Outline
What is cancer
Cancer heterogeneity and implications for
treatment
General cancer treatments.
Targeted cancer therapy
The Story of BCR-ABL and chronic
myelogenous leukemia.
BRAF and melanoma.

49. What Is Cancer?
What Has Happened?

50. Cancer Is a Genetic Disease
Cancer is a genetic disease that develops in a
predictable sequence of steps
 Carcinogenesis
 Transformation of a normal cell into a cancerous
cell
 Occurs by a step-by-step transformation
 Involves an abnormal change in cell DNA called a
mutation.
 These mutations facilitate the cell to divide,
invade, and metastasize independent of normal
cell controls.

51. Cancer Often Involves
Multiple Mutations

52. Multiple Mutations Influence
Cancer Cells Survival

53. Carcinogenesis Occurs
In Predictable Steps

54. Cancer Heterogeneity
and Implications
for Treatment

55. How is Cancer Heterogeneous?

56. We Are Just Beginning
to Understand

57. General Cancer Treatments

58. How Does An Oncologist
Treat Cancer?
Chemotherapy
Radiation Therapy
Immunotherapy
Targeted Therapy

59. Targeted Cancer Therapy

60. Targeted Cancer Therapy
Identifying specific gene abnormalities which
facilitate or allow cancer to grow and divide, and
“targets” that abnormality with a specific drug.
“Dumb Cancer”- Cancer has developed just a few
mutations which are vital to the cancer cell’s
survival.
“Smart Cancer”- Cancer has developed multiple
mutations which facilitate its growth. Each is
important but not necessarily vital to cancer cell
survival.

61. Targeted Cancer Therapy
The Story of BCR-ABL and
Chronic Myelogenous Leukemia

62. Chronic Myelogenous Leukemia
A Simple Cancer
Normal blood smear Leukemia blood
smear
Translocation
of DNA in
Chromosome

63. Variations in Chromosomal
Deletions Patterns in Patients
with Glioblastoma Brain Tumor
p53
locus
Chromosomal Loss:
PTEN
locus
CDKN2
locus
RB1
locus

64. Chronic Myelogenous Leukemia
Normal blood smear
Leukemia blood smear
Translocation of DNA
in Chromosome

65. Imatinib (Gleevac) in Chronic
Myelogenous Leukemia

66. Impact of Treatment on Patients
Lives Treated with Gleevac

67. Targeted Cancer Therapy
Melanoma & BRAF

68. Melanoma

69. Mutational Frequency
In Melanoma
Hodis, Cell 2012

70. How BRAF Works in Melanoma

71. Drug Targeting BRAF

72. 14-Day Response to Vemurafenib

73. Effects of Vemurafenib On
Survival in Metastatic Melanoma

74. THANK YOU!