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THERAPEUTIC CLASS OVERVIEW
Moderate to Severe Pain: Novel Abuse Deterrent
Formulation Technologies and Emergence of Novel
Mechanisms in the Management of Pain
PainManagement
Table Of Contents : Pain Management
Therapeutic Class Overview : Pain Management
Moderate to Severe Pain: Novel Abuse Deterrent
Formulation Technologies and Emergence of Novel
Mechanisms in the Management of Pain
PainManagement
Table Of Contents : Pain Management / 01
Therapeutic Class Overview : Pain Management
Table of Contents
i. Implantable pump for intrathecal delivery
j. OPTIGEL Lock
k. Small molecule delivery
l. Bio-MD-prodrugs platform
m. Ligand activated Therapy (LAT)
n. NOBUSE
o. ORADUR
p. EGALET
q. Inspirion delivery Technologies
r. Intellitab Technology
s. Trigger lock platform –Micropump
t. Fenrock
u. Smart Patch PNS system
5. Pipeline analysis of Novel Mechasim in Pain Therapy
a. Multi-day formulation of Tramadol
b. Bio-MD Platform
c. Angiotension II antagonist
d. Anti-NGF
e. Ligand Activate Therapy
f. Nav1. 7 inhibitor
g. GPCR –Dimer Screen Technology
h. CB agonist
i. Peptide Therapeutics (conopeptide)
j. TRPV1 antagonist
k. Fentanyl based therapy formulation modification (micro and nano tab)
l. Oromucosal delivery
m. Opioid alternatives (dexmedetomidine)
n. Steroidal intraarticular injection
o. TrkA receptor antagonist
Therapeutic Class Overview : Pain Management
Table Of Contents : Pain Management / 02
6. Late stage pipeline developments in neuropathic pain
a. Cebranopadol
b. Mirogabalin
c. CNV-2197944
d. Sativex
e. Once daily pregabalin
f. Topical clonidine gel
g. Topical ketamine and amitraline
h. Eladur
i. GRC-17536
j. DWP05195
7. FDA Perspective on Abuse deterrent formulations (Opioids) Companies mentioned:
• AbbVie
• AcelRx
• Acorda Therapeutics
• Actavis
• Acura Pharma
• Altus formulations
• Amorsa Therapeutics
• AstraZeneca
• BioDelivery Sciences International Inc
• Cara Therapeutics
• Catalent
• Charleston
• Collegium Pharma
• Convergence
• Daiichi
• Daewoong
Therapeutic Class Overview : Pain Management
Table Of Contents : Pain Management / 03
PainManagement
• Depomed
• Durect
• Egalet
• Eli Lilly
• Elite Pharma
• Endo
• Flamel Technologies
• Flexion Therapeutics
• Glenmark
• Grunenthal
• Immune Pharmaceuticals
• Impax Pharmaceuticals
• Inspirion Delivery technologies
• Intelli Pharmaceutics
• Johnson and Johnson
• KemPharm
• Kineta
• Kunwha Pharmaceutical
• Medallion Therapeutics
• Nektar
• Orbis Biosciences
• Orexo
• Pain Therapeutics
• Pfizer
• Purdue
• Recro
• Relmada Therapeutics
• Signature Therapeutics
• Spinifex pharma
Therapeutic Class Overview : Pain Management
Table Of Contents : Pain Management / 04
• SPR Therapeutics
• Teikoku
• Teva
• Trevena Inc
• Tris Pharma
• Valeant
• Xenon Pharma
• XenoPort
Tables :
Table-1: US Pain Market Size
Table-2: Classification Based on Intensity of Pain
Table-3: Marketed Fentanyl Dosage Forms (Us): Transdermal Patches, Buccal And Sublingual
Tablets And Films For Pain Relief
Table-4: Commonly Used Opioids For Pain Management
Table-5: Marketed Drugs for Neuropathic Pain
Table-6: Drug Enforcement Authority (DEA) Controlled Substances Schedule Criteria
Table-7: Summary of Controlled Substances Act requirements
Table-8: Common Non-Opioids – Acetaminophen and NSAIDs
Table-9: Benefits of Sublingual Microtablets vs. IV morphine Patient Controlled Analgesia
Chart -1: Classification of Pain
Chart-2: Pain Relief Ladder -WHO
Chart-3: Neuropathic Pain market size and projection through 2020
Chart-4: Global Healthcare Market Expenditure through 2018: Therapy Class
Chart-5: Global NME (2008-12) Availability in 2013
Chart-6: Death Rates from Prescription opioids overdose in the US
Chart-7: DETERx Multiparticulate system
Chart-8: PF614: Prodrug of Oxycodone (ER Oxycodone)
Charts:
Therapeutic Class Overview : Pain Management
Table Of Contents : Pain Management / 05
PainManagement

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Paing management

  • 1. THERAPEUTIC CLASS OVERVIEW Moderate to Severe Pain: Novel Abuse Deterrent Formulation Technologies and Emergence of Novel Mechanisms in the Management of Pain PainManagement Table Of Contents : Pain Management Therapeutic Class Overview : Pain Management
  • 2. Moderate to Severe Pain: Novel Abuse Deterrent Formulation Technologies and Emergence of Novel Mechanisms in the Management of Pain PainManagement Table Of Contents : Pain Management / 01 Therapeutic Class Overview : Pain Management Table of Contents
  • 3. i. Implantable pump for intrathecal delivery j. OPTIGEL Lock k. Small molecule delivery l. Bio-MD-prodrugs platform m. Ligand activated Therapy (LAT) n. NOBUSE o. ORADUR p. EGALET q. Inspirion delivery Technologies r. Intellitab Technology s. Trigger lock platform –Micropump t. Fenrock u. Smart Patch PNS system 5. Pipeline analysis of Novel Mechasim in Pain Therapy a. Multi-day formulation of Tramadol b. Bio-MD Platform c. Angiotension II antagonist d. Anti-NGF e. Ligand Activate Therapy f. Nav1. 7 inhibitor g. GPCR –Dimer Screen Technology h. CB agonist i. Peptide Therapeutics (conopeptide) j. TRPV1 antagonist k. Fentanyl based therapy formulation modification (micro and nano tab) l. Oromucosal delivery m. Opioid alternatives (dexmedetomidine) n. Steroidal intraarticular injection o. TrkA receptor antagonist Therapeutic Class Overview : Pain Management Table Of Contents : Pain Management / 02
  • 4. 6. Late stage pipeline developments in neuropathic pain a. Cebranopadol b. Mirogabalin c. CNV-2197944 d. Sativex e. Once daily pregabalin f. Topical clonidine gel g. Topical ketamine and amitraline h. Eladur i. GRC-17536 j. DWP05195 7. FDA Perspective on Abuse deterrent formulations (Opioids) Companies mentioned: • AbbVie • AcelRx • Acorda Therapeutics • Actavis • Acura Pharma • Altus formulations • Amorsa Therapeutics • AstraZeneca • BioDelivery Sciences International Inc • Cara Therapeutics • Catalent • Charleston • Collegium Pharma • Convergence • Daiichi • Daewoong Therapeutic Class Overview : Pain Management Table Of Contents : Pain Management / 03 PainManagement
  • 5. • Depomed • Durect • Egalet • Eli Lilly • Elite Pharma • Endo • Flamel Technologies • Flexion Therapeutics • Glenmark • Grunenthal • Immune Pharmaceuticals • Impax Pharmaceuticals • Inspirion Delivery technologies • Intelli Pharmaceutics • Johnson and Johnson • KemPharm • Kineta • Kunwha Pharmaceutical • Medallion Therapeutics • Nektar • Orbis Biosciences • Orexo • Pain Therapeutics • Pfizer • Purdue • Recro • Relmada Therapeutics • Signature Therapeutics • Spinifex pharma Therapeutic Class Overview : Pain Management Table Of Contents : Pain Management / 04
  • 6. • SPR Therapeutics • Teikoku • Teva • Trevena Inc • Tris Pharma • Valeant • Xenon Pharma • XenoPort Tables : Table-1: US Pain Market Size Table-2: Classification Based on Intensity of Pain Table-3: Marketed Fentanyl Dosage Forms (Us): Transdermal Patches, Buccal And Sublingual Tablets And Films For Pain Relief Table-4: Commonly Used Opioids For Pain Management Table-5: Marketed Drugs for Neuropathic Pain Table-6: Drug Enforcement Authority (DEA) Controlled Substances Schedule Criteria Table-7: Summary of Controlled Substances Act requirements Table-8: Common Non-Opioids – Acetaminophen and NSAIDs Table-9: Benefits of Sublingual Microtablets vs. IV morphine Patient Controlled Analgesia Chart -1: Classification of Pain Chart-2: Pain Relief Ladder -WHO Chart-3: Neuropathic Pain market size and projection through 2020 Chart-4: Global Healthcare Market Expenditure through 2018: Therapy Class Chart-5: Global NME (2008-12) Availability in 2013 Chart-6: Death Rates from Prescription opioids overdose in the US Chart-7: DETERx Multiparticulate system Chart-8: PF614: Prodrug of Oxycodone (ER Oxycodone) Charts: Therapeutic Class Overview : Pain Management Table Of Contents : Pain Management / 05 PainManagement