3. Noäi dung
I. Tính chaát virus
II. Sinh beänh hoïc
III. Mieãn dòch
IV. Trieäu chöùng
V. Chaån ñoaùn virus hoïc
VI. Dòch teã hoïc
VII. Phoøng
VIII. Ñieàu trò
16. Infection Transmission Modification of
behaviour
Death
? 10 days 2-5 Days
Viral excretion
Base de la période de mise sous surveillance
(Dogs and cats)
17. V. Chaån ñoaùn virus hoïc
1. Ñoái vôùi ÑV:
a. nhanh : khaûo saùt moâ naõo
- Tìm KN virus baèng KT HQ:
pp nhanh (sau 2 giôø)
caàn tieâm ngöøa hay khoâng
- Tìm theå Negri / TBTK
b. Phaân laäp virus:
caàn nhieàu thôøi gian
19. Level 2 (3) of biological safety
Lab coats
Masks
Goggles
Gloves
Overshoes
Safety hoods
Safety Measures
Vaccination of the staff
20. Specimens for
rabies diagnostic
Intra-vitam diagnosis
Specimens Clinical phase Temperature
0-8 days >8 days of shipment
Saliva +++ +++ -20°C
Urine +++ ?? -20°C
Skin biopsy +++ ++ -20°C
Serum + ++ -20°C
CSF (+) (+) -20°C
Post-mortem diagnosis
Brain biopsy (reference test) (+4 or -20°C)
Skin biopsy (-20°C)
Shipment according to regulation concerning
infectious material (Class 6.2)
21. TRANSCRIPTION
leader
N P G L3' 5'
GENOME (negative polarity) 12 kb
PPP
TRANSLATION
Nucleo-
protein
Phospho-
protein
Matrix
protein
Glyco-
protein
Polymerase
M
REPLICATION
Genome (-)
Antigenome (+)
MORPHOGENESIS
Trailer
Polymerase complex
Targets of diagnosis
RT-PCR
IF, ELISA
Isolation
MNT, RFFIT, ELISA
Routine
post mortem
diagnosis
in humans
and animals
24. TRANSCRIPTION
leader
N P G L3' 5'
GENOME (negative polarity) 12 kb
PPP
TRANSLATION
Nucleo-
protein
Phospho-
protein
Matrix
protein
Glyco-
protein
Polymerase
M
REPLICATION
Genome (-)
Antigenome (+)
MORPHOGENESIS
Trailer
Polymerase complex
Targets of diagnosis
RT-PCR
IF, ELISA
Isolation
MNT, RFFIT, ELISA
Intra vitam diagnosis