1. VISION Protects eyeballs from foreign object.
o Lacrimal Apparatus
ANATOMY o Group of structures that produces and drains lacrimal
Eyelids fluid or tears.
o ―Palpebrae‖ o Lacrimal Glands
o Upper eyelid, more movable than the lower eyelid. Produces 1mL lacrimal fluid/ day
o Palpebral fissure Shape and size of an almond
Space between upper and lower eyelids. Secrete lacrimal fluid.
Exposes eyeball. o Excretory lacrimal ducts
o Lacrimal Caruncle Empty tears on the surface of the conjunctiva of
1. Reddish elevation at the medial commissure. the upper eyelid.
2. Has sebaceous and sudoriferous glands. o Lacrimal punctum
o Commissures Two small openings where tears enter after
1. Medial commissure passing medially over the anterior surface of the
Broader. eyeball
Near nasal bone. o Lacrimal canals
2. Lateral commissure Two ducts that leads to the lacrimal sac
Narrower. o Nasolacrimal duct
Closer to temporal bone. Duct that carries lacrimal fluid into the nasal cavity
o Conjunctiva o Lacrimation
Thin, protective mucous membrane. Lacrimal glands over secrete tears if there is
2 divisions: irritant present
Bulbar Conjunctiva Protective mechanism
Anterior surface of eyeball. Tears dilute and wash away irritating substance
o SORE EYES - Dilation and congestion of Tears contains lysozyme(protective bactericidal
blood vessesl on this area. enzyme), salts and some mucus.
Palpebral Conjunctiva Lubricates ,protects and moistens the eyeball.
Inner aspect of eyelids. *Colds, obstruction of nasolacrimal ductsand bloacks
o Tarsal Plate drainage of tears.
Fold of connective tissue. *Crying, response to parasympathetic stimulation. Lacrimal
Gives form and support to the eyelids. gland produces excessive lacrimal fluid that spill over the
Embeded in it: edges of the eyelids and fill nasal cavity with fluid (runny
Tarsal or Meibomian Glands nose).
Modified sebaceous gland
Keeps eyelids from adhering to each EXTERIOR OF THE EYEBALL
other Eyeball
- CHALAZION - infection of the tarsal o 2.5 cm in diameter, anterior 1/6 is exposed
gland o Composed of 3 Layers:
o Eyelashes and Eyebrows 1. Fibrous Tunic
o Sebaceous ciliary glands (Glands of Zeis) Superficial coat of eyeball.
Release fluid at the base of the hair follicles. Avascular.
STYE - infection on this gland. Anterior cornea
o Eyelashes Transparent coat, covers colored iris.
Project from border of the eyelid. Focus light onto the retina.
o Eyebrows Outer surface: nonkeratinized startified
Arch transversely above upper eyelid. squamous epithlium.
2. Middle surface: collagen fibers and Parasympympathetic, bright
fibroblasts. light, iris contract decrease pupil
Inner surface: simple squamous epithelium. size
Posterior sclera Pupil
―Scler-‖= hard. Hole at the center of Iris.
White of the eye. Autonomic reflexes regulate pupil
Layer of dense CT (collagen fibers and diameter in response to light levels.
fibroblasts) 3. Retina
rd
Covers entire eyeball except cornea. Inner and 3 coat of eyeball.
Give shapes and rigidity to eyeball. Lines posterior ¾ of eyeball.
Protects inner part. Beginning of visual pathway.
Scleral Venous Sinus Optic disc- where optic nerve, central retinal
Canal of Schlemm artery and vein exits.
- Where aqueous humor drains. Blind spot (no rods or cones).
2. Vascular Tunic Cosnsists of:
―Uvea‖ - Pigmented layer
Middle layer of the eyeball Sheet of melanin-containing
Has 3 parts: epithelial cells.
Choroid Melanin- absorbs stray
Posterior portion of vascular tunic. light.
Lines internal surface of sclera. Prevent reflection and
Provides nutrients to the surface of scattering of light w/in
sclera. eyeball
Anterior: ciliary body. Location between choroid and
Extends to ora serrata, jagged anterior neural part of retina.
margin of retina. Other cell types: horizontal and amacrine cells.
Ciliary Body Neural Layer
A. Cilliary processes Outgrowth of brain that processes visual data.
Protrusions on the internal surface of the 3 layers: separated by outer and inner
retina. synaptic layer
Contains blood capillaries—secretes Bipolar cell layer
aqueous humor. Ganglion cell layer
Where zonular fibers extends. Photoreceptor layer
B. Ciliary muscle Rods: low light threshold, no
Circular band of smooth muscle that color vision
alters shape of lens. Cones: higher threshold,
For adaptation to near and far vision. produce color vision
Iris Macula Lutea
Colored portion of eyeball. At the exact center of the posterior portion of
Suspended between cornea and lens. retina.
Consists of smooth muscles: Central fovea
- Radial (dilator pupillae) Small depression at the center of
Sympathetic, dim light, iris macula lutea.
contract, increase in pupil size Contains only cones.
- Circular (sphincter pupillae) Has the highest visual acuity or
resolution.
3. Lens 1-3 new discs are added to the base of outer
o Behind pupil and iris. segment every hour.
o Crystallins - make up the lens. Cones:
o Transparent and lacks blood vessels. Tapered/Cone-shaped.
o Focus images of retina for clear vision. Old discs go at the tip and phagocytized by
INTERIOR OF THE EYEBALL pigment epithelial cells.
Divided in 2 cavities by the lens o Inner segments
o Anterior cavity Cell nucleus, golgi complex and many
Filled with aqueous humor – watery fluid that mitochondria.
nourishes lens and cornea. o Proximal end
Produce intraocular pressure (16mmhg)- Expands into bulblike synaptic terminals.
maintains shape of eyeball and prevents it
CONES RODS
from collapsing.
Drains at the canal of schlemm and are being Center (Macula) Periphery
replaced.
Bright Dim
Posterior chamber
Iodopsin Rhodopsin
Behind iris, in front of zonular fibers and lens.
Anterior chamber 1 ganglion : 1 2 ganglion : 4
Between cornea and iris. Form and color (Photopic) Intensity/Movement
o Vitreous membrane (Scotopic)
Lies between lens and retina. Visual acuity and color Visual firlds, light and dark -
Has vitreous body. perception adaptatiom
Jelly-like substance , contributes to intraocular
pressure. Photopigments
Vitreal floaters o Integral colored proteins in the plasma membrane.
Collection of debris, can cast shadow to o Absorption of light leads to chemical changes.
retina. o Two parts of photopigments:
Harmless, common to old individuals. Opsin
Hyaloid canal Glycoprotein.
Narrow channel runs through vitreous Different amino acid sequence, different
body from the optic disk to the posterior colors are absorbed.
of the lens. Retinal
Holds retina flush against choroid Light-absorbing part.
For even surface of reception of ear Vitamin A derivative (from carotenoids).
images. o Rods:
Does not undergo constant replacement. Rhodopsin
Absorbs blue to green light.
PHOTORECEPTORS AND COLOR BLINDESS Pleates pinch off from plasma membrane forming
Photoreceptors discs.
o Outer segments o Cones:
Transduction of light energy into a receptor 3 different cone photopigments.
potential occurs here. Absorbs blue, green, yellow orange
They are easily replaced. Blue/Short wavelength (S)
Rods: Green/Medium wavelength (M)
Cylindrical/Rod-shaped. Red/Long wavelength (L)
4. Plasma membrane folds back and forth in a Rods: Contribute little to daylight.
pleated fashion. Cones: Regenerate rapidly.
Cis retinal always present
Photopigments – Visual Transduction
o Isomerization o When light level decreases
Retinal is in bent shape (cis-retinal) fitted to Increased sensitivity and then more slowly.
opsin. In complete darkness
When it absorbs light, retinal straightens (trans- A threshold, light flash is seen as having a
retinal). color.
Isomerization is the transformation from cis-to- Rhodopsin regenerates more slowly,
trans retinal. increasing the visual sensitivity.
Chemical stability is affected. Even a single photon can be detected.
Leads to receptor potential. At low light levels, only rods are functioning.
o Bleaching
Occurs for about a minute. Release of Neurotransmitters by Photoreceptors
Trans-retinal separates from opsin. o Photoreceptor in the absence of light
Final colorless product. Na inflow (“dark current”) into photoreceptor
o After bleaching outer segment.
Rods: Half of them regenerate in 5 minutes. Ligand-gated Na channels.
Cones: Half of them regenerate in 90 seconds. Guanosine monophosphate (cGMP).
o Enzyme retinal isomerase o Inflow partially depolarizes the photoreceptor.
An enzyme converting the trans retinal to cis Membrane potential: -30 mV
retinal again. Triggers release of NT at synaptic terminals
o Regeneration NT in rods and cones: Amino Acid Glutamate
Cis retinal back to opsin to form a functional (Glutamic Acid)
photopigment. o Glutamate
In rods, Between rods and bipolar cells at synaptic
Pigmented layer adjacent to photoreceptors terminals.
has high quantity of Vitamin A. Inhibitory NT
Regeneration of rods. Inhibits postsynaptic potentials.
If retina detaches from pigmented layer, Hyperpolarizes bipolar cells.
regeneration of rhodopsin is low. o Photoreceptor in the presence of light
In cones, Cis retinal goes isomerization.
Photopigments regenerate more quickly. Enzymes are activated leading to breakdown of
Less dependent on pigmented layer. cGMP.
Some cGMP ligand-gated Na channels
Light and Dark Adaptation closes.
o From darks surroundings, light adaptation Na inflow decreases.
Visual system adjusts into bright surroundings. Membrane potential: -70 mV
Visual system decreases sensitivity. Hyperpolarize receptor potential
o Into a darkened room, dark adaptation Decrease in release of NT
Visual system increases sensitivity over minutes. o Dim Lights
o When light level increases Cause small and brief receptor potentials.
More photopigments are bleached. Partial shutdown of some NT release.
In daylight, regeneration of rhodopsin cannot o Brighter lights
keep up with the bleaching process. Elicit larger and longer receptor potentials.
5. Complete shutdown of NT release. Visual Pathway Process
RETINA
Color Blindness o Receptor potentials arise in rods and cones
o Inability to distinguish between certain colors. o Spread through the inner segments to the synaptic
o Absence or deficiency of one of three cone terminals.
photopigments. o Neurotransmitter molecules (glutamate) are released.
o Red-green color blindness o Neurotransmitters induce local graded local potentials
Most common. in bipolar cells and horizontal cells.
Photopigment sensitive to orange-red/ green 6 and 600 rods synapse with bipolar cells.
light is missing. Increases the light sensitivity of rod vision but
Person cannot distinguish between red and green. slightly blurs the image perceived.
o Vitamin A deficiency and consequent below normal Stimulation of rods by light excites their
amount of rhodopsin bipolar cells.
o Night blindness/ Nyctalopia. Cone more often synapses with just one bipolar
Inability to see well at low light levels. cell.
o Deuteranopia Less light sensitivity but has higher acuity due
Absence of green cones. to one-to-one synapses between cones and
o Protanopia their bipolar cells.
Absence of red cones. Stimulation of rods by light may either excite
o Tritanopia or inhibit cone bipolar cells.
Absence of blue cones. o Horizontal cells transmit inhibitory signals to bipolar
cells in the areas lateral to excited rods and cones.
VISUAL PATHWAY AND VISUAL FIELDS Enhances contrasts in the visual scene between
Neuronal cell types: areas of the retina that are strongly stimulated and
o Photoreceptors (rods and cones) – transmit signals to adjacent areas that are more weakly stimulated.
the outer plexiform layer, where they synapse with Assist in the differentiation of various colors.
bipolar cells and horizontal cells. o Amacrine cells are excited by bipolar cells, synapse
o Horizontal cells – transmit signals horizontally in the with ganglion cells and transmit information to them.
outer plexiform layer from the rods and cones to Signals a change in the level of illumination of the
bipolar cells. retina.
o Amacrine cells – transmit signals in two directions, o Ganglion cells become depolarized and initiate nerve
either directly from bipolar cells to ganglion cells or impulses.
horizontally from axons of bipolar cells to dendrites of OPTIC NERVE
the ganglion cells or to other amacrine cells. o Axons within the optic nerve pass through the optic
o Ganglion cells – transmit output signals from the retina chiasm.
through the optic nerve into the brain. Crossing point of the optic nerves.
o Interproximal cell o Medial half of the axons cross the opposite side and
Transmits signals in the retrograde direction from the lateral half of the axons remained uncrossed.
the inner plexiform layer to the outer plexiform o After passing to the optic chiasm, the axons, now part
layer. of the optic tract, enter the brain and terminate in the
The signals are inhibitory and control lateral lateral geniculate nucleus in thalamus.
spread of visual signlas THALAMUS
Help control the degree of contrast in the viual o The axons synapse with neurons whose axons form
image. the optic radiations, which project to the primary
visual area in the occipital lobes of the cerebral cortex.
6. CORTEX o Both surfaces of the lens of the eye further refract the
o Large number of optic fibers project to the lateral light rays so they come into exact focus on the retina.
geniculate nucleus of the thalamus, where information 25% of focusing power (changes the focus to view
from the different ganglion cell types is kept distinct. near or distant objects)
o Receive input from the brainstem reticular formation o Image is focused on the retina: upside down and
and input relayed back from the visual cortex. undergo right to left reversal.
Control the transmission of information from the o Focusing power of the lens:
retinal to the visual cortex. Object is 6 meters (20 feet) or more: light reflected
Involved in our ability to shift attention between from the object are nearly parallel to one another.
vision and the other sensory modalities The rays must be bent enough to be focused
o Lateral geniculate nucleus sends action potentials to on the retina.
the visual cortex. Object is closer than 6 meters (20 feet): light rays
Processed simultaneously in a number of reflected from the object are divergent.
independent ways in different parts of the cerebral The rays must be refracted more to be
cortex. focused on the retina.
Reintegrated to produce the conscious sensation 2. Accommodation
of sight and the perceptions associated with it. o When the eye is focusing on a close object, the lens
Constriction of pupil. becomes more curved and refracts the light more.
Suprachiasmatic nucleus: establishes pattern The lens of the eye is convex on both its anterior
of sleep and other activities in response to and posterior surfaces.
intervals of light and darkness. Increase curvature of lens (for near vision) =
Brainstem and cerebellum: coordination of Increase focusing power
head and eye movements. o Near point vision: minimum distance from the eye
o Cells are organized to handle information about line, that an object can be clearly focused with maximum
contrast, movement, and color. accommodation.
Form a spatial and temporal pattern of electrical
activity. Contraction of ciliary muscle
Visual Field Relaxation of zonular fibers
o Visual area seen by an eye at a given instant.
Relaxation of lens (becoming more
o Nasal field of vision - area seen to the nasal side.
spherical)
Light rays fall on the temporal half of the retina.
o Temporal field of vision - the area seen to the lateral Near objects brought into focus
side.
Light rays fall on the nasal half of the retina. 3. Constriction
o Extend farthest on the temporal sides o Narrowing of the diameter of the pupil through which
o Limited by: light enters.
Superiorly – Brows Contraction of the circular muscles of iris to
Inferiorly – Cheeks constrict the pupil.
Medially – Nose o Occurs simultaneously with accommodation.
o Prevents light rays from entering the eye through the
IMAGE FORMATION periphery of the lens.
1. Refraction
o As light rays enter the eye, they are refracted at the
anterior and posterior surfaces of the cornea.
75% of the total refraction of light
7. VISUAL ACUITY AND PUPILARY REACTION TO LIGHT Pupillary Light Reflex
Visual Acuity o A reflex that controls the diameter of the pupil, in
o Measure of the eyes’ ability to distinguish object details response to the intensity of light that falls on the retina
and shape at a given distance. of the eye.
o Normal Vision o When light is shown into the eyes, the pupils constrict.
Occurs when light is focused directly on the retina o ↑ light intensity= ↑ intensity of signals transmitted by
rather than in front or behind it. the bipolar, horizontal, amacrine, and ganglion cells
o Far Vision (neural adaptation).
Typically measured at twenty feet. o Mechanism of Pupillary light reflex:
Rays of light from a distant object are Optic nerve/ CN II- responsible for the afferent
practically parallel. limb of the reflex. It senses the incoming light.
Little accommodation is required. Oculomotor nerve- responsible for efferent limb of
o Snellen Chart pupillary reflex. It drives the muscles to constrict.
Numerator: the distance the patient is from the Its pathway begins with retinal ganglion cells,
chart which convey information from photoreceptors to
Denominator: the distance at which an normal eye the optic nerve.
could see the optotype on the chart.
Visual Acuity OCULAR MOVEMENTS
Eg. 20/50 Innervated by CN III, IV, VI
A patient sees at twenty feet what the patient o Superior Rectus
with no refractive error or ocular pathology Elevation, adduction and medial rotation of the
would see at fifty feet. eyeball
20/20 visual acuity- ―normal visual acuity‖ o Inferior Rectus
denominator value, the better the acuity; elevation, adduction and lateral rotation of the
denominator value, the poorer the acuity. eyeball
20/40 vision in at least one eye is the vision o Lateral Rectus
required to pass the driving test Abduction of eyeball
20/200- ―legally blind‖ o Medial Rectus
o Hyperopia Adduction of eyeball
The eyeball is short relative to the focusing power o Superior Oblique
of the lens and cornea. Depression, abduction and medial rotation of
Timid or lazy lens. eyeball
Corrected by using eye glasses with convex lens. o Inferior Oblique
o Myopia ELevation, abduction and lateral rotation of
The eyeball is too long relative to the refractive eyeball.
power of the lens and cornea.
Enthusiastic lens. DISORDERS OF THE EYE
Corrected by using eye glasses with concave lens. CATARACT
o Presbyopia o Clouding of the eye's natural lens.
Lens loses elasticity and thus its ability to The lens is mostly made of water and protein. The
accommodate. Therefore, older people cannot protein is arranged in a precise way that keeps the
read print at the same close range as can lens clear and lets light pass through it. But as we
youngsters. age, some of the protein may clump together and
Usually begins in the mid-forties. start to cloud area of the lens.
Age 40: 20 cm (8 in) o Most common cause of vision loss in people over age
Age 60: 80 cm (31 in) 40.
8. o Principal cause of blindness in the world. shadowy areas in your central vision or unusually
Signs and Symptoms fuzzy or distorted vision.
o Vision is blurred a little. o Slow, painless loss of vision
st
Note on 1 bullet. like looking through a cloudy rare case, however, vision loss can be sudden
piece of glass or viewing an impressionist painting Causes
o May make light from the sun or a lamp seem too bright o Hereditary disorders
or glaring o Infections
o The oncoming headlights cause more glare than o Trauma
before o Tumor
o Colors may not appear as bright as they once did o Advancing age
*A cataract starts out small and at first has little effect on your o Smoking
vision o High blood pressure
Causes o Obesity
o Advancing of age o Lighter eye color
o Infection Like in the skin (melanin)
o Trauma Prevention
o Ultraviolet radiation o Diet with high levels of:
o Diabetes Antioxidants
o Smoking Omega-3 fatty acids
o Heavy alcohol consumption Lutein (eggs, spinach, turnips)
Prevention o Amsler grid
o Regular eye check-up straight lines, with a reference dot in the center
o Wearing of sunglasses Treatment
o diet high in antioxidants o No satisfactory medical treatment
Beta-carotene (vitamin A) o Optical aids (i.e. glasses)
Selenium
Vitamins C and E GLAUCOMA
Treatment o Silent thief of sight
o Severe condition Typically cause no pain and produce no symptoms
Surgical removal of lens and is replaced with an until noticeable vision loss occurs
artificial lens o Excessive pressure build-up in the aqueous humor
*Plastic intraocular lens (IOL) – artificial lens Producing too much fluid, or it's not draining
o For impaired vision properly
Visual aids i.e. glasses, bifocals, appropriate o Results from an interference with normal re-entry of
lighting aqueous humor into the blood or from an
overproduction of aqueous humor
MACULA DEGENERATION Pressure within the eye can close off the blood
o Common in older people. vessels entering the eye and may destroy the
o Central vision loss may occur. retina or optic nerve, resulting to blindness
Signs and Symptoms *Normally, IOP should be below 21 mmHg
o Yellowish spots (drusen) Signs and Symptoms
form in the back of the eye or retina are an early *The word "glaucoma" came from a Greek word which means,
sign of "dry" macular degeneration. "opacity of the crystalline lens." (Cataracts and glaucoma were
It is believed these spots are deposits or debris not distinguished until c.1705)
from deteriorating tissue. o Typically, none
o Early signs o In a specific type of glaucoma
9. Blurry vision, halos around lights, intense eye
pain, nausea and vomiting
Prevention
o Exercise
Lowers OPP or ocular perfusion pressure
* OPP is a mathematical value that is calculated using a
person's intraocular pressure and his or her blood pressure.
o Gonioscopy
Make sure the aqueous humor (or "aqueous") can
drain freely from the eye
In gonioscopy, special lenses are used with a
biomicroscope to enable your eye doctor to see
the structure inside the eye (called the drainage
angle) that controls the outflow of aqueous and
thereby affects intraocular pressure.
o Visual field testing
to determine if you are experiencing vision loss
from glaucoma
o Imaging technology
create baseline images and measurements of the
eye's optic nerve and internal structures.
o Tonometer
measure your intraocular pressure, or IOP
Treatment
o Depending on the severity
glaucoma surgery
Lasers
medications
o Glaucoma eye drops
Keeps IOP low