2010Waterswallcalendar

First to market. T he ultimate pain reliever for a generic pharmaceutical company.
In the world of generic pharmaceuticals, there’s a simple saying: He who reaches the market And with its ACQUITY UPLC® System, Waters also helped put Apotex on the fast track to
first gets the biggest return. Little wonder Apotex wanted to decrease their overall cycle time success. You see, the ACQUITY UPLC System does the work of about three traditional HPLC
from inception through to product launch. Naturally, they called Waters. systems, and it helped Apotex conduct mandatory bio-equivalent studies in less time. For
yet another generic drug, Waters helped Apotex complete a critical U.S. FDA filing in a mere
First order of business was talk, not about solutions, but about Apotex. Waters goes beyond the
three months, reducing chemistry time from 88 to 30 days.
norm in order to truly understand a client’s key issues. The meetings were frequent and in-depth.
Because of Waters, Apotex today is better able to launch their generic drugs in the
Waters quickly realized their global capabilities would come into play. For example, both
fast-paced way that leads to success. And because of Apotex’s generic medications,
companies had major operations in the same city in India, making it easier to deploy Waters
patients everywhere have the opportunity to be properly treated in an affordable manner.
Informatics Solutions into the facility, while ensuring consistency and smooth integration.
Efficiency improved. Deliverables increased.

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Chemist discovered inside engineering student.
Engineering students are not chemists. But at the University of Massachusetts, Amherst, And with Waters equipment comes Waters professionals. W hen the students were recently
engineering majors participate in an analytical experience normally reserved for chemists – faced with a challenging study, a team from Waters arrived on campus to help. Patiently,
conducting research on water contaminants. they walked the students through the methodologies, even suggesting alternatives in case
of problems. In the end, an analytical perplexity that would have been a brain-bender for a
T he engineers of tomorrow collect and analyze sensitive data using the latest in high
laboratory full of highly-trained chemists was completed by a classroom of student engineers.
performance technology and equipment. A bit overwhelming, perhaps? Not really.
Because the instruments in the laboratories at UMass-Amherst are Waters instruments. T he hope of UMass-Amherst and Waters Corporation is that by involving students in this
So easy to use even that wide-eyed underclassmen quickly grow comfortable operating unique experience they become more attuned to the importance of water quality as both an
the most sophisticated pieces of technology, like the ACQUITY UPLC® System. environmental and public health issue. And armed with that knowledge, be they civil or
environmental engineers, the projects they develop in the future reflect what they learned
in the classroom normally reserved for chemists.

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Waters brings a healthy dose of productivity to nutritional supplement company.
Pharmavite is the company behind Nature Made, the #1 selling broadline vitamin, mineral,
®
T he uniformity of having all Waters equipment further boosted productivity. Shared parts.
and supplement brand in America. A real stickler for quality, Pharmavite won’t release Same training. Chemists can go from one system to another without confusion.
a single lot of product until confirming it meets FDA requirements. As their sales keep
T he end result for Pharmavite: greater speed, greater performance, dramatically
growing, their LC systems need to keep up.
improved productivity.
So for more speed and better performance, Pharmavite switched to Waters instrumentation:
For a nutritional supplement brand about to go global, that is an easy pill to swallow.
eight LCs and three ACQUITY UPLC® Systems. W hat a difference! T he biotin assay that used
to take 45 minutes is now done in 10. T he Gingko Biloba report that used to take all night
is now finished in a single shift. Echinacea now flies out the door in a couple of days.

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Metabolic disorder: Find it early, save a child.
Skipping across the playground. Trotting off to school. Flying kites in the park. T he Results have revealed over 1,800 cases of inborn errors of metabolism. Early detection
researchers at the Centre Hospital Universitaire de Sherbrooke (CHUS) in Quebec offers a better chance for preventing serious conditions, such as mental retardation,
need not look far to see reminders of why their work is so important. metabolic acidosis, even death. It also offers the opportunity for an improved quality
of life by beginning proper treatments early.
T he children of this French-Canadian province are the reason for a voluntary screening
program to detect metabolic disorders in newborns. Parents collect urine samples from Critical to the proper diagnosis of sick patients is the analytical instrumentation. It provides
their babies at 21 days of age and bring them in for analysis: 500 samples a day, over the high quality results needed to put patients on the right course of treatment. It can, has,
2.6 million samples to date. and will continue to help Quebec’s newest citizens lead healthier and longer lives.

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Farmer dies mysteriously. Only witnesses are the livestock.
Clutching his cell phone, a farmer called his wife from the animal barn. “Help me,” was It was later learned that the farmer had been treating animals in the barn with this drug.
all he said. By the time anyone got to him, it was too late. T he tragedy of his unexpected Somehow he lost his footing and fell to the ground, accidently injecting himself. After yanking
death was compounded by the mystery of what caused it. No signs of a crime. No clues out the syringe, he tossed it aside, before grabbing his cell phone to call his wife. For the
to an accident. No previous health concerns. T he sheriff was stumped. farmer’s widow, law enforcement, and the coroner, there was finally closure. T he cause of
death had been identified with absolute certainty by Waters ACQUITY UPLC/MS System.
Blood samples were sent to one of the most highly regarded forensic laboratories in the
country, AIT Laboratories. Using Waters ACQUITY UPLC® System and time-of-flight Mass Had AIT Laboratories not been using the latest analytical equipment, the drug would not
Spectrometry, the forensic scientists detected a compound they had never seen before. have been discovered. Another example of how Waters technology elevates testing to levels
Additional research identified it as a powerful veterinary antibiotic. Safe for animals, never seen before.
deadly to humans.

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Problem peppers put UK in a pickle. Waters helps prevent a repeat.
T he United Kingdom had a pepper problem of prodigious proportions. A 40,000-pound Aided by the American Spice Trade Council, Certified Laboratories has been able to
shipment of chili peppers was brought in from a foreign country, converted into food utilize Waters technology and analytical science to detect Sudan Red in chili peppers
products, and distributed far and wide. T hat’s when the government discovered that before they enter the country.
the peppers contained Sudan Red, a dye that’s okay in furniture wax and floor polish,
Much of what we eat today comes from all over the world. Waters technology is
but hardly in food. T he resulting food recall was one of the largest in history.
helping companies like Certified Laboratories ensure the foods we import are safe
T he challenge of making sure unsafe chemicals, like Sudan Red, never took another ride on for human consumption.
a pack of peppers again fell to Certified Laboratories, a leader in food safety. T hey relied
on Waters equipment. T he low levels of detection required as well as the wide variety of
products undergoing tests could not have been accomplished without Waters ACQUITY
UPLC ®/MS/MS System.

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Protecting T he Empire from unseen invaders.
Protecting the citizens of the United Kingdom from dangerous food contaminants is the job An important combination when dealing with perishable imports like fish from the Far East.
of the scientists at the Central Science Laboratory (CSL). In a single year, they will test tens Typically, the fish are held at port while samples are taken to CSL to look for prohibited
of thousands of samples, running their equipment hard, 24/7. antibiotics or their residues. Since the cargo is perishable, test results are needed very quickly.
With that kind of volume and with so much riding on the accuracy of the results, is it Waters high quality, speedy analysis allows the laboratory to respond rapidly and either
any wonder CSL uses Waters instrumentation? T he tandem quadrupole MS system along reject the fish right there on the dock or approve it for import. Swift, accurate results like
with Waters AutoSpec Premier™ GC/MS Detector monitor for a myriad of contaminants these are what continues to earn the UK a reputation for food safety vigilance.
including pesticides, veterinary drugs, and even packaging chemicals. T he equipment
provides extremely sensitive analysis at very high speeds.

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Separating record breakers from rule breakers in record time.
Members of the Drug Control Center at King’s College London are already gearing up for With so much at stake and the whole world watching, the toxicology team at King’s College
the 2012 Olympics. T hey won’t be running in any events; they’ll be running drug tests London made a big decision – they decided to convert their analytical equipment from
on the Olympic competitors. gas chromatography/mass spectrometry to Waters ACQUITY UPLC ®/tandem MS. W hy?
T hree reasons:
Every year, more and more forbidden substances enter the athletic arena. T he challenge
is to detect the new drugs and to do it as quickly as possible. For the Olympics, testing 1. T he analysis is significantly faster
results must be back in 24 hours, which means the analysis needs to be completed in 2. Prep time is significantly shorter
about 8 hours, allowing the remaining time for possible re-testing, confirming results, 3. Sensitivity is significantly higher because of the lower flow rates
gathering results, etc. T he 2012 Olympic Games may still be years away, but the scientists at King’s College
London are already off and running.

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Want to know what drugs are in a patient’s body? Doctors know not to ask the patient.
How does a doctor determine whether a drug will work if he doesn’t know what other Because of the ACQUITY UPLC ® MS/MS System, Dominion Diagnostics can quickly and
drugs the patient is taking? T his perplexing question challenged Dominion Diagnostics, accurately produce a metabolic profile for the patient and then deliver – in real-time –
a laboratory specializing in urine drug testing and medication monitoring. a comprehensive report and interpretation. Now able to determine the possible drug
interactions on the spot, the clinician can make an immediate and fully-informed decision
Without knowing exactly what the medications are, the number of possible drug interactions
as to which medications are working and which are not.
is mind-numbing. Questioning the patient is no guarantee of accuracy. With herbal remedies
and nutritional supplements readily available, even patients don’t know what’s bouncing T hanks to Waters, clinicians now know exactly what’s in a patient’s body, even if the
around their insides. patient doesn’t.
So what did Dominion Diagnostics do when faced with this challenge? T hey called Waters.

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From a 30-minute stress test to a 1-minute waltz.
T here’s a lot of pressure in the quality control lab of a fast-paced company like Alexza Into the quality control lab rolled the ACQUITY UPLC® System from Waters.
Pharmaceuticals. New products have to get to market as quickly as possible. T he lab has
T he lab completed testing on a migraine medication in one week instead of two.
to provide quick results. T he faster the data turn around, the better for production and
Seventeen minutes instead of 90 minutes for another test. And on another drug,
profitability. But speed is not enough. T he data must also be ultra reliable and compliant
testing time fell from 30 minutes all the way down to 1 minute!
with FDA regulations. If that’s not pressure enough, factor in multiple projects with tight
time lines, and you can see why every test is a stress test. T hat’s the ACQUITY UPLC story: shorter run time, higher quality data.
Fortunately, it didn’t take long for Alexza Pharmaceuticals, a company known for their And a load of pressure off the shoulders of quality control.
innovative products, to realize it needed an instrument equally as innovative to do the job.

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Some see milk. Others see mega-contaminants.
At the Jaume I University in Castellon, Spain, you’ll find the Research Institute of Pesticides In the future, a much more daunting challenge awaits these scientists – identifying the
and Water. Scientists here focus on identifying contaminants in the environment and in food. dangerous mega-contaminants sometimes found in food today. Unregulated, these are
the compounds nobody knows to search for. A classic example is melamine. It was found
Recently the laboratory scientists were asked to analyze popcorn for mycotoxins. Using
in baby formula and other milk products, but only after it had caused the death of four
two new ACQUITY UPLC® Systems coupled to two Waters mass spectrometers, they quickly
Chinese children and severe illness in hundreds of thousands.
located the mycotoxins. Best of all, the results confirmed there was no reason to panic. T he
mycotoxins were well below regulated levels. Waters equipment allowed them to work much T he scientists at Jaume I University hope that by using the latest advances, like
faster, as well as detect compounds at the lowest levels. Waters ACQUITY UPLC/MS/MS Systems, they can find the unexpected contaminant
and help prevent such tragic events in the future.

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Necessity is the mother of mass spectrometry.
W hen the scientists at the University of Warwick (UK) are in need, they call Waters. As luck would have it, Waters had already been working along similar lines. So with
input from the scientists, a new mass spectrometer was created. It became known as
From the latest in analytical instrumentation and software, to just needing an ear to listen
SYNAPT™ High Definition Mass Spectrometry, or HDMS™ for short, the first commercial
™
to their ideas and plans for the future. In one particular case, the necessity involved
shape-selective mass spectrometry instrument. Originally purchased to study misfolded
instrumentation that was only dreamt about. T he scientists were studying misfolded
proteins, it also allows the scientists at the University of Warwick to collect 200 high-
proteins, the ones that are thought to create diseases such as Alzheimer’s and Parkinson’s.
quality mass spectra in 18 milliseconds.
But traditional instrumentation wasn’t enough to get the job done. T he university asked
Waters if they could build a shape-selective mass spectrometer. It was a necessity. And that’s how necessity led to a new form of mass spectrometry.

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www.waters.com
Waters and ACQUITY UPLC are registered trademarks of Waters Corporation. AutoSpec Premier, SYNAPT, High Definition Mass Spectrometry,
HDMS, and The Science of What’s Possible are trademarks of Waters Corporation. All other trademarks are the property of their respective owners.

©2009 Waters Corporation. Printed in the U.S.A.
October 2009 720001963EN LB-CP

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