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Arguments in favor of and against the HPV vaccine school-entry
requirement in Puerto Rico: a content analysis of newspaper
media
Coralia Vázquez-Otero1, Dinorah Martinez Tyson2, Cheryl A. Vamos2, Nancy Romero-
Daza3, Jason Beckstead2, Ellen M. Daley2
1.College for Health, Community and Policy at the University of Texas at San Antonio, San
Antonio, TX 78249, USA
2.University of South Florida College of Public Health, 13201 Bruce B. Downs Bld., MDC 56,
Tampa, FL 33612, USA
3.Department of Anthropology, University of South Florida College of Arts and Sciences, 4202 E.
Fowler Ave., SOC 134, Tampa, FL 33620, USA
Abstract
Purpose—Vaccine requirements are effective population-based strategies to increase vaccination
rates. In 2018, Puerto Rico’s DOH announced that the HPV vaccine would be required for school
entrance. This study explored arguments in favor of and against the HPV vaccine school-entry
requirement in PR.
Methods—We conducted a content analysis of two Puerto Rican newspapers. Articles (n = 286)
published between 1/1/2015 and 7/31/2018 containing the Spanish terms for “HPV” and “human
papillomavirus” were included. Data were summarized using descriptive statistics. Articles that
mentioned the HPV vaccine school-entry requirement (n = 33) were reviewed qualitatively using
applied thematic analysis.
Results—The top five primary focus areas were education about HPV and the HPV vaccine,
advertisements promoting the HPV vaccine, general vaccine information, cervical cancer and
screening information, and the HPV vaccine school-entry requirement. Of the 33 articles that
mentioned the requirement, 61% presented arguments in favor, 15% presented arguments against,
12% presented both arguments, and 12% only mentioned the existence of the requirement or were
the DOH announcement. Arguments in favor centered on cancer prevention, high rates of HPV-
associated cancers, and population wellness. Arguments against included worries about sexual
transmission of HPV, HPV vaccine’s side effects, issues related to the policy (e.g., mandatory),
and lack of education.
Coralia Vázquez-Otero, coralia.vazquez-otero@utsa.edu.
Conflict of Interest One of the authors, Dr. Daley, previously served on the US HPV Vaccine Advisory Board of Merck
Pharmaceuticals. The remaining authors declare no conflicts of interest.
Availability of data and material Available upon request.
HHS Public Access
Author manuscript
Cancer Causes Control. Author manuscript; available in PMC 2022 August 01.
Published in final edited form as:
Cancer Causes Control. 2021 August ; 32(8): 793–802. doi:10.1007/s10552-021-01431-3.
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Conclusion—Understanding reasons people support or oppose an HPV vaccine school-entry
requirement is important for the policy processes to be successful. Education efforts must continue
to change the HPV vaccine narrative. Messages should be crafted to educate and gain support
among parents and stakeholders towards this population-based cancer prevention strategy.
Keywords
HPV vaccine; HPV vaccine school-entry requirement; Vaccine requirements; Cancer prevention;
Puerto Rico
Introduction
Vaccine interventions have contributed to the improvement of the overall health of our
society. Consequently, the reduction of vaccine-preventable diseases through vaccination
is celebrated as one of the ten greatest public health achievements [1, 2]. Among
vaccine interventions, vaccination mandates for school entrance are recommended by the
Community Preventive Services Task Force [3] as a highly effective strategy commonly
used in the U.S. to increase adolescent vaccine uptake [4-6]. For instance, while education-
only requirements do not increase meningococcal conjugate and human papillomavirus
(HPV) vaccine coverage, middle-school vaccine requirements are associated with higher
coverage of vaccines such as tetanus/diphtheria (Td) or tetanus/diphtheria/pertussis (TdaP)
[7, 8]. Moreover, these mandates have been found to be effective in reducing racial/ethnic
disparities in vaccine uptake [9].
In the case of the HPV vaccine, a primary prevention strategy for HPV-associated cancers,
there has been considerable resistance towards it. Such resistance derives from the framing
of HPV prevention as a women’s only issue (i.e., feminization) and the emphasis on the
mode of transmission (i.e., sexual contact) [10, 11]. Thus, a limited number of states and
territories have made the HPV vaccine a requirement for school entrance [12]. In 2007,
Virginia was the first state to enact an HPV vaccine requirement, implementing it in 2009,
and only requiring girls to receive the vaccination [12, 13]. Washington, D.C. first required
the HPV vaccine for girls in 2009 and later included boys in 2014 [1]. The Department
of Health (DOH) of Rhode Island implemented the HPV vaccine school-entry requirement
for both sexes during the fall of 2015 [10, 14]. Hawaii’s DOH adopted the HPV vaccine
school-entry requirement on July 1, 2020 (to be implemented on July 2021) for adolescents
entering seventh grade [15].
During the summer of 2018, Puerto Rico’s DOH Secretary announced that the HPV vaccine
was going to be required for school entrance for boys and girls between the ages of 10 to 12
for the start (fall) of the 2018 academic year [16]. This created an opportunity to investigate
the arguments in favor of and against the HPV vaccine school-entry requirement in Puerto
Rico (PR) presented in the newspaper media.
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Methods
Overview
The data presented here are part of an exploratory sequential mixed-methods study [17] that
entailed two phases. Details of Phase 1 of this study have been published elsewhere; briefly,
Phase 1 consisted of interviews with stakeholders from PR who participated in the adoption
process of the HPV vaccine school-entry requirement [18]. These interviews informed Phase
2 (analysis reported here) which included a content analysis of two newspapers from PR.
The University of South Florida Institutional Review Board approved this study.
Data collection
The methodology of Phase 2 was guided by the seven steps for a content analysis
presented by Bernard & Ryan [19]. Additionally, guidelines from Neuendorf [20] on the
design of descriptive quantitative content analysis (i.e., the addition of a second coder, the
recommendation for coder training, and the calculation of Kappa for the assessment of
inter-rater reliability) were used. Also, previously published content analyses about the HPV
vaccine [21-23] and the HPV vaccine school-entry requirement newspapers’ coverage [24]
informed this study. The information included in the protocol is described below.
Unit of analysis and key terms
We reviewed two of the most circulated Puerto Rican newspapers and their respective
websites [25, 26]: El Nuevo Diía and El Vocero. Both newspapers are available online.
Each article was considered a unit of analysis. The words ‘VPH’ and ‘virus del papilloma
humano,’ Spanish for ‘HPV’ and ‘Human Papillomavirus,’ were the key terms used to
search the articles on each of the newspapers’ search engines and websites.
Inclusion and Exclusion criteria.
We included articles published from January 1, 2015 to July 31, 2018 that had at least one
of the key terms. We chose the year 2015 as the starting date because in May 2015 the
VOCES HPV Panel Report was published [27] by VOCES (PR’s vaccine coalition). This
report, among other things, summarizes HPV and HPV-related cancers epidemiological data,
and HPV vaccination uptake and completion rates, all in the context of PR. It also included
the HPV vaccine school-entry requirement as one of the strategies to help achieve the goals
of Healthy People 2020. Additionally, the report was mentioned by the stakeholders who
participated in the interviews as an important document that guided the process of adoption
of the HPV vaccine school-entry requirement [18]. We reviewed the titles and dates of
articles to eliminate articles that were not relevant or could be excluded based on the date.
We also excluded repeated articles and unrelated advertisements from the content analysis.
The remaining articles were accessed in full. Figure 1 shows the screening and selection
processes.
Instrumentation
We created the variables abstracted for this study based on previous research and findings
from Phase 1. A data collection form was developed, and two coders tested the form with
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a sample of 10% of the articles. This step allowed for revisions to the data collection form
[19]. The final version of the data collection form was transformed into a case-by-variable
matrix in Excel.
Data abstraction
Data were abstracted from the articles and entered into the case-by-variable matrix. The
primary researcher (CVO) and a second coder independently coded a random sample of
10% of the articles. An inter-coder agreement Kappa score of 0.80 was achieved and coding
of the rest of the articles was completed by the first author. As an additional assurance of
reliability, intra-coder reliability, or stability reliability [20] was assessed when the primary
researcher coded the first 100 articles. A randomly selected sample of 10% of these articles
was coded a second time by the primary researcher. An intra-coder Kappa score of 0.95 was
achieved. Both inter- and intra-coder Kappa scores were calculated using SPSS version 25.
Data analysis
We summarized the data from the 286 articles using descriptive statistics (i.e., frequencies
and percentages). Articles (n = 33) that specifically mentioned the requirement were also
analyzed qualitatively to identify the arguments presented in favor of and against the
HPV vaccine school-entry requirement. This qualitative analysis was conducted following
techniques of applied thematic analysis [28], such as coding, categorization, summarization,
and the selection of exemplary quotes. Quotes that illustrated the arguments were selected
and translated into English.
Results
Sample description
After removing the duplicate articles, there was a total of 286 news articles that included the
key terms (Fig. 1). News articles were classified by year to get a perspective on publication
activity. On average, most articles were published in 2016 (n = 92, x̄ = 7.67), followed by
2017 (n = 82, x̄ = 6.83), then 2018 (n = 47, x̄ = 6.71), and lastly 2015 (n = 65, x̄ = 5.42).
Note that the average number of articles per month by year is provided because data for
2018 only covers the first seven months of the year.
Primary focus
For this study, the primary focus refers to the main message the article was providing.
Each article could have more than one message, but the main message was captured
during data abstraction. To make this decision the researcher was guided by the title and
the first paragraph of the article. The most common primary focus categories included
educational articles with information about HPV and the HPV vaccine (23.8%), followed
by the advertisement category (16.8%). The advertisement category included ads promoting
the HPV vaccine (e.g., by VOCES and others by Merck), announcements of health fairs
providing the HPV vaccine, and ads about professional and health conferences. The third
most common focus was articles providing general information about vaccines (11.2%),
such as types available, benefits, and appropriate ages for inoculation. Articles with a
primary focus of providing information about cervical cancer and the importance of cervical
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cancer screening comprised about 11% of the sample. The HPV vaccine school-entry
requirement was the primary focus of 19 articles (6.6%). Figure 2 shows the top five primary
focus categories by year (using the average number of articles per month because data for
2018 only covers the first seven months of the year). Other areas of focus included general
health information (5.9%), cancer information (5.9%), or information on other types of
HPV-related cancers such as oropharyngeal, penile, and anal (4.2%). A complete list of the
articles, based on their primary focus by year, can be found in Table 1.
News articles that mentioned the HPV vaccine school-entry requirement in PR.
Of the 286 news articles, 33 newspaper articles (11.5%) mentioned the HPV vaccine
school-entry requirement. This category includes all articles that mentioned the requirement,
regardless of the primary focus. From the 33 articles, 20 (60.6%) presented arguments
in favor of the HPV vaccine school-entry requirement, five articles (15.2%) presented
arguments against, and four articles (12.1%) showed both sides of the arguments. Four
(12.1%) articles only mentioned the HPV vaccine school-entry requirement (n = 2) or
were the DOH’s HPV vaccine school-entry requirement announcement (n = 2). These four
articles were grouped in an ‘other’ category. Figure 3 shows the number of articles of each
argument category by the year of publication. No articles with the HPV vaccine school-entry
requirement as the primary focus or mention were found published during 2016. However,
this finding should be considered within the limitations of the content analysis that are
discussed later.
Themes
Arguments in favor of the HPV vaccine school-entry requirement in PR
Topics abstracted from the newspaper articles in favor of the HPV vaccine school-entry
requirement (n = 35) covered four areas. First, the need for cancer prevention (n = 16/35),
which included cervical cancer prevention (n = 8/16), cancer prevention in general (n =
5/16), and the prevention of other HPV-associated cancers (n = 3/16). Second, the increasing
incidence of cervical cancer, oropharyngeal cancer, and other HPV-related cancers (n =
9/35). Third, the importance of overall wellness and protection of the population (i.e.,
minors) (n = 6/35), and fourth, arguments related to the HPV vaccine (n = 4/35). Table
2 includes exemplary quotes for the arguments in favor of the HPV vaccine school-entry
requirement.
Arguments against the HPV vaccine school-entry requirement in PR
The arguments against the HPV vaccine school-entry requirement (n = 26) abstracted from
the newspaper articles were summarized in four broad themes. These included: (1) aspects
of HPV (n = 4/26), 2) concerns related to the HPV vaccine (n = 9/26), 3) issues about the
school-entry policy (n = 9/26), and (4) concerns related to lack information and education (n
= 4/26).
The aspects noted about HPV were its mode of transmission (i.e., sexual transmission) (n
= 2/4) and its transient nature (i.e., clears by itself) (n = 2/4). The concerns about the HPV
vaccine included the belief that the vaccine does not provide long-term protection or does
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not protect against all the types of the virus (n = 3/9). Other concerns were the safety and
side effects of the vaccine, including the belief that it causes cervical cancer (n = 4/9).
The least noted concern was related to the children’s sexual behavior and getting the HPV
vaccine (n = 2/9). The issues against the school-entry policy included two areas: (1) the
requirement’s infringement on parental rights over their children’s health decision-making
process (n = 5/9) and (2) opinions against the mandatory aspect of the policy (n = 4/9).
In some newspaper articles, the interviewees noted their concerns on a lack of unbiased
information (n = 2/4) and noted that it was the government’s responsibility to provide
information about the vaccine and sexual education (n = 2/4) to the population. Themes and
subthemes with the corresponding quotes are shown in Table 2.
Discussion
The purpose of this study was to investigate the arguments in favor of and against the HPV
vaccine school-entry requirement in PR presented in the newspaper media. Previous research
on the arguments supporting HPV vaccine mandates was framed under the umbrella of
women’s health and children’s welfare [11]. Moreover, numerous topics represent the
various arguments in favor of the HPV vaccine school entrance mandates, including cost-
effectiveness, appropriate age for vaccination for best immune response, need for cervical
cancer prevention and reduction, the importance of parental participation in health decisions
concerning their children, need to increase vaccination uptake, and the need to achieve herd
immunity [29, 30]. Conversely, arguments against the need for HPV vaccine school-entry
requirements are based on the lack of viral transmission through casual contact, intrusion
into parental autonomy, public distrust due to pharmaceutical lobbying during the policy
development process, and the potential economic burden on the government and health care
system (e.g., health departments and private physicians’ offices) [30-33].
In PR, the framing strategy used was to describe the HPV vaccine school-entry requirement
as a tool for cancer prevention, notably based on the need to reduce the high rates of cervical
cancer among Puerto Rican women. Additionally, the public health impact on population
wellness was found as a common argument in favor of the vaccine requirement. Studies
among physicians have reported similar reasons for supporting the HPV school-entry
requirement such as its effectiveness in increasing immunization and its public health impact
on immunization [34-36]. Among parents or guardians, research has found that arguments in
favor of the requirement were about the prevention of cervical cancer and the requirement as
a public health intervention that could benefit all [37], having positive views about the HPV
vaccine [38], and the overall protection of their child’s health [35].
Findings showed that arguments against the HPV vaccine school-entry requirement were, for
the most part, related to the HPV vaccine and the virus. Regarding the HPV vaccine, the
concerns focused on its side effects and safety. These reasons have also been discussed in
previous research among parents who thought that the vaccine was new and had concerns
about its safety and side effects [37, 39-42] and, thus, were more likely to be against
the HPV vaccine school-entry requirement. Physicians have also noted similar arguments
including concerns about the long-term efficacy and safety of the HPV vaccine [34, 36].
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The mode of transmission of the virus and its association with sexual activity was another
area of concern in this study. Parents have discussed the sexual nature of HPV transmission
[13] as a reason to be against the HPV vaccine school-entry requirement, as well as the
lack of casual transmission [35, 43]. Similarly, Casciotti et al. (2014) [24] found that, in
print media, the encouragement of sexual activity was an argument against the requirement.
Moreover, Vercruysse et al. (2016) [35] found that several parents in their study believed that
some adolescents are not sexually active; thus, there is no need for the HPV vaccine to be
required for school entrance. The concern of HPV not being casually transmitted has been
also voiced among physicians [34, 36].
Finally, the parents’ right to decide what is best for their children was a theme noted in
the Puerto Rican news articles. This finding is similar to previous research with parents and
physicians who reported parents’ choice or decision to vaccinate their children [13, 35, 36,
38, 42-44], as an argument against the HPV vaccine school-entry requirement. Furthermore,
Casciotti et al. (2014) [24] found that the government’s imposition of the HPV vaccine over
parental autonomy was the most common theme reported in print news media from Texas,
Virginia, and Washington, D.C. between 2005 and 2009.
Research has shown that the media plays an important role in influencing the way people
think by framing messages and emphasizing issues to the general public [45, 46]. Moreover,
this agenda-setting function of the media, based on collaborations with diverse sectors
of society, provides opportunities for public health interventions to highlight specific
problems [46]. Since support from different stakeholders and the public’s involvement are
necessary for the policy process to be successful, targeted messages could be created to
raise awareness and educate, not only about the HPV vaccine but also about the societal
value of school-entry requirements. Crafting clear informational campaigns about vaccine
requirements has been recommended as a way to increase their acceptance [47]. Therefore,
engaging the public[48, 49], including policymakers [50], via a variety of media such as
social and print media, and using different formats (e.g., narratives) to offer the correct
information could contribute to change opinions towards this type of population-based
strategy.
Strengths and Limitations
This study has limitations that should be discussed. A limitation specific to the content
analysis methodology is that the search process for each of the newspaper’s database
differed. Newspapers’ search engines are created for everyday use and leisure reading
and are not designed with the rigorous algorithms needed for research [51]. Thus, there
is a possibility that not all the published news articles were captured. To address this
limitation, two newspaper search engines and websites were used. However, by using
these two mainstream sources, news articles from fringe media sources may have been
missed. Moreover, this study captured what was presented in online print news media;
thus, future research should look at other modes of news transmission such as social media
and television, as additional sources of information to get a better understanding of the
arguments for and against the HPV vaccine school-entry requirement.
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Nonetheless, this study has several strengths. Conducting a content analysis of the
newspaper media, an important mean of communication, provided a look at the arguments
presented from several different sides or points of view. A unique contribution of the
current content analysis is its special focus on the news articles that mentioned the HPV
vaccine school-entry requirement in PR. Focusing on the news media provides a deeper
understanding of the arguments in favor of and against this policy in the general population.
Additionally, data collection of this study was timely because it took place during the
adoption process of the HPV vaccine school-entry requirement; therefore, capturing the
arguments presented at that moment. Lastly, this study focuses on PR’s newspaper media
from a territory with particularly high rates of HPV-related cancers. Therefore, framing the
HPV vaccine school-entry requirement as a tool for cancer prevention, as was done in PR,
may serve to promote the use of this population-based intervention in other high prevalence
areas in the U.S.
Conclusion
The HPV vaccine school-entry requirement provides an opportunity to increase HPV
vaccine coverage among adolescents and promote long-term cancer prevention. Educating
the public about the HPV vaccine and engaging them in the policy process continues to
be an important role for public health practitioners. Thus, understanding the arguments
surrounding vaccination mandates and providing the correct information via a variety of
media can contribute to allowing our society to continue enjoying the success of vaccine
interventions.
Funding
Funding for the completion of this project came from the USF COPH Student Honorary Awards for Research
and Practice (‘SHARP’) Award and the USF Office of Graduate Studies Scholarships and Fellowships. Coralia
Vazquez-Otero is currently supported by the Cancer Prevention Fellowship from the National Cancer Institute and
Harvard T.H. Chan School of Public Health—NIH grant number 2T32CA057711-27. Its contents are solely the
responsibility of the authors and do not necessarily represent the official views of the NIH.
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36. Kahn JA, Cooper HP, Vadaparampil ST, Pence BC, Weinberg AD, LoCoco SJ, Rosenthal SL
(2009) Human papillomavirus vaccine recommendations and agreement with mandated human
papillomavirus vaccination for 11-to-12-year-old girls: a statewide survey of Texas physicians.
Cancer Epidemiol Biomarkers Prevent 18(8):2325–2332. 10.1158/1055-9965.epi-09-0184
37. Perkins RB, Pierre-Joseph N, Marquez C, Iloka S, Clark JA (2010) Parents’ opinions of mandatory
human papillomavirus vaccination: does ethnicity matter? Womens Health Issues 20(6):420–426
[PubMed: 21051001]
38. St John B III, Pitts MJ, Tufts KA, (2010) Disconnects between news framing and parental
discourse concerning the state-mandated HPV vaccine: implications for dialogic health
communication and health literacy. Commun Med 7(1):75–84 [PubMed: 21462859]
39. Horn L, Howard C, Waller J, Ferris DG (2010) Opinions of parents about school-entry mandates
for the human papillomavirus vaccine. J Low Genit Tract Dis 14(1):43–48 [PubMed: 20040835]
40. Carlos RC, Dempsey AF, Resnicow K, Ruffin M, Patel DA, Straus CM, Vanessa KD (2011)
Maternal characteristics that predict a preference for mandatory adolescent HPV vaccination. Hum
Vaccin 7(2):225–229 [PubMed: 21325877]
41. Robitz R, Gottlieb SL, De Rosa CJ, Guerry SL, Liddon N, Zaidi A, Walker S, Smith JS, Brewer
NT, Markowitz LE (2011) Parent attitudes about school requirements for human papillomavirus
vaccine in high-risk communities of Los Angeles, California. Cancer Epidemiol Biomarkers
Prevent 20(7):1421–1429. 10.1158/1055-9965.epi-10-1236
42. Smith JS, Brewer NT, Chang Y, Liddon N, Guerry S, Pettigrew E, Markowitz LE, Gottlieb
SL (2011) Acceptability of school requirements for human papillomavirus vaccine. Hum Vaccin
7(9):952–957 [PubMed: 22024912]
43. Perkins RB, Tipton H, Shu E, Marquez C, Belizaire M, Porter C, Clark JA, Pierre-Joseph N (2013)
Attitudes toward HPV vaccination among low-income and minority parents of sons: a qualitative
analysis. Clin Pediatr 52(3):231–240. 10.1177/0009922812473775
44. Niccolai LM, North AL, Footman A, Hansen CE (2018) Lack of school requirements and clinician
recommendations for human papillomavirus vaccination. J Public Health Res 7(1):1324. 10.4081/
jphr.2018.1324 [PubMed: 29780768]
45. Borah P (2011) Conceptual issues in framing theory: a systematic examination of a decade’s
literature. J Commun 61(2):246–263
46. Viswanath K, Finnegan JR, Gollust SE (2015) Communication and health behavior in a changing
media environment. In: Glanz K, Rimer BK, Viswanath K (eds) Health behavior: theory, research,
and practice, 5th edn. Wiley, New York
47. Mitilian E, Malli F, Verger P (2020) Image of the new vaccination obligation through the media.
Vaccine 38(3):498–511. 10.1016/j.vaccine.2019.10.069 [PubMed: 31711675]
Vázquez-Otero et al. Page 10
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48. National Vaccine Advisory Committee (2018) Strengthening the effectiveness of national, state,
and local efforts to improve HPV vaccination coverage in the United States: recommendations
from the national vaccine advisory committee. Public Health Rep (Washington, DC: 1974)
133(5):543–550. 10.1177/0033354918793629
49. National Vaccine Advisory Committee (2020) 2020 National vaccine plan development:
recommendations from the national vaccine advisory committee. Public Health Rep (Washington,
DC: 1974) 135(2):181–188. 10.1177/0033354920904074
50. Brownson RC, Dodson EA, Kerner JF, Moreland-Russell S (2016) Framing research for state
policymakers who place a priority on cancer. Cancer Causes Control 27(8):1035–1041. 10.1007/
s10552-016-0771-0 [PubMed: 27299656]
51. Lacy S, Watson BR, Riffe D, Lovejoy J (2015) Issues and best practices in content analysis.
Journal Mass Commun Q 92(4):791–811
Vázquez-Otero et al. Page 11
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Fig. 1.
Article selection process for the content analysis
Vázquez-Otero et al. Page 12
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Fig. 2.
Top five primary focus categories by year. *Note: until July 31st, 2018
Vázquez-Otero et al. Page 13
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Fig. 3.
Number of articles of each argument category by year of publication*
Vázquez-Otero et al. Page 14
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Table 1
Complete list of articles published by primary focus category by year (n = 286)
Primary focus 2015 2016 2017 2018* Total %
Educational/informative about HPV & HPV vaccine 14 25 18 11 68 23.8
Advertisement 4 22 13 9 48 16.8
Vaccines in general 12 7 6 7 32 11.2
Cervical cancer/screening 4 15 9 3 31 10.8
HPV vaccine school-entry requirement 1 0 13 5 19 6.6
Health in general 5 5 5 2 17 5.9
Cancer in general 5 7 3 2 17 5.9
Other HPV-related cancers 3 3 6 0 12 4.2
Scientific/research advancements 4 3 0 2 9 3.1
About STIs including HIV 4 1 3 0 8 2.8
School-entry/other policies 2 1 2 3 8 2.8
DOH/government announcement 2 2 1 2 7 2.4
Salud/obamacare/insurance 2 0 1 0 3 1.0
Contraceptives 3 0 0 0 3 1.0
Rhaiza (a woman from PR who died of cervical cancer) 0 1 1 0 2 0.7
Other 0 0 1 1 2 0.7
Total 65 92 82 47 286 100
*
Note: until July 31st, 2018
Cancer
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Table 2
Arguments in favor of and against the HPV vaccine school-entry requirement in Puerto Rico from the newspaper media
Arguments in favor of the HPV vaccine school-entry
requirement
Themes Subthemes Exemplary quotes, source, and year
Cancer prevention Cervical cancer Cervical cancer, as well as other HPV-associated cancers, can be prevented thanks to a vaccine, for this reason, from the next academic year
2018–2019, the vaccine against the human papillomavirus (HPV) will be part of the vaccines required for school-entry for students 11–12
years old.—El Nuevo Día, 2018
Other HPV-related cancers Cervical cancer as well as other cancers associated with the human papillomavirus (HPV), can be prevented thanks to a vaccine.
For this reason, the vaccine against HPV is part of the required vaccines to enter school for students 11 to 12 years old. This decision makes
it possible for more young people to be protected against it and associated cancers.—El Vocero, 2018
Increasing incidence Cervical cancer The secretary of health, concerned with the increase of cases of cancer caused by HPV in Puerto Rico (cervical, anal, and oropharyngeal),
responsibly decided that beginning on the 2018 school year, the vaccine to prevent the infection with the virus will be required.—El Nuevo
Día, 2017
Oropharyngeal cancer Beginning in August 2018, all 11 and 12-year-old students will be asked to be vaccinated against the human papillomavirus (HPV). It was
announced by the secretary of health [name], who indicated that this new requirement to the vaccination schedule was motivated by the rise
in HPV-associated cancers, such as oropharyngeal.—El Nuevo Día, 2017
Wellness and protection
of the population
– Puerto Rico must take advantage of this opportunity [the HPV vaccine school-entry requirement] to strengthen prevention by expanding the
public health protection arsenal.—El Nuevo Día, 2017
HPV vaccine Not a new vaccination “This is not a new vaccine. It has been recommended for 12 years. In Puerto Rico around a million vaccines have been administered”—said
the physician [name], advisor for the Vaccination Program of the DOH.—endi.com, 2018
Cancer prevention “This is the only vaccine in the market that can prevent the development of cancer. […]”—pediatrician, El Nuevo Día, 2018
Arguments against the HPV vaccine school-entry
requirement
Theme Subthemes Exemplary quotes, source, and year
Aspects of HPV Sexual transmission What is the reason for a boy or a girl in school-age that has not initiated sexual activity to be protected against a disease that is acquired by
sexual contact? […] This is not a disease that a boy sneezing will transmit to another one”, indicated [name], […]”—a member of autism
organization, endi.com, 2018
Transient nature [physician leader of a pro-family organization] added that the HPV, in many cases, cures by itself, and not all [HPV types] cause cancer or
genital warts.—El Nuevo Día, 2017
Concerns about the HPV
vaccine
No long-term protection or
no protection against all
types
Although 16 and the 28 types have been associated with 70% of the reported cases of cervical cancer, the [name of feminist organization]
emphasized that the vaccine does not offer overall protection.—elvocero.com, 2017
Safety and side effects During March of this year the US official program to overlook vaccine safety, known as VAERS, has reported more than 50,463 adverse
reactions to the vaccine. Among those there are 317 deaths; 1,771 kids disabled, 14,299 emergency room visits,
4,606 kids have needed hospitalization, and from those 304 have remained in the hospital for long periods.—[name of concerned mother], El
Nuevo Día, 2017
Sexual behavior [name of a member of feminist organization], “[…], the vaccine could result in a lot of people engaging in more risks, falsely assuming that
the vaccine protects them from all the HPV types transmitted sexually and that this protection lasts their whole lives”.—elvocero.com, 2017
Cancer
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Arguments in favor of the HPV vaccine school-entry
requirement
Themes Subthemes Exemplary quotes, source, and year
Issues related to the
school-entry policy
Infringement on parental
rights
“The vaccines against HPV are a tool for cervical cancer prevention. However, the vaccine should not be mandated. Each family, after being
rightly informed about the advantages and risks of the vaccine, should freely decide which of the strategies they would like to use to protect
their health and their family’s health”—a member of a feminist organization, endi.com, 2017
Mandatory aspect The HPV vaccines are a tool for cancer prevention. However, the vaccine should not be compulsory”, said [name], spokeswoman of a
feminist organization, in a press release.—endi.com, 2017
Concerns about education
and information
Lack of unbiased
information
The organization highlighted that ‘biased’ information publicly provided does not offer the objective judgment tools for men and women, that
is the reason why they [feminist organization] required the Department of Health to provide complete information about the vaccine, as well
as access to sexual and reproductive health prevention services to young people.—feminist organization, elvocero.com, 2017
The government should
provide information and
education
“[…] it is the Government’s responsibility to guarantee access to complete and objective information about the benefits, risks, and limitations
of every preventive option available.” –member feminist organization, endi.com, 2017
Cancer
Causes
Control
.
Author
manuscript;
available
in
PMC
2022
August
01.

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Arguments In Favor Of And Against The HPV Vaccine School-Entry Requirement In Puerto Rico A Content Analysis Of Newspaper Media

  • 1. Arguments in favor of and against the HPV vaccine school-entry requirement in Puerto Rico: a content analysis of newspaper media Coralia Vázquez-Otero1, Dinorah Martinez Tyson2, Cheryl A. Vamos2, Nancy Romero- Daza3, Jason Beckstead2, Ellen M. Daley2 1.College for Health, Community and Policy at the University of Texas at San Antonio, San Antonio, TX 78249, USA 2.University of South Florida College of Public Health, 13201 Bruce B. Downs Bld., MDC 56, Tampa, FL 33612, USA 3.Department of Anthropology, University of South Florida College of Arts and Sciences, 4202 E. Fowler Ave., SOC 134, Tampa, FL 33620, USA Abstract Purpose—Vaccine requirements are effective population-based strategies to increase vaccination rates. In 2018, Puerto Rico’s DOH announced that the HPV vaccine would be required for school entrance. This study explored arguments in favor of and against the HPV vaccine school-entry requirement in PR. Methods—We conducted a content analysis of two Puerto Rican newspapers. Articles (n = 286) published between 1/1/2015 and 7/31/2018 containing the Spanish terms for “HPV” and “human papillomavirus” were included. Data were summarized using descriptive statistics. Articles that mentioned the HPV vaccine school-entry requirement (n = 33) were reviewed qualitatively using applied thematic analysis. Results—The top five primary focus areas were education about HPV and the HPV vaccine, advertisements promoting the HPV vaccine, general vaccine information, cervical cancer and screening information, and the HPV vaccine school-entry requirement. Of the 33 articles that mentioned the requirement, 61% presented arguments in favor, 15% presented arguments against, 12% presented both arguments, and 12% only mentioned the existence of the requirement or were the DOH announcement. Arguments in favor centered on cancer prevention, high rates of HPV- associated cancers, and population wellness. Arguments against included worries about sexual transmission of HPV, HPV vaccine’s side effects, issues related to the policy (e.g., mandatory), and lack of education. Coralia Vázquez-Otero, coralia.vazquez-otero@utsa.edu. Conflict of Interest One of the authors, Dr. Daley, previously served on the US HPV Vaccine Advisory Board of Merck Pharmaceuticals. The remaining authors declare no conflicts of interest. Availability of data and material Available upon request. HHS Public Access Author manuscript Cancer Causes Control. Author manuscript; available in PMC 2022 August 01. Published in final edited form as: Cancer Causes Control. 2021 August ; 32(8): 793–802. doi:10.1007/s10552-021-01431-3. Author Manuscript Author Manuscript Author Manuscript Author Manuscript
  • 2. Conclusion—Understanding reasons people support or oppose an HPV vaccine school-entry requirement is important for the policy processes to be successful. Education efforts must continue to change the HPV vaccine narrative. Messages should be crafted to educate and gain support among parents and stakeholders towards this population-based cancer prevention strategy. Keywords HPV vaccine; HPV vaccine school-entry requirement; Vaccine requirements; Cancer prevention; Puerto Rico Introduction Vaccine interventions have contributed to the improvement of the overall health of our society. Consequently, the reduction of vaccine-preventable diseases through vaccination is celebrated as one of the ten greatest public health achievements [1, 2]. Among vaccine interventions, vaccination mandates for school entrance are recommended by the Community Preventive Services Task Force [3] as a highly effective strategy commonly used in the U.S. to increase adolescent vaccine uptake [4-6]. For instance, while education- only requirements do not increase meningococcal conjugate and human papillomavirus (HPV) vaccine coverage, middle-school vaccine requirements are associated with higher coverage of vaccines such as tetanus/diphtheria (Td) or tetanus/diphtheria/pertussis (TdaP) [7, 8]. Moreover, these mandates have been found to be effective in reducing racial/ethnic disparities in vaccine uptake [9]. In the case of the HPV vaccine, a primary prevention strategy for HPV-associated cancers, there has been considerable resistance towards it. Such resistance derives from the framing of HPV prevention as a women’s only issue (i.e., feminization) and the emphasis on the mode of transmission (i.e., sexual contact) [10, 11]. Thus, a limited number of states and territories have made the HPV vaccine a requirement for school entrance [12]. In 2007, Virginia was the first state to enact an HPV vaccine requirement, implementing it in 2009, and only requiring girls to receive the vaccination [12, 13]. Washington, D.C. first required the HPV vaccine for girls in 2009 and later included boys in 2014 [1]. The Department of Health (DOH) of Rhode Island implemented the HPV vaccine school-entry requirement for both sexes during the fall of 2015 [10, 14]. Hawaii’s DOH adopted the HPV vaccine school-entry requirement on July 1, 2020 (to be implemented on July 2021) for adolescents entering seventh grade [15]. During the summer of 2018, Puerto Rico’s DOH Secretary announced that the HPV vaccine was going to be required for school entrance for boys and girls between the ages of 10 to 12 for the start (fall) of the 2018 academic year [16]. This created an opportunity to investigate the arguments in favor of and against the HPV vaccine school-entry requirement in Puerto Rico (PR) presented in the newspaper media. Vázquez-Otero et al. Page 2 Cancer Causes Control. Author manuscript; available in PMC 2022 August 01. Author Manuscript Author Manuscript Author Manuscript Author Manuscript
  • 3. Methods Overview The data presented here are part of an exploratory sequential mixed-methods study [17] that entailed two phases. Details of Phase 1 of this study have been published elsewhere; briefly, Phase 1 consisted of interviews with stakeholders from PR who participated in the adoption process of the HPV vaccine school-entry requirement [18]. These interviews informed Phase 2 (analysis reported here) which included a content analysis of two newspapers from PR. The University of South Florida Institutional Review Board approved this study. Data collection The methodology of Phase 2 was guided by the seven steps for a content analysis presented by Bernard & Ryan [19]. Additionally, guidelines from Neuendorf [20] on the design of descriptive quantitative content analysis (i.e., the addition of a second coder, the recommendation for coder training, and the calculation of Kappa for the assessment of inter-rater reliability) were used. Also, previously published content analyses about the HPV vaccine [21-23] and the HPV vaccine school-entry requirement newspapers’ coverage [24] informed this study. The information included in the protocol is described below. Unit of analysis and key terms We reviewed two of the most circulated Puerto Rican newspapers and their respective websites [25, 26]: El Nuevo Diía and El Vocero. Both newspapers are available online. Each article was considered a unit of analysis. The words ‘VPH’ and ‘virus del papilloma humano,’ Spanish for ‘HPV’ and ‘Human Papillomavirus,’ were the key terms used to search the articles on each of the newspapers’ search engines and websites. Inclusion and Exclusion criteria. We included articles published from January 1, 2015 to July 31, 2018 that had at least one of the key terms. We chose the year 2015 as the starting date because in May 2015 the VOCES HPV Panel Report was published [27] by VOCES (PR’s vaccine coalition). This report, among other things, summarizes HPV and HPV-related cancers epidemiological data, and HPV vaccination uptake and completion rates, all in the context of PR. It also included the HPV vaccine school-entry requirement as one of the strategies to help achieve the goals of Healthy People 2020. Additionally, the report was mentioned by the stakeholders who participated in the interviews as an important document that guided the process of adoption of the HPV vaccine school-entry requirement [18]. We reviewed the titles and dates of articles to eliminate articles that were not relevant or could be excluded based on the date. We also excluded repeated articles and unrelated advertisements from the content analysis. The remaining articles were accessed in full. Figure 1 shows the screening and selection processes. Instrumentation We created the variables abstracted for this study based on previous research and findings from Phase 1. A data collection form was developed, and two coders tested the form with Vázquez-Otero et al. Page 3 Cancer Causes Control. Author manuscript; available in PMC 2022 August 01. Author Manuscript Author Manuscript Author Manuscript Author Manuscript
  • 4. a sample of 10% of the articles. This step allowed for revisions to the data collection form [19]. The final version of the data collection form was transformed into a case-by-variable matrix in Excel. Data abstraction Data were abstracted from the articles and entered into the case-by-variable matrix. The primary researcher (CVO) and a second coder independently coded a random sample of 10% of the articles. An inter-coder agreement Kappa score of 0.80 was achieved and coding of the rest of the articles was completed by the first author. As an additional assurance of reliability, intra-coder reliability, or stability reliability [20] was assessed when the primary researcher coded the first 100 articles. A randomly selected sample of 10% of these articles was coded a second time by the primary researcher. An intra-coder Kappa score of 0.95 was achieved. Both inter- and intra-coder Kappa scores were calculated using SPSS version 25. Data analysis We summarized the data from the 286 articles using descriptive statistics (i.e., frequencies and percentages). Articles (n = 33) that specifically mentioned the requirement were also analyzed qualitatively to identify the arguments presented in favor of and against the HPV vaccine school-entry requirement. This qualitative analysis was conducted following techniques of applied thematic analysis [28], such as coding, categorization, summarization, and the selection of exemplary quotes. Quotes that illustrated the arguments were selected and translated into English. Results Sample description After removing the duplicate articles, there was a total of 286 news articles that included the key terms (Fig. 1). News articles were classified by year to get a perspective on publication activity. On average, most articles were published in 2016 (n = 92, x̄ = 7.67), followed by 2017 (n = 82, x̄ = 6.83), then 2018 (n = 47, x̄ = 6.71), and lastly 2015 (n = 65, x̄ = 5.42). Note that the average number of articles per month by year is provided because data for 2018 only covers the first seven months of the year. Primary focus For this study, the primary focus refers to the main message the article was providing. Each article could have more than one message, but the main message was captured during data abstraction. To make this decision the researcher was guided by the title and the first paragraph of the article. The most common primary focus categories included educational articles with information about HPV and the HPV vaccine (23.8%), followed by the advertisement category (16.8%). The advertisement category included ads promoting the HPV vaccine (e.g., by VOCES and others by Merck), announcements of health fairs providing the HPV vaccine, and ads about professional and health conferences. The third most common focus was articles providing general information about vaccines (11.2%), such as types available, benefits, and appropriate ages for inoculation. Articles with a primary focus of providing information about cervical cancer and the importance of cervical Vázquez-Otero et al. Page 4 Cancer Causes Control. Author manuscript; available in PMC 2022 August 01. Author Manuscript Author Manuscript Author Manuscript Author Manuscript
  • 5. cancer screening comprised about 11% of the sample. The HPV vaccine school-entry requirement was the primary focus of 19 articles (6.6%). Figure 2 shows the top five primary focus categories by year (using the average number of articles per month because data for 2018 only covers the first seven months of the year). Other areas of focus included general health information (5.9%), cancer information (5.9%), or information on other types of HPV-related cancers such as oropharyngeal, penile, and anal (4.2%). A complete list of the articles, based on their primary focus by year, can be found in Table 1. News articles that mentioned the HPV vaccine school-entry requirement in PR. Of the 286 news articles, 33 newspaper articles (11.5%) mentioned the HPV vaccine school-entry requirement. This category includes all articles that mentioned the requirement, regardless of the primary focus. From the 33 articles, 20 (60.6%) presented arguments in favor of the HPV vaccine school-entry requirement, five articles (15.2%) presented arguments against, and four articles (12.1%) showed both sides of the arguments. Four (12.1%) articles only mentioned the HPV vaccine school-entry requirement (n = 2) or were the DOH’s HPV vaccine school-entry requirement announcement (n = 2). These four articles were grouped in an ‘other’ category. Figure 3 shows the number of articles of each argument category by the year of publication. No articles with the HPV vaccine school-entry requirement as the primary focus or mention were found published during 2016. However, this finding should be considered within the limitations of the content analysis that are discussed later. Themes Arguments in favor of the HPV vaccine school-entry requirement in PR Topics abstracted from the newspaper articles in favor of the HPV vaccine school-entry requirement (n = 35) covered four areas. First, the need for cancer prevention (n = 16/35), which included cervical cancer prevention (n = 8/16), cancer prevention in general (n = 5/16), and the prevention of other HPV-associated cancers (n = 3/16). Second, the increasing incidence of cervical cancer, oropharyngeal cancer, and other HPV-related cancers (n = 9/35). Third, the importance of overall wellness and protection of the population (i.e., minors) (n = 6/35), and fourth, arguments related to the HPV vaccine (n = 4/35). Table 2 includes exemplary quotes for the arguments in favor of the HPV vaccine school-entry requirement. Arguments against the HPV vaccine school-entry requirement in PR The arguments against the HPV vaccine school-entry requirement (n = 26) abstracted from the newspaper articles were summarized in four broad themes. These included: (1) aspects of HPV (n = 4/26), 2) concerns related to the HPV vaccine (n = 9/26), 3) issues about the school-entry policy (n = 9/26), and (4) concerns related to lack information and education (n = 4/26). The aspects noted about HPV were its mode of transmission (i.e., sexual transmission) (n = 2/4) and its transient nature (i.e., clears by itself) (n = 2/4). The concerns about the HPV vaccine included the belief that the vaccine does not provide long-term protection or does Vázquez-Otero et al. Page 5 Cancer Causes Control. Author manuscript; available in PMC 2022 August 01. Author Manuscript Author Manuscript Author Manuscript Author Manuscript
  • 6. not protect against all the types of the virus (n = 3/9). Other concerns were the safety and side effects of the vaccine, including the belief that it causes cervical cancer (n = 4/9). The least noted concern was related to the children’s sexual behavior and getting the HPV vaccine (n = 2/9). The issues against the school-entry policy included two areas: (1) the requirement’s infringement on parental rights over their children’s health decision-making process (n = 5/9) and (2) opinions against the mandatory aspect of the policy (n = 4/9). In some newspaper articles, the interviewees noted their concerns on a lack of unbiased information (n = 2/4) and noted that it was the government’s responsibility to provide information about the vaccine and sexual education (n = 2/4) to the population. Themes and subthemes with the corresponding quotes are shown in Table 2. Discussion The purpose of this study was to investigate the arguments in favor of and against the HPV vaccine school-entry requirement in PR presented in the newspaper media. Previous research on the arguments supporting HPV vaccine mandates was framed under the umbrella of women’s health and children’s welfare [11]. Moreover, numerous topics represent the various arguments in favor of the HPV vaccine school entrance mandates, including cost- effectiveness, appropriate age for vaccination for best immune response, need for cervical cancer prevention and reduction, the importance of parental participation in health decisions concerning their children, need to increase vaccination uptake, and the need to achieve herd immunity [29, 30]. Conversely, arguments against the need for HPV vaccine school-entry requirements are based on the lack of viral transmission through casual contact, intrusion into parental autonomy, public distrust due to pharmaceutical lobbying during the policy development process, and the potential economic burden on the government and health care system (e.g., health departments and private physicians’ offices) [30-33]. In PR, the framing strategy used was to describe the HPV vaccine school-entry requirement as a tool for cancer prevention, notably based on the need to reduce the high rates of cervical cancer among Puerto Rican women. Additionally, the public health impact on population wellness was found as a common argument in favor of the vaccine requirement. Studies among physicians have reported similar reasons for supporting the HPV school-entry requirement such as its effectiveness in increasing immunization and its public health impact on immunization [34-36]. Among parents or guardians, research has found that arguments in favor of the requirement were about the prevention of cervical cancer and the requirement as a public health intervention that could benefit all [37], having positive views about the HPV vaccine [38], and the overall protection of their child’s health [35]. Findings showed that arguments against the HPV vaccine school-entry requirement were, for the most part, related to the HPV vaccine and the virus. Regarding the HPV vaccine, the concerns focused on its side effects and safety. These reasons have also been discussed in previous research among parents who thought that the vaccine was new and had concerns about its safety and side effects [37, 39-42] and, thus, were more likely to be against the HPV vaccine school-entry requirement. Physicians have also noted similar arguments including concerns about the long-term efficacy and safety of the HPV vaccine [34, 36]. Vázquez-Otero et al. Page 6 Cancer Causes Control. Author manuscript; available in PMC 2022 August 01. Author Manuscript Author Manuscript Author Manuscript Author Manuscript
  • 7. The mode of transmission of the virus and its association with sexual activity was another area of concern in this study. Parents have discussed the sexual nature of HPV transmission [13] as a reason to be against the HPV vaccine school-entry requirement, as well as the lack of casual transmission [35, 43]. Similarly, Casciotti et al. (2014) [24] found that, in print media, the encouragement of sexual activity was an argument against the requirement. Moreover, Vercruysse et al. (2016) [35] found that several parents in their study believed that some adolescents are not sexually active; thus, there is no need for the HPV vaccine to be required for school entrance. The concern of HPV not being casually transmitted has been also voiced among physicians [34, 36]. Finally, the parents’ right to decide what is best for their children was a theme noted in the Puerto Rican news articles. This finding is similar to previous research with parents and physicians who reported parents’ choice or decision to vaccinate their children [13, 35, 36, 38, 42-44], as an argument against the HPV vaccine school-entry requirement. Furthermore, Casciotti et al. (2014) [24] found that the government’s imposition of the HPV vaccine over parental autonomy was the most common theme reported in print news media from Texas, Virginia, and Washington, D.C. between 2005 and 2009. Research has shown that the media plays an important role in influencing the way people think by framing messages and emphasizing issues to the general public [45, 46]. Moreover, this agenda-setting function of the media, based on collaborations with diverse sectors of society, provides opportunities for public health interventions to highlight specific problems [46]. Since support from different stakeholders and the public’s involvement are necessary for the policy process to be successful, targeted messages could be created to raise awareness and educate, not only about the HPV vaccine but also about the societal value of school-entry requirements. Crafting clear informational campaigns about vaccine requirements has been recommended as a way to increase their acceptance [47]. Therefore, engaging the public[48, 49], including policymakers [50], via a variety of media such as social and print media, and using different formats (e.g., narratives) to offer the correct information could contribute to change opinions towards this type of population-based strategy. Strengths and Limitations This study has limitations that should be discussed. A limitation specific to the content analysis methodology is that the search process for each of the newspaper’s database differed. Newspapers’ search engines are created for everyday use and leisure reading and are not designed with the rigorous algorithms needed for research [51]. Thus, there is a possibility that not all the published news articles were captured. To address this limitation, two newspaper search engines and websites were used. However, by using these two mainstream sources, news articles from fringe media sources may have been missed. Moreover, this study captured what was presented in online print news media; thus, future research should look at other modes of news transmission such as social media and television, as additional sources of information to get a better understanding of the arguments for and against the HPV vaccine school-entry requirement. Vázquez-Otero et al. Page 7 Cancer Causes Control. Author manuscript; available in PMC 2022 August 01. Author Manuscript Author Manuscript Author Manuscript Author Manuscript
  • 8. Nonetheless, this study has several strengths. Conducting a content analysis of the newspaper media, an important mean of communication, provided a look at the arguments presented from several different sides or points of view. A unique contribution of the current content analysis is its special focus on the news articles that mentioned the HPV vaccine school-entry requirement in PR. Focusing on the news media provides a deeper understanding of the arguments in favor of and against this policy in the general population. Additionally, data collection of this study was timely because it took place during the adoption process of the HPV vaccine school-entry requirement; therefore, capturing the arguments presented at that moment. Lastly, this study focuses on PR’s newspaper media from a territory with particularly high rates of HPV-related cancers. Therefore, framing the HPV vaccine school-entry requirement as a tool for cancer prevention, as was done in PR, may serve to promote the use of this population-based intervention in other high prevalence areas in the U.S. Conclusion The HPV vaccine school-entry requirement provides an opportunity to increase HPV vaccine coverage among adolescents and promote long-term cancer prevention. Educating the public about the HPV vaccine and engaging them in the policy process continues to be an important role for public health practitioners. Thus, understanding the arguments surrounding vaccination mandates and providing the correct information via a variety of media can contribute to allowing our society to continue enjoying the success of vaccine interventions. Funding Funding for the completion of this project came from the USF COPH Student Honorary Awards for Research and Practice (‘SHARP’) Award and the USF Office of Graduate Studies Scholarships and Fellowships. Coralia Vazquez-Otero is currently supported by the Cancer Prevention Fellowship from the National Cancer Institute and Harvard T.H. Chan School of Public Health—NIH grant number 2T32CA057711-27. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. References 1. Centers for Disease Control and Prevention (2011) Ten great public health achievements–United States, 2001–2010. MMWR Morb Mortal Wkly Rep 60(19):619 [PubMed: 21597455] 2. Larson HJ, Jarrett C, Eckersberger E, Smith DM, Paterson P (2014) Understanding vaccine hesitancy around vaccines and vaccination from a global perspective: a systematic review of published literature, 2007–2012. Vaccine 32(19):2150–2159. 10.1016/j.vaccine.2014.01.081 [PubMed: 24598724] 3. Guide to Community Preventive Services (2019) Vaccination programs: requirements for child care, school, and college attendance. https://www.thecommunityguide.org/findings/vaccination- programs-requirements-child-care-school-and-college-attendance. Accessed 8 Feb, 2020 4. Averhoff F, Linton L, Peddecord KM, Edwards C, Wang W, Fishbein D (2004) A middle school immunization law rapidly and substantially increases immunization coverage among adolescents. Am J Public Health 94(6):978–984 [PubMed: 15249302] 5. Hinman AR, Orenstein WA, Williamson DE, Darrington D (2002) Childhood immunization: laws that work. JL Med Ethics 30:122 6. Field RI, Caplan AL (2008) A proposed ethical framework for vaccine mandates: competing values and the case of HPV. Kennedy Inst Ethics J 18(2):111–124 [PubMed: 18610781] Vázquez-Otero et al. Page 8 Cancer Causes Control. Author manuscript; available in PMC 2022 August 01. Author Manuscript Author Manuscript Author Manuscript Author Manuscript
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  • 11. 48. National Vaccine Advisory Committee (2018) Strengthening the effectiveness of national, state, and local efforts to improve HPV vaccination coverage in the United States: recommendations from the national vaccine advisory committee. Public Health Rep (Washington, DC: 1974) 133(5):543–550. 10.1177/0033354918793629 49. National Vaccine Advisory Committee (2020) 2020 National vaccine plan development: recommendations from the national vaccine advisory committee. Public Health Rep (Washington, DC: 1974) 135(2):181–188. 10.1177/0033354920904074 50. Brownson RC, Dodson EA, Kerner JF, Moreland-Russell S (2016) Framing research for state policymakers who place a priority on cancer. Cancer Causes Control 27(8):1035–1041. 10.1007/ s10552-016-0771-0 [PubMed: 27299656] 51. Lacy S, Watson BR, Riffe D, Lovejoy J (2015) Issues and best practices in content analysis. Journal Mass Commun Q 92(4):791–811 Vázquez-Otero et al. Page 11 Cancer Causes Control. Author manuscript; available in PMC 2022 August 01. Author Manuscript Author Manuscript Author Manuscript Author Manuscript
  • 12. Fig. 1. Article selection process for the content analysis Vázquez-Otero et al. Page 12 Cancer Causes Control. Author manuscript; available in PMC 2022 August 01. Author Manuscript Author Manuscript Author Manuscript Author Manuscript
  • 13. Fig. 2. Top five primary focus categories by year. *Note: until July 31st, 2018 Vázquez-Otero et al. Page 13 Cancer Causes Control. Author manuscript; available in PMC 2022 August 01. Author Manuscript Author Manuscript Author Manuscript Author Manuscript
  • 14. Fig. 3. Number of articles of each argument category by year of publication* Vázquez-Otero et al. Page 14 Cancer Causes Control. Author manuscript; available in PMC 2022 August 01. Author Manuscript Author Manuscript Author Manuscript Author Manuscript
  • 15. Author Manuscript Author Manuscript Author Manuscript Author Manuscript Vázquez-Otero et al. Page 15 Table 1 Complete list of articles published by primary focus category by year (n = 286) Primary focus 2015 2016 2017 2018* Total % Educational/informative about HPV & HPV vaccine 14 25 18 11 68 23.8 Advertisement 4 22 13 9 48 16.8 Vaccines in general 12 7 6 7 32 11.2 Cervical cancer/screening 4 15 9 3 31 10.8 HPV vaccine school-entry requirement 1 0 13 5 19 6.6 Health in general 5 5 5 2 17 5.9 Cancer in general 5 7 3 2 17 5.9 Other HPV-related cancers 3 3 6 0 12 4.2 Scientific/research advancements 4 3 0 2 9 3.1 About STIs including HIV 4 1 3 0 8 2.8 School-entry/other policies 2 1 2 3 8 2.8 DOH/government announcement 2 2 1 2 7 2.4 Salud/obamacare/insurance 2 0 1 0 3 1.0 Contraceptives 3 0 0 0 3 1.0 Rhaiza (a woman from PR who died of cervical cancer) 0 1 1 0 2 0.7 Other 0 0 1 1 2 0.7 Total 65 92 82 47 286 100 * Note: until July 31st, 2018 Cancer Causes Control . Author manuscript; available in PMC 2022 August 01.
  • 16. Author Manuscript Author Manuscript Author Manuscript Author Manuscript Vázquez-Otero et al. Page 16 Table 2 Arguments in favor of and against the HPV vaccine school-entry requirement in Puerto Rico from the newspaper media Arguments in favor of the HPV vaccine school-entry requirement Themes Subthemes Exemplary quotes, source, and year Cancer prevention Cervical cancer Cervical cancer, as well as other HPV-associated cancers, can be prevented thanks to a vaccine, for this reason, from the next academic year 2018–2019, the vaccine against the human papillomavirus (HPV) will be part of the vaccines required for school-entry for students 11–12 years old.—El Nuevo Día, 2018 Other HPV-related cancers Cervical cancer as well as other cancers associated with the human papillomavirus (HPV), can be prevented thanks to a vaccine. For this reason, the vaccine against HPV is part of the required vaccines to enter school for students 11 to 12 years old. This decision makes it possible for more young people to be protected against it and associated cancers.—El Vocero, 2018 Increasing incidence Cervical cancer The secretary of health, concerned with the increase of cases of cancer caused by HPV in Puerto Rico (cervical, anal, and oropharyngeal), responsibly decided that beginning on the 2018 school year, the vaccine to prevent the infection with the virus will be required.—El Nuevo Día, 2017 Oropharyngeal cancer Beginning in August 2018, all 11 and 12-year-old students will be asked to be vaccinated against the human papillomavirus (HPV). It was announced by the secretary of health [name], who indicated that this new requirement to the vaccination schedule was motivated by the rise in HPV-associated cancers, such as oropharyngeal.—El Nuevo Día, 2017 Wellness and protection of the population – Puerto Rico must take advantage of this opportunity [the HPV vaccine school-entry requirement] to strengthen prevention by expanding the public health protection arsenal.—El Nuevo Día, 2017 HPV vaccine Not a new vaccination “This is not a new vaccine. It has been recommended for 12 years. In Puerto Rico around a million vaccines have been administered”—said the physician [name], advisor for the Vaccination Program of the DOH.—endi.com, 2018 Cancer prevention “This is the only vaccine in the market that can prevent the development of cancer. […]”—pediatrician, El Nuevo Día, 2018 Arguments against the HPV vaccine school-entry requirement Theme Subthemes Exemplary quotes, source, and year Aspects of HPV Sexual transmission What is the reason for a boy or a girl in school-age that has not initiated sexual activity to be protected against a disease that is acquired by sexual contact? […] This is not a disease that a boy sneezing will transmit to another one”, indicated [name], […]”—a member of autism organization, endi.com, 2018 Transient nature [physician leader of a pro-family organization] added that the HPV, in many cases, cures by itself, and not all [HPV types] cause cancer or genital warts.—El Nuevo Día, 2017 Concerns about the HPV vaccine No long-term protection or no protection against all types Although 16 and the 28 types have been associated with 70% of the reported cases of cervical cancer, the [name of feminist organization] emphasized that the vaccine does not offer overall protection.—elvocero.com, 2017 Safety and side effects During March of this year the US official program to overlook vaccine safety, known as VAERS, has reported more than 50,463 adverse reactions to the vaccine. Among those there are 317 deaths; 1,771 kids disabled, 14,299 emergency room visits, 4,606 kids have needed hospitalization, and from those 304 have remained in the hospital for long periods.—[name of concerned mother], El Nuevo Día, 2017 Sexual behavior [name of a member of feminist organization], “[…], the vaccine could result in a lot of people engaging in more risks, falsely assuming that the vaccine protects them from all the HPV types transmitted sexually and that this protection lasts their whole lives”.—elvocero.com, 2017 Cancer Causes Control . Author manuscript; available in PMC 2022 August 01.
  • 17. Author Manuscript Author Manuscript Author Manuscript Author Manuscript Vázquez-Otero et al. Page 17 Arguments in favor of the HPV vaccine school-entry requirement Themes Subthemes Exemplary quotes, source, and year Issues related to the school-entry policy Infringement on parental rights “The vaccines against HPV are a tool for cervical cancer prevention. However, the vaccine should not be mandated. Each family, after being rightly informed about the advantages and risks of the vaccine, should freely decide which of the strategies they would like to use to protect their health and their family’s health”—a member of a feminist organization, endi.com, 2017 Mandatory aspect The HPV vaccines are a tool for cancer prevention. However, the vaccine should not be compulsory”, said [name], spokeswoman of a feminist organization, in a press release.—endi.com, 2017 Concerns about education and information Lack of unbiased information The organization highlighted that ‘biased’ information publicly provided does not offer the objective judgment tools for men and women, that is the reason why they [feminist organization] required the Department of Health to provide complete information about the vaccine, as well as access to sexual and reproductive health prevention services to young people.—feminist organization, elvocero.com, 2017 The government should provide information and education “[…] it is the Government’s responsibility to guarantee access to complete and objective information about the benefits, risks, and limitations of every preventive option available.” –member feminist organization, endi.com, 2017 Cancer Causes Control . Author manuscript; available in PMC 2022 August 01.