Antigens, hapteins, immunogens lectures 10.1.06
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An antigen is any substance that reacts with lymphocytes, while immunogens generate immune responses. Haptens are small molecules that require coupling to carriers to induce responses. Antibody-antigen binding depends on weak interactions between sites on antibodies and epitopes on antigens. Antibodies are produced with a wide variety of binding sites to recognize different antigenic determinants. Factors like foreignness, size, structure, and route of administration influence a substance's immunogenicity.
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Antigens, hapteins, immunogens lectures 10.1.06
- 1. Antigens, haptens and immunogens
- 27. Conventional Antigen Superantigen αC βC CHO CHO CHO CHO βV αV α2 β2 β1 α1 CHO CHO CHO αC βC CHO CHO CHO CHO βV αV α2 β2 β1 α1 CHO CHO CHO MHC Class II T cell receptor Antigen Super antigen T lymphocyte Antigen presenting cell
- 31. Pathway of Antigen Presentation by Antigen-Presenting Cells
- 38. T cell Membrane T Cell Receptor Antigen Recognition
- 39. Antibody Structure Figure 13.3, p. 251 TCR like this portion of Ab Complement Binding Site Phagocyte Receptor Binding Site
- 41. APC = e.g., Macrophage TCR Peptide Antigen CD4 CD4 T Cell MHC Class II
Notas del editor
- Antibody-antigen Interactions Antibodies and antigens can both be multivalent.
- The flexibility of the hinge region improves the efficiency of antigen binding and cross-linking.
- Schematic Drawing of a typical antibody molecule. There are two identical light chains and two identical heavy chains. The heavy chain determines the antibody subclass. We will use the IgG molecule in lab.