Species Malassezia is part of the normal flora, particularly present in sebumrich areas of the skin.

1. Infection: Species Malassezia Part -2

2. Predisposig factors
• Factors responsible for mycelial transition : warm,
humid environment, oral contraceptive use, heredity,
systemic corticosteroid, immunosuppression,
hyperhidrosis, occlusion, malnourished state, Diabetes
mellitus, Cushing disease, occlusion dressing & antibiotic
therapy.
• The increase in humidity, temperature, and CO2 tension
appear to be important factors that make the skin
susceptible to infection.
Gupta AK et al: Skin diseases associated with Malassezia species. J Am Acad Dermatol 51:785, 2004
Gupta AK, Bluhm R, Summerbell R: Pityriasis versicolor. J Eur Acad Dermatol Venereol 16:19, 2002

3. PV in Children
• M. pachydermatis- neonate
• M. sympodialis with neonatal cephalic pustulosis

4. Hypopigmentation in PV
• Malassezia synthesizes compound Pityriacitrin that absorbs
ultraviolet light.
• Metabolites: Azaleic acid, & Dicarboxylic acid cause
hypopigmentation by inhibiting tyrosinase and injuring
melanocytes.

5. Microscopically: Malassezia sp.
• Have long and short
septate.
• Occasionally branching
hyphae with a “spaghetti
and meatballs”
appearance

6. Number of Pityrosporum in skin
• Malassezia furfur is abundant in normal skin
(504,000 organisms/cm2 vs. 922,000 in
individuals with dandruff and 665,000 in
patients with seborrheic dermatitis).

7. Colour of TV
• Malassezia synthesizes pityriacitrin that absorbs
ultraviolet light.
•
• Metabolites like as azaleic acid, a dicarboxylic acid,
cause hypopigmentation by inhibiting tyrosinase and
injuring melanocytes.
Mayser P et al: Pityriacitrin—an ultraviolet-absorbing indole alkaloid from the yeast Malassezia furfur.
Arch Dermatol Res 294:131, 2002

8. Pathogenesis
• Ability of Malassezia to produce phospholipase,
which directly correlates with skin infection.

10. D D
• IGH
• Guttate LSA
• Epidermodyplasia verrusiformis
• Erythrasma
• Evolving PRP

11. Infection: Species Malassezia Part -3
Coming soon
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