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REQUEST # 67278
                   Aqueous Coatings on Corrugated Board for
                 Preservation of Packaged Fruits and Vegetables
 RESPONSE DUE DATE: December 2, 2011
 SOLUTION PROVIDER HELP DESK
 EMAIL: PhD@ninesigma.com         PHONE: +1-216-283-3901

 Opportunity
 The goal of this request is to identify key opportunities this
 year, and identify key partners to work with in early 2012.
 Funding and timing of partnership to be scoped during initial
                                                                                             (click buttons above)
 introductions.




REQUEST FOR PROPOSAL DESCRIPTION                                     BACKGROUND
NineSigma, representing a global packaging                           Corrugated boxes in the form of open
company invites proposals for aqueous package                        containers with vent and hand holes are a
coatings for preservation of fruit and                               popular form of packaging fresh fruits and
vegetables packaged in open corrugated                               vegetables. Corrugated containers are
containers. Permanganate based sachets are                           economical, recyclable and renewable
used today to scavenge volatiles such as ethylene                    packaging solutions. Strength and stability
within produce transport. The goal of this request                   during transport and cold chain storage are key
is to identify alternative solutions (such as                        challenges met by specialized designs.
coatings) that can be incorporated directly into the
production of corrugated boxes (preferably at the                    Harvested fruit and vegetables generate
corrugator).                                                         volatiles such as ethylene that promote
                                                                     accelerated ripening during storage and
Characteristics of a successful coating technology                   transport, reducing their shelf life. Common
include the following:                                               strategies for mitigating the generation of
   Safe for food contact                                            volatiles include reduced temperature,
   Can be applied in aqueous form at the                            controlled or modified atmospheres and various
     corrugator for the production of boxes                          gas exchange or scavenging technologies for
   Low cost                                                         removing these compounds. Many current
   Shows capacity to absorb ethylene                                solutions for eliminating ethylene are based on
     comparable with permanganate sachets                            immobilizing permanganate salts on inert
   Can be shown to measurably improve shelf                         mineral supports into a sachet format.
     life of post harvest fruit and vegetables (i.e.,
     20% improvement over existing shelf life                        Volatile or gaseous antagonists of ethylene
     which is variable depending on the species)                     biosynthesis, such as 1-methylcyclopopene,
   Coating needs to be compatible with current                      nitric or nitrous oxides, are known to extend the
     recycling processes for corrugated containers                   shelf life of fresh produce. Volatile naturally

                Offices: Cleveland - USA, Tokyo - Japan, Leuven - Belgium               www.ninesigma.com
                                    RFP format and graphics© Copyright 2011 NineSigma, Inc
NineSigma Request #67278             Aqueous Coatings on Corrugated Board for                                      Page 2
                                   Preservation of Packaged Fruits and Vegetables

occurring essential oils have been shown to
reduce spoilage through an antimicrobial                          Other comments to include in the proposal:
mechanism.                                                         ○ Additional details / overview of the
                                                                      proposed coating solution
What is needed is a delivery system that can be                    ○ Discuss the commercial readiness of
coupled with the production of corrugated                             the solution (i.e., concept only and
packaging that is safe for food contact, and does                     needing development, proof of concept
not require the use of plastics (i.e., NineSigma’s                    shown on a small scale, ready-to-
client does not want the equivalent of modified                       commercialize, sample available for
atmosphere packaging which requires sealing the                       testing/evaluation, etc.)
box with plastic or using a bag in the box - the box               ○ Discussion of potential hurdles or road
will be a stand alone product made by an aqueous                      blocks to commercialization (especially
coating on the corrugator). The system should be                      with respect to food contact)
effective in increasing the post harvest shelf life of             ○ Background / information on the
fruit and vegetables from the farm to the market in                   proposer organization
open containers.
                                                               RESPONDING TO THIS REQUEST

POSSIBLE APPROACHES
                                                                 NON-CONFIDENTIAL DISCLOSURE
Possible approaches might include, but are not
                                                                 By submitting a Response you represent that the
limited to:                                                      Response does not and will not be deemed to contain
    Coatings with ethylene oxidants, absorbents,                any confidential information of any kind whatsoever.
      and ethylene reactive catalysts
                                                                 Your Response should be an executive summary (about
    Micro/nano-encapsulation technologies to
                                                                 3 pages). The Response should briefly describe the
      protect active agents for extended periods                 technical approach and provide information on
                                                                 technology performance, background, and description of
APPROACHES NOT OF INTEREST                                       the responding team and their related experience.

      Modified atmosphere packaging solutions                   By submitting a Response, you acknowledge that
       calling for plastics to contain a specified               NineSigma’s client reserves the sole and absolute right
       atmosphere are out of scope                               and discretion to select for award all, some, or none of
                                                                 the Responses received for this announcement.
      Solutions that do not contain FDA                         NineSigma’s client also may choose to select only
       approved components                                       specific tasks within a proposal for award. NineSigma's
      Solutions which would chemically taint the                client has the sole and absolute discretion to determine
       food product                                              all award amounts.


APPROPRIATE RESPONSES TO THIS REQUEST                            RESPONSE EVALUATION
Responses from companies, academic                               NineSigma’s client will evaluate the Response using the
researchers, government labs or other research                   following criteria:
institutes, consultants, venture capitalists,
entrepreneurs, or inventors are welcome.                              Overall scientific and technical merit of the
                                                                       proposed approach
                                                                      Approach to proof of concept or performance
Appropriate responses will use the proposal                           Potential for proprietary position (i.e., is the
template and address the following:                                    technology novel or protectable)
                                                                      Economic potential of concept
   To be considered “interesting” for follow-up,                     Respondent’s capabilities and related experience
                                                                      Realism of the proposed plan and cost estimates
    proposers should at a minimum:
     ○ Outline how the solution / proposed                       The client will contact respondents with highly
       solution would be applied on the                          responsive proposals for next steps.
       corrugator
     ○ Describe efficiency in absorbing ethylene
     ○ Confirm that the solution / proposed
       solution is safe for food contact


                Offices: Cleveland - USA, Tokyo - Japan, Leuven - Belgium        www.ninesigma.com

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Ethylene Scavenging Additives / Technologies

  • 1. REQUEST # 67278 Aqueous Coatings on Corrugated Board for Preservation of Packaged Fruits and Vegetables RESPONSE DUE DATE: December 2, 2011 SOLUTION PROVIDER HELP DESK EMAIL: PhD@ninesigma.com PHONE: +1-216-283-3901 Opportunity The goal of this request is to identify key opportunities this year, and identify key partners to work with in early 2012. Funding and timing of partnership to be scoped during initial (click buttons above) introductions. REQUEST FOR PROPOSAL DESCRIPTION BACKGROUND NineSigma, representing a global packaging Corrugated boxes in the form of open company invites proposals for aqueous package containers with vent and hand holes are a coatings for preservation of fruit and popular form of packaging fresh fruits and vegetables packaged in open corrugated vegetables. Corrugated containers are containers. Permanganate based sachets are economical, recyclable and renewable used today to scavenge volatiles such as ethylene packaging solutions. Strength and stability within produce transport. The goal of this request during transport and cold chain storage are key is to identify alternative solutions (such as challenges met by specialized designs. coatings) that can be incorporated directly into the production of corrugated boxes (preferably at the Harvested fruit and vegetables generate corrugator). volatiles such as ethylene that promote accelerated ripening during storage and Characteristics of a successful coating technology transport, reducing their shelf life. Common include the following: strategies for mitigating the generation of  Safe for food contact volatiles include reduced temperature,  Can be applied in aqueous form at the controlled or modified atmospheres and various corrugator for the production of boxes gas exchange or scavenging technologies for  Low cost removing these compounds. Many current  Shows capacity to absorb ethylene solutions for eliminating ethylene are based on comparable with permanganate sachets immobilizing permanganate salts on inert  Can be shown to measurably improve shelf mineral supports into a sachet format. life of post harvest fruit and vegetables (i.e., 20% improvement over existing shelf life Volatile or gaseous antagonists of ethylene which is variable depending on the species) biosynthesis, such as 1-methylcyclopopene,  Coating needs to be compatible with current nitric or nitrous oxides, are known to extend the recycling processes for corrugated containers shelf life of fresh produce. Volatile naturally Offices: Cleveland - USA, Tokyo - Japan, Leuven - Belgium www.ninesigma.com RFP format and graphics© Copyright 2011 NineSigma, Inc
  • 2. NineSigma Request #67278 Aqueous Coatings on Corrugated Board for Page 2 Preservation of Packaged Fruits and Vegetables occurring essential oils have been shown to reduce spoilage through an antimicrobial  Other comments to include in the proposal: mechanism. ○ Additional details / overview of the proposed coating solution What is needed is a delivery system that can be ○ Discuss the commercial readiness of coupled with the production of corrugated the solution (i.e., concept only and packaging that is safe for food contact, and does needing development, proof of concept not require the use of plastics (i.e., NineSigma’s shown on a small scale, ready-to- client does not want the equivalent of modified commercialize, sample available for atmosphere packaging which requires sealing the testing/evaluation, etc.) box with plastic or using a bag in the box - the box ○ Discussion of potential hurdles or road will be a stand alone product made by an aqueous blocks to commercialization (especially coating on the corrugator). The system should be with respect to food contact) effective in increasing the post harvest shelf life of ○ Background / information on the fruit and vegetables from the farm to the market in proposer organization open containers. RESPONDING TO THIS REQUEST POSSIBLE APPROACHES NON-CONFIDENTIAL DISCLOSURE Possible approaches might include, but are not By submitting a Response you represent that the limited to: Response does not and will not be deemed to contain  Coatings with ethylene oxidants, absorbents, any confidential information of any kind whatsoever. and ethylene reactive catalysts Your Response should be an executive summary (about  Micro/nano-encapsulation technologies to 3 pages). The Response should briefly describe the protect active agents for extended periods technical approach and provide information on technology performance, background, and description of APPROACHES NOT OF INTEREST the responding team and their related experience.  Modified atmosphere packaging solutions By submitting a Response, you acknowledge that calling for plastics to contain a specified NineSigma’s client reserves the sole and absolute right atmosphere are out of scope and discretion to select for award all, some, or none of the Responses received for this announcement.  Solutions that do not contain FDA NineSigma’s client also may choose to select only approved components specific tasks within a proposal for award. NineSigma's  Solutions which would chemically taint the client has the sole and absolute discretion to determine food product all award amounts. APPROPRIATE RESPONSES TO THIS REQUEST RESPONSE EVALUATION Responses from companies, academic NineSigma’s client will evaluate the Response using the researchers, government labs or other research following criteria: institutes, consultants, venture capitalists, entrepreneurs, or inventors are welcome.  Overall scientific and technical merit of the proposed approach  Approach to proof of concept or performance Appropriate responses will use the proposal  Potential for proprietary position (i.e., is the template and address the following: technology novel or protectable)  Economic potential of concept  To be considered “interesting” for follow-up,  Respondent’s capabilities and related experience  Realism of the proposed plan and cost estimates proposers should at a minimum: ○ Outline how the solution / proposed The client will contact respondents with highly solution would be applied on the responsive proposals for next steps. corrugator ○ Describe efficiency in absorbing ethylene ○ Confirm that the solution / proposed solution is safe for food contact Offices: Cleveland - USA, Tokyo - Japan, Leuven - Belgium www.ninesigma.com