2. What percentage of
people with a
mental illness seek
professional help?
A. 90%
B. 55%
C. 40%
D. 10%
90%
55%
40%
10%
0%
25%
71%
4%
3. Mental Illness
The National Alliance
on Mental Illness
defines mental
illnesses as: “medical
conditions that disrupt
a person’s thinking,
feeling, mood, ability
to relate to others and
daily functioning”
4. Demographics
10-15% of the general population receive
drugs for emotional problems each year
43% of people with mental disorders reside
in the US and Europe
1 in 3 Americans suffer from a mental
disorder
Antidepressants are the medication most
frequently used by people aged 18–44
5. Early Treatment of Mental
Disorders
Before 1950, people
with mental illness
were subjected to
abysmal treatment
Depression was
treated with
amphetamines; other
types of mental
illnesses were
treated with
sedatives
6. History
Electroconvulsive therapy (ECT), first developed in
1938, was used to treat depression and psychosis
Electrical activity in the brain is temporarily
interrupted and a seizure within the brain is triggered
Many patients experienced adverse cognitive effects
Despite concerns, ECT is still a treatment option
8. Diagnosis of Mental Disorders
DSM-5 criteria
Clinically significant distress or impairment in social,
academic (occupational) or other important areas of
functioning
Not attributable to the physiological effects of a
substance or another medical condition
Dual-diagnosis
VERY QUICK OVERVIEW – YOU WILL NOT BE ABLE
TO DIAGNOSE ANYONE, EVEN YOURSELF!
9. It is important to rule out substance use
as a cause of symptoms because
A. Patients could be lying
about their use of
drugs
B. Intoxication can
resemble some
symptoms of mental
disorders
C. A patient can’t be
diagnosed with both
mental illness and
substance abuse
Patientscould
belying
...
Intoxication
can
resem
bl...
A
patientcan’tbe
diag...
0%
8%
92%
10. How are you keeping up?
A. Great, this makes
sense.
B. Pretty well, but I’m
going to need to
do some reading.
C. Michelle, I’m lost.
Great,thism
akessense.
Pretty
w
ell,butI’m
going...
M
ichelle,I’m
lost.
71%
0%
29%
11. Disorders with Anxiety
Symptoms
Anxiety Disorders
Panic Disorder
Social Anxiety
Phobias
Obsessive
Compulsive Disorder
Post-traumatic Stress
Disorder
Treatment often
includes
use of sedative-
hypnotic
drugs
19. Depression
Depressed mood most of the day, nearly every day
Diminished interest or pleasure in activities
Disturbances in appetite
Disturbances in sleep
Psychomotor agitation or retardation
Fatigue/loss of energy
Feelings of worthlessness/
guilt
Diminished ability to
concentrate
Recurrent thoughts of
death
21. Before giving antidepressants to
children:
A. The medications were
tested for effectiveness
B. The medications were
tested for safety
C. The medications were
not tested on children
Them
edicationsw
erete...
Them
edicationsw
erete...
Them
edicationsw
ereno...
0% 0%0%
24. Anti-depressant
Medications
Monoamine oxidase inhibitors (MAOIs)
Tricyclic antidepressants
Selective serotonin reuptake inhibitors
(SSRIs)
Serotonin and norepinephrine reuptake
inhibitors (SNRIs)
Atypical antidepressants that do not fall
into one of the above categories
25. SSRIs
Selective serotonin reuptake
inhibitors (SSRIs)
Antidepressant medications that increase the
concentration of serotonin in the brain
Reduce aggressive and violent behavior
Adverse effects include sexual dysfunction,
increase in weight, and altered sleep patterns
Not much more effective than placebos
26. Although antidepressants
are only slightly more
effective than placebos,
most patients feel they help.
A. True
B. False
True
False
0%0%
27. Manic Episode
Inflated self-esteem
Decreased need for sleep
Talkative
Flight of ideas
Distractibility
Increase in goal-directed activity
Excessive involvement in risky behavior
29. A manic episode can resemble:
A. Being drunk
B. Being high on
marijuana
C. Being high on
cocaine
BeingdrunkBeinghigh
on
m
arijuanaBeinghigh
on
cocaine
0%
100%
0%
30. Medications for Bipolar
Disorder/Manic Episode
Lithium
Effective for acute mania and prevents
recurrence
Maximal benefit is achieved in one to two weeks
Effective for unipolar depression not responsive
to other antidepressant drugs
The therapeutic window is small – three to four
times the therapeutic level can cause grave
consequences
Chlorpromazine
Fewer toxic side effects
31. Non-compliance with med
schedules is a problem with lithium
because
A. Patients are
hallucinating
B. Patients like the feeling
of a manic episode
C. It takes several months
for the dose to reach
therapeutic threshold
Patientsarehallucinating
Patientslikethe
feeling..
Ittakesseveralm
onthsf..
0%
13%
88%
32. Psychosis
Psychosis
Severe mental condition marked by loss of contact with
reality
Organic psychoses
Have physical causes such as excessive drug use, brain
infections, metabolic or endocrine disorders, brain tumors,
and neurological diseases
Functional psychoses
Have no known or apparent cause (e.g. schizophrenia)
34. The number of children taking
antipsychotic drugs has increased
in the US. In Europe:
A. Rates have slightly
increased as well
B. Rates have remained
the same
C. Rates have decreased
D. Rates have increased
at an alarming rate,
doubling the numbers
Rateshaveslightlyincre...
Rateshaverem
ained
the...
Rateshavedecreased
Rateshaveincreased
ata...
38%
19%19%
24%
35. Psychosis is
A. Blunting of
emotional
expression
B. A loss of touch
with reality
C. Always marked by
hallucinations
Bluntingofem
otionalex...
A
lossoftouch
w
ith
reality
Alw
aysm
arked
byhalluc...
0% 0%
100%
37. Antipsychotic Drugs
Antipsychotic drugs (neuroleptics) used
particularly for schizophrenia
Pharmacologically different from other
sedative-hypnotic drugs
They block dopamine
Four to six weeks for maximum
effectiveness
38. Antipsychotic Drugs
Absorbed erratically
Sometimes given by injection so the drug
can be released slowly into the
bloodstream
Build up in fatty areas of brain and lungs,
and cross the placenta to affect the fetus
39. Antipsychotic Drugs
Patients almost always show improvement,
but a small percentage gets worse
Improvement is most rapid during the first
several weeks of treatment
Although many people taking antipsychotic
drugs relapse, it appears that these drugs
reduce violent behavior
40. Side Effects
Parkinsonism
tremor, slow movement, impaired speech or
muscle stiffness — especially resulting from the
loss of dopamine
Tardive dyskinesia
Motor disorders such as involuntary repetitive
facial movements, lip smacking, involuntary
movement of trunk and limbs, and twitching
41. Which is not true of
antipsychotic drugs?
A. Takes 4-6 weeks for max
effect
B. Side-effects are mild and
easily reversed
C. They are absorbed
unevenly
D. They block dopamine
Takes4-6w
eeksform
ax...
Side-effectsare
m
ild
and...
Theyare
absorbed
unevenly
Theyblockdopam
ine
0% 0%
10%
90%
42. Dual Diagnosis
• Two or more
co-existing
mental
illnesses
• Common
Example:
• Substance
Use Disorder
& Depression
43. Increased Medication Use =
Consequences for Society
Number of hospitalizations decreased
Lack of outpatient services
Psychiatrists spend much time
prescribing/managing medications
Civil Rights issues around hospitalization
Non-compliance with medication regimen
Jail
Homelessness
Syphilitic infection and malaria therapy
In the early twentieth century, many psychotic patients were suffering from syphilitic infection of the nervous system (general paresis)
Fever associated with malaria was thought to improve the condition
Antibiotics were developed that cured syphilis
Early drug therapy
Narcosis therapy: depressants used to induce sleep
Intravenous thiopental sodium (“truth serum”) used during psychotherapy to help patients express themselves
Insulin-shock therapy
Electroconvulsive therapy: it was incorrectly believed that inducing convulsions with drugs or electric shocks would cure schizophrenia
Sedatives used in severely disturbed patients
Called tranquilizers, neuroleptics, or antipsychotics
Reduce psychotic symptoms without causing sedation
Following introduction of drug therapy, restraints and treatments like convulsive therapy were reduced or discontinued among hospitalized patients
Before 1950, mentally ill people were subjected to bloodletting, given sneezing powder, were flogged and starved, and had hot irons applied to their bodies
Psychoanalysis grew in popularity starting with Freud – today, it seldom is used to treat mental problems
Depression was treated with drugs such as amphetamines; other types of mental illnesses were treated with antihistamines, barbiturates and other depressants
Electroconvulsive therapy (ECT), first developed in 1938, was used to treat depression and psychosis
Electrical activity in the brain is temporarily interrupted and a seizure within the brain is triggered
Many patients experienced adverse cognitive effects
Despite concerns, ECT is still a treatment option
10-15% of the general population receive drugs for emotional problems each year
43% of people with mental disorders reside in the US and Europe
1 in 3 Americans suffer from a mental disorder
Antidepressants are the medication most frequently used by people aged 18–44
Model: symptoms diagnosis
determination of cause treatment cure
Criticisms of model:
Usually the only symptoms of mental disorders are behavioral
Behaviors are varied and can have many causes
Model guides much of current thinking
Psychoactive drugs are used to control symptoms of mental illness
Researchers seek to identify chemical imbalances associated with specific mental disorders
APA Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) provides criteria for classifying mental disorders
Includes hundreds of specific diagnostic categories
Widely used classification system
The National Alliance on Mental Illness defines mental illnesses as: “medical conditions that disrupt a person’s thinking, feeling, mood, ability to relate to others and daily functioning”
Serious mental illnesses include major depression, schizophrenia, bipolar disorder, obsessive compulsive disorder (OCD), panic disorder, posttraumatic stress disorder (PTSD), and borderline personality disorder
One definition of a mental disorder is “an abnormal state of mind (whether of a continuous or an intermittent nature), characterized by delusions, or by disorders of mood or perception or volition or cognition”
Medical model
The premise that a pathogen is responsible for a person’s illness or disease
Pathogen
Any organism that produces disease
The application of the medical model to emotional problems gives rise to some concern – behaviors deemed inappropriate might not be the result of any given disease
Ethnic and racial minorities often face cultural and social stressors that pose greater risk factors for mental illness
People of lowest socioeconomic status are more likely than those of higher strata to suffer from a mental illness
American adolescents are experiencing major depressive episodes and dysthymia at an increasing rate
Other groups affected by depression include postpartum women and the elderly
Model: symptoms diagnosis
determination of cause treatment cure
Criticisms of model:
Usually the only symptoms of mental disorders are behavioral
Behaviors are varied and can have many causes
Model guides much of current thinking
Psychoactive drugs are used to control symptoms of mental illness
Researchers seek to identify chemical imbalances associated with specific mental disorders
APA Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) provides criteria for classifying mental disorders
Includes hundreds of specific diagnostic categories
Widely used classification system
The National Alliance on Mental Illness defines mental illnesses as: “medical conditions that disrupt a person’s thinking, feeling, mood, ability to relate to others and daily functioning”
Serious mental illnesses include major depression, schizophrenia, bipolar disorder, obsessive compulsive disorder (OCD), panic disorder, posttraumatic stress disorder (PTSD), and borderline personality disorder
One definition of a mental disorder is “an abnormal state of mind (whether of a continuous or an intermittent nature), characterized by delusions, or by disorders of mood or perception or volition or cognition”
Medical model
The premise that a pathogen is responsible for a person’s illness or disease
Pathogen
Any organism that produces disease
The application of the medical model to emotional problems gives rise to some concern – behaviors deemed inappropriate might not be the result of any given disease
Ethnic and racial minorities often face cultural and social stressors that pose greater risk factors for mental illness
People of lowest socioeconomic status are more likely than those of higher strata to suffer from a mental illness
American adolescents are experiencing major depressive episodes and dysthymia at an increasing rate
Other groups affected by depression include postpartum women and the elderly
Model: symptoms diagnosis
determination of cause treatment cure
Criticisms of model:
Usually the only symptoms of mental disorders are behavioral
Behaviors are varied and can have many causes
Model guides much of current thinking
Psychoactive drugs are used to control symptoms of mental illness
Researchers seek to identify chemical imbalances associated with specific mental disorders
APA Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) provides criteria for classifying mental disorders
Includes hundreds of specific diagnostic categories
Widely used classification system
Criteria for Major Depressive Episode: DSM-5
A. Five (or more) of the following symptoms have been present during the same 2-
week period and represent a change from previous functioning; at least one of the
symptoms is either (1) depressed mood or (2) loss of interest or pleasure.
Note: Do not include symptoms that are clearly due to a general medical condition, or
mood-incongruent delusions or hallucinations.
• Depressed mood most of the day, nearly every day, as indicated by either
subjective report (e.g., feels sad or empty) or observation made by others (e.g.,
appears tearful). Note: In children and adolescents, can be irritable mood.
• Markedly diminished interest or pleasure in all, or almost all, activities most of the
day, nearly every day (as indicated by either subjective account or observation
made by others).
• Significant weight loss when not dieting or weight gain (e.g., a change of more
than 5 percent of body weight in a month), or decrease or increase in appetite
nearly every day. Note: In children, consider failure to make expected weight
gains.
• Insomnia or hypersomnia nearly every day.
• Psychomotor agitation or retardation nearly every day (observable by others, not
merely subjective feelings of restlessness or being slowed down).
• Fatigue or loss of energy nearly every day.
• Feelings of worthlessness or excessive or inappropriate guilt (which may be
delusional) nearly every day (not merely self-reproach or guilt about being sick).
• Diminished ability to think or concentrate, or indecisiveness, nearly every day
(either by subjective account or as observed by others).
• Recurrent thoughts of death (not just fear of dying), recurrent suicidal ideation
without a specific plan, or a suicide attempt or a specific plan for committing
suicide.
B. The symptoms cause clinically significant distress or impairment in social,
occupational or other important areas of functioning.
C. The symptoms are not due to the direct physiological effects of a substance (e.g., a
drug of abuse, a medication) or a general medical condition (e.g., hypothyroidism).
Source: DSM-V, American Psychiatric Association
Anxiety disorders—characterized by excessive worry, fears, or avoidance
Panic disorder
Specific phobia
Social phobia
Social anxiety
Generalized anxiety disorder
Other, related disorders
Obsessive-compulsive disorder
Posttraumatic stress disorder
Neurosis
Long-term disorder featuring the symptoms of anxiety and/or exaggerated behavior dedicated to avoiding anxious feelings
Includes obsessive-compulsive behaviors, psychosomatic ailments, phobias, and panic attacks
Anxiety typically is treated with antianxiety drugs
DSM-5 Disorders
Anxiety DisordersSeparation Anxiety DisorderSelective MutismSpecific PhobiaSocial Anxiety Disorder (Social Phobia)Panic DisorderPanic Attack (Specifier)AgoraphobiaGeneralized Anxiety DisorderSubstance/Medication-Induced Anxiety DisorderAnxiety Disorder Due to Another Medical ConditionOther Specified Anxiety DisorderUnspecified Anxiety Disorder Obsessive-Compulsive and Related DisordersObsessive-Compulsive DisorderBody Dysmorphic DisorderHoarding DisorderTrichotillomania (Hair-Pulling Disorder)Excoriation (Skin-Picking) DisorderSubstance/Medication-Induced Obsessive-Compulsive and Related DisorderObsessive-Compulsive and Related Disorder Due to Another Medical ConditionOther Specified Obsessive-Compulsive and Related DisorderUnspecified Obsessive-Compulsive and Related Disorder Trauma- and Stressor-Related DisordersReactive Attachment DisorderDisinhibited Social Engagement DisorderPosttraumatic Stress DisorderAcute Stress DisorderAdjustment DisordersOther Specified Trauma- and Stressor-Related DisorderUnspecified Trauma- and Stressor-Related DisorderDepressive DisordersDisruptive Mood Dysregulation DisorderMajor Depressive Disorder, Single and Recurrent EpisodesPersistent Depressive Disorder (Dysthymia)Premenstrual Dysphoric DisorderSubstance/Medication-Induced Depressive DisorderDepressive Disorder Due to Another Medical ConditionOther Specified Depressive DisorderUnspecified Depressive DisorderSomatic Symptom and Related Disorders Illness Anxiety Disorder (additional disorders not listed)
People with generalized anxiety disorder (GAD) experience constant, chronic, and unsubstantiated worry, often about health, family, money, or work. This worrying goes on every day, possibly all day. It disrupts social activities and interferes with work, school, or family.
Physical symptoms of GAD include the following:
muscle tension
fatigue
restlessness
difficulty sleeping
irritability
Edginess
A panic attack is the abrupt onset of intense fear or discomfort that reaches a peak within minutes and includes at least four of the following symptoms:
Palpitations, and/or accelerated heart rate
Sweating
Trembling or shaking
Sensations of shortness of breath or being smothered
Feeling of choking
Chest pain or discomfort
Nausea or abdominal distress
Feeling dizzy, unsteady, lightheaded, or faint
De-realization (feelings of unreality) or depersonalization (being detached from oneself)
Fear of losing control or going insane
Sense of impending death
Paresthesias (numbness or tingling sensations)
Chills or hot flashes
Specific Symptoms of Panic Disorder:
A person with panic disorder experiences recurrent either expected or unexpected Panic Attacks and at least one of the attacks has been followed by one month (or more) of one or more of the following:
Persistent concern about about the implications of the attack, such as its consequences (e.g., losing control, having a heart attack, “going crazy”) or fears of having additional attacks
A significant change in behavior related to the attacks (e.g., avoid exercise or unfamiliar situations)
The Panic Attacks may not be due to the direct physiological effects of use or abuse of a substance (alcohol, drugs, medications) or a general medical condition (e.g., hyperthyroidism).
Though panic attacks can occur in other mental disorders (most often anxiety-related disorders), the panic attacks in Panic Disorder itself cannot occur exclusive to symptoms in another disorder. In other words, attacks in Panic Disorder cannot be better accounted for by another mental disorder, such as Social Phobia (e.g., occurring on exposure to feared social situations),Specific Phobia (e.g., on exposure to a specific phobic situation), Obsessive-Compulsive Disorder (e.g., on exposure to dirt in someone with an obsession about contamination),Posttraumatic Stress Disorder (e.g., in response to stimuli associated with a severe stressor), or Separation Anxiety Disorder (e.g., in response to being away from home or close relatives).
Panic disorder is associated with high levels of social, occupational, and physical disability; considerable economic costs; and the highest number of medical visits among the anxiety disorders, although the effects are strongest with the presence of agoraphobia. Though Agoraphobia may also be present, it isn’t required in order to diagnose panic disorder.
The Diagnostic and Statistical Manual of the American Psychiatric Association (APA) currently defines social anxiety disorder as follows:
The Current DSM-5 Definition:
A. A persistent fear of one or more social or performance situations in which the person is exposed to unfamiliar people or to possible scrutiny by others. The individual fears that he or she will act in a way (or show anxiety symptoms) that will be embarrassing and humiliating.
B. Exposure to the feared situation almost invariably provokes anxiety, which may take the form of a situationally bound or situationally pre-disposed Panic Attack.
C. The person recognizes that this fear is unreasonable or excessive.
D. The feared situations are avoided or else are endured with intense anxiety and distress.
E. The avoidance, anxious anticipation, or distress in the feared social or performance situation(s) interferes significantly with the person's normal routine, occupational (academic) functioning, or social activities or relationships, or there is marked distress about having the phobia.
F. The fear, anxiety, or avoidance is persistent, typically lasting 6 or more months.
G. The fear or avoidance is not due to direct physiological effects of a substance (e.g., drugs, medications) or a general medical condition not better accounted for by another mental disorder...
Copyright 2013, The American Psychiatric Association
Under DSM-5, several changes have been made to prevent the over diagnosis of specific phobias based on the overestimation of danger or occasional fears. A person no longer has to demonstrate excessive or unreasonable anxiety for a diagnosis of specific phobia. Instead, the anxiety must be “out of proportion” to the threat considering the environment and situation.
Specific Phobia Symptoms
A person who has a specific phobia disorder experiences significant and persistent fear when in the presence of, or anticipating the presence of, the object of fear, which may be an object, place or situation.
The DSM-5 criteria for a specific phobia are:
Marked and out of proportion fear within an environmental or situational context to the presence or anticipation of a specific object or situation
Exposure to the phobic stimulus provokes an immediate anxiety response, which may take the form of a situationally bound or situationally predisposed panic attack.
The person recognizes that the fear is out of proportion.
The phobic situation(s) is avoided or else is endured with intense anxiety or distress.
The avoidance, anxious anticipation or distress in the feared situation(s) interferes significantly with the person's normal routine, occupational (or academic) functioning, or social activities or relationships, or there is marked distress about having the phobia.
The new DSM-5 criteria states that the symptoms for all ages must have a duration of at least 6 months.
The anxiety, panic attack, or phobic avoidance associated with the specific object or situation is not better accounted for by another mental disorder.
Impact of Specific Phobia on Daily Life
One sign that a fear is a phobia is when it limits family, social and professional lives, as per the DSM-5 requirements. A person who has a specific phobia may turn down a job opportunity because it involves flying, or a meeting that is on a high floor. A fear that limits professional and social opportunities, and has a negative effect on performance, confidence and relationships could be a phobia. Whether specific phobias are learned or inherited is still being researched. Twin studies suggest that genetic factors can play a role in the development of a phobia. Brain imaging shows hyperactivation of the amygdala and other areas of the brain in those with phobias.
A person can have one phobia that significantly impacts his/her quality of life. Those with multiple types of phobias with an early onset are the most likely to experience significant impacts on quality of life. They are also more likely to develop other mental disorders. Females are more likely to have multiples type of phobias (Burnstein et al., 2012). Phobias can lead to other medical and mental disorders if not treated early. Individuals with a phobia of vomiting, for example, have developed eating disorders.
Individuals who have phobias score lower on the quality of life scale. Therapy has produced improvements in QOL. Subjects with injection phobia treated with behavioral therapy have achieved normal quality of life levels (Agdal, Raadal, Öst, & Skaret, 2012).
Specific Phobia Therapy
Neuroscientists have identified abnormal hyperactivation in threat processing in those who have anxiety disorders. Cognitive behavioral therapy (CBT) has been shown to be successful in downregulating the threat response. In response to subliminal threats, however, the same study produced hyperactivation rather than downregulation in parts of the brain (Lipka, Hoffman, Miltner, & Straube, 2013). CBT for phobias can be of short duration. Soldiers following a two-day intensive CBT session for specific phobia to wearing a protective mask experienced decreases in cortisol secretion and overcame their phobia (Brand, Annen, Holsboer-Trachsler, & Blaser, 2011). CBT is increasingly being delivered through multimedia. Children have been offered 6-week CBT over the internet with their parents.
Virtual reality exposure therapy (VRET), a form of desensitization therapy, provides a way of facing one’s fears in a safe but realistic environment. Among the features produced in a virtual environment in one study – involvement, realness, presence, spacial presence – involvement produced a treatment response (Price, Mehta, Tone, & Anderson, 2011). An increasingly popular approach is to use VRET with behavioral or cognitive behavioral therapy. Other types of therapies used to treat specific phobia include medication, anxiety management, exposure therapy and meditation.
OBSESSIVE COMPULSIVE DISORDER
Obsessions: persistent ideas, thoughts, impulses, or images that are experienced as inappropriate or intrusive and that cause anxiety and distress. The content of the obsession is often perceived as alien and not under the person's control.
Compulsions: repetitive behaviours or mental acts that are carried out to reduce or prevent anxiety or distress and are perceived to prevent a dreaded event or situation.
Diagnostic criteriaObsessional symptoms or compulsive acts or both must be present on most days for at least 2 successive weeks and be a source of distress or interference with activities.
Eitherobsessions orcompulsions (or both) are present on most days for a period of at least 2 weeks.
The obsessions or compulsions cause marked distress, are time consuming (take more than 1 hour a day) or significantly interfere with the person's normal routine, occupational (or academic) functioning, or usual social activities or relationships.
2.Obsessional symptoms should have the following characteristics:
they must be recognised as the individual's own thoughts or impulses.
there must be at least one thought or act that is still resisted unsuccessfully, even though others may be present which the sufferer no longer resists.
the thought of carrying out the act must not in itself be pleasurable (simple relief of tension or anxiety is not regarded as pleasure in this sense).
the thoughts, images, or impulses must be unpleasantly repetitive.
2.Obsessions (thoughts, ideas, or images) andcompulsions (acts) share the following features, all of which must be present:
they are acknowledged as originating in the mind of the patient, and are not imposed by outside persons or influences.
they are repetitive and unpleasant, and at least one obsession or compulsion that is acknowledged as excessive or unreasonable must be present.
the patient tries to resist them (but resistance to very long-standingobsessions orcompulsionsmay be minimal). At least one obsession or compulsion that is unsuccessfully resisted must be present.
experiencing the obsessive thought or carrying out the compulsive act is not in itself pleasurable. (This should be distinguished from the temporary relief of tensions or anxiety.)
2.If another Axis I disorder is present, the content of the obsessions or compulsionsis not restricted to it (e.g., preoccupation with food in the presence of an Eating Disorder; hair pulling in the presence of Trichotillomania; concern with appearance in the presence of Body Dysmorphic Disorder; preoccupation with drugs in the presence of a Substance Use Disorder; preoccupation with having a serious illness in the presence of Hypochondriasis; preoccupation with sexual urges or fantasies in the presence of a Paraphilia; or guilty ruminations in the presence of a Major Depressive Disorder.
3.The obsessions orcompulsions cause distress or interfere with the patient's social or individual functioning, usually by wasting time.
3.The disturbance is not due to the direct physiological effects of a substance (e.g., a drug of abuse, a medication) or a general medical condition.
PTSD
In DSM-5, published in May, 2013, PTSD is classified as a trauma- and stress-related disorder.[1]
Criterion A: (applicable to adults, adolescents and children over 6. There is a separate Posttraumatic stress disorder for children 6 years and younger.) Exposure to real or threatened death, injury, or sexual violence.
Several items in Criterion B (intrusion symptoms) are rewritten to add or augment certain distinctions now considered important.
Special consideration is given to developmentally appropriate criteria for use with children and adolescents. This is especially evident in the restated Criterion B—intrusion symptoms. Development of age-specific criteria for diagnosis of PTSD is ongoing at this time.
Criterion C (avoidance and numbing) has been split into "C" and "D":
Criterion C (new version) now focuses solely on avoidance of behaviors or physical or temporal reminders of the traumatic experience(s). What were formerly two symptoms are now three, due to slight changes in descriptions.
New Criterion D focuses on negative alterations in cognition and mood associated with the traumatic event(s) and contains two new symptoms, one expanded symptom, and four largely unchanged symptoms specified in the previous criteria.
Criterion E (formerly "D"), which focuses on increased arousal and reactivity, contains one modestly revised, one entirely new, and four unchanged symptoms.
Criterion F (formerly "E") still requires duration of symptoms to have been at least one month.
Criterion G (formerly "F") stipulates symptom impact ("disturbance") in the same way as before.
Criterion H stipulated the disturbance is not due to the effects of a substance or another medical condition.
Specify whether:With dissociative symptoms: (not due to effects of a substance or another medical condition)In addition, meets the criteria of Depersonalization
In addition, meets the criteria of Derealization
Specify if:With delayed expression Full criteria not met until more than 6 months after the event
Panic Attack
Palpitations
Sweating
Trembling/shaking
Sensation of shortness of breath/smothering
Feelings of choking
Chest pain
Nausea
Feeling dizzy/unsteady/light-headed
Chills or heat sensations
Numbness or tingling
Feelings of unreality or being detached from oneself
Fear of losing control/going crazy
Fear of dying
Attack followed by one month of
Persistent worry about additional panic attacks
Maladaptive change in behavior related to attacks (behaviors designed to avoid having another attack)
Generalized Anxiety Disorder
Excessive anxiety/worry
Difficulty controlling the worry
Associated w/3 or more: restlessness, easily fatigued, difficulty concentrating, irritability, muscle tension, sleep disturbances
Social Anxiety
Fear of social situations
Fears of being humiliated
Social situations almost always provoke fear/anxiety
Social situations are avoided or endured with intense fear/anxiety
Fear is out of proportion to actual threat
Persistent (6 months or more)
Specific Phobia
Marked fear/anxiety about a specific object/situation
Object almost always provokes immediate fear/anxiety
Object is actively avoided
Out of proportion to actual danger
Persistent (6 months or more)
Obsessive Compulsive Disorder
A. Presence of obsessions, compulsions or both
Obsessions:
Recurrent/persistent thoughts/urges/images that are experienced as intrusive or unwanted causing marked anxiety/distress
Attempts to ignore/suppress such thoughts/urges/images or to neutralize them by performing another thought/action
Compulsions
Repetitive behaviors the individual feels driven to perform in response to an obsession or according to rigid rules
Behaviors are aimed at preventing/reducing anxiety/distress or preventing some dreaded event/situation, but not connected in a realistic way or are clearly excessive
B. Obsessions/compulsions are time-consuming or cause significant distress/impairment
POST TRAUMATIC STRESS DISORDER
Exposure to actual or threatened death/serious injury/sexual violence
Presence of intrusive symptoms associated with traumatic event
Recurrent, involuntary, intrusive , distressing memories of event
Recurrent distressing dreams
Dissociative reactions/flashbacks
Intense/prolonged psychological distress at exposure to cues that symbolize/resemble an aspect of the traumatic event
Marked physiological reactions to cues that symbolize/resemble an aspect of the event
Persistent avoidance of stimuli associated with the traumatic event
Negative alterations in cognitions and mood associated with the traumatic event (inability to remember important aspects of event,
Exaggerated negative beliefs about self/others, distorted cognitions about the cause/consequence of the traumatic event, persistently negative emotional state, feelings of detachment/estrangement, inability to experience positive emotions)
Marked alterations in arousal or reactivity associated with the traumatic event (irritable, angry, reckless, self-destructive, hypervigilance, sleep disturbance)
Anxiety disorders—characterized by excessive worry, fears, or avoidance
Panic disorder
Specific phobia
Social phobia
Social anxiety
Generalized anxiety disorder
Other, related disorders
Obsessive-compulsive disorder
Posttraumatic stress disorder
Neurosis
Long-term disorder featuring the symptoms of anxiety and/or exaggerated behavior dedicated to avoiding anxious feelings
Includes obsessive-compulsive behaviors, psychosomatic ailments, phobias, and panic attacks
Anxiety typically is treated with antianxiety drugs
DSM-5 Disorders
Anxiety DisordersSeparation Anxiety DisorderSelective MutismSpecific PhobiaSocial Anxiety Disorder (Social Phobia)Panic DisorderPanic Attack (Specifier)AgoraphobiaGeneralized Anxiety DisorderSubstance/Medication-Induced Anxiety DisorderAnxiety Disorder Due to Another Medical ConditionOther Specified Anxiety DisorderUnspecified Anxiety Disorder Obsessive-Compulsive and Related DisordersObsessive-Compulsive DisorderBody Dysmorphic DisorderHoarding DisorderTrichotillomania (Hair-Pulling Disorder)Excoriation (Skin-Picking) DisorderSubstance/Medication-Induced Obsessive-Compulsive and Related DisorderObsessive-Compulsive and Related Disorder Due to Another Medical ConditionOther Specified Obsessive-Compulsive and Related DisorderUnspecified Obsessive-Compulsive and Related Disorder Trauma- and Stressor-Related DisordersReactive Attachment DisorderDisinhibited Social Engagement DisorderPosttraumatic Stress DisorderAcute Stress DisorderAdjustment DisordersOther Specified Trauma- and Stressor-Related DisorderUnspecified Trauma- and Stressor-Related DisorderDepressive DisordersDisruptive Mood Dysregulation DisorderMajor Depressive Disorder, Single and Recurrent EpisodesPersistent Depressive Disorder (Dysthymia)Premenstrual Dysphoric DisorderSubstance/Medication-Induced Depressive DisorderDepressive Disorder Due to Another Medical ConditionOther Specified Depressive DisorderUnspecified Depressive DisorderSomatic Symptom and Related Disorders Illness Anxiety Disorder (additional disorders not listed)
People with generalized anxiety disorder (GAD) experience constant, chronic, and unsubstantiated worry, often about health, family, money, or work. This worrying goes on every day, possibly all day. It disrupts social activities and interferes with work, school, or family.
Physical symptoms of GAD include the following:
muscle tension
fatigue
restlessness
difficulty sleeping
irritability
Edginess
A panic attack is the abrupt onset of intense fear or discomfort that reaches a peak within minutes and includes at least four of the following symptoms:
Palpitations, and/or accelerated heart rate
Sweating
Trembling or shaking
Sensations of shortness of breath or being smothered
Feeling of choking
Chest pain or discomfort
Nausea or abdominal distress
Feeling dizzy, unsteady, lightheaded, or faint
De-realization (feelings of unreality) or depersonalization (being detached from oneself)
Fear of losing control or going insane
Sense of impending death
Paresthesias (numbness or tingling sensations)
Chills or hot flashes
Specific Symptoms of Panic Disorder:
A person with panic disorder experiences recurrent either expected or unexpected Panic Attacks and at least one of the attacks has been followed by one month (or more) of one or more of the following:
Persistent concern about about the implications of the attack, such as its consequences (e.g., losing control, having a heart attack, “going crazy”) or fears of having additional attacks
A significant change in behavior related to the attacks (e.g., avoid exercise or unfamiliar situations)
The Panic Attacks may not be due to the direct physiological effects of use or abuse of a substance (alcohol, drugs, medications) or a general medical condition (e.g., hyperthyroidism).
Though panic attacks can occur in other mental disorders (most often anxiety-related disorders), the panic attacks in Panic Disorder itself cannot occur exclusive to symptoms in another disorder. In other words, attacks in Panic Disorder cannot be better accounted for by another mental disorder, such as Social Phobia (e.g., occurring on exposure to feared social situations),Specific Phobia (e.g., on exposure to a specific phobic situation), Obsessive-Compulsive Disorder (e.g., on exposure to dirt in someone with an obsession about contamination),Posttraumatic Stress Disorder (e.g., in response to stimuli associated with a severe stressor), or Separation Anxiety Disorder (e.g., in response to being away from home or close relatives).
Panic disorder is associated with high levels of social, occupational, and physical disability; considerable economic costs; and the highest number of medical visits among the anxiety disorders, although the effects are strongest with the presence of agoraphobia. Though Agoraphobia may also be present, it isn’t required in order to diagnose panic disorder.
The Diagnostic and Statistical Manual of the American Psychiatric Association (APA) currently defines social anxiety disorder as follows:
The Current DSM-5 Definition:
A. A persistent fear of one or more social or performance situations in which the person is exposed to unfamiliar people or to possible scrutiny by others. The individual fears that he or she will act in a way (or show anxiety symptoms) that will be embarrassing and humiliating.
B. Exposure to the feared situation almost invariably provokes anxiety, which may take the form of a situationally bound or situationally pre-disposed Panic Attack.
C. The person recognizes that this fear is unreasonable or excessive.
D. The feared situations are avoided or else are endured with intense anxiety and distress.
E. The avoidance, anxious anticipation, or distress in the feared social or performance situation(s) interferes significantly with the person's normal routine, occupational (academic) functioning, or social activities or relationships, or there is marked distress about having the phobia.
F. The fear, anxiety, or avoidance is persistent, typically lasting 6 or more months.
G. The fear or avoidance is not due to direct physiological effects of a substance (e.g., drugs, medications) or a general medical condition not better accounted for by another mental disorder...
Copyright 2013, The American Psychiatric Association
Under DSM-5, several changes have been made to prevent the over diagnosis of specific phobias based on the overestimation of danger or occasional fears. A person no longer has to demonstrate excessive or unreasonable anxiety for a diagnosis of specific phobia. Instead, the anxiety must be “out of proportion” to the threat considering the environment and situation.
Specific Phobia Symptoms
A person who has a specific phobia disorder experiences significant and persistent fear when in the presence of, or anticipating the presence of, the object of fear, which may be an object, place or situation.
The DSM-5 criteria for a specific phobia are:
Marked and out of proportion fear within an environmental or situational context to the presence or anticipation of a specific object or situation
Exposure to the phobic stimulus provokes an immediate anxiety response, which may take the form of a situationally bound or situationally predisposed panic attack.
The person recognizes that the fear is out of proportion.
The phobic situation(s) is avoided or else is endured with intense anxiety or distress.
The avoidance, anxious anticipation or distress in the feared situation(s) interferes significantly with the person's normal routine, occupational (or academic) functioning, or social activities or relationships, or there is marked distress about having the phobia.
The new DSM-5 criteria states that the symptoms for all ages must have a duration of at least 6 months.
The anxiety, panic attack, or phobic avoidance associated with the specific object or situation is not better accounted for by another mental disorder.
Impact of Specific Phobia on Daily Life
One sign that a fear is a phobia is when it limits family, social and professional lives, as per the DSM-5 requirements. A person who has a specific phobia may turn down a job opportunity because it involves flying, or a meeting that is on a high floor. A fear that limits professional and social opportunities, and has a negative effect on performance, confidence and relationships could be a phobia. Whether specific phobias are learned or inherited is still being researched. Twin studies suggest that genetic factors can play a role in the development of a phobia. Brain imaging shows hyperactivation of the amygdala and other areas of the brain in those with phobias.
A person can have one phobia that significantly impacts his/her quality of life. Those with multiple types of phobias with an early onset are the most likely to experience significant impacts on quality of life. They are also more likely to develop other mental disorders. Females are more likely to have multiples type of phobias (Burnstein et al., 2012). Phobias can lead to other medical and mental disorders if not treated early. Individuals with a phobia of vomiting, for example, have developed eating disorders.
Individuals who have phobias score lower on the quality of life scale. Therapy has produced improvements in QOL. Subjects with injection phobia treated with behavioral therapy have achieved normal quality of life levels (Agdal, Raadal, Öst, & Skaret, 2012).
Specific Phobia Therapy
Neuroscientists have identified abnormal hyperactivation in threat processing in those who have anxiety disorders. Cognitive behavioral therapy (CBT) has been shown to be successful in downregulating the threat response. In response to subliminal threats, however, the same study produced hyperactivation rather than downregulation in parts of the brain (Lipka, Hoffman, Miltner, & Straube, 2013). CBT for phobias can be of short duration. Soldiers following a two-day intensive CBT session for specific phobia to wearing a protective mask experienced decreases in cortisol secretion and overcame their phobia (Brand, Annen, Holsboer-Trachsler, & Blaser, 2011). CBT is increasingly being delivered through multimedia. Children have been offered 6-week CBT over the internet with their parents.
Virtual reality exposure therapy (VRET), a form of desensitization therapy, provides a way of facing one’s fears in a safe but realistic environment. Among the features produced in a virtual environment in one study – involvement, realness, presence, spacial presence – involvement produced a treatment response (Price, Mehta, Tone, & Anderson, 2011). An increasingly popular approach is to use VRET with behavioral or cognitive behavioral therapy. Other types of therapies used to treat specific phobia include medication, anxiety management, exposure therapy and meditation.
OBSESSIVE COMPULSIVE DISORDER
Obsessions: persistent ideas, thoughts, impulses, or images that are experienced as inappropriate or intrusive and that cause anxiety and distress. The content of the obsession is often perceived as alien and not under the person's control.
Compulsions: repetitive behaviours or mental acts that are carried out to reduce or prevent anxiety or distress and are perceived to prevent a dreaded event or situation.
Diagnostic criteriaObsessional symptoms or compulsive acts or both must be present on most days for at least 2 successive weeks and be a source of distress or interference with activities.
Eitherobsessions orcompulsions (or both) are present on most days for a period of at least 2 weeks.
The obsessions or compulsions cause marked distress, are time consuming (take more than 1 hour a day) or significantly interfere with the person's normal routine, occupational (or academic) functioning, or usual social activities or relationships.
2.Obsessional symptoms should have the following characteristics:
they must be recognised as the individual's own thoughts or impulses.
there must be at least one thought or act that is still resisted unsuccessfully, even though others may be present which the sufferer no longer resists.
the thought of carrying out the act must not in itself be pleasurable (simple relief of tension or anxiety is not regarded as pleasure in this sense).
the thoughts, images, or impulses must be unpleasantly repetitive.
2.Obsessions (thoughts, ideas, or images) andcompulsions (acts) share the following features, all of which must be present:
they are acknowledged as originating in the mind of the patient, and are not imposed by outside persons or influences.
they are repetitive and unpleasant, and at least one obsession or compulsion that is acknowledged as excessive or unreasonable must be present.
the patient tries to resist them (but resistance to very long-standingobsessions orcompulsionsmay be minimal). At least one obsession or compulsion that is unsuccessfully resisted must be present.
experiencing the obsessive thought or carrying out the compulsive act is not in itself pleasurable. (This should be distinguished from the temporary relief of tensions or anxiety.)
2.If another Axis I disorder is present, the content of the obsessions or compulsionsis not restricted to it (e.g., preoccupation with food in the presence of an Eating Disorder; hair pulling in the presence of Trichotillomania; concern with appearance in the presence of Body Dysmorphic Disorder; preoccupation with drugs in the presence of a Substance Use Disorder; preoccupation with having a serious illness in the presence of Hypochondriasis; preoccupation with sexual urges or fantasies in the presence of a Paraphilia; or guilty ruminations in the presence of a Major Depressive Disorder.
3.The obsessions orcompulsions cause distress or interfere with the patient's social or individual functioning, usually by wasting time.
3.The disturbance is not due to the direct physiological effects of a substance (e.g., a drug of abuse, a medication) or a general medical condition.
PTSD
In DSM-5, published in May, 2013, PTSD is classified as a trauma- and stress-related disorder.[1]
Criterion A: (applicable to adults, adolescents and children over 6. There is a separate Posttraumatic stress disorder for children 6 years and younger.) Exposure to real or threatened death, injury, or sexual violence.
Several items in Criterion B (intrusion symptoms) are rewritten to add or augment certain distinctions now considered important.
Special consideration is given to developmentally appropriate criteria for use with children and adolescents. This is especially evident in the restated Criterion B—intrusion symptoms. Development of age-specific criteria for diagnosis of PTSD is ongoing at this time.
Criterion C (avoidance and numbing) has been split into "C" and "D":
Criterion C (new version) now focuses solely on avoidance of behaviors or physical or temporal reminders of the traumatic experience(s). What were formerly two symptoms are now three, due to slight changes in descriptions.
New Criterion D focuses on negative alterations in cognition and mood associated with the traumatic event(s) and contains two new symptoms, one expanded symptom, and four largely unchanged symptoms specified in the previous criteria.
Criterion E (formerly "D"), which focuses on increased arousal and reactivity, contains one modestly revised, one entirely new, and four unchanged symptoms.
Criterion F (formerly "E") still requires duration of symptoms to have been at least one month.
Criterion G (formerly "F") stipulates symptom impact ("disturbance") in the same way as before.
Criterion H stipulated the disturbance is not due to the effects of a substance or another medical condition.
Specify whether:With dissociative symptoms: (not due to effects of a substance or another medical condition)In addition, meets the criteria of Depersonalization
In addition, meets the criteria of Derealization
Specify if:With delayed expression Full criteria not met until more than 6 months after the event
Panic Attack
Palpitations
Sweating
Trembling/shaking
Sensation of shortness of breath/smothering
Feelings of choking
Chest pain
Nausea
Feeling dizzy/unsteady/light-headed
Chills or heat sensations
Numbness or tingling
Feelings of unreality or being detached from oneself
Fear of losing control/going crazy
Fear of dying
Attack followed by one month of
Persistent worry about additional panic attacks
Maladaptive change in behavior related to attacks (behaviors designed to avoid having another attack)
Generalized Anxiety Disorder
Excessive anxiety/worry
Difficulty controlling the worry
Associated w/3 or more: restlessness, easily fatigued, difficulty concentrating, irritability, muscle tension, sleep disturbances
Social Anxiety
Fear of social situations
Fears of being humiliated
Social situations almost always provoke fear/anxiety
Social situations are avoided or endured with intense fear/anxiety
Fear is out of proportion to actual threat
Persistent (6 months or more)
Specific Phobia
Marked fear/anxiety about a specific object/situation
Object almost always provokes immediate fear/anxiety
Object is actively avoided
Out of proportion to actual danger
Persistent (6 months or more)
Obsessive Compulsive Disorder
A. Presence of obsessions, compulsions or both
Obsessions:
Recurrent/persistent thoughts/urges/images that are experienced as intrusive or unwanted causing marked anxiety/distress
Attempts to ignore/suppress such thoughts/urges/images or to neutralize them by performing another thought/action
Compulsions
Repetitive behaviors the individual feels driven to perform in response to an obsession or according to rigid rules
Behaviors are aimed at preventing/reducing anxiety/distress or preventing some dreaded event/situation, but not connected in a realistic way or are clearly excessive
B. Obsessions/compulsions are time-consuming or cause significant distress/impairment
POST TRAUMATIC STRESS DISORDER
Exposure to actual or threatened death/serious injury/sexual violence
Presence of intrusive symptoms associated with traumatic event
Recurrent, involuntary, intrusive , distressing memories of event
Recurrent distressing dreams
Dissociative reactions/flashbacks
Intense/prolonged psychological distress at exposure to cues that symbolize/resemble an aspect of the traumatic event
Marked physiological reactions to cues that symbolize/resemble an aspect of the event
Persistent avoidance of stimuli associated with the traumatic event
Negative alterations in cognitions and mood associated with the traumatic event (inability to remember important aspects of event,
Exaggerated negative beliefs about self/others, distorted cognitions about the cause/consequence of the traumatic event, persistently negative emotional state, feelings of detachment/estrangement, inability to experience positive emotions)
Marked alterations in arousal or reactivity associated with the traumatic event (irritable, angry, reckless, self-destructive, hypervigilance, sleep disturbance)
Mood disorders— characterized by depressed or manic symptoms
Major depression
Manic episodes
Bipolar disorder
Symptoms don’t always fit neatly into diagnostic categories
Mood disorders
Forms of mental illness that affect the person’s emotions
Can be depression or mania
Depression
Dejection characterized by withdrawal or lack of response to stimulation
Mania
Characterized by inappropriate elation, an irrepressible mood, and extreme cheerfulness
Bipolar affective disorder
A mental condition characterized by alternating moods of depression and mania
Formerly called manic-depression
Unipolar depression
Mental disorder marked by alternating periods of depression and normalcy
Depression can cause substance abuse, but substance abuse also can lead to depression
Clinical depression is a real illness that can be treated effectively
Some individuals with substance abuse problems are misdiagnosed with bipolar illness
A frequent problem among people with bipolar disorder is noncompliance with medications
Women experience twice the rate of depression as men, regardless of race or ethnic background
Criteria for Manic Episode: DSM-5
A. A distinct period of abnormally and persistently elevated, expansive, or irritable
mood, lasting at least 1 week (or any duration if hospitalization is necessary).
B. During the period of mood disturbance, three (or more) of the following
symptoms have persisted (four if the mood is only irritable) and have been
present to a significant degree:
• inflated self-esteem or grandiosity
• decreased need for sleep (e.g., feels rested after only 3 hours of sleep)
• more talkative than usual or pressure to keep talking
• flight of ideas or subjective experience that thoughts are racing
• distractibility (i.e., attention too easily drawn to unimportant or irrelevant
external stimuli)
• increase in goal-directed activity (either socially, at work or school, or
sexually) or psychomotor agitation
• excessive involvement in pleasurable activities that have a high potential for
painful consequences (e.g., engaging in unrestrained buying sprees, sexual
indiscretions, or foolish business investments)
C. The mood disturbance is sufficiently severe to cause marked impairment in
occupational functioning or in usual social activities or relationships with others,
or to necessitate hospitalization to prevent harm to self or others, or there are
psychotic features.
D. The symptoms are not due to the direct physiological effects of a substance (e.g.,
a drug of abuse, a medication, or other treatment) or a general medical condition
(e.g., hyperthyroidism).
Note: Manic-like episodes that are clearly caused by somatic antidepressant treatment
(e.g., medication, electroconvulsive therapy, light therapy) should not count toward a
diagnosis of Bipolar I Disorder.
Source: DSM-V, American Psychiatric Association
Criteria for Major Depressive Episode: DSM-5
A. Five (or more) of the following symptoms have been present during the same 2-
week period and represent a change from previous functioning; at least one of the
symptoms is either (1) depressed mood or (2) loss of interest or pleasure.
Note: Do not include symptoms that are clearly due to a general medical condition, or
mood-incongruent delusions or hallucinations.
• Depressed mood most of the day, nearly every day, as indicated by either
subjective report (e.g., feels sad or empty) or observation made by others (e.g.,
appears tearful). Note: In children and adolescents, can be irritable mood.
• Markedly diminished interest or pleasure in all, or almost all, activities most of the
day, nearly every day (as indicated by either subjective account or observation
made by others).
• Significant weight loss when not dieting or weight gain (e.g., a change of more
than 5 percent of body weight in a month), or decrease or increase in appetite
nearly every day. Note: In children, consider failure to make expected weight
gains.
• Insomnia or hypersomnia nearly every day.
• Psychomotor agitation or retardation nearly every day (observable by others, not
merely subjective feelings of restlessness or being slowed down).
• Fatigue or loss of energy nearly every day.
• Feelings of worthlessness or excessive or inappropriate guilt (which may be
delusional) nearly every day (not merely self-reproach or guilt about being sick).
• Diminished ability to think or concentrate, or indecisiveness, nearly every day
(either by subjective account or as observed by others).
• Recurrent thoughts of death (not just fear of dying), recurrent suicidal ideation
without a specific plan, or a suicide attempt or a specific plan for committing
suicide.
B. The symptoms cause clinically significant distress or impairment in social,
occupational or other important areas of functioning.
C. The symptoms are not due to the direct physiological effects of a substance (e.g., a
drug of abuse, a medication) or a general medical condition (e.g., hypothyroidism).
Source: DSM-V, American Psychiatric Association
Criteria for Major Depressive Episode: DSM-5
A. Five (or more) of the following symptoms have been present during the same 2-
week period and represent a change from previous functioning; at least one of the
symptoms is either (1) depressed mood or (2) loss of interest or pleasure.
Note: Do not include symptoms that are clearly due to a general medical condition, or
mood-incongruent delusions or hallucinations.
• Depressed mood most of the day, nearly every day, as indicated by either
subjective report (e.g., feels sad or empty) or observation made by others (e.g.,
appears tearful). Note: In children and adolescents, can be irritable mood.
• Markedly diminished interest or pleasure in all, or almost all, activities most of the
day, nearly every day (as indicated by either subjective account or observation
made by others).
• Significant weight loss when not dieting or weight gain (e.g., a change of more
than 5 percent of body weight in a month), or decrease or increase in appetite
nearly every day. Note: In children, consider failure to make expected weight
gains.
• Insomnia or hypersomnia nearly every day.
• Psychomotor agitation or retardation nearly every day (observable by others, not
merely subjective feelings of restlessness or being slowed down).
• Fatigue or loss of energy nearly every day.
• Feelings of worthlessness or excessive or inappropriate guilt (which may be
delusional) nearly every day (not merely self-reproach or guilt about being sick).
• Diminished ability to think or concentrate, or indecisiveness, nearly every day
(either by subjective account or as observed by others).
• Recurrent thoughts of death (not just fear of dying), recurrent suicidal ideation
without a specific plan, or a suicide attempt or a specific plan for committing
suicide.
B. The symptoms cause clinically significant distress or impairment in social,
occupational or other important areas of functioning.
C. The symptoms are not due to the direct physiological effects of a substance (e.g., a
drug of abuse, a medication) or a general medical condition (e.g., hypothyroidism).
Source: DSM-V, American Psychiatric Association
Monoamine oxidase (MAO) inhibitors
Examples: phenelzine, tranylcypromine
Tricyclic antidepressants
Examples: amitriptyline, doxepin, nortriptyline
Selective serotonin reuptake inhibitors (SSRIs)
Examples: fluoxetine, sertraline, venlafaxine
Monoamine Oxidase Inhibitors
Discovered when a drug for tuberculosis was found to also elevate mood
Work by increasing the availability of serotonin, norepinephrine, and dopamine
Limited use due to side effects and toxicity
Users must avoid certain foods and drugs to prevent severe side effects
TRICYCLICS
Discovered when researchers were working to create a better phenothiazine antipsychotic and found a drug that improved mood
May work by reducing the uptake (and thereby increasing the availability) of norepinephrine, dopamine, and serotonin
Not effective in all patients, but they reduce the severity and duration of depressive episodes
SSRI
SSRIs may work by reducing the uptake (and thereby increasing the availability) of serotonin
Safer than tricyclic antidepressants, less likely to lead to overdose deaths
Only a little more effective than placebo
Strong warning from FDA about an increased risk of suicidal tendencies in children and adolescents
MECHANISMS OF ACTION
Appear to work by increasing the availability of norepinephrine or serotonin
A lag period before improvement in mood is seen
We don’t yet have the complete picture of how antidepressants work
ECT
Most effective treatment for relieving severe depression
Works very rapidly, more quickly than antidepressant drugs
Best treatment choice in cases with a risk of suicide
Can be used in conjunction with drugs
MOOD STABILIZERS
Lithium: Approved for U.S. sale in 1970
Early studies found it to be effective in manic patients
Acceptance slow in United States
Previous history of poisonings
Low perception of seriousness of mania
U.S. drug approval and sale process
Can be safe or toxic; blood levels must be monitored
High rate of patient noncompliance
Lithium
Normalizes mood in bipolar patients, preventing both mania and depressed mood swings
Little effect in treating unipolar depression
Other mood stabilizers are anticonvulsant drugs (valproic acid, carbamazepine, lamotrigine)
Depression is treated with five major classes of drugs:
Monoamine oxidase inhibitors (MAOIs)
Tricyclic antidepressants
Selective serotonin reuptake inhibitors (SSRIs)
Serotonin and norepinephrine reuptake inhibitors (SNRIs)
Atypical antidepressants that do not fall into one of the above categories
Monoamine oxidase (MAO) is an enzyme on the outer membranes of mitochondria – inactivates the neurotransmitters serotonin, dopamine, and norepinephrine
MAOIs block the action of monoamine oxidase
Four principal MAOIs in the US:
Tranylcypromine (Parnate)
Phenelize (Nardil)
Isocarboxazid (Marplan)
Selegiline (Emsam)
Work well for neurotic conditions such as acute anxiety, obsessive-compulsive behavior, phobias, panic attacks
Toxic effects occur when MAOIs interact with foods containing tyramine – release of catecholamines produces sympathomimetic effects
MAOIs interact dangerously with certain medications, especially dextromethorphan, Demerol, and other antidepressants that affect serotonin such as Prozac
Tricyclic
Amitriptyline (Elavil) is used for depression accompanied by agitation
Imipramine (Tofranil) is given for depression involving psychomotor retardation, as well as for agoraphobia, panic attacks, and obsessive-compulsive behavior
Clomipramine (Anafranil) also has been used to treat obsessive-compulsive behaviors
Antidepressant action takes 3-4 weeks
Tricyclics are also effective in moderating pain, and can be beneficial in treatment of the eating disorder bulimia
Common side effects are distorted vision, tachycardia, dry mouth, constipation, sleepiness, and urinary retention
With alcohol, risk of a deadly reaction increases – overdose causes coma, cardiac difficulties, and respiratory problems
If patients cease taking tricyclics abruptly, they demonstrate withdrawal symptoms
Even at low dosage, tricyclics can be toxic – excessive levels can be fatal
Another side effect is development of type 2 diabetes, especially when taken with the newer antidepressants
Side Effects
Tachycardia
Dry mouth
Confusion
Hypotension
Disorientation
Impotence
Glaucoma
Distorted vision
Sleepiness
Constipation
Urinary retention
Tremors
Rashes
Jaundice
Respiratory problems
Coma
Death
Selective serotonin reuptake inhibitors (SSRIs)
Antidepressant medications that increase the concentration of serotonin in the brain
Reduce aggressive and violent behavior
Adverse effects include sexual dysfunction, increase in weight, and altered sleep patterns
Not much more effective than placebos
Prozac (fluoxetine)
Fewer serious side effects
Also used for bulimia, obesity, anxiety, and OCD
Implicated in a number of suicides
Zoloft (sertraline)
Especially effective with elderly patients
Prescribed for patients with acute coronary syndrome
Also used to treat OCD
Paxil (paroxetine)
Increased risk of suicides in children
When taken during pregnancy, increases risk of cardiac malformations and neonatal complications
New version: PaxilCR
Lexapro (escitalopram)
Also used for OCD, panic disorder, social anxiety disorder, PTSD, premenstrual dysphoric disorder, menstrual mood swing and irritability, and compulsive gambling
ATYPICAL
Nefazodone (Serzone)
No longer available in the US
Reported as causing severe liver failure
Trazodone
Mood elevator
Side effects may include confusion, concentration difficulties, headaches, and nervousness
Mirtazapine
May cause mood changes, unusual thought processes, seizures, lowered libido, and changes in menstrual cycle
Bupropion (Wellbutrin)
Inhibits uptake of dopamine and norepinephrine.
Also used for smoking cessation and seasonal affective disorder
Side effects are usually mild
Serotonin and norepinephrine reuptake inhibitors (SNRIs)
Work by decreasing the reabsorption of both serotonin and norepinephrine in the brain
Side effects may include pain in the eyes, vision blurring, or blindness
May cause a variety of other side effects, from diarrhea and agitation to irregular heartbeats and convulsion
Venlafaxine (Effexor XR)
Side effects similar to SSRIs
Overdose can be dangerous or fatal
Desvenlafaxine (Pristiq)
Similar to venlafaxine and causes similar side effects
Duloxetine (Cymbalta)
May help relieve physical pain in addition to depression
Side effects include nausea, dry mouth, constipation
Heavy drinkers or those with certain liver or kidney problems should not take duloxetine
Lithium
A positively charged ion, similar to sodium
Used to treat symptoms associated with mania
Side effects include tremors, excessive thirst, frequent urination, fluid retention, and weight gain
Inability to excrete lithium can lead to toxic levels in the body
Chlorpromazine
Alternative antimanic with fewer toxic effects
Lithium is effective for acute mania and for preventing mania and depression from recurring
Maximal benefit is achieved in one to two weeks
Effective for people who have unipolar depression and do not respond to tricyclic antidepressant drugs
The therapeutic window is small – three to four times the therapeutic level can cause grave consequences
SIDE EFFECTS
Nausea
Excessive perspiration
Water retention
Vomiting
Confusion
Drowsiness
Tinnitus
Kidney dysfunction
Respiratory depression
Polydipsia
Hand tremors
Polyuria
Diarrhea
Weight gain
Muscular weakness
Distorted vision
Coma
Death
Monoamine oxidase (MAO) inhibitors
Examples: phenelzine, tranylcypromine
Tricyclic antidepressants
Examples: amitriptyline, doxepin, nortriptyline
Selective serotonin reuptake inhibitors (SSRIs)
Examples: fluoxetine, sertraline, venlafaxine
Serotonin and norepinephrine reuptake inhibitors (SNRIs)
Work by decreasing the reabsorption of both serotonin and norepinephrine in the brain
Side effects may include pain in the eyes, vision blurring, or blindness
May cause a variety of other side effects, from diarrhea and agitation to irregular heartbeats and convulsion
Venlafaxine (Effexor XR)
Side effects similar to SSRIs
Overdose can be dangerous or fatal
Desvenlafaxine (Pristiq)
Similar to venlafaxine and causes similar side effects
Duloxetine (Cymbalta)
May help relieve physical pain in addition to depression
Side effects include nausea, dry mouth, constipation
Heavy drinkers or those with certain liver or kidney problems should not take duloxetine
Monoamine Oxidase Inhibitors
Discovered when a drug for tuberculosis was found to also elevate mood
Work by increasing the availability of serotonin, norepinephrine, and dopamine
Limited use due to side effects and toxicity
Users must avoid certain foods and drugs to prevent severe side effects
TRICYCLICS
Antidepressant action takes 3-4 weeks
Tricyclics are also effective in moderating pain, and can be beneficial in treatment of the eating disorder bulimia
Common side effects are distorted vision, tachycardia, dry mouth, constipation, sleepiness, and urinary retention
With alcohol, risk of a deadly reaction increases – overdose causes coma, cardiac difficulties, and respiratory problems
If patients cease taking tricyclics abruptly, they demonstrate withdrawal symptoms
Even at low dosage, tricyclics can be toxic – excessive levels can be fatal
Another side effect is development of type 2 diabetes, especially when taken with the newer antidepressants
Amitriptyline (Elavil) is used for depression accompanied by agitation
Imipramine (Tofranil) is given for depression involving psychomotor retardation, as well as for agoraphobia, panic attacks, and obsessive-compulsive behavior
Clomipramine (Anafranil) also has been used to treat obsessive-compulsive behaviors
SIDE EFFECTS
Tachycardia
Dry mouth
Confusion
Hypotension
Disorientation
Impotence
Glaucoma
Distorted vision
Sleepiness
Constipation
Urinary retention
Tremors
Rashes
Jaundice
Respiratory problems
Coma
Death
Discovered when researchers were working to create a better phenothiazine antipsychotic and found a drug that improved mood
May work by reducing the uptake (and thereby increasing the availability) of norepinephrine, dopamine, and serotonin
Not effective in all patients, but they reduce the severity and duration of depressive episodes
SSRI
SSRIs may work by reducing the uptake (and thereby increasing the availability) of serotonin
Safer than tricyclic antidepressants, less likely to lead to overdose deaths
Only a little more effective than placebo
Strong warning from FDA about an increased risk of suicidal tendencies in children and adolescents
MECHANISMS OF ACTION
Appear to work by increasing the availability of norepinephrine or serotonin
A lag period before improvement in mood is seen
We don’t yet have the complete picture of how antidepressants work
ECT
Most effective treatment for relieving severe depression
Works very rapidly, more quickly than antidepressant drugs
Best treatment choice in cases with a risk of suicide
Can be used in conjunction with drugs
MAO
Monoamine oxidase (MAO) is an enzyme on the outer membranes of mitochondria – inactivates the neurotransmitters serotonin, dopamine, and norepinephrine
MAOIs block the action of monoamine oxidase
Interact dangerously with dextromethorphan, Demerol and SSRIs and some foods
Four principal MAOIs in the US:
Tranylcypromine (Parnate)
Phenelize (Nardil)
Isocarboxazid (Marplan)
Selegiline (Emsam)
Work well for neurotic conditions such as acute anxiety, obsessive-compulsive behavior, phobias, panic attacks
Toxic effects occur when MAOIs interact with foods containing tyramine – release of catecholamines produces sympathomimetic effects
Aged cheeses, such as aged cheddar and Swiss; blue cheeses such as Stilton and Gorgonzola; and Camembert. Cheeses made from pasteurized milk are less likely to contain high levels of tyramine, including American cheese, cottage cheese, ricotta, farm cheese and cream cheese.
Cured meats, which are meats treated with salt and nitrate or nitrite, such as dry-type summer sausages, pepperoni and salami.
Fermented cabbage, such as sauerkraut and kimchee.
Soy sauce, fish sauce and shrimp sauce.
Yeast-extract spreads, such as Marmite.
Improperly stored foods or spoiled foods.
Broad bean pods, such as fava beans
MAOIs interact dangerously with certain medications, especially dextromethorphan, Demerol, and other antidepressants that affect serotonin such as Prozac
Nefazodone (Serzone)
No longer available in the US
Reported as causing severe liver failure
ATYPICAL
Trazodone
Mood elevator
Side effects may include confusion, concentration difficulties, headaches, and nervousness
Mirtazapine
May cause mood changes, unusual thought processes, seizures, lowered libido, and changes in menstrual cycle
Bupropion (Wellbutrin)
Inhibits uptake of dopamine and norepinephrine.
Also used for smoking cessation and seasonal affective disorder
Side effects are usually mild
Four principal MAOIs in the US:
Tranylcypromine (Parnate)
Phenelize (Nardil)
Isocarboxazid (Marplan)
Selegiline (Emsam)
Work well for neurotic conditions such as acute anxiety, obsessive-compulsive behavior, phobias, panic attacks
Toxic effects occur when MAOIs interact with foods containing tyramine – release of catecholamines produces sympathomimetic effects
Aged cheeses, such as aged cheddar and Swiss; blue cheeses such as Stilton and Gorgonzola; and Camembert. Cheeses made from pasteurized milk are less likely to contain high levels of tyramine, including American cheese, cottage cheese, ricotta, farm cheese and cream cheese.
Cured meats, which are meats treated with salt and nitrate or nitrite, such as dry-type summer sausages, pepperoni and salami.
Fermented cabbage, such as sauerkraut and kimchee.
Soy sauce, fish sauce and shrimp sauce.
Yeast-extract spreads, such as Marmite.
Improperly stored foods or spoiled foods.
Broad bean pods, such as fava beans
MAOIs interact dangerously with certain medications, especially dextromethorphan, Demerol, and other antidepressants that affect serotonin such as Prozac
Antidepressant action takes 3-4 weeks
Tricyclics are also effective in moderating pain, and can be beneficial in treatment of the eating disorder bulimia
Common side effects are distorted vision, tachycardia, dry mouth, constipation, sleepiness, and urinary retention
With alcohol, risk of a deadly reaction increases – overdose causes coma, cardiac difficulties, and respiratory problems
If patients cease taking tricyclics abruptly, they demonstrate withdrawal symptoms
Even at low dosage, tricyclics can be toxic – excessive levels can be fatal
Another side effect is development of type 2 diabetes, especially when taken with the newer antidepressants
mitriptyline (Elavil) is used for depression accompanied by agitation
Imipramine (Tofranil) is given for depression involving psychomotor retardation, as well as for agoraphobia, panic attacks, and obsessive-compulsive behavior
Clomipramine (Anafranil) also has been used to treat obsessive-compulsive behaviors
SIDE EFFECTS
Tachycardia
Dry mouth
Confusion
Hypotension
Disorientation
Impotence
Glaucoma
Distorted vision
Sleepiness
Constipation
Urinary retention
Tremors
Rashes
Jaundice
Respiratory problems
Coma
Death
Prozac (fluoxetine)
Fewer serious side effects
Also used for bulimia, obesity, anxiety, and OCD
Implicated in a number of suicides
Zoloft (sertraline)
Especially effective with elderly patients
Prescribed for patients with acute coronary syndrome
Also used to treat OCD
Paxil (paroxetine)
Increased risk of suicides in children
When taken during pregnancy, increases risk of cardiac malformations and neonatal complications
New version: PaxilCR
Lexapro (escitalopram)
Also used for OCD, panic disorder, social anxiety disorder, PTSD, premenstrual dysphoric disorder, menstrual mood swing and irritability, and compulsive gambling
Venlafaxine (Effexor XR)
Side effects similar to SSRIs
Overdose can be dangerous or fatal
Desvenlafaxine (Pristiq)
Similar to venlafaxine and causes similar side effects
Duloxetine (Cymbalta)
May help relieve physical pain in addition to depression
Side effects include nausea, dry mouth, constipation
Heavy drinkers or those with certain liver or kidney problems should not take duloxetine
Lithium
Lithium is effective for acute mania and for preventing mania and depression from recurring
Maximal benefit is achieved in one to two weeks
Effective for people who have unipolar depression and do not respond to tricyclic antidepressant drugs
The therapeutic window is small – three to four times the therapeutic level can cause grave consequences
Chlorpromazine
Fewer toxic side effects
Lithium
A positively charged ion, similar to sodium
Used to treat symptoms associated with mania
Side effects include tremors, excessive thirst, frequent urination, fluid retention, and weight gain
Inability to excrete lithium can lead to toxic levels in the body
Chlorpromazine
Alternative antimanic with fewer toxic effects
LITHIUM SIDE EFFECTS
Nausea
Excessive perspiration
Water retention
Vomiting
Confusion
Drowsiness
Tinnitus
Kidney dysfunction
Respiratory depression
Polydipsia
Hand tremors
Polyuria
Diarrhea
Weight gain
Muscular weakness
Distorted vision
Coma
Death
Schizophrenia—chronic psychosis characterized by delusions, hallucinations, disorganized speech and behavior, and lack of emotional response; causes significant interference with social and/or occupational functioning
Psychosis—a serious mental disorder involving loss of contact with reality
Psychosis
Severe mental condition marked by loss of contact with reality
Organic psychoses
Have physical causes such as excessive drug use, brain infections, metabolic or endocrine disorders, brain tumors, and neurological diseases
Functional psychoses
Have no known or apparent cause (e.g. schizophrenia)
According to the DSM-5, (Diagnostic and Statistical Manual of Mental Disorders, fifth edition) Schizophrenia is a disorder in which a person will experience gross deficits in reality testing, manifested with at least two or more the following symptoms, which must be present for at least one month (unless treatment produces symptom remission):
At least one symptom collectively referred to as positive symptoms: must be in categories 1, 2, or 3,
1.Delusions- strange beliefs and ideas which are resistant to rational/logical dispute or contradiction from others. 2.Hallucinations- typically auditory, or less frequently, visual. 3. Disorganized Speech- incoherence, irrational content. 4. Disorganized or Catatonic behavior- repetitive, senseless movements, or adopting a pose which may be maintained for hours. The individual may be resistant to efforts to move them into a different posture, or will assume a new posture they are placed in.
5. Negative symptoms- flat affect, amotivation, anergia, failure to maintain hygiene (American Psychiatric Association, 2013).
1. Marked reduction in level of functioning in one or more areas, such as occupational, social, or personal care or hygiene . If symptom onset occurs during childhood or adolescence, there is inability to reach age-typical functioning in academic, social or interpersonal areas. 2. Symptoms must persist at least six months, during which at least one month of symptoms (unless treatment produces symptom remission) meet the criteria for positive symptoms and may include periods of prodromal or residual symptoms. During prodromal or residual periods, the signs of the disturbance may be manifested by negative symptoms or by two or more positive symptoms present in a less prominent form (e.g.,unusual beliefs or perceptions). 3.Schizoaffective disorder and depressive or bipolar disorder with psychotic features have been ruled out. 4 The psychotic episode cannot be attributed to substance use (ethanol withdrawal, cocaine abuse) or a medical condition. 5. If autism spectrum disorder or a communication disorder of childhood onset has been previously diagnosed, the diagnosis of schizophrenia is made only if prominent delusions or hallucinations, in addition to the other symptoms of schizophrenia, are present for at least one month, excluding successful treatment (American Psychiatric Association, 2013).
If symptoms have persisted for one year, and if there are no contradictory diagnostic criteria, the clinician may include specifiers:
1. First episode, currently in acute episode: First apparent onset of the disorder as defined by the above diagnostic criteria. 2. First episode, currently in partial remission: First apparent onset of the disorder with a period of improvement in which the symptoms are only partially present. 3. First episode, currently in full remission: Absence of apparent symptoms after a first episode. 4. Multiple episodes, currently in acute episode: 5. Two or more episodes, current one acute. 6. Multiple episodes, currently in partial remission
7. Multiple episodes, currently in full remission 8. Continuous: maintenance of symptoms fulfilling the diagnostic symptom criteria for the majority of time. 8. Unspecified- With catatonia 9. Current severity: Severity can be rated by a quantitative assessment of positive and negative symptoms on a Five point Likert scale for the previous seven days- e.g.- zero- absent to Four, present and severe. (American Psychiatric Association, 2013).
Called tranquilizers, neuroleptics, or antipsychotics
Reduce psychotic symptoms without causing sedation
Following introduction of drug therapy, restraints and treatments like convulsive therapy were reduced or discontinued among hospitalized patients
Treatment with phenothiazines found to be more effective than a placebo
Patients relapse when therapy is discontinued
Two groups of antipsychotics
Conventional (introduced before mid-1990s)
Atypical (introduced in the past 10 years)
Antipsychotics produce pseudoparkinsonism, indicating a link to dopamine receptors
Time delay in drug effects indicates that the mechanism of action is probably more complex
Atypical antipsychotics block both D2 dopamine and 5HT2A serotonin receptors
Produce less pseudoparkinsonism
Safe in that they are not addictive and are difficult to use to commit suicide
Side effects
Some allergic reactions (jaundice, skin rashes)
Photosensitivity (easily sunburned)
Agranulocytosis (low white blood cell count)
Movement disorders (tremors, muscle rigidity, shuffling walk, masklike face)
Tardive dyskinesia
LONG TERM
Even patients experiencing success tend to stop taking the drug
Short-term efficacy exists, but long-term appears to be considerably lower
No clear evidence that atypical antipsychotics work better than conventional
When used in children there is a high risk of weight gain and metabolic changes
Elderly patients with dementia have a significant increase in death risk from cardiovascular and other problems.
Antipsychotic drugs (major tranquilizers or neuroleptics) used particularly for schizoprenia
Antipsychotic drugs, are pharmacologically different from minor tranquilizers and other sedative-hypnotic drugs
Chlorpromazine – an anesthetic used to ameliorate anxiety and shock during surgery – was marketed for mental disorders in 1955 under the trade name Thorazine
Well-known antipsychotic drugs:
Haloperidol (Haldol)
Trifluoperazine (Stelazine)
Fluphenazine (Prolixin)
Olanzipine (Zyprexa)
Quetiapine (Seroquel)
Promazine (Sparine)
Thioridazine (Mellaril)
Schizophrenic patients have to take antipsychotic drugs for four to six weeks for maximum effectiveness
One problem is that they are absorbed erratically
Some patients receive injections of antipsychotic drugs so the drug can be released slowly into the bloodstream
These drugs build up in fatty areas of brain and lungs, and cross the placenta to affect the fetus
CHILDREN/ANTIPSYCHOTICS
Antipsychotic drugs are prescribed more often to children in the US than to children in other developed countries
Adverse effects in children (particularly females):
Excessive weight gain
Type 2 diabetes
Neurological symptoms
Digestive problems
Cardiovascular conditions
EFFECTIVENESS
Schizophrenics receiving antipsychotic drugs almost always show improvement, but a small percentage gets worse
Improvement is most rapid during the first several weeks of treatment
Although many people taking antipsychotic drugs relapse, it appears that these drugs reduce violent behavior
SIDE EFFECTS
Antipsychotic drugs produce undesirable motor problems (extrapyramidal symptoms)
Inappropriate motor movements (acute dyskinesias) sometimes appear within a year after treatment:
Parkinsonism
Dystonia
Akathesia
Tardive dyskinesia
Motor disorders such as involuntary repetitive facial movements, lip smacking, involuntary movement of trunk and limbs, and twitching
Less severe side effects:
Difficulty urinating, constipation, dry mouth
Altered skin pigmentation, jaundice, and extreme sensitivity to sunlight
Changes in heart rate
Well-known antipsychotic drugs:
Chlorpromazine – an anesthetic used to ameliorate anxiety and shock during surgery – was marketed for mental disorders in 1955 under the trade name Thorazine
Haloperidol (Haldol)
Trifluoperazine (Stelazine)
Fluphenazine (Prolixin)
Olanzipine (Zyprexa)
Quetiapine (Seroquel)
Promazine (Sparine)
Thioridazine (Mellaril)
Antipsychotics
Tranquilizers, neuroleptics, antipsychotics
Conventional (Before 1990s), Atypical (past 10 years)
More effective than placebo
Relapse when discontinued
SIDE EFFECTS
Tardive dyskenesia
Pseudoparkinsonism
Called tranquilizers, neuroleptics, or antipsychotics
Reduce psychotic symptoms without causing sedation
Following introduction of drug therapy, restraints and treatments like convulsive therapy were reduced or discontinued among hospitalized patients
Treatment with phenothiazines found to be more effective than a placebo
Patients relapse when therapy is discontinued
Two groups of antipsychotics
Conventional (introduced before mid-1990s)
Atypical (introduced in the past 10 years)
Antipsychotics produce pseudoparkinsonism, indicating a link to dopamine receptors
Time delay in drug effects indicates that the mechanism of action is probably more complex
Atypical antipsychotics block both D2 dopamine and 5HT2A serotonin receptors
Produce less pseudoparkinsonism
Safe in that they are not addictive and are difficult to use to commit suicide
Side effects
Some allergic reactions (jaundice, skin rashes)
Photosensitivity (easily sunburned)
Agranulocytosis (low white blood cell count)
Movement disorders (tremors, muscle rigidity, shuffling walk, masklike face)
Tardive dyskinesia
LONG TERM
Even patients experiencing success tend to stop taking the drug
Short-term efficacy exists, but long-term appears to be considerably lower
No clear evidence that atypical antipsychotics work better than conventional
When used in children there is a high risk of weight gain and metabolic changes
Elderly patients with dementia have a significant increase in death risk from cardiovascular and other problems.
Antipsychotic drugs (major tranquilizers or neuroleptics) used particularly for schizoprenia
Antipsychotic drugs, are pharmacologically different from minor tranquilizers and other sedative-hypnotic drugs
Chlorpromazine – an anesthetic used to ameliorate anxiety and shock during surgery – was marketed for mental disorders in 1955 under the trade name Thorazine
Well-known antipsychotic drugs:
Haloperidol (Haldol)
Trifluoperazine (Stelazine)
Fluphenazine (Prolixin)
Olanzipine (Zyprexa)
Quetiapine (Seroquel)
Promazine (Sparine)
Thioridazine (Mellaril)
Schizophrenic patients have to take antipsychotic drugs for four to six weeks for maximum effectiveness
One problem is that they are absorbed erratically
Some patients receive injections of antipsychotic drugs so the drug can be released slowly into the bloodstream
These drugs build up in fatty areas of brain and lungs, and cross the placenta to affect the fetus
CHILDREN/ANTIPSYCHOTICS
Antipsychotic drugs are prescribed more often to children in the US than to children in other developed countries
Adverse effects in children (particularly females):
Excessive weight gain
Type 2 diabetes
Neurological symptoms
Digestive problems
Cardiovascular conditions
EFFECTIVENESS
Schizophrenics receiving antipsychotic drugs almost always show improvement, but a small percentage gets worse
Improvement is most rapid during the first several weeks of treatment
Although many people taking antipsychotic drugs relapse, it appears that these drugs reduce violent behavior
SIDE EFFECTS
Antipsychotic drugs produce undesirable motor problems (extrapyramidal symptoms)
Inappropriate motor movements (acute dyskinesias) sometimes appear within a year after treatment:
Parkinsonism
Dystonia
Akathesia
Tardive dyskinesia
Motor disorders such as involuntary repetitive facial movements, lip smacking, involuntary movement of trunk and limbs, and twitching
Less severe side effects:
Difficulty urinating, constipation, dry mouth
Altered skin pigmentation, jaundice, and extreme sensitivity to sunlight
Changes in heart rate
Called tranquilizers, neuroleptics, or antipsychotics
Reduce psychotic symptoms without causing sedation
Following introduction of drug therapy, restraints and treatments like convulsive therapy were reduced or discontinued among hospitalized patients
Treatment with phenothiazines found to be more effective than a placebo
Patients relapse when therapy is discontinued
Two groups of antipsychotics
Conventional (introduced before mid-1990s)
Atypical (introduced in the past 10 years)
Antipsychotics produce pseudoparkinsonism, indicating a link to dopamine receptors
Time delay in drug effects indicates that the mechanism of action is probably more complex
Atypical antipsychotics block both D2 dopamine and 5HT2A serotonin receptors
Produce less pseudoparkinsonism
Safe in that they are not addictive and are difficult to use to commit suicide
Side effects
Some allergic reactions (jaundice, skin rashes)
Photosensitivity (easily sunburned)
Agranulocytosis (low white blood cell count)
Movement disorders (tremors, muscle rigidity, shuffling walk, masklike face)
Tardive dyskinesia
LONG TERM
Even patients experiencing success tend to stop taking the drug
Short-term efficacy exists, but long-term appears to be considerably lower
No clear evidence that atypical antipsychotics work better than conventional
When used in children there is a high risk of weight gain and metabolic changes
Elderly patients with dementia have a significant increase in death risk from cardiovascular and other problems.
Antipsychotic drugs produce undesirable motor problems (extrapyramidal symptoms)
Inappropriate motor movements (acute dyskinesias) sometimes appear within a year after treatment:
Parkinsonism
Dystonia
Akathesia
Less severe side effects:
Difficulty urinating, constipation, dry mouth
Altered skin pigmentation, jaundice, and extreme sensitivity to sunlight
Changes in heart rate
Dual diagnosis (co-occurring disorders) describes a person with two or more existing mental illnesses, each of which can be diagnosed independent of the others
Common co-occurring disorders include substance abuse/addiction or alcoholism and a mental illness such as depression, anxiety, or a personality disorder
Major psychiatric disorders increases an individual’s risk for substance abuse
Number of people in mental hospitals declined dramatically following the introduction of drugs that control the symptoms of schizophrenia to a great degree
Outpatient community mental health programs were set up to treat patients closer to home in a more natural environment at less expense
Changes for psychiatrists
Less time spent doing psychotherapy
Priority and emphasis on establishing an appropriate drug regimen
Civil rights issues relating to hospitalization
Indefinite commitment to a hospital is unconstitutional
Periodic review of a patient’s status helps determine if patient presents a danger to self or others
Problems
Patients may have well-controlled symptoms while on medication in a hospital but may stop taking medication upon release
Unmedicated patients, although not overtly dangerous, may still be too ill to care for themselves
From hospital to jail or the street
More mentally ill persons are jailed each year than are admitted to state mental hospitals
About one-third of all homeless people have some form of serious mental illness
About 7 million Americans over age 12 report recent use of psychotherapeutic drugs for nonmedical purposes
Unintentional poisoning deaths involving psychotherapeutic drugs, such as sedative-hypnotics and antidepressants, increased by 84% from 1999 to 2004
In many cases, individuals had been abusing multiple drugs of different classes, compounding the toxicity