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Advances in Pulmonary Embolism Imaging Kelly MacLean; David Tso; Ferco Berger;  Anja Reimann; Chris Davison; Joao Inacio;  Ahmed Albuali; Savvas Nicolaou   ASER 2010
Objectives ,[object Object],[object Object],[object Object],[object Object],[object Object]
Outline ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Introduction ,[object Object],[object Object],[object Object],[object Object],[object Object],Horlander KT; Mannino DM; Leeper KV. Arch Intern Med. 2003 Jul; 163(14):1711-7. Carson JL  et al.  N. Engl. J. Med. 1992 May 7; 326(19):1240-5.
Pathophysiology  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Moser, KM. Am. Rev. Respir. Dis. 1990; 141:235. Weinmann, EE; Salzman, EW. N. Engl. J. Med. 1994; 331:1630.
Pathophysiology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Nakos G; Kitsiouli EI; Lekka ME. Am. J. Respir. Crit. Care Med. 1998 Nov; 158(5 Pt 1):1504-10.  Goldhaber Z; Elliot CG. Circulation 2003; 108:2726-2729.
Clinical Presentation - Symptoms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Goldhaber SZ; Visani L; De Rosa M. Lancet 1999 Apr 24; 353(9162):1386-9. Stein PD et al. Am. J. Med. 2007 Oct;120(10):871-9.
Clinical Presentation – Signs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Goldhaber SZ; Visani L; De Rosa M. Lancet 1999 Apr 24;353(9162):1386-9. Stein PD et al. Am. J. Med. 2007 Oct;120(10):871-9.
Work-up of patient with suspected PE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Writing Group for the Christopher Study Investigators JAMA.  2006; 295:172-179.
The Christopher Study - Outcomes ,[object Object],[object Object],[object Object],Writing Group for the Christopher Study Investigators JAMA.  2006; 295:172-179.
Modified Wells Criteria Wells PS et al. Thromb Haemost 2000 Mar; 83(3):416-20.   Clinical symptoms of DVT (leg swelling, pain with palpation) 3.0 Other diagnosis less likely than PE 3.0 Heart rate >100 1.5 Immobilization or surgery in previous 4 weeks 1.5 Previous DVT/PE 1.5 Hemoptysis 1.0 Malignancy 1.0 PE Likely >4 PE Unlikely </= 4
D-Dimer Screening ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Stein PD et al. Ann Intern Med. 2004 Apr 20;140(8):589-602. De Monye W et al. Am. J. Respir. Crit. Care Med. 2002 Feb 1;165(3):345-8.  Perrier et al. Am. J. Respir. Crit. Care Med. 2003; 167:39-44.
The Christopher Study – Workup  Algorithm Writing Group for the Christopher Study Investigators JAMA.  2006; 295:172-179.  Patient with clinically suspected pulmonary embolism Modified Wells Score PE Unlikely D-Dimer ELISA PE Likely MDCT-PA Indicated Normal Abnormal
Overview of Imaging Modalities for Pulmonary Embolism ,[object Object],[object Object],[object Object],[object Object]
Lower extremity venous ultrasonography ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Turkstra F; Kuijer PM; van Beek EJ; Brandjes DP; ten Cate JW; Buller HR. Ann Intern Med. 1997 May 15;126(10):775-81.
Venous Ultrasonography ,[object Object],[object Object],[object Object],[object Object],Anderson DR; Barnes D. Semin. Nucl. Med. 2008 Nov;38(6)412-7.
Multidetector helical CT pulmonary angiography ,[object Object],[object Object],[object Object],[object Object],[object Object],Stein PD et al. N. Engl. J. Med. 2006 Jun 1;354(22):2317-27.
Multidetector helical CT pulmonary angiography –  Advantages ,[object Object],[object Object],[object Object],[object Object],[object Object],Schoepf J; Costello P. Radiology. 2004 Feb; 230:329-337.
Multidetector helical CT pulmonary angiography –  Limitations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Schoepf J; Costello P. Radiology. 2004 Feb; 230:329-337.
MRI ,[object Object],[object Object],[object Object],[object Object],Stein PD et al. Ann Intern Med. 2010;152:434-43. Image: 59 y.o. male with severe dyspnea MR angiogram depicts large amounts of embolic material ( arrowheads ) in right pulmonary artery, in right upper and lower lobes, and in left lingual pulmonary artery. Nonenhancing masses ( arrow ) are present in liver. Kluge, A. et al. Am. J. Roentgenol. 2006;187:W7-W14
MRI ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Tapson, VF. N. Engl. J. Med. 1997; 336:1449. Haage P et al.  Am. J. Respir. Crit. Care Med. 2003 Mar 1;167(5):729-34. Epub 2002 Nov 21.   Spuentrup E et al. Am. J. Respir. Crit. Care Med. 2005 Aug 15;172(4):494-500. Epub 2005 Jun 3.
Ventilation-perfusion scintigraphy ,[object Object],The PIOPED Investigators.   JAMA. 1990 May 23-30;263(20):2753-9.  Table: Likelihood of pulmonary embolism according to scan category and clinical probability in PIOPED study Scan Probability Clinical Probability of Pulmonary Emboli High Intermediate Low High 95 86 56 Intermediate 66 28 15 Low 40 15 4 Normal or near normal  0 6 2
V/Q Scan ,[object Object],[object Object],[object Object],[object Object],[object Object],Sostman HD et al. Radiology. 2008;246:941-6.
CT-PA vs. V/Q scan ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Anderson DR et al. JAMA. 2007 Dec 19;298(23):2743-53. Sostman DH et al. Radiology. 2008 Jan 14;246:941-946.
Imaging in Pregnancy ,[object Object],[object Object],[object Object],[object Object],[object Object],Stein P et al. Radiology. 2007 Jan;242:15-21. Marik PE; Plante LA. N. Engl. J. Med. 2008;359:2025-33.
Multidetector-CT Technique ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Schaefer-Prokop C; Prokop M. Eur. Radiol. Suppl. 2005;15(4):d37-d41.
Multidetector-CT Findings ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Macdonald S; Mayo J. Semin. Ultrasound CT. 2003;24(4):271-231.
MDCT Findings Large saddle thrombus with extensive clot burden. Arrows demonstrating tram-track sign (A), rim sign (B), complete filling defect (C), and a fully non-contrasted vessel (D)  A B C D
Arrow indicating rim sign Arrow indicating tram-track sign
Multidetector-CT: Artifacts ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Macdonald S; Mayo J. Semin. Ultrasound CT. 2003;24(4):231-271.
Clinical relevance of MDCT findings I. Subsegmental Emboli ,[object Object],[object Object],[object Object],[object Object],Le Gal G et al. 2006;4(4):724-731. Goodman LR. Radiology. 2005;234(3)654-658. Glassroth J. JAMA. 2007;298(23):2788-2789.
Patient with pneumonectomy Lingular subsegmental pulmonary embolism (arrow)
Clinical Relevance of MDCT findings   II. RV Strain ,[object Object],[object Object],Sanchez O et al. Eur. Heart J. 2008;29:1569–77. Massive bilateral PE with signs of RV strain. Dilated RV with visible thrombus (arrow).
Contrast seen in IVC, indicating RV strain Bilateral mosaic attenuation
Clinical Relevance of MDCT findings III. Clot Burden ,[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical Relevance of MDCT findings iv. Mosaic Perfusion ,[object Object],[object Object],[object Object],[object Object],Wittram C et al.   AJR 2006;186:S421-S429. Massive PE with RV strain and mosaic attenuation (arrow)
 
Diagnostic Imaging Algorithm Adapted from Agnelli G; Becattini C. N. Engl. J. Med. 2010;363:266-74. Elevated D-Dimer or High clinical probability MDCT-PA V/Q Scan if contraindication to contrast Negative PE confirmed May consider venous U/S  but will be positive in less than 1% of patients Diagnostic Non-diagnostic PE confirmed   PE ruled out Venous U/S
New Imaging Approaches ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Pontana F et al.  Acad. Radiol. 2008;15(12):1494. Multiple thrombi in main PA with extensive clot burden. Perfusion defects seen on iodine mapping
 
New Imaging Approaches ,[object Object],[object Object],[object Object],Left lower lobe subsegmental embolism (arrow) with associated atelectasis using high-pitch technique
 
Conclusion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
References ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
References  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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076 advances in pulmonary imaging

  • 1. Advances in Pulmonary Embolism Imaging Kelly MacLean; David Tso; Ferco Berger; Anja Reimann; Chris Davison; Joao Inacio; Ahmed Albuali; Savvas Nicolaou ASER 2010
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11. Modified Wells Criteria Wells PS et al. Thromb Haemost 2000 Mar; 83(3):416-20. Clinical symptoms of DVT (leg swelling, pain with palpation) 3.0 Other diagnosis less likely than PE 3.0 Heart rate >100 1.5 Immobilization or surgery in previous 4 weeks 1.5 Previous DVT/PE 1.5 Hemoptysis 1.0 Malignancy 1.0 PE Likely >4 PE Unlikely </= 4
  • 12.
  • 13. The Christopher Study – Workup Algorithm Writing Group for the Christopher Study Investigators JAMA.  2006; 295:172-179. Patient with clinically suspected pulmonary embolism Modified Wells Score PE Unlikely D-Dimer ELISA PE Likely MDCT-PA Indicated Normal Abnormal
  • 14.
  • 15.
  • 16.
  • 17.
  • 18.
  • 19.
  • 20.
  • 21.
  • 22.
  • 23.
  • 24.
  • 25.
  • 26.
  • 27.
  • 28. MDCT Findings Large saddle thrombus with extensive clot burden. Arrows demonstrating tram-track sign (A), rim sign (B), complete filling defect (C), and a fully non-contrasted vessel (D) A B C D
  • 29. Arrow indicating rim sign Arrow indicating tram-track sign
  • 30.
  • 31.
  • 32. Patient with pneumonectomy Lingular subsegmental pulmonary embolism (arrow)
  • 33.
  • 34. Contrast seen in IVC, indicating RV strain Bilateral mosaic attenuation
  • 35.
  • 36.
  • 37.  
  • 38. Diagnostic Imaging Algorithm Adapted from Agnelli G; Becattini C. N. Engl. J. Med. 2010;363:266-74. Elevated D-Dimer or High clinical probability MDCT-PA V/Q Scan if contraindication to contrast Negative PE confirmed May consider venous U/S but will be positive in less than 1% of patients Diagnostic Non-diagnostic PE confirmed PE ruled out Venous U/S
  • 39.
  • 40.  
  • 41.
  • 42.  
  • 43.
  • 44.
  • 45.

Notas del editor

  1. ASER limits to 40 slides per presentation. Suggest tightening intro to make more succint
  2. Discuss pathophysiology of tissue death, preload, RV strain
  3. Incorporate this into a table with Signs &amp; Symptoms together
  4. Perhaps cut out this table and stick with summaries points
  5. Zoom into MDCT
  6. Using positive U/S as diagnosis of PE would mean: Sensitivity 29% Specificity 97% Benefits: Avoid 14% of lung scans and 9% of angiograms Drawbacks: Unnecessary treatment in false positives (13%)
  7. Flow chart
  8. David/Dr. Nicolaou – should I mention here anything about pros/cons of adding lower-limb CT venography?
  9. Incorporate PIOPED III Trial into limitations section next slide
  10. CT- PA: spell out acronym CT able to determine other causes
  11. Awaiting Charles Uh for protocols Need to get VGH protocols
  12. Need to make arrows more accentuated, use “Shapes” under drawing tools in Powerpoint Make image bigger,
  13. Increase afterload, can’t generate enough pressures Restate why contrast may end up in IVC
  14. Mosaic attenuation – should use lung window
  15. Is it okay we use these slides – technically is this presentation for educational purposes? Question: How do we score clot burden?
  16. Please have this in lung windows
  17. Where is CXR in this diagram. Also need to eliminate Venous U/S since it’s not done.