1. Open Science Meets Personalized Health David Ewing Duncan Director, Center for Life Science Policy, UC Berkeley

2. Two Great Movements Citizen patients Citizen scientists

3. Historical Moment

4. People + Technology = Empowerment

5. “With great power comes great responsibility...”- Ben Parker (Spiderman’s Uncle)

7. Feel it coming: early adopters

8. Outmoded paradigms

9. Tired of hearing no

10. Bad customer service

12. Age of Personalized Health

14. 9,366 genotypes

15. 320 environmental toxins

16. 22 hours of MRI brain scans

17. ~ 2 liters of blood

18. ~ $150,000The Experiment

19. Healthy

20. Not Just Genes... Environment Brain Body

21. Experimental Family Alzheimer’s (rs4420638) Father Mother AG AA David Brother AA AG Daughter AA Heart Attack (rs1075728) Father Mother AG AG David Brother GGAA Daughter AG

22. Favorite Genetic Marker CYP1A2 Caffeine Fast Metabolizer

23. Mercury and Me

24. Mercury andMe

25. Mercury and Me Halibut (lunch) Swordfish (dinner)

26. Mercury Before: 4 ppb Mercury After: 13 ppb

27. My genetic sensitivity to mercury(Envirogenomics)

28. High Anxiety

29. Fear and Anxiety Emotional incongruence (emotional conflict) Emotional conflict resolution (emotion regulation)

30. (Don’t) Be Still My Beating Heart

31. First Add Genomics Copyright 2008 Entelos, Inc.

32. Biomarkers (Chemistry) Copyright 2008 Entelos, Inc.

33. Scans: Ultrasound and CT Copyright 2008 Entelos, Inc.

34. Genes + Environment + Biomarkers + Ultrasound + CT Scan Entelos Project Combine Risk Factors

35. Prediction of my future… ? Copyright 2008 Entelos, Inc.

36. Lost 10 pounds

38. Skeptical public

39. Resistance from traditional medicine

40. Expensive

42. The Obama Effect

43. Discrimination

44. Genetic thrallism (Gattaca)

45. Unleashing monsters

47. Integration is key

48. Get creative with law, policy, education, ethics, media

49. Private sector and early adopters

51. Be proactive with government and law enforcement

52. Work with Big Science – they need you, you need them

54. Still going… more tests

56. www.ExperimentalMan.com