Latest Advances in Clinical Senology and Oncology

1. Senology Newsletter Page 1 of 3
Senology.org - Newsletter
International Senologic and Oncologic Scientific Community
"Connecting specialists worldwide"
Editor-in-chief: Gian Paolo Andreoletti, MD
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Literature Selection
Anderson LN et al.: "Ultraviolet Sunlight Exposure During Adolescence and Adulthood and Breast
Cancer Risk: A Population-based Case-Control Study Among Ontario Women", Am J Epidemiol. 2011
Jun 9. [Epub ahead of print]
Richter-Ehrenstein C et al.: "Intraductal papillomas of the breast: Diagnosis and management of 151
patients", Breast. 2011 Jun 1. [Epub ahead of print]
Allin KH et al.: "Elevated pre-treatment levels of plasma C-reactive protein are associated with poor
prognosis after breast cancer: a cohort study", Breast Cancer Res. 2011 Jun 3;13(3):R55. [Epub ahead
of print]
Barton SR et al.: "The role of ipsilateral breast radiotherapy in management of occult primary breast
cancer presenting as axillary lymphadenopathy", Eur J Cancer. 2011 Jun 7. [Epub ahead of print]
Hadad S et al.: "Evidence for biological effects of metformin in operable breast cancer: a pre-
operative, window-of-opportunity, randomized trial", Breast Cancer Res Treat. 2011 Jun 8. [Epub
ahead of print]
Goss PE et al.: "Exemestane for Breast-Cancer Prevention in Postmenopausal Women", N Engl J
Med. 2011 Jun 4. [Epub ahead of print]
Truin W et al.: "Influence of histology on the effectiveness of adjuvant chemotherapy in patients with
hormone receptor positive invasive breast cancer", Breast. 2011 Jun 10. [Epub ahead of print]
McArthur HL et al.: "Adjuvant trastuzumab with chemotherapy is effective in women with small, node-
negative, HER2-positive breast cancer", Cancer. 2011 Jun 16. doi: 10.1002/cncr.26171. [Epub ahead of
print]
Badwe R et al.: "Single-Injection Depot Progesterone Before Surgery and Survival in Women With
Operable Breast Cancer: A Randomized Controlled Trial", J Clin Oncol. 2011 Jun 13. [Epub ahead of
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2. Senology Newsletter Page 2 of 3
print]
Harkenrider MM et al.: "Reirradiation as a component of the multidisciplinary management of locally
recurrent breast cancer", Clin Breast Cancer. 2011 Jun;11(3):171-6
Chockalingam P et al.: "Isolated Sternal Involvement in Breast Cancer: Is it Truly Stage IV Disease?",
Clin Breast Cancer. 2011 Jun;11(3):191-4
Saloustros E et al.: "Cytokeratin-19 mRNA-positive circulating tumor cells during follow-up of patients
with operable breast cancer: prognostic relevance for late relapse", Breast Cancer Res. 2011 Jun
10;13(3):R60. [Epub ahead of print]
Discussion
Abdulkarim BS et al.: "Increased Risk of Locoregional Recurrence for Women With T1-2N0 Triple-
Negative Breast Cancer Treated With Modified Radical Mastectomy Without Adjuvant Radiation
Therapy Compared With Breast-Conserving Therapy", J Clin Oncol. 2011 Jun 13. [Epub ahead of print]
"Is breast-conserving surgery followed by radiotherapy better than mastectomy for
patients with triple-negative breast cancer?" - Share your opinion on LinkedIn®.
Comment
"Breast screening with ultrasound in patients with mammography-negative dense breasts" - Stefano
Ciatto, Centro di Prevenzione Senologica, Verona, Italy
"A previous study showed an incremental cancer detection rate of about 30% by adding routine
ultrasonography in subjects with negativa mammography and dense breast. Still such an increase in detection
might not be necessarily a benefit, e.g., it might account for overdiagnosis of not aggressive tumors. This
study analyses the frequency of interval cancer in non-dense breast screened by mammography and in dense
breasts screened by mammography + ultrasonography. In theory one would expect more interval cancers in
dense breasts, as density reduces mammography sensitivity due to a masking effect. The finding of a similar
(higher over age 50) frequency of interval cancers in dense as compared to non-dense breast is a convincing
prove that ultrasonography really improves the sensitivity of mammography by reducing its false negatives"
(Comment on: Corsetti V et al.: "Evidence of the effect of adjunct ultrasound screening in women with
mammography negative dense breasts: Interval breast cancers at 1year follow-up", Eur J Cancer.
2011:47(7): 1021-6)
Fragments of History
Charles H. Moore:, Royal Medical and Chirugical Society, London, 1867: “On the influence of inadequate
operations on the theory of cancer", Med Chir Trans 32: 245-80: “It is not sufficient to remove the cancer
or any portion only of the breast in which it is situated; mammary cancer requires the careful extirpation of the
entire organ. It is desirable to avoid not only cutting into the tumor but also seeing it. No actually morbid
texture should be exposed, lest the active microscopic elements in it should be set free and lodge in the
wound. Diseased axillary glands should be taken away at the same dissection as the breast itsel"
Calendar of Events
Breast Cancer Symposium 2011, September 8-10, 2011, San Francisco, California
7th Meet the Professor. Modena International Breast Cancer Conference (MIBCC)
October 5-7, 2011, Modena, Italy - with the Patronage of Senology.org
1st Advanced Breast Cancer International Consensus Conference, November 3-5, 2011, Lisbon,
Portugal
33rd Congress of the French Senologic Society November 9-11, 2011 Marseille France
AORTIC (African Organisation for Research and Training in Cancer) - 8th International Conference,
November 28 - December 2, 2011, Cairo, Egypt
Literature Selection
Friedberg JS et al.: "Photodynamic therapy and the evolution of a lung-sparing surgical treatment for
mesothelioma", Ann Thorac Surg. 2011 Jun;91(6):1738-45
Biagi JJ et al.: "Association between time to initiation of adjuvant chemotherapy and survival in
colorectal cancer: a systematic review and meta-analysis", JAMA. 2011 Jun 8;305(22):2335-42
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3. Senology Newsletter Page 3 of 3
Maughan TS et al.: "Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy
for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial",
Lancet. 2011 Jun 3. [Epub ahead of print]
Buys SS et al.: "Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and
Ovarian (PLCO) Cancer Screening Randomized Controlled Trial", JAMA. 2011 Jun 8;305(22):2295-303
Chapman PB et al.: "Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation", N
Engl J Med. 2011 Jun 5. [Epub ahead of print]
Robert C et al.: "Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma", N Engl
J Med. 2011 Jun 5. [Epub ahead of print]
Bannuru RR et al.: "Comparative Evaluation of Radiation Treatments for Clinically Localized Prostate
Cancer: An Updated Systematic Review", Ann Intern Med. 2011 Jun 6. [Epub ahead of print]
van Walraven C et al.: "Association of Diagnostic Radiation Exposure and Second Abdominal-Pelvic
Malignancies After Testicular Cancer", J Clin Oncol. 2011 Jun 20. [Epub ahead of print]
Literature Selection
Carmody JF et al.: "Mindfulness training for coping with hot flashes: results of a randomized trial",
Menopause. 2011Jun:18(6):611-20
Stay informed....
Recent Advances in Clinical Medicine
Pergola PE et al.: "Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes ", N Engl J
Med June 24, 2011
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