Lipid profile is an important group of tests used to diagnose hyperlipidemias. it is also used in Investigating Myocardial infarction , Diabetes mellitus & nephrotic syndrome

1. LIPID PROFILE

4. CLASSIFICATION OF LIPIDS LIPIDS SIMPLE LIPIDS DERIVED LIPIDS FATS WAXES COMPOUND LIPIDS PHOSPHO LIPIDS CEREBROSIDES SULFO LIPIDS FATTY ACIDS STEROIDS

7. LIPOPROTEINS-CLASSIFICATION LIPOPROTEINS MAJOR LIPOPROTEINS MINOR/ABNORMAL LIPOPROTEINS CHYLOMICRONS V.L.D.L L.D.L H.D.L I.D.L Lp (a) Lp X Beta – V.L.D.L

8. PLASMA LIPOPROTEINS 1.063-1.125 HDL 2 5 Beta 0-12 1.019-1.063 180-300 A LDL 4 Beta OR Pre-Beta 12-20 1.006-1.019 IDL 3 PRE-Beta 20-400 0.95-1.006 300-700 A VLDL 2 ORIGIN >400 < 0.95 750-12,000 A CHYLOMICRONS 1 MOBILITY Sf DENSITY(Kg/L) DIAMETER TYPE

9. PLASMA LIPOPROTEINS PRE-Beta 1.045-1.080 Lp (a) 7 ORIGIN >400 1.125-1.210 50-20 A HDL 3 6 MOBILITY Sf DENSITY(Kg/L) DIAMETER TYPE

10. PLASMA LIPOPROTEINS 26-32 2-7 15-20 3-5 45-55 HDL 18-24 4-8 45-50 6-8 18-22 LDL 15-20 45-65 16-22 4-8 6-10 VLDL 3-6 80-95 2-4 1-3 1-2 CHYLOMICRON PL % TG % Ch. ESTERS % CHOLESTEROL % PROTEIN % LIPOPROTEIN

12. MAJOR APOLIPOPROTEINS Structural protein for chylomicrons Chylomicrons Intestine Apo-B48 Unknown VLDL Liver Apo-AV Unknown HDL,Chylomicrons Intestine, Apo-AIV Structural protein for hdl HDL,Chylomicrons Liver Apo-AII Structural protein for hdl, activates LCAT HDL,Chylomicrons Intestine, Liver Apo-AI Function Lipoprotein association Source Apolipo- protein

13. MAJOR APOLIPOPROTEINS Unknown HDL Spleen,brain, Testes, adrenal Apo-D Inhibits lipoprotein binding to receptiors Chylomicrons,VLDL,HDL Liver Apo-CIII Cofactor for LPL Chylomicrons,VLDL,HDL Liver Apo-CII Unknown Chylomicrons,VLDL,HDL Liver Apo-CI Structural protein for VLDL,LDL,IDL,Lp(a) VLDL,IDL,LDL,Lp(a) Liver Apo-B100 Function Lipoprotein association Source Apolipo- protein

14. MAJOR APOLIPOPROTEINS Unknown Lp(a) Liver Apo-(a) Unknown Chylomicrons,VLDL,HDL Unknown Apo-L Unknown Chylomicrons,VLDL,HDL Liver Apo-J B2 glycoprotein Chylomicrons,VLDL,LDL,HDL Liver Apo-H Ligand for binding to LDL receptor Chylomicrons remnants,IDL,HDL Liver Apo-E Function Lipoprotein association Source Apolipo- protein

57. NORMAL LEVELS 8.0-11.0 MG/DL PHOSPHOLIPID PHOSPHORUS 6 9.0-15.0 MMOL/L FREE FATTY ACIDS 5 150-380 MG/DL PHOSPHOLIPIDS 4 10-90 MG/DL TRIGLYCERIDES 3 150-250 MG/DL TOTAL CHOLESTEROL 2 400-800 MG/DL TOTAL LIPIDS 1 level lipid S.No

58. SERUM CHOLESTEROL & TG RISK CATEGORIES > or = 500 > or = 190 > 6.0 > 11.0 > or = 240 < 40 HIGH RISK 200-499 > or = 160 3.0-6.0 7.1-11.0 200-239 MODERATE RISK 150-199 < or = 130 4.4-7.1 AVERAGE RISK < 150 < 30 < 100 0.5-3.0 3.3-4.4 150- 250 > Or = 50 NORMAL SERUM-TG VLDL-C LDL-C LDL/HDL TC/HDL-C TC HDL-C RISK CAT.