Apoptosis market research report

RITMIR008: Apoptosis – A Market Insight Report, July 2013
© RI Technologies - www.researchimpact.com Sample Page - 1
APOPTOSIS MARKET SIZE
Scope of the Study
This report gives an insight into Apoptosis Mechanism, by Molecular Pathways – Caspase Activators and
Inhibitors, Protease/Proteasome Inhibitors, Bcl-2 Modulators and p53 Modulators. The study also focuses
on major diseases for which the treatment is based on apoptosis comprising Cancer, Neurodegenerative
Diseases, Cardiovascular Diseases and other apoptosis based diseases including HIV infection, Organ
Transplant Rejection and MODS. The study provides global market analysis for apoptosis related
therapeutic products by the above apoptosis molecular pathways and also by the disease areas. The study
includes estimates and projections for the total global apoptosis related therapeutic products market.
Projections and estimates are also graphically illustrated by geographic regions encompassing United
States, Europe, Japan and Rest of World.
Business profiles of 59 major companies are discussed in the report. The report serves as a guide to global
apoptosis market, as it covers more than 290 companies that are engaged in apoptosis research, testing
and supply of products and services. Major Contract Research Organizations and Universities serving
apoptosis market are also covered in the Corporate Directory section of this report. Information related
product developments, partnerships, collaborations, and mergers and acquisitions are also covered in the
report.
Apoptosis Mechanism report is an ideal research tool providing strategic business intelligence to the
corporate sector. This report may help strategists, investors, laboratories, pharmaceutical companies,
contract research organizations, biotechnology companies and drug approval authorities in--
 Gauging Competitive Intelligence
 Identifying Key Growth Areas and Opportunities
 Understanding Geographic Relevance to Product
 Knowing Regional Market Sizes and Growth Opportunities and Restraints
 Keeping Tab on Emerging Technologies
 Equity Analysis
 Tapping New Markets
Analytics and data presented in this report pertain to several parameters such as –
 Global And Regional Market Sizes, Market Shares, Market Trends
 Product (Global And Regional) Market Sizes, Market Shares, Market Trends
 Technology Trends
 Corporate Intelligence
 Key Companies By Sales, Brands, Products
 Consumer Behavioral Patterns

 Other Strategic Business Affecting Data
Research Methodology
RI Technologies publishes business intelligence reports by going through a cycle of diligent research and
analysis activity. Research is done using both online and offline resources. The study outline of this report is
sketched on the following lines – global market analysis, regional market analysis, product segmentation,
global and regional market analysis by product segment, market trends, M&A, R&D, competitive landscape,
technology trends, and other key drivers. Current data helps in analyzing the future of the industry and is
also helpful for doing market evaluations, and estimating the market size for the future.
This report is uniquely researched and the methodology includes:
 Need and Scope of Study
 Product Definitions
 Segmental Analysis
 Regional Analysis
 Exclusive Data Analytics
 Corporate Intelligence
 Feedback
Right from concept to final compilation of this report, both primary and secondary research methods are
applied. We have provided exclusive feedback forms/pre-release questionnaires for this report to use the
information for authentication of our own findings. Secondary research includes government publications,
investment research reports, web based surveys, website information of both companies and markets, and
other offline resources such as print publications and CDs.
Our compilation of easy to navigate PDF reports are essential value addition resources for leading and
growing companies.

II. REPORT SYNOPSIS
FOREWORD
Apoptosis
Apoptosis is a method of planned life relinquishment by a cell in a multicellular organism. With the
defective process of this biological occurrence being recognized in several life threatening diseases,
research work in this area has increased dramatically.
Apoptosis is considered to play a prominent and pivotal role in growth and homeostasis of metazoans. The
enormous research carried out in the past few years in the field of apoptosis has led to the detection of
thousands of genes that contribute and rule the phenomenon of execution, initiation, and regulation of
apoptosis. The research pattern earlier was more focused on creating a better understanding of genetic
and cell biological features. Attention has now shifted towards organized biochemical and structural
analysis, which has led to transparency in the study of various phenomena involved in apoptosis process.
Sometimes, the phenomenon of apoptosis comes as a boon, especially when a virus invades the body and
causes some viral infections. In such conditions apoptosis can prevent an invading virus and deprive it of a
safe place to breed. In a similar way, useless cells are wiped out during growth, metamorphosis, and tissue
turnover. This systematic phenomenon is termed commonly as programmed cell death or apoptosis. This
phenomenon plays a central role in the operation of the immune and nervous systems. Apoptosis also plays
a major role in eradicating cancerous cells.
This report analyzes global market for the following apoptosis molecular pathways and the therapeutics
products for apoptosis based diseases. Synopsis chapter of the report gives the summary of the global
market for apoptosis related therapeutic products by apoptosis molecular pathways and by therapeutic
areas for each geographic region – the US, Europe, Japan and Rest of World.
Segmentation of Apoptosis
Exhibit 1. Segmentation of Global Apoptosis Related Products Market by Molecular Pathways and
Therapeutic Areas
Molecular Pathways Therapeutic Areas
Caspases Cancer
Protease Inhibitors Neurodegenerative Diseases
Bcl-2 Modulators Cardiovascular Diseases
p53 Modulators *Other (2)
*Other (1)
(1) Includes TRAIL, IAPs, MLK Inhibitor, Factor 5A, Protein
Kinase Pathway Modulators, Lysophosphatidic Acid
Acyltransferase, Nicotinic Acetylcholine Receptor Agonist
and HSP27
(2) Includes MODS, organ transplant rejection and HIV
infection
© RIT, 2013

Exhibit 2. Segmentation of Global Apoptosis Market by Imaging/Detection Technologies for Cancer
Apoptosis Imaging Technologies (Cancer)
Molecular Imaging
Flow Cytometry
Optical Imaging
*Other (3)
(3) Includes Fluorescence Microscopy,Ultrasound, etc.
© RIT, 2013
Analysis of Apoptosis Related Products by Molecular Pathways
Caspases
Caspases are considered as the members of cysteine proteases. These are the enzymes containing critical
cysteine residues responsible for cleaving other proteins after aspartic acid residue. This process is
considered an exception among the regular proteases. The name ‘caspases’ comes from the molecular
function of the compound "cysteine-aspartic-acid-proteases”. Caspases are considered a vital requirement
to undergo cell apoptosis or rather programmed cell death in enhancement of various stages of adult life.
This vital role has earned it the name of “executioner”. The other function of caspases includes maturating
of cytokines of immune system. Unsuccessful apoptosis is considered to breed tumor growth and
autoimmune disorders. The study of apoptosis and the one that occurs in Ischemia or Alzheimer’s disease is
the center of research these days. These researches have identified the prominence of caspases.
Caspases are broadly classified into – Initiator Caspases and Effector Caspases
Global caspase activators and inhibitors market is projected to reach US$XX.XX billion by 2020 from an
estimated US$ XX.XX billion in 2012, registering a CAGR of XX.XX % during the analysis period 2005-2020.
The United States caspase activators and inhibitors market was estimated at US$ XX.XX million in 2012 and
is projected to reach about US$ XX.XX billion in 2020. Growing at a CAGR of XX.XX % during the period
2005-2020, the US is further projected to retain the leading position. The US also represents the fastest
growing market during the same analysis period.
Europe represents the second largest market for caspase activators and inhibitors, while Japan represents
the second fastest growing market. European market was estimated at US$ XX.XX million in 2012 and is
projected to attain the value of US$ XX.XX billion by 2020.

Exhibit 3. Caspase Activators and Inhibitors - Global Value Market Estimations & Predictions (2005 -2020)
in US$ Million by Geographic Region for United States, Europe, Japan and Rest of World†
Year /Region United States Europe Japan Rest of World Total
2005 XX.XX XX.XX XX.XX XX.XX XX.XX
CAGR% XX.XX XX.XX XX.XX XX.XX XX.XX
# Represents Western Europe only
† Comprises Asia-Pacific (excluding Japan), Eastern Europe, Latin America, Middle East and Africa
© RIT Figures, 2013
2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020
US$ Million
United States Europe Japan Rest of World

REGIONAL MARKET ANALYSIS
Europe
Growing at a CAGR of XX.XX % for the period 2005 through 2020, European apoptosis related therapeutic
products market is projected to reach US$ XX.XX billion by 2020 from an estimated US$ XX.XX billion in 2012.
Exhibit 4. Apoptosis Related Products – European Value Market Estimations & Predictions (2005 - 2020)
in US$ Million
Year Value
2005 XX.XX
2006 XX.XX
2007 XX.XX
2008 XX.XX
2009 XX.XX
2010 XX.XX
2011 XX.XX
2012 XX.XX
2013 XX.XX
2014 XX.XX
2015 XX.XX
2016 XX.XX
2017 XX.XX
2018 XX.XX
2019 XX.XX
2020 XX.XX
CAGR% XX.XX
2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020
US$ Million

III. MARKET DYNAMICS
Market Overview
Over the last half a decade, availability of apoptosis related products (drugs, kits and reagents) has
increased enormously. The global market for apoptosis related products is growing fast owing to increasing
evidence of role of apoptosis in mechanism of action for large number of diseases such as Cancer;
Neurodegenerative Diseases including Alzheimer’s, Parkinson’s, Multiple Sclerosis and Rheumatoid
Arthritis; Cardiovascular Disease; and other apoptosis based diseases including organ transplant rejection
and HIV infection.
In terms of application, majority of apoptosis related products find application in various cancers such as
breast melanoma, lung and prostate. Neurodegenerative diseases is the second largest end use sector for
apoptosis related products followed by cardiovascular diseases. This phenomenon is expected to continue
throughout the analysis period 2005-2020.
Global Market Analysis
Global market for apoptosis related products is projected to reach about US$ XX.XX billion by 2020 from an
estimated US$ XX.XX billion in 2012, growing at a Compounded Annual Growth Rate (CAGR) of XX.XX %
during the analysis period, 2005-2020.
The United States was estimated as the largest market for apoptosis related products in 2012 with a share
of XX.XX %, valued at US$ XX.XX billion (2012), and is projected to reach US$ XX.XX billion by 2020 to retain
its position with market share increasing to XX.XX %. The US is also projected to be the fastest growing
market with a CAGR of XX.XX %.
Europe is projected as the second largest (XX.XX % market share in 2012) market during the same analysis
period, while Japan is projected to be the second fastest growing (XX.XX % during 2005-2020) market. In
2012, the market for apoptosis related therapeutic products in Europe and Japan was estimated at US$
XX.XX billion and US$ XX.XX billion respectively
Rest of World, Asia-Pacific (excluding Japan), Eastern Europe, Latin America, Africa and Middle East,
region’s market for apoptosis related products was estimated at about US$ XX.XX million for 2012.

Exhibit 5. Apoptosis Related Products – Global Value Market Estimations & Predictions (2005 - 2020) in
US$ Million by Geographic Region for United States, Europe#, Japan and Rest of World†
Year /Region United States Europe Japan Rest of World Total
CAGR% XX.XX XX.XX XX.XX XX.XX XX.XX
# Represents Western Europe only
† Comprises Asia-Pacific (excluding Japan), Eastern Europe, Latin America, Middle East and Africa
2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020
US$ Million
United States Europe Japan Rest of World

IV. PRODUCT RESEARCH
Disease Areas Connected with Apoptosis
Diseases requiring apoptosis-based treatments include cancer, neurodegenerative diseases, cardiovascular
diseases and other important apoptosis based diseases including organ transplant rejection, HIV infection,
and multiple organ dysfunction syndrome (MODS).
Cancer
Cancer research has delivered outstanding progress in understanding the biology and genomics of cancer,
in the last 5-6 years. Foremost of these progresses is that the recognition of apoptosis and its regulatory
genes have an effect on melanoma. In return, other oncogenical changes stimulate apoptosis and override
apoptosis during multistage carcinogenesis by making selective pressures. Apoptosis associates cancer
therapeutics with cancer genetics by providing conceptual structure, as similar changes that suppress
apoptosis during tumor development.
Major Companies in Global Cancer Market
In 2010, Roche Group/ Genentech bagged top position for cancer therapeutic products market with XX.XX
% of total sales of global top 10 companies. Novartis AG, Sanofi-Aventis and Amgen, Inc. ranked second,
third and fourth respectively in the above year.
Exhibit 6. Global Market for Cancer Therapeutic Products (2010): Percentage Breakdown of Market Share
for Top 10 Companies
Company Name Market Share
Roche Group XX.XX
Novartis AG XX.XX
Sanofi-Aventis XX.XX
Amgen, Inc. XX.XX
AstraZeneca plc XX.XX
Eli Lily & Co. XX.XX
Celgene Corp. XX.XX
Pfizer, Inc. XX.XX
Bristol Myers Squibb Co. XX.XX
Merck & Co. XX.XX
Total 100.00

Exhibit 7. Sales of Approved Drugs - Apoptosis Inhibitors & Inducers
Brand Name Generic Name Indication Sales (2009)
Tarceva erlotinib hydrochloride Non-Small Cell Lung Cancer US$1.3 billion
Sutent sunitinib malate Advanced renal cell carcinoma and gastrointestinal stromal tumor (GIST) XX.XX
Thalomid thalidomide Oncology & Immunomodulators XX.XX
XXXXX XXXXX Human Pancreatic Cancer XX.XX
XXXXX XXXXX Peripheral T-cell lymphoma XX.XX
XXXXX XXXXX B-cell non-Hodgkin lymphoma XX.XX
XXXXX XXXXX Cutaneous t-cell lymphoma XX.XX
XXXXX XXXXX Colon Cancer XX.XX
XXXXX XXXXX CML, GIST Chronic Myelogenous Leukemia, GI Stromal Tumors XX.XX
XXXXX XXXXX Cancer XX.XX
XXXXX XXXXX Prostate Cancer XX.XX
XXXXX XXXXX Bone Cancer XX.XX
XXXXX XXXXX Breast Cancer XX.XX
XXXXX XXXXX Breast Cancer XX.XX
© RIT, 2013
APOPTOSIS MOLECULAR PATHWAYS - THE MARKET OUT LOOK
Global apoptosis related products market is projected to grow at an unbelievable CAGR XX.XX % during the
analysis period 2005 through 2020. This enormous growth is mainly due to the evidence of apoptosis’
pivotal role in the mechanism of action in key disease areas including cancer, neurodegenerative diseases
and cardiovascular disorders. The growth is also owing to increasing incidences of neurodegenerative cases
in major markets such as the United States and Japan.
Intense research and development efforts by pharmaceutical giants such as Roche, Novartis, Sanofi-
Aventis, Astra-Zeneca, Johnson & Johnson, Pfizer, Eli-Lilly and Bristol-Myers Squibb, new and innovative
apoptosis related products (kinase kits and reagents) and drugs are being introduced into the market. The
phenomenon keeps the hopes of apoptosis market growth alive in the years to come.
Currently, apoptosis market is experiencing quite a few consolidations such as acquisition of stake in Tanox
by Genetech, research partnership between Takeda and XOMA, acquisition of Qiaer Bio by Aida, acquisition
of Serologicals by Millipore and acquisition of BioSource by Invitrogen. These amalgamations are expected
to create a tough and neck-to-neck competition between major players in the industry.
The United States, expected to account for about XX.XX % of global market in 2010, is projected to remain
the single largest market for apoptosis related therapeutic products. Japan is also expected to increase its
market share from XX.XX % estimated in 2012 to XX.XX % in 2020. As this report covers only key Western
European markets such as Germany, the UK and France, the estimated market for Europe represents
Western Europe only. Western European market is projected to lose its dominance partially by the end of
the review period, due to the emerging markets in Rest of World such as Asia-Pacific countries, Eastern
European countries, and Latin American countries. The key upcoming markets in Rest of World region
include China, India, Brazil and Eastern European countries.

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 Understanding Geographic Relevance to Product
 Knowing Regional Market Sizes and Growth Opportunities and Restraints
 Keeping Tab on Emerging Technologies
 Equity Analysis
 Tapping New Markets
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Apoptosis market research report

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Apoptosis market research report