SlideShare una empresa de Scribd logo

Beta cell stress en dm2 b

•Descargar como PPT, PDF•
•
Ruy Pantoja
Ruy Pantoja

Figura B do tema stress de célula beta no DM2.

Educación
1 de 1
Interfering with Insulin Production. Kaufman RJ. N Engl J Med 2011;365:1931-1933.

Recomendados

Dpp4 e angiogênese
Dpp4 e angiogêneseDpp4 e angiogênese
Dpp4 e angiogêneseRuy Pantoja
 
Figura 1 ritmos circadianos
Figura 1 ritmos circadianosFigura 1 ritmos circadianos
Figura 1 ritmos circadianosRuy Pantoja
 
Insulina intranasal e cognição
Insulina intranasal e cogniçãoInsulina intranasal e cognição
Insulina intranasal e cogniçãoRuy Pantoja
 
Proteinas 14 3-3 e insulina
Proteinas 14 3-3 e insulinaProteinas 14 3-3 e insulina
Proteinas 14 3-3 e insulinaRuy Pantoja
 
Glicemia e fat food ingestion
Glicemia e fat food ingestionGlicemia e fat food ingestion
Glicemia e fat food ingestionRuy Pantoja
 
To my colleagues from many parts of the world
To my colleagues from many parts of the worldTo my colleagues from many parts of the world
To my colleagues from many parts of the worldRuy Pantoja
 
Dm e efeitos da canela
Dm e efeitos da canelaDm e efeitos da canela
Dm e efeitos da canelaRuy Pantoja
 
Drug discovery
Drug discoveryDrug discovery
Drug discoveryRuy Pantoja
 

Recomendados

Dpp4 e angiogênese
Dpp4 e angiogêneseDpp4 e angiogênese
Dpp4 e angiogêneseRuy Pantoja
 
Figura 1 ritmos circadianos
Figura 1 ritmos circadianosFigura 1 ritmos circadianos
Figura 1 ritmos circadianosRuy Pantoja
 
Insulina intranasal e cognição
Insulina intranasal e cogniçãoInsulina intranasal e cognição
Insulina intranasal e cogniçãoRuy Pantoja
 
Proteinas 14 3-3 e insulina
Proteinas 14 3-3 e insulinaProteinas 14 3-3 e insulina
Proteinas 14 3-3 e insulinaRuy Pantoja
 
Glicemia e fat food ingestion
Glicemia e fat food ingestionGlicemia e fat food ingestion
Glicemia e fat food ingestionRuy Pantoja
 
To my colleagues from many parts of the world
To my colleagues from many parts of the worldTo my colleagues from many parts of the world
To my colleagues from many parts of the worldRuy Pantoja
 
Dm e efeitos da canela
Dm e efeitos da canelaDm e efeitos da canela
Dm e efeitos da canelaRuy Pantoja
 
Drug discovery
Drug discoveryDrug discovery
Drug discoveryRuy Pantoja
 
Dieta hiperproteica para obeso com resistência à insulina
Dieta hiperproteica para obeso com resistência à insulinaDieta hiperproteica para obeso com resistência à insulina
Dieta hiperproteica para obeso com resistência à insulinaRuy Pantoja
 
Ressecção parcial de pâncreas x regeneração x terapia incretínica humanos
Ressecção parcial de pâncreas x regeneração x terapia incretínica humanosRessecção parcial de pâncreas x regeneração x terapia incretínica humanos
Ressecção parcial de pâncreas x regeneração x terapia incretínica humanosRuy Pantoja
 
Brown adipose tissue
Brown adipose tissueBrown adipose tissue
Brown adipose tissueRuy Pantoja
 
Não somos quentes o suficiente ?
Não somos quentes o suficiente ?Não somos quentes o suficiente ?
Não somos quentes o suficiente ?Ruy Pantoja
 
MACROPHAGE AND BROWN FAT
MACROPHAGE AND BROWN FATMACROPHAGE AND BROWN FAT
MACROPHAGE AND BROWN FATRuy Pantoja
 
Beta cell stres in dm2 a
Beta cell stres in dm2 aBeta cell stres in dm2 a
Beta cell stres in dm2 aRuy Pantoja
 
Beta cell failure, stress and dm2
Beta cell failure, stress and dm2Beta cell failure, stress and dm2
Beta cell failure, stress and dm2Ruy Pantoja
 
DIABETES AND CANCER
DIABETES AND CANCERDIABETES AND CANCER
DIABETES AND CANCERRuy Pantoja
 
Sitagliptina e proteção em ca diferenciado da tireóide.x
Sitagliptina e proteção em ca diferenciado da tireóide.xSitagliptina e proteção em ca diferenciado da tireóide.x
Sitagliptina e proteção em ca diferenciado da tireóide.xRuy Pantoja
 
Exetimibe melhora dm diminuindo nafld.x
Exetimibe melhora dm diminuindo nafld.xExetimibe melhora dm diminuindo nafld.x
Exetimibe melhora dm diminuindo nafld.xRuy Pantoja
 
Dpp4 i for the treatment of ACNE
Dpp4 i for the treatment of ACNEDpp4 i for the treatment of ACNE
Dpp4 i for the treatment of ACNERuy Pantoja
 
GLP 1 E GIP: DIFERENÇAS E SEMELHANÇAS
GLP 1 E GIP: DIFERENÇAS E SEMELHANÇASGLP 1 E GIP: DIFERENÇAS E SEMELHANÇAS
GLP 1 E GIP: DIFERENÇAS E SEMELHANÇASRuy Pantoja
 
FENTERMIN DOENSNT INCREASE HYPERTENSION
FENTERMIN DOENSNT INCREASE HYPERTENSIONFENTERMIN DOENSNT INCREASE HYPERTENSION
FENTERMIN DOENSNT INCREASE HYPERTENSIONRuy Pantoja
 
Doença cardiovascular
Doença cardiovascularDoença cardiovascular
Doença cardiovascularRuy Pantoja
 
Cancer cell metabolism
Cancer cell metabolismCancer cell metabolism
Cancer cell metabolismRuy Pantoja
 
Dpp4 beta cell preservation
Dpp4 beta cell preservationDpp4 beta cell preservation
Dpp4 beta cell preservationRuy Pantoja
 
Insulina e cérebro
Insulina e cérebroInsulina e cérebro
Insulina e cérebroRuy Pantoja
 
O futuro na terapia baseada em incretins.
O futuro na terapia baseada em incretins.O futuro na terapia baseada em incretins.
O futuro na terapia baseada em incretins.Ruy Pantoja
 
Probioticos e CVD
Probioticos e CVDProbioticos e CVD
Probioticos e CVDRuy Pantoja
 
Obesity , Circadian rythms
Obesity , Circadian rythmsObesity , Circadian rythms
Obesity , Circadian rythmsRuy Pantoja
 
How to Make a Pirate ship Primary Education.pptx
How to Make a Pirate ship Primary Education.pptxHow to Make a Pirate ship Primary Education.pptx
How to Make a Pirate ship Primary Education.pptxmanuelaromero2013
 
Privatization and Disinvestment - Meaning, Objectives, Advantages and Disadva...
Privatization and Disinvestment - Meaning, Objectives, Advantages and Disadva...Privatization and Disinvestment - Meaning, Objectives, Advantages and Disadva...
Privatization and Disinvestment - Meaning, Objectives, Advantages and Disadva...RKavithamani
 

Más contenido relacionado

Más de Ruy Pantoja

Dieta hiperproteica para obeso com resistência à insulina
Dieta hiperproteica para obeso com resistência à insulinaDieta hiperproteica para obeso com resistência à insulina
Dieta hiperproteica para obeso com resistência à insulinaRuy Pantoja
 
Ressecção parcial de pâncreas x regeneração x terapia incretínica humanos
Ressecção parcial de pâncreas x regeneração x terapia incretínica humanosRessecção parcial de pâncreas x regeneração x terapia incretínica humanos
Ressecção parcial de pâncreas x regeneração x terapia incretínica humanosRuy Pantoja
 
Brown adipose tissue
Brown adipose tissueBrown adipose tissue
Brown adipose tissueRuy Pantoja
 
Não somos quentes o suficiente ?
Não somos quentes o suficiente ?Não somos quentes o suficiente ?
Não somos quentes o suficiente ?Ruy Pantoja
 
MACROPHAGE AND BROWN FAT
MACROPHAGE AND BROWN FATMACROPHAGE AND BROWN FAT
MACROPHAGE AND BROWN FATRuy Pantoja
 
Beta cell stres in dm2 a
Beta cell stres in dm2 aBeta cell stres in dm2 a
Beta cell stres in dm2 aRuy Pantoja
 
Beta cell failure, stress and dm2
Beta cell failure, stress and dm2Beta cell failure, stress and dm2
Beta cell failure, stress and dm2Ruy Pantoja
 
DIABETES AND CANCER
DIABETES AND CANCERDIABETES AND CANCER
DIABETES AND CANCERRuy Pantoja
 
Sitagliptina e proteção em ca diferenciado da tireóide.x
Sitagliptina e proteção em ca diferenciado da tireóide.xSitagliptina e proteção em ca diferenciado da tireóide.x
Sitagliptina e proteção em ca diferenciado da tireóide.xRuy Pantoja
 
Exetimibe melhora dm diminuindo nafld.x
Exetimibe melhora dm diminuindo nafld.xExetimibe melhora dm diminuindo nafld.x
Exetimibe melhora dm diminuindo nafld.xRuy Pantoja
 
Dpp4 i for the treatment of ACNE
Dpp4 i for the treatment of ACNEDpp4 i for the treatment of ACNE
Dpp4 i for the treatment of ACNERuy Pantoja
 
GLP 1 E GIP: DIFERENÇAS E SEMELHANÇAS
GLP 1 E GIP: DIFERENÇAS E SEMELHANÇASGLP 1 E GIP: DIFERENÇAS E SEMELHANÇAS
GLP 1 E GIP: DIFERENÇAS E SEMELHANÇASRuy Pantoja
 
FENTERMIN DOENSNT INCREASE HYPERTENSION
FENTERMIN DOENSNT INCREASE HYPERTENSIONFENTERMIN DOENSNT INCREASE HYPERTENSION
FENTERMIN DOENSNT INCREASE HYPERTENSIONRuy Pantoja
 
Doença cardiovascular
Doença cardiovascularDoença cardiovascular
Doença cardiovascularRuy Pantoja
 
Cancer cell metabolism
Cancer cell metabolismCancer cell metabolism
Cancer cell metabolismRuy Pantoja
 
Dpp4 beta cell preservation
Dpp4 beta cell preservationDpp4 beta cell preservation
Dpp4 beta cell preservationRuy Pantoja
 
Insulina e cérebro
Insulina e cérebroInsulina e cérebro
Insulina e cérebroRuy Pantoja
 
O futuro na terapia baseada em incretins.
O futuro na terapia baseada em incretins.O futuro na terapia baseada em incretins.
O futuro na terapia baseada em incretins.Ruy Pantoja
 
Probioticos e CVD
Probioticos e CVDProbioticos e CVD
Probioticos e CVDRuy Pantoja
 
Obesity , Circadian rythms
Obesity , Circadian rythmsObesity , Circadian rythms
Obesity , Circadian rythmsRuy Pantoja
 

Más de Ruy Pantoja (20)

Dieta hiperproteica para obeso com resistência à insulina
Dieta hiperproteica para obeso com resistência à insulinaDieta hiperproteica para obeso com resistência à insulina
Dieta hiperproteica para obeso com resistência à insulina
 
Ressecção parcial de pâncreas x regeneração x terapia incretínica humanos
Ressecção parcial de pâncreas x regeneração x terapia incretínica humanosRessecção parcial de pâncreas x regeneração x terapia incretínica humanos
Ressecção parcial de pâncreas x regeneração x terapia incretínica humanos
 
Brown adipose tissue
Brown adipose tissueBrown adipose tissue
Brown adipose tissue
 
Não somos quentes o suficiente ?
Não somos quentes o suficiente ?Não somos quentes o suficiente ?
Não somos quentes o suficiente ?
 
MACROPHAGE AND BROWN FAT
MACROPHAGE AND BROWN FATMACROPHAGE AND BROWN FAT
MACROPHAGE AND BROWN FAT
 
Beta cell stres in dm2 a
Beta cell stres in dm2 aBeta cell stres in dm2 a
Beta cell stres in dm2 a
 
Beta cell failure, stress and dm2
Beta cell failure, stress and dm2Beta cell failure, stress and dm2
Beta cell failure, stress and dm2
 
DIABETES AND CANCER
DIABETES AND CANCERDIABETES AND CANCER
DIABETES AND CANCER
 
Sitagliptina e proteção em ca diferenciado da tireóide.x
Sitagliptina e proteção em ca diferenciado da tireóide.xSitagliptina e proteção em ca diferenciado da tireóide.x
Sitagliptina e proteção em ca diferenciado da tireóide.x
 
Exetimibe melhora dm diminuindo nafld.x
Exetimibe melhora dm diminuindo nafld.xExetimibe melhora dm diminuindo nafld.x
Exetimibe melhora dm diminuindo nafld.x
 
Dpp4 i for the treatment of ACNE
Dpp4 i for the treatment of ACNEDpp4 i for the treatment of ACNE
Dpp4 i for the treatment of ACNE
 
GLP 1 E GIP: DIFERENÇAS E SEMELHANÇAS
GLP 1 E GIP: DIFERENÇAS E SEMELHANÇASGLP 1 E GIP: DIFERENÇAS E SEMELHANÇAS
GLP 1 E GIP: DIFERENÇAS E SEMELHANÇAS
 
FENTERMIN DOENSNT INCREASE HYPERTENSION
FENTERMIN DOENSNT INCREASE HYPERTENSIONFENTERMIN DOENSNT INCREASE HYPERTENSION
FENTERMIN DOENSNT INCREASE HYPERTENSION
 
Doença cardiovascular
Doença cardiovascularDoença cardiovascular
Doença cardiovascular
 
Cancer cell metabolism
Cancer cell metabolismCancer cell metabolism
Cancer cell metabolism
 
Dpp4 beta cell preservation
Dpp4 beta cell preservationDpp4 beta cell preservation
Dpp4 beta cell preservation
 
Insulina e cérebro
Insulina e cérebroInsulina e cérebro
Insulina e cérebro
 
O futuro na terapia baseada em incretins.
O futuro na terapia baseada em incretins.O futuro na terapia baseada em incretins.
O futuro na terapia baseada em incretins.
 
Probioticos e CVD
Probioticos e CVDProbioticos e CVD
Probioticos e CVD
 
Obesity , Circadian rythms
Obesity , Circadian rythmsObesity , Circadian rythms
Obesity , Circadian rythms
 

Último

How to Make a Pirate ship Primary Education.pptx
How to Make a Pirate ship Primary Education.pptxHow to Make a Pirate ship Primary Education.pptx
How to Make a Pirate ship Primary Education.pptxmanuelaromero2013
 
Privatization and Disinvestment - Meaning, Objectives, Advantages and Disadva...
Privatization and Disinvestment - Meaning, Objectives, Advantages and Disadva...Privatization and Disinvestment - Meaning, Objectives, Advantages and Disadva...
Privatization and Disinvestment - Meaning, Objectives, Advantages and Disadva...RKavithamani
 
18-04-UA_REPORT_MEDIALITERAСY_INDEX-DM_23-1-final-eng.pdf
18-04-UA_REPORT_MEDIALITERAСY_INDEX-DM_23-1-final-eng.pdf18-04-UA_REPORT_MEDIALITERAСY_INDEX-DM_23-1-final-eng.pdf
18-04-UA_REPORT_MEDIALITERAСY_INDEX-DM_23-1-final-eng.pdfssuser54595a
 
Employee wellbeing at the workplace.pptx
Employee wellbeing at the workplace.pptxEmployee wellbeing at the workplace.pptx
Employee wellbeing at the workplace.pptxNirmalaLoungPoorunde1
 
Call Girls in Dwarka Mor Delhi Contact Us 9654467111
Call Girls in Dwarka Mor Delhi Contact Us 9654467111Call Girls in Dwarka Mor Delhi Contact Us 9654467111
Call Girls in Dwarka Mor Delhi Contact Us 9654467111Sapana Sha
 
Grant Readiness 101 TechSoup and Remy Consulting
Grant Readiness 101 TechSoup and Remy ConsultingGrant Readiness 101 TechSoup and Remy Consulting
Grant Readiness 101 TechSoup and Remy ConsultingTechSoup
 
1029 - Danh muc Sach Giao Khoa 10 . pdf
1029 - Danh muc Sach Giao Khoa 10 . pdf1029 - Danh muc Sach Giao Khoa 10 . pdf
1029 - Danh muc Sach Giao Khoa 10 . pdfQucHHunhnh
 
CARE OF CHILD IN INCUBATOR..........pptx
CARE OF CHILD IN INCUBATOR..........pptxCARE OF CHILD IN INCUBATOR..........pptx
CARE OF CHILD IN INCUBATOR..........pptxGaneshChakor2
 
Beyond the EU: DORA and NIS 2 Directive's Global Impact
Beyond the EU: DORA and NIS 2 Directive's Global ImpactBeyond the EU: DORA and NIS 2 Directive's Global Impact
Beyond the EU: DORA and NIS 2 Directive's Global ImpactPECB
 
Organic Name Reactions for the students and aspirants of Chemistry12th.pptx
Organic Name Reactions for the students and aspirants of Chemistry12th.pptxOrganic Name Reactions for the students and aspirants of Chemistry12th.pptx
Organic Name Reactions for the students and aspirants of Chemistry12th.pptxVS Mahajan Coaching Centre
 
Hybridoma Technology ( Production , Purification , and Application )
Hybridoma Technology ( Production , Purification , and Application ) Hybridoma Technology ( Production , Purification , and Application )
Hybridoma Technology ( Production , Purification , and Application ) Sakshi Ghasle
 
BASLIQ CURRENT LOOKBOOK LOOKBOOK(1) (1).pdf
BASLIQ CURRENT LOOKBOOK LOOKBOOK(1) (1).pdfBASLIQ CURRENT LOOKBOOK LOOKBOOK(1) (1).pdf
BASLIQ CURRENT LOOKBOOK LOOKBOOK(1) (1).pdfSoniaTolstoy
 
Web & Social Media Analytics Previous Year Question Paper.pdf
Web & Social Media Analytics Previous Year Question Paper.pdfWeb & Social Media Analytics Previous Year Question Paper.pdf
Web & Social Media Analytics Previous Year Question Paper.pdfJayanti Pande
 
Mastering the Unannounced Regulatory Inspection
Mastering the Unannounced Regulatory InspectionMastering the Unannounced Regulatory Inspection
Mastering the Unannounced Regulatory InspectionSafetyChain Software
 
Z Score,T Score, Percential Rank and Box Plot Graph
Z Score,T Score, Percential Rank and Box Plot GraphZ Score,T Score, Percential Rank and Box Plot Graph
Z Score,T Score, Percential Rank and Box Plot GraphThiyagu K
 
Introduction to ArtificiaI Intelligence in Higher Education
Introduction to ArtificiaI Intelligence in Higher EducationIntroduction to ArtificiaI Intelligence in Higher Education
Introduction to ArtificiaI Intelligence in Higher Educationpboyjonauth
 
Q4-W6-Restating Informational Text Grade 3
Q4-W6-Restating Informational Text Grade 3Q4-W6-Restating Informational Text Grade 3
Q4-W6-Restating Informational Text Grade 3JemimahLaneBuaron
 

Último (20)

How to Make a Pirate ship Primary Education.pptx
How to Make a Pirate ship Primary Education.pptxHow to Make a Pirate ship Primary Education.pptx
How to Make a Pirate ship Primary Education.pptx
 
Privatization and Disinvestment - Meaning, Objectives, Advantages and Disadva...
Privatization and Disinvestment - Meaning, Objectives, Advantages and Disadva...Privatization and Disinvestment - Meaning, Objectives, Advantages and Disadva...
Privatization and Disinvestment - Meaning, Objectives, Advantages and Disadva...
 
18-04-UA_REPORT_MEDIALITERAСY_INDEX-DM_23-1-final-eng.pdf
18-04-UA_REPORT_MEDIALITERAСY_INDEX-DM_23-1-final-eng.pdf18-04-UA_REPORT_MEDIALITERAСY_INDEX-DM_23-1-final-eng.pdf
18-04-UA_REPORT_MEDIALITERAСY_INDEX-DM_23-1-final-eng.pdf
 
Employee wellbeing at the workplace.pptx
Employee wellbeing at the workplace.pptxEmployee wellbeing at the workplace.pptx
Employee wellbeing at the workplace.pptx
 
Mattingly "AI & Prompt Design: Structured Data, Assistants, & RAG"
Mattingly "AI & Prompt Design: Structured Data, Assistants, & RAG"Mattingly "AI & Prompt Design: Structured Data, Assistants, & RAG"
Mattingly "AI & Prompt Design: Structured Data, Assistants, & RAG"
 
Call Girls in Dwarka Mor Delhi Contact Us 9654467111
Call Girls in Dwarka Mor Delhi Contact Us 9654467111Call Girls in Dwarka Mor Delhi Contact Us 9654467111
Call Girls in Dwarka Mor Delhi Contact Us 9654467111
 
Grant Readiness 101 TechSoup and Remy Consulting
Grant Readiness 101 TechSoup and Remy ConsultingGrant Readiness 101 TechSoup and Remy Consulting
Grant Readiness 101 TechSoup and Remy Consulting
 
INDIA QUIZ 2024 RLAC DELHI UNIVERSITY.pptx
INDIA QUIZ 2024 RLAC DELHI UNIVERSITY.pptxINDIA QUIZ 2024 RLAC DELHI UNIVERSITY.pptx
INDIA QUIZ 2024 RLAC DELHI UNIVERSITY.pptx
 
1029 - Danh muc Sach Giao Khoa 10 . pdf
1029 - Danh muc Sach Giao Khoa 10 . pdf1029 - Danh muc Sach Giao Khoa 10 . pdf
1029 - Danh muc Sach Giao Khoa 10 . pdf
 
CARE OF CHILD IN INCUBATOR..........pptx
CARE OF CHILD IN INCUBATOR..........pptxCARE OF CHILD IN INCUBATOR..........pptx
CARE OF CHILD IN INCUBATOR..........pptx
 
Beyond the EU: DORA and NIS 2 Directive's Global Impact
Beyond the EU: DORA and NIS 2 Directive's Global ImpactBeyond the EU: DORA and NIS 2 Directive's Global Impact
Beyond the EU: DORA and NIS 2 Directive's Global Impact
 
Organic Name Reactions for the students and aspirants of Chemistry12th.pptx
Organic Name Reactions for the students and aspirants of Chemistry12th.pptxOrganic Name Reactions for the students and aspirants of Chemistry12th.pptx
Organic Name Reactions for the students and aspirants of Chemistry12th.pptx
 
Mattingly "AI & Prompt Design: The Basics of Prompt Design"
Mattingly "AI & Prompt Design: The Basics of Prompt Design"Mattingly "AI & Prompt Design: The Basics of Prompt Design"
Mattingly "AI & Prompt Design: The Basics of Prompt Design"
 
Hybridoma Technology ( Production , Purification , and Application )
Hybridoma Technology ( Production , Purification , and Application ) Hybridoma Technology ( Production , Purification , and Application )
Hybridoma Technology ( Production , Purification , and Application )
 
BASLIQ CURRENT LOOKBOOK LOOKBOOK(1) (1).pdf
BASLIQ CURRENT LOOKBOOK LOOKBOOK(1) (1).pdfBASLIQ CURRENT LOOKBOOK LOOKBOOK(1) (1).pdf
BASLIQ CURRENT LOOKBOOK LOOKBOOK(1) (1).pdf
 
Web & Social Media Analytics Previous Year Question Paper.pdf
Web & Social Media Analytics Previous Year Question Paper.pdfWeb & Social Media Analytics Previous Year Question Paper.pdf
Web & Social Media Analytics Previous Year Question Paper.pdf
 
Mastering the Unannounced Regulatory Inspection
Mastering the Unannounced Regulatory InspectionMastering the Unannounced Regulatory Inspection
Mastering the Unannounced Regulatory Inspection
 
Z Score,T Score, Percential Rank and Box Plot Graph
Z Score,T Score, Percential Rank and Box Plot GraphZ Score,T Score, Percential Rank and Box Plot Graph
Z Score,T Score, Percential Rank and Box Plot Graph
 
Introduction to ArtificiaI Intelligence in Higher Education
Introduction to ArtificiaI Intelligence in Higher EducationIntroduction to ArtificiaI Intelligence in Higher Education
Introduction to ArtificiaI Intelligence in Higher Education
 
Q4-W6-Restating Informational Text Grade 3
Q4-W6-Restating Informational Text Grade 3Q4-W6-Restating Informational Text Grade 3
Q4-W6-Restating Informational Text Grade 3
 

Beta cell stress en dm2 b

Notas del editor

  1. Figure 2. Interfering with Insulin Production. The production of mature insulin takes place within the beta cell and depends on the cleavage of the preproinsulin and proinsulin molecules. The cleavage site at the junction of the A chain and the C-peptide contains a lysine residue, which is critical for cleavage.