Comprehensive Skin Health Solutions from ZO Skin Health

Comprehensive Skin Health Solutions

Beverly Hills

ZO® Skin Health Difference

“Making Healthy Skin Possible for Every Patient”

Fo Z in b g M
rm e O a i, D

• Poe t c rc r o sin ae n vtn
rvn r k eod fk cr in oa s
a io
s a n goe 3 yas
p n in vr 5 er

• T o g t a e adp n e b h dS in el
h u h l d r n io er e in k H ah
e t
C c p rd m
irl aa ig
e

• Cetr f 1bado R ata in sin ae
ra o # rn f X ni- g g k cr
o

• V io ay n f n e o Z ® S I H A T
is n r a d o d r f O KN E L H
u

• L a e in em tl yra e t f df e t
ed r d r a o t t ns o ifrn
og em r e
e n its
t icie
h

• B adC r ie D r a l is
o r et d em to t
if og

• W r - e o n da toit l trrin oa r
ol rn we uh r , e ue, n vt
d y c o
a de u a r
n d ct o

The Vision

D vl a dm re Z ® S in el a te n c m le o re f ol
ee p n akt O k H ah s h o l o p t suc o w r -
o t y e d
c s sin ae rd c a dslio s
l s k cr po u t n o tn.
a s u

Poid rsl- rne slio s aoe t m e te p cic ed o
rv e eusoie t o tn t rd o eth s eif n e s f
t d u il
eey esna eey g a deey t e te l .
vr p ro t vr a e n vr s g in h ir e
a if

D le c icl poe rsl ta c r c a dm ina h ah sin h t
e r l ay rvn eus h t or t n a t ely k ta is
iv in l t e in t
s o g s o t a df , ee ltn d flhda da df e f isae
t n , m oh n ir vn o e , uy yrt n r o d es.
r m y l e e

ZO® Skin Health Difference

The Science and Theory

Healthy Skin vs. Damaged Skin
Age, genetics, environmental influences (UV polutants), diet, stress, hormones, sleep and skin care:
all play a role.

A balanced lifestyle and effective skin care, can restore healthy skin.

Dr. Obagi defines the difference between healthy skin and damaged skin as follows:

Healthy Skin Elements Damaged Skin Elements

Texture Smooth Rough

Moisture Hydrated Dry

Strength Tight/Firm Loose and weak with fine lines

Tone Even Tone Discoloration (dark spots, rosacea)

Volume Full Lax

Disease Free of active disease Presence of active disease

Skin Tolerance Strong/Tolerant Sensitive

Skin Aging
Age Appearance Physiology
< 15 Nearly perfect skin. Excellent repair capabilities.
Smooth texture, pores small. Low sebaceous gland activity.
Skin hydration good.
15 - 25 Acne key factor in surface texture. High sebaceous gland activity.
Fine lines start to appear, pore size Mild drop in dermal repair, immune system and collagen
increasing synthesis.
Strong cohesion between skin layers and rapid cell turnover.
Small drop in skin hydration, noticed particularly in winter.
25 - 45 More fine lines and appearance of Moderate decrease in dermal repair, resulting in less collagen
first wrinkles and increasing accumulation of damaged corrective tissue.
Early signs of sagging near the eye. Noticeable and significant drop in skin hydration.
Some loss of elasticity.
Adult acne.
45 - 55 More wrinkles, rough texture. Significant decrease in dermal repair and immune system.
Sallow yellow color Continued dermal degradation.
Pores, age spots enlarge and define. Cohesion between skin layers continues to decline.
Sagging near eye and cheek. Thinning of epidermis and stratum corneum.
Skin tends now to be dry.
55 + Wrinkles and fine lines in abundance. Compromised dermal repair, abundance of damaged connective
tissue.
Uneven color, pigmentation. Low production of collagen and sebum. Increased local over-
Sagging worsens. production of melanin.
Dark circles under eye.

Science & Theory

EPIDERMIS
This is the outer protective, non vascular layer
of the skin.

DERMIS
The dermis consists mostly of connective tissue
and is much thicker than the epidermis.

SUBCUTANEOUS LAYER
The subcutaneous layer below the dermis
consists of loose connective tissue and much
fat. It acts as a protective cushion and helps to
insulate the body by monitoring heat gain and
heat loss.

THE GOALS
Stabilization

•Maintain even skin tone

•Prevent future potential for hyperpigmentation

•Stabilize melanocytes for pigment control

Activate and Stimulate Cellular Function

•Exfoliate dead surface cells

•Activate new cell production

•Increase collagen production

Improve overall appearance

•Smooth texture

•Tight pores

•Firmness and density

THE TOOLS

Zo Skin Health Products are the Tools!
Us ing thes e tools is not a new c onc ept, how they are us ed is ….

C ombining thes e tools into programs that us e high c onc entrations of ac tive

ingredients in protec ted delivery s ys tems , ZO S kin Health c an deliver the mos t

targeted, effec tive, s us tainable res ults on the market today.

Tool Drivers:

Peptides: a o c lf m db j in too m r a in aid
m l u o e yo g w r oe m o c s
e e r in

Enzymes: in rae h rt o a ec n
ces te a f rat
e io

Antioxidants: in ib te x a n f te m l u s
h ith oid t o oh r o c l
io e e

Retinol: acla s e troe a dc lg n rd c n
ce rt clun vr n oa e po u t
e e l l io

Cellular Function

• ZO® Skin Health works at the cellular level
so that skin nourishes, repairs and maintains
itself.

• Anti-oxidants (Vitamins C & E, Coenzyme Q10)

neutralizes free radicals to help reverse the
signs of aging.

• ZO® Skin Health Programs help to achieve
optimum skin health by “layering” protected
retinol, anti-oxidants and vitamins to increase
and enhance repair.

• Dr. Obagi recommends a 5-step targeted
program approach.

Microsponge
• T e icop n e e ey ytm( D )is u iq e e h o g f te o t ldrl s o tp a
h M rs o g D l r S s
iv e M S a n u tc n l yo h c nr l e ae fo ic l
o r oe e
aet
g ns

• C nis o m co oo s e d , t ic l 1 - 5m rn ind m trl d dwha te g n
o s t f arp ru b a s y ay 02 ico s ia ee, o e it civ a e t
s p l a

• W e a p dt te k , te D rl ss s civ in rd n o a im m d a da oinrs o s
h n p l o h sin h M S e ae it ate ge ie t n t e o e n l
ie e s ep ne
t oh r t u (u b g tm eaue p , ec
o te s lrb in , e p rtr, H t)
im i

• M Stc n l y b in ue c r nlinc s eic, oe- h - o ne ( T )sincr, snce n
D e h o g is e g sd ur t
o e y om ts vr ec u trO C k ae u sre s
t
a dpecipio po u t
n rsr tn rd cs

• B d lein te civ ga u l t te k , M Srto f ea p , h s xee t f a y it
y e rg h a te rd ay o h sin D - ein lo xm l a ecln eic c wh
iv l , r e l f
m im lr tn
in air aio
it

Clinical Study: Re-emergence of
topical retinol in dermatology
Clinical Study: Journal of Dermatological Treatment (2000) LH Kligman and EH Gans

Once abandoned because of its instability, ROL can now be sequestered in Microsponge Polymers
with low irritancy and cosmetic acceptability for treating the visible signs of aging and photoaging.

Protected from oxidation by antioxidants such as vitamins C and E, it remains stable with a shelf life of
at least 2 years. By obviating the rapid degradation that ROL would otherwise undergo, the new
formulation has permitted the resumption of research with this agent.

It was found that ROL was metabolized primarily to retinyl esters and to relatively small amounts of RA
which activated nuclear RA receptors.

ROL can be effective in inducing beneficial epidermal changes with less irritation than RA.

**1.6% ROL induced significant epidermal thickening similar to that of 0.025% RA.

Trace erythema, occurred with ROL whereas RA induced measurable erythema.

ROL penetration was more effective than that of RA, but required a 10-fold higher concentration than
RA.

ROL increased epidermal thickness without the erythema induced by RA.

Studies demonstrated that ROL has lower potency than RA, requiring higher concentrations than RA to
produce similar epidermal effects.

ROL is more effectively delivered into skin, inducing retinoid changes in the epidermis without irritation.

Liposome
• L oo e ae in t s h rao do ls e aae f ma a u o s e iu b a h s h lid
ip sm s r m ue p eiclilrp t sp rtd r n q e u m d m y p op o
e o ip
bae
il r
y

• T e m l iz o loo e e a l te t p s tru he id r is n at s c r ro lu
h s a s e f sm s n b s h m o as ho g p em a d c a a ar f iq id
l ip e ie r
sb tn e, wic ae n l e wh teip sm ’s oo inen lait
u s cs h h r e c sd itin h loo e h lw tracvy
a o l

Enzymes
An enzyme is a protein molec ule that is a biologic al c atalys t with three c harac teris tic s :

2.h b s f cio o a e zm is oin rae h rt o a ecio . M s cll rat n o c r b u
T e aic u t n f n ny e t ce s te ae f ra tn ot eu recio s c u a o t
n la
a il nt e f trh nte wu inte b e c o a e zm .
ml im sa e ta h y o l h a sn e f n ny e
io s d

3. ot ny e at p cic l who lo e e ca tclda ubs trate)t po u e rd cs
M s e zm s c s e ifay it n n ra tn ( ae s
l y l o rd c po u t.

4. ny e ae e u tdf ma tt o l atitt h hatita dv e es.
E zm s r rg le r
a o s e f w civyo ig civy n ic vr
a o a

Peptides
• P pid is m l u f m db j in too m r a in aid
e t e a o c l o e yo g w r oe m o c s
e e r in

• T e h v te a e e t e o d a toe poe sb t r sotr l gh
h y ae h sm p pid b n s s h s in rtin, u ae h r ine t
e n

• P pid s r n m db sdo te u b r f m oaid inte h in d e t e ( ) t e t e ( )
e t e ae a e ae n h n m e o a in c s h c a : ip pid s2 r pid s3
, ip ,
tt p pid s4 p na e t e ( )
er e t e ( ) e tp pid s5
a ,

• W e te u b r f m oaid ises h n5 tee o c l ae a e p pid s heag r
h n h n m e o a in c s l ta 0 h s m l u s r n m d e t e will e
s e e r
sq e c s r rf rdt a poe s
e u n e ae e r o s rtin
ee

• Ap pid b n is s eialkg inwic te it g nao o o e m oaidb d t te ab xl
e te o d a p c l a e
in h h h nr e tm f n a in c in s o h croy
o
cro ao o a oh r
ab n tm f n te

• M t y3 0 ue tt p pid ( )a do o e t e ( - 0 t m im e rk s n aif geet
ar l0 0 ss er e t e 4 n l p pid s22 ) o in iz w l a d lin fc
ix a ig in e t f

Lipopeptides
• L o e t e a e t e t c e t aip ( t
ip p pid is p pid at h d o lid f )
a a

• L o e t e h v b e so ninsie t s d st b ot e's auapo u titl e
ip p pid s ae en h w c nif t ie, o o s cl n trl rd civye l
ic u l vs

• C nid rdt b o e f aue m s p wr lni- g r b ineatgwhcl e ba e t b ot
o s ee o e n o n tr's ot o ef a ta es y trcin it e m m rn s o o s
u l
n trl n t no te es rn w gte t m x u go t p tnia
auaf cio fh cl, e e in h m o aim m rw oe tl
u l h .

• S r cinis b l ic l ateip p pid a dis rd m a t a iouf tn
uf t a io g ay civ lo e t e n pe o in nl b sr ca t
a o l y a

• I a rcivdc nid rb atnio whrg r t it ecln sr c c a s gpo ets
t s ee e o s ea l t tn it e ad o s xee t uf e l nin rp r
h e e l a e ie

Antioxidants
• A antioxidant is m l u cp b o in ib in te x aio o oh r o c l
n a o c l a a l f h itg h oid tn f te m l u s
e e e e e

• O id tnis c e ic l a tnta t nf s l t n o hdo e f ma u s n e oa oid in
x aio a h m ar cio h tr s r e cr s r yrg n r
e a e e o o sb t c t n x iz g
a
aet
gn

• O id tnra tn c npo u e re a icl tee re a ic ls rc a ra tn
x aio ecio s a rd c f rd a , h s f rd a t t h in e cio s
e s e s a

• W e te h inra tno c r ina e, it a cue a a e r e t t te e
h n h c a ecio cus cl c n a s d m g o d ah o h cl
l l

• A tx a t tr in t tee h inrat n b rm v gf e a icl tr e iae, a din ib oh r
nioid ns em ae h s c a e cio s y e oin r rd ainem d ts n h it te
e
oid t nrat n
x aio ecio s

Vitamin A
• Vitamin A is a key vitamin that the skin needs topically.

• Oxidizes easily and is unstable.

• Oral consumption does not address the topical deficiency.

• Application of stabilized Vitamin A, in sufficient levels,
will give optimum benefits.

• Retinol at higher levels can cause irritation.

• Most OTC products do not deliver enough retinol to the skin.

• Needs a stabilized delivery system.

• ZO® uses an encapsulated delivery system that sends
stabilized retinol in a time-released form, that reduces
potential irritation.

Retinol
• Retinol is considered one of the most effective anti-aging ingredients

• Natural form of Vitamin A

• Most effective over-the-counter vitamin for aging skin

• Improves overall skin health

• Able to go inside the cell to stimulate cellular function at the dermal level

• Simultaneously repairs damage at the epidermal level

Retinol
Benefits of regular use:

Reduces appearance of fine lines, wrinkles, sun damage and age spots

• Improves brightness and tone

• Increases collagen production, firmness and elasticity

• Retinol is preventative and corrective

Early use helps prevent fine lines, wrinkles, age spots and uneven tone

Later use of retinol will help correct visible signs of aging

Retinol Cascade
• The retinol cascade is the process where special enzymes convert retinol to retinoic acid

• The majority of over-the-counter skin care products have very low levels of retinol

• Products that have a low concentration of retinol produce less retinol cascade

• When the conversion rate is low, little retinoic acid becomes bio-available to the cells

• A high concentration of retinol increases the conversion rate of retinol-to-retinoic acid

Vitaine (Encapsulated Retinol)
• A liposome containing 0.5% stabilized retinol

• Found in: Daily Power Defense, Intense Eye Repair, Daily Renewal Crème, Overnight
Recovery Creme

• Liposomal delivery can increase retinol levels retained in the stratum corneum

• Liposome structure protects retinol from degradation

• Ratio of retinol to lipid is engineered to ensure maximum stability

• Retinol is carefully stacked in the liposome to protect from hydrolysis

• Liposome entrapment of retinol gives stability

Photosomes (DNA Repair)
• Photosomes repair sun-induced damage to DNA

• Found in: Daily Renewal Crème

• Photosomes is photolyase in multilamellar liposomes

• Photolase is a light-activated marine enzyme

• Photolase is derived from photosynthetic plankton called Anacystis nidulans

• These liposomes are formed from pure egg phospholipids

• Photolyase absorbs visible light to directly adhere to and reverse short UV wavelength damage
(uvb)

• Photosomes protect the cells of the skin’s immune system

• Photsomes are used at a 1% concentration

Oxysomes (antioxidants C and E)
• Vitamin C and E together reduce free radical damage by 50%

• Found in: Daily Renewal Creme

• Oxysomes deliver vitamin C within 1 hour and increase bioavailability by 85%

• Vitamin C boosts collagen synthesis

• Internalized vitamin C protects the vitamin E

• UV-absorbing properties of vitamin E protects the photosensitivity of vitamin C

• Provides powerful antioxidant properties at a 1% concentration

• Contains: 2% VC-PMG (LA c ric h s h t M g eiu )d raiv o Lac ric c (itm C
- sob P op ae a n s m eivte f - sob aid va in )

• Contains: 12% alpha-tocopherol (vitamin E)

Ultrasomes (DNA Repair)
• Natural DNA repair activity is facilitated by endonuclease enzyme

• Ultr s
a omesa e UV don clea e en y
r -en u s z mesen ps la ed in mu ila
ca u t lt mella lipos
r omes

• Endonuclease recognizes UV damage and accelerates repair by 4 times

• Protects immune system by repairing UV-DNA damage

• Provides post exposure sun damage recovery

• n u s epa ed r ococcu lu eu wh is b ceiu f n a p ro te om l
E don clea e ispr r f om micr s t s ich a a trm o d s at fh n r a
u
fr o te a m lnsin
l a fh m m a
o ia k

• Liposomes are formed from pure egg phospholipids

• Ultrasomes are used at a 1% concentration

Roxisomes (DNA Repair)
• Roxisomes repair DNA damage from free radicals generated by UVA sunlight

• Found in: Daily Power Defense

• Roxisomes shorten the time for nucleus DNA repair from 24 hours to 2 hours

• Roxisomes is the enzyme glycolase (8-oxo-guanine glycolase) in multilamellar liposomes

• Glycolase recognizes oxidative damage to DNA and initiates the repair process in the nucleus and
mitochondria

• These liposomes are formed from pure egg phospholipids

• Gy o s n trl o c r inaa id p is h ln , as a f wr gp n n tet E rp , A ia
l l e auay c us rb o s ta a m ll ein l t aiv o uo e s
ca l ia lo a
a dAr ata is sdinm l u r io g a dlh s n in
n f ic h t u e o c l b l y n ig t e s g
e a o

• Roxisomes are used at a 1% concentration

Phytopresome Q 10 (CoQ10)
• CoQ10 (ubiquinone) is a powerful antioxidant

• Found in: Radical Night Repair

• Photopresome Q 10 provides stable liposomes containing Coenzyme Q 10

• Provides superior skin barrier function

• Supports collagen

• Penetration of CoQ10 is enhanced in liposome delivery

• Photopresome Q 10 is a lipid complex of phospholipids and sterols

Ceremides (fatty acids)
• Rebuilds the skin barrier and increases barrier efficacy in 2 weeks

• Found in: Overnight Recovery Crème, Daily Power Defense

• C eramides are a family of lipid molec ules that are c ompos ed of fatty ac ids

• C rm e ae o n inh hc n e t tn wh te e ba e f es
ea id s r f d ig o cnr io s itin h m m rn o cl
u a l

• Aging and environmental exposure diminishes the replenishment capacity of the skin

• Provides the skin with a bioavailable, biostabilized form of linoleic acid

• Protects overall skin integrity

• Anti-inflammatory

Matrixyl 3000 (collagen production)
• Thes e peptides ac t in s ynergy to res tore c ollagen produc tion s timulating fibroblas t c ells
enabling them to reduc e the appearanc e of wrinkles

• F u din Daily Power Defens e, Intens e E ye Repair
on :

• Peptides are mes s engers of s kin res truc turation and repair. T e atae h n w yteis f
h y civt te e snh s o
te x aeu r ar poid ga tw k eicc.
h et cll m t rv in ni- r l f ay
r la ix in e f

• A m se g r o c l , p pid s r cp b o rg lin cl civie.
s esn e m l u s e t e ae a a l fe u tg e a tits
e e e a l

• M t y 3 0 c na s w p pid s P l H a dP l Q R( a ityOligopeptide a d
ar l 0 0 o tin t o e t e, a G K n a G P P l ol
ix ™ - - m n
P lityTetrapeptide-7) ( aryc na s n o e e t e P lityP na Oig p pid )
a ol
m . M t lo tin o l n p pid , a ol e t ( lo e t e
ix y m

• P lityT t p pid is bek ru hin rd n wic in ib s n rvr sre a icla a e
a oler e t e a rat o g ge ie t h h h it a d ees f rd ad m g .
m a h e e

•

Matrixyl 3000
• E c c m o e t f ary 3 0 h s enso nt h v d tc a ta in b n f
a h o p n n o M t l 0 0 a b e h w o ae is t ni- g g e e s
ix ™ in it

• T ee e t e ue inc m in tnh v a yeg t a ta in eet
h s p pid s sd o b aio ae sn ris ni- g g fc
ic f

• I eat nwhs eif rc pos civt cr ing n s te rcs o et cll m t rn wl
n rcio it p cic ee tr a tae et e e in h po es f x aeu r ar e e a
t a r la ix
a dc l rl rtn wha e h s m c a is s eo e rges e wae
n e po eaio , it g tee eh n m b c m po rsivl ekr
l if y

• O e n t f io t te te, P lityP na r a ityT t p pid
n is o in r ro h oh r a ol e t o P l oler e t e
e m m a

• E c a dess ifrn ap cs fh sina in po es ue inc m in tnte b oth p wr
a h d rse df e t s et o te k g g rcs, sd o b aio h y o s te o e
e
o ec o e
fah n

• M t y3 0 is sdina % c n e t tn
ar l0 0 ue
ix 3 o c nr io
a

MDI Complex (protects collagen)
• Inhibits the MMP enzymes that degrade and destroy collagen (matrix metalloproteinase)

• Found in: Intense Eye Repair, Overnight Hand Recovery

• MDI Complex (Gyoa in g c n)inhibits 80% of MMP enzyme activity
l sm o l a s
c y

• These enzymes (MMP) are activated with sun exposure, stress and environmental irritants

• Activity of these enzymes affects the health of the extracellular matrix

• Important to both preserve the matrix and maintain enzymatic equilibrium

• MDI Complex neutralizes excessive MMP activity

• Enzymatic equilibrium allows for greater skin elasticity and increased resistance to stress and
environmental exposure

ZO® Five Step Approach

STEP 1 CLEANSE
To enhance the effects and benefits of the following steps

STEP 2 ACTIVATE
To increase the penetration of active ingredients,

STEP 3 STIMULATE
To improve uneven pigmentation, reduce fine lines and
wrinkles, reduce collagen degradation and improve the
elasticity of the skin

STEP 4 CALM + NOURISH
To soothe and calm skin after the surface has been
exfoliated and potent concentrations have been applied

STEP 5 PROTECT
To protect skin against future sun damage

ZO® Skin Health Programs
LEVEL I: DAILY SKINCARE PROGRAM
LITTLE OR NO apparent sign of chronological or photo aging
Our Daily Skincare Program is an everyday skincare regimen to maintain healthy looking skin. These
basic tools have retinol and specialized enzymes to encourage cellular activity, repair damaged cells and
protect against future damage.

LEVEL II: ANTI-AGING PROGRAM
EARLY s ig ns of intrins ic ag ing – fine lines , uneven s kin tone, los s of firmnes s
T is o eae a ges epo rm w hh h a vn e a t g gsin aeto , h l t rp ir n
h m d rtl g rsiv rga , it ig l d a c d ni-a in k c r o l e s o e a a d
y y s p
pe e t a a e sin A tein rd ns s c a go t fcos rt o a ds e if
rvn d m g d k . civ ge ie t, u h s rwh a tr, ein l n p c ic
e zm s sis inim rv gtec ll rp iru cio a drsoin tea p aa c o
ny e a s t po in h eu re a fn t n n e tr g h p e rn e f
la
y uhu h a h sin
o tfl e l y k .
, t

LEVEL III: AGGRESSIVE ANTI-AGING PROGRAM
DEFINITE signs of aging skin – wrinkles, brown patches, loose skin, large pores,
obvious damage
This aggressive program, using high concentrations of retinol, is for anyone with chronological and
environmental skin damage and skin aging concerns. Using these tools can help correct and rejuvenate
the skin, revealing radical improvement of wrinkles, fine lines, rough texture and sagging skin.

3 Level Kit Program …A SIMPLE SELLING STRATEGY

LEVEL I:
DAILY SKINCARE PROGRAM
NO apparent s ig n of chronolog ical or photo ag ing

CLEANSE: Exfoliating Cleanser
ACTIVATE: Exfoliating Polish
STIMULATE: Daily Power Defense
PROTECT: Sunscreen Primer

LEVEL II:
ANTI-AGING PROGRAM
EARLY s ig ns of intrins ic ag ing – fine lines , uneven tone,
los s of firmnes s

CLEANSE: Exfoliating Cleanser
STIMULATE: Daily Power Defense (AM)
STIMULATE: Growth Factor Serum (PM)


LEVEL III:
AGGRESSIVE ANTI-AGING PROGRAM
DE FINITE s igns of aging s kin – wrinkles , brown patc hes ,
loos e s kin, large pores , obvious s un damage

CLEANSE: Hydrating Cleanser
STIMULATE: Daily Power Defense (AM)
STIMULATE: Radical Night Repair (PM)
CALM + NOURISH: Daily Renewal Crème

Step 1: Cleanse

Offects® Hydrating Cleanser
• Dual-action cleanser thoroughly cleans while
it replenishes moisture with hyaluronic acid.

• Natural moisturizers Panthenol and
Allantoin prevent over-drying, leaving skin
fresh and clean.

• Advanced lipopeptides boost and maintain
skin’s natural production of collagen.

• Cleanse every morning
and evening.

• pH 6.5

• Size: 150 mL / 5 Fl. Oz.

$45.00 (USSRP)

Step 1: Cleanse

Offects® Exfoliating Cleanser
• Encapsulated beads of Vitamin E neutralize
free radicals and nourish skin cells.

• Micro-beads exfoliate surface dull,
dry skin cells.

• Advanced lipopeptides boost and maintain
skin’s natural production of collagen.

• Cleanse every morning and evening.

• pH 6.0

• Size: 150 mL / 5 Fl. Oz.

$45.00 (USSRP)

Step 2: Activate

Offects® Exfoliating Polish
• Combines therapeutic minerals of the Dead
Sea with the benefits of microdermabrasion.

• Magnesium crystals slough off dry skin,
improve skin texture and help combat stress
and fluid retention.

• Four vitamins (A, C, C-Ester & E) deliver
anti-oxidant protection

• Natural exothermic reaction warms skin.

• Apply 2-3 times per week.

• Size: 65 g / 2 Oz.

$75.00 (USSRP)

Step 2: Activate

Offects® TE-Pads Acne Pore Treatment
• Controls skin breakouts.

• Reduces oiliness.

• Exfoliates pore-clogging dead
skin cells.

• Contains 2% salicylic acid

• Botanical extracts calm and soothe.

• Apply 2-3 times per week.

• Size: 60 pads

• pH 3.5

$45.00 (USSRP)

Step 3: Stimulate

Ossential® Radical Night Repair Plus

Better than any other topical skincare:

• Reduces lines and wrinkles
• Decreases hyperpigmentation
• Increases skin thickness and elasticity
• Accelerates cellular turnover, helps stimulate
collagen production

Named a Beauty Breakthrough

Why ZO®?

ZO® uses a 1.0% concentration of retinol

• For retinol to be topically effective, it must reach
a concentration of at least 0.6% in the skin

• Currently, the strongest available over-the-counter
retinol products are at a concentration of 0.21%

• The leading brand concentration is 0.15%

This is why the ZO® Skin Health Program
approach of “layering” retinol delivers the needed
amount of retinol to the skin.

Retinol Delivery System
Time-Released Microspheres
Traditional retinol products cause a sudden release and
"downpour" of retinol—which can be irritating. That’s why
manufacturers use a very low concentration of retinol.

ZO® Skin Health’s Radical Night Repair Plus
uses a unique delivery system–the retinol is encapsulated
in a time-released microsponge. So unlike the "downpour",
microspheres causes a slow, steady, continuous “drizzle”.

Anhydrous (water-free)
formula increases the potency of active ingredients.

Antioxidants (Vitamins C & E, Co-Q10)

Skinasensyl®
a peptide that increases skin’s natural tolerance threshold.
Users are much less likely to experience any discomfort,
which is especially beneficial to over-reactive and sensitive
skin.

Step 3: Stimulate

Dr. Obagi’s Recommended Regimen:

Olluminate Intensive Eye Repair can be added both AM and PM

PRODUCT AM PM

Offects® Hydrating Cleanser X X

Offects® Exfoliating Polish X

Ossential® Daily Power Defense X

Ommerse® Daily Renewal Creme X

Oclipse® Sunscreen + Primer SPF 30 X

Ossential® Radical Night
X
Repair Plus


Step 3: Stimulate

Usage

• Initially, Radical Night Repair Plus should be
applied twice per week. After two weeks,
increase to three times per week. After 6-8
weeks, apply nightly.
• This product is best used in combination with
other products that complement it, and do not
compete with it or irritate it.


Step 3: Stimulate

Ossential® Daily Power Defense
• Advanced DNA repair complex features enzymes that
initiate repair to increase cell survival, thereby reducing
collagen degradation.

• Contains Ultrasomes with UV-endonuclease

• Contains Roxisomes with glycolase

• Uses the powerful anti-oxidant, vitamin E and retinol
liposomes (Vitaine), to help correct and prevent
damage caused by age and UV rays.

• Increases skin’s natural moisture barrier to help skin
stay hydrated with Ceremide 6.

• Botanical extracts help soothe and calm.

• Lightweight serum leaves skin soft and smooth.

Step 3: Stimulate

Ossential® Daily Power Defense
• Reduced appearance of fine lines and wrinkles.

• Increases epidermal thickness, firmness & elasticity.

• Apply every morning.

• pH 6.8

• Size: 30 mL / 1 Fl. Oz.

$175.00 (USSRP)

Step 3: Stimulate

Ossential® Growth Factor Serum
• Synthetic growth factors.

• Advanced lipopeptides boost and support
collagen to help firm and tone.

• Nanoemulsion™ penetration technology
improves delivery.

• Proprietary lipopeptides are enhanced with
anti-aging Vitamins A, B & C plus essential
amino acids. These are the building blocks
necessary to stimulate cell renewal and
collagen production.

• Retinol reduces pigmentation and the
appearance of fine lines and wrinkles.

• pH 6.5

Step 3: Stimulate

• Highly effective topical anti-aging therapy
suitable for even the most sensitive skin
types.

• Lightweight gel formula glides
on easily.

• Apply every morning and evening.

• pH 6.5

• Size: 30 mL / 1.0 oz

$195.00 (USSRP)

Step 3: Stimulate

Clinicals (Kligman)

• Wrinkle Visibility (Superficial Facial Lines):
Statistically significant reduction after Week 1
(10%) and increased to 33% by Week 8.

• Expert Grader Assessment of Improvement:
High resolution digital photos revealed all
twenty subjects demonstrated “moderately to
very noticeable improvement”.

• Skin Texture: Skin roughness, pore visibility,
hyper pigmented spots and blotchy/redness
were significantly reduced from Week 2 on
and these reductions reached between 20 -
25% at Week 8.

Step 3: Stimulate

Clinicals (Kligman)

• Skin Tautness and Elasticity: From Week 1
on, skin was significantly tauter and more
elastic. At Week 8, skin was 28% tauter and
25% more elastic.

• Self Assessment (Diaries): All twenty subjects
felt their skin was smoother
and softer. Eighty percent perceived a
reduction in wrinkles and sixty percent found
their skin less oily and noticed a reduction in
age spots. No one reported any dryness or
peeling.

Step 4: Calm + Nourish

Ommerse® Daily Renewal Crème
• Hydrates with Hyaluronic Acid, Jojoba
Esters and natural emollients like
Coconut Oil.

• Soothes with an advanced anti-irritant
complex that contains Oat and
Canadian Willowherb Extracts to reduce
skin inflammation.

•Contains Oxysomes and Vitaine (retinol)

• Protects with Ectoin, a multi-functional
agent that protects against photo-aging,
the formation of sunburn cells and
induces faster formation of heat-shock
proteins under stress.

•pH 6.8

• Size: 50 mL / 1.7 oz

$95.00 (USSRP)


Ommerse® Overnight Recovery Crème
• Hydrates the skin by creating a barrier that
protects against trans-epidermal water loss
with Ceramide 2, Soline, Squalane and Shea
Butter to maintain optimum water levels.

• Repairs DNA damage caused by aging and sun
exposure by using encapsulated enzymes called
Ultrasomes (endonuclease) to increase cell
survival

• Soothes, protects and reduces redness and
inflammation with Canadian Willowherb and
Evodia Fruit Extracts

• Encourages skin to look and feel healthy and
luminous with encapsulated Retinol (vitaine)

•pH 5.5

• Size: 50 mL / 1.7 oz

$95.00 (USSRP)

Step 5: Protect

Oclipse® Sunscreen + Primer SPF 30
• Broad spectrum UVA/UVB protection with
titanium dioxide (10.2%) and zinc oxide
(3.7%), plus unique and superior
antioxidant protection.

• Contains natural melanin

• Melanins are natural, photo-protective
compounds which are excellent anti-
oxidants and free radical quenchers.

• Increased melanin reduces incidence of
skin cancer, photo-aging and photo-
sensitive disorders.

• Silicone-based formula primes the skin for
cosmetics application.


$65.00 (USSRP)

Step 5: Protect

Oclipse® Sunscreen + Primer SPF 30

The “smartest” sun-protection duo
under the sun:

•Daily Power Defense
DNA Repair

•Sunscreen Primer
SPF 30

Skin Cancer
Prevention is Critical

500,000
new cases of skin cancer
every year (US)

27,000
cases of malignant melanoma

80%
of damage occurs before
18 years old

Melanin

• A natural skin pigment

• Single most important factor in the
photo protection of the skin

• 10 times more powerful than Vitamin E

Specialty: Eye

Olluminate® Intense Eye Repair
• Dual action formula instantly reduces the
appearance of fine lines and wrinkles while
providing long-lasting results.
• Rich blend of time release retinol (Vitaine),
advanced peptides and optical diffusers (mica
and titanium dioxide) helps repair and diminish
dark circles, fine lines and wrinkles.
• Cooling formula reduces puffiness and the
appearance of yellow skin tone.
• Combination of Glycosaminoglycans, Vitamin E
and Matrixyl 3000 protects against free radical
damage and boosts skin’s natural collagen
production.
• Apply every morning and evening.
• pH 6.2
• Size: 15 mL / .5 Fl. Oz.
$130.00 (USSRP)

Specialty: Hand

Oraser® Microderm Hand Renewal
• Sugar crystals exfoliate the skin, leaving it
smooth, hydrated and
super-soft.

• Retinol, an active form of Vitamin A, helps
restore a youthful appearance.

• Shea butter moisturizes and leaves
a light after-feel. Rinses easily.

• Massage at least once a week.

• Size: 30 g / 1.0 Oz.

$50.00 (USSRP)

Specialty: Hand

Oraser® Daily Hand Repair SPF 20
• Retinol reduces age spots and the look of
deeper lines and wrinkles.

• Powerful vitamin E and anti-oxidants help
neutralize damaging free radicals.

• Skin whiteners help normalize skin tone and
reduce the appearance of age spots.

• Broad spectrum protection (avobenzone)
against UVA (aging rays) and UVB (burning
rays)


• pH 6.0

• Size: 100 mL / 3.4 Fl. Oz.

$65.00 (USSRP)

Specialty: Hand

Oraser® Overnight Hand Recovery
• A complex of retinol, vitamins and Coenzyme
Q10 protects against the damaging effects
• of free radicals, thereby improving skin
elasticity, firmness and tone.

• Vitamin C brightens the skin
and boosts collagen synthesis.

• Natural emollients provide
8-hour barrier protection.

• Apply every evening.

• pH 6.0

• Size: 100 mL / 3.4 Fl. Oz.

$65.00 (USSRP)

Specialty: Body

Oraser® Body Emulsion
• Intense combination of Lactic Acid (11.5%),
active Retinol and emollients lock in moisture
and stimulate cell renewal.

• Anti-oxidant rich complex softens rough patches
and strengthens skin’s natural moisture barrier.

• Lifts away the look of dark spots with natural
extracts such as Glucosamine. Skin brighteners
help normalize skin tone.

• Apply morning and evening.

• pH 3.7

• Size: 200 mL / 8.1 Fl. Oz.

$80.00 (USSRP)

Step 1: Cleanse

Product Name Ingredients & Benefits
Offects® Exfoliating Cleanser Gently remove impurities and repairs surface damage with:

Vitamin E encapsulated beads:
• Neutralize free radicals and exfoliate dead skin cells

Salicylic Acid
•targets excess oil

Advanced Lipopeptide:
• Boosts skin’s natural production of collagen

Offects® Hydrating Cleanser Gently remove impurities and repairs surface damage with:

Hyaluronic acid, Panthenol and Allantoin:
• Lock in necessary moisture for a healthy complexion
• Stimulate the growth of healthy tissue

Advanced Lipopeptide:

Step 2: Activate

Offects® TE-Pads Enhance the penetration of active ingredients.
Acne Pore Treatment Control oiliness, breakouts and removes dead cells with:

2% Salicylic Acid
• Exfoliates pore-clogging skin cells
• Reduces oiliness to help prevent breakouts

Botanical Extracts
• Calm and soothe skin

Offects® Exfoliating Polish Enhances the penetration of active ingredients. Remove
dead skin cells and sebum with:

Round Magnesium Crystals
• Slough off dry skin
• Improve skin texture (smoothness)
• Restores glow
• At-home benefits of microdermabrasion activate and
repair skin cells

Four Vitamins (A, C, C-esters and E)
• Provide a powerful anti-oxidant protection

Step 3: Stimulate
Ossential® Daily DNA repair and anti-oxidant protection with:
Daily Power Defense Enzymes (Ultrasomes and Roxisomes)
• Encourage the skin’s DNA repair mechanism to self-correct
Powerful anti-oxidants (Vitamin A & E)
• Speed recovery from past UV damage
• Help prevent future photo damage
Retinol and Matrixyl 3000
• Reduce appearance of fine lines and wrinkles
• Even skin tone and improve hyper pigmentation
• Increase dermal thickness and firmness
Omega-6 Ceramide
• Lock-in moisture
• Reduce inflammation
Ossential® Collagen booster helps firm and tone with:
Growth Factor Serum Lipopeptides, Amino-Acids and Vitamins A, B & C Derivative
• Boost collagen production
• Increase dermal thickness and elasticity
Epidermal Growth Factor
• Stimulates cellular function
• Reduces fine lines and wrinkles
• Well tolerated by sensitive skin types
Retinol
• Reduces appearance of fine lines and wrinkles
• Evens skin tone and improves hyper pigmentation
• Increases dermal thickness and firmness

Step 3: Stimulate
Ossential® Radical Night Repair Plus Restore functionality, skin elasticity and improve uneven
pigmentation with:
Ultra-high concentration of Retinol: 1%
• 10 times the industry average
• Encapsulated time-release formula to increase penetration
and reduce irritation
Vitamin C:
• Boosts skin brightness; improves skin tone and clarity
• Provides anti-oxidant protection
• Continuously stimulates cells for optimal collagen production
and elasticity improvement
Antioxidants (Vitamins C & E, Co-Q10)
• Neutralizes free radicals to help reverse the signs of aging
• A Crithmum Maritinum Marine Extract
• Regulates sebum to help control acne and oiliness

Ommerse® Hydrate,calm and nourish skin with:
Daily Renewal Crème Hyaluronic Acid, Jojoba Esters and natural Emollients
• Nourish skin
Advanced anti-irritant complex with Oat and Canadian Willowherb extracts
• Soothes and reduces inflammation
Retinol
Advanced Oxysome liposome system
• Delivers Vitamins C & E deeper beneath the surface
• Evens skin tone
Ectoin
• Protects skin’s immune system
• Protects against photo-aging and the formation of sunburn cells

Ommerse® Deeply soothe, calm and nourish skin with:
Overnight Recovery Ceramide 2, Soline, Squalane and Shea Butter
Crème • Nourish skin
• Protect against Trans Epidermal Water Loss
Advanced anti-irritant complex with Oat and Canadian Willowherb extracts
• Soothes and reduces inflammation
Ultrasomes (enzymes)
• Repairs DNA damage to increase cell survival
Retinol

Step 5: Protect, Specialty: Eye

Oclipse® Sunscreen + Primer Protect, smooth and prime skin for even makeup application with:
SPF 30 Natural Melanin, Titanium Dioxide (10.2%) and Zinc Oxide (3.7%)
• Protect against UVA/UVB sun damage to reduce the visible signs of
aging
Lipopeptides
• Stimulate collagen production
Humectants and Emollients:
• Hydrate and moisturize skin

Olluminate® Intense Eye Repair, brighten and decrease puffiness with:
Repair A blend of encapsulated Retinol, Advanced Peptides and Optical
Diffusers
• Instantly and continuously help to repair fine lines and wrinkles
• Increase epidermal thickness, firmness, elasticity and hydration
Mica and Titanium Dioxide
• Brightens eye area, minimizes dark circles, reduces puffiness, and
the appearance of yellow skin tone
MDI Complex (Glycosaminoglycans)
• Boost skin’s natural collagen production
Vitamin E
• Protects against free radical damage

Specialty: Hand + Body
Oraser® Body Emulsion Smooth, hydrate and even skin tone with:
Lactic Acid (11.5%) and an anti-oxidant rich complex
• Remove dead surface cells
• Smooth rough, dry patches
Glucosamine
• Reduces the appearance of dark spots
• Evens skin tone
• Boost cellular turnover
• Even skin tone and improves hyper pigmentation
Emollients
• Hydrate immediately
• Deliver long lasting moisture

Oraser® Microderm Hand Renewal Exfoliate, soften and condition hands with:
Shea Butter, Mango Butter and Safflower Oil
• Resurface and condition even ultra-dry skin
Sugar Crystals and Salicylic Acid
• Exfoliate dry skin, improve skin texture and leave hands
smooth
Retinol
Natural emollients
• Leave skin soft and moisturized with light after feel

Specialty: Hand
Oraser® Daily Hand Repair Protect against UVA/UVB sun damage (avobenzone 3%) and restore
SPF 20 younger-looking hands with:
• Boost cellular turnover
• Even skin tone and improve hyper pigmentation
Amino-Acid Complex (Panthenol, Shea Butter and Hyaluronic acid)
• Moisturizes and leaves skin soft and smooth
Anti-oxidants Vitamins C, E and Coenzyme-Q10
• Neutralize damaging free radicals

Oraser® Overnight Hand Relieve dryness and fight signs of aging with:
Recovery Encapsulated Retinol, Vitamins C, E and Coenzyme-10
• Improve skin elasticity, firmness and tone
• Protect against the damaging effects of free radicals
Vitamin C
• Brightens skin
• Boosts collagen production
Natural Emollients (Avocado Oil, Shea Butter, Meadowfoam Seed Oil
and Hyaluronic Filling Spheres)
• Moisturize continuously overnight
• Prevent Trans-Epidermal Water Loss (TEWL)
Bisabolol
• Soothes inflammation

Unique & Compelling
Brand Proposition

Systems and Programs that produce results

•System approach to correct, stimulate and saturate
•Luxury and performance should not be mutually exclusive
•Unique value proposition
•Worldwide brand recognition and reputation
•Higher concentrations, more actives, stabilized retinol
•Results driven, serious skincare

Linda Nelson Director of Education
lnelson@zoskinhealth.com
858-794-9601 Office
619-438-3554 Mobile

www.zoskinhealth.com

Comprehensive Skin Health Solutions from ZO Skin Health

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