Conferencia: “El Cerebro: ese gran desconocido”, a cargo del Dr. Niels Birbaumer, Profesor de la Universidad de Tübingen. TECNALIA Perspectives 2015. “Industria y Tecnología: Investigación traslacional, de la ciencia al mercado” es el título del evento que contó con la participación del Dr. Niels Birbaumer, experto mundial en el desarrollo de interfaces cerebro-computador y del investigador Dr. Ander Ramos, Premio al Mejor Investigador Joven de Alemania en 2014 por la Academia Alemana para las Ciencias y las Letras. También presentamos dos novedosas iniciativas de TECNALIA como son un dispositivo de estimulación eléctrica funcional para rehabilitación de pacientes de ictus y el robot quirúrgico con visión 3D y sensaciones táctiles. Más información en http://www.tecnalia.com

1. 1

3. Nicolelis, Nature 2001

4. Andrew Schwartz, Nature( 2008)

5. Cortical Neuroprosthesis for Restoring Motor Functions
Nicolelis & Chapin. Scientific American,
2002
Nicolelis, Sc.American

7. Kotchoubey et al. (2001) Epilepsia

8. training
Neurofeedback in ADHD
patient‘s screen
trainer‘s screenpatient
amplifier
Strehl et al. Pediatrics (2006)

9. Near Infrared Spectroscopy-
BCI in Attention
Deficit Disorder
From Ranganatha Sitaram et al Neuroimage, 2007

10. The fMRI-BCI

11. Birbaumer et al., Arch.Gen.Psychiatry (2005)

12. Near Infrared Spectroscopy (NIRS) for Operant Training of Cerebral Oxygenation
R R R
session 1 session 2 session 3
t-wert
fMRI-BCI-Training of BOLD-Increase in the Right Anterior Insula
Caria et al, Neuroimage 2007

13. Caria et al. (2010) Biol.Psychiatry

14. Session number
Linear increase of activation over time in the left insula
Criminal Psychopaths
Caria et al 2013
Sitaram et al 2014

15. 15
• Significant reductions in Physical Aggression (pre-post)
Pre-Post Measure Results
r= -.492,
p=.037
PhysicalAggressiont2-t1
(BPAQ)
SCP- Differentiation
• are sign. related to SCP-Training
performance
• Reductions in Behavioral
Approach are sign. related to
SCP-Training performance
• Reactive Agg. & Agg. Inhibition (FAF)
are sign. related to SCP-Training
performance (Konicar et
al., 2014)

16. Science, 2002

17. Birbaumer et al. Nature (1999)
Kübler & Birbaumer(2008) Clin.Neurophysiol.
Birbaumer et al. Current Opinion in Neurology, 2008

18. Source:Report in Newsweek of Birbaumer et al. Nature (1999)

19. George (with patient‘s permission)

20. Completely locked-in patient GR with 120 electrode grid implanted
êpidurally left fronto-central cortex
Imagery of hand movement"
“Yes"
Imagery of foot movement
“no“
Ramos et al (2011)

21. Semantic Classical Conditioning
Thinking
YES
„Berlin is the Capital of Germany“
No Stim
&
CS Left
Change in
EEG
(EKG)
Thinking
NO
„Berlin is the Capital of Spain“
Aversive Stim.
&
CS
Change in
EEG
(EKG)
Furdea et al. (2012) J.Neurosc.MethodsDeMassari et al, Brain (2013)

22. NIRS Signal for
Yes and No
EEG Signal for
Yes and No
NIRS Signal Acquisition System EEG Signal Acquisition System
NIRS Feedback
ALS patient attending to
auditory stimuli
NIRS optodes + EEG
electrodes placed on the
motor region of the patient
Feature Extraction
Changes in oxy or de-oxy
hemoglobin for Yes and No
Train the NIRS SVM
classifer
Patient are presented 20 personal
questions, 10 true and 10 true false
in random order in each session
Patient thinking “ja” and “Nein,”
for true and false sentence,
respectively for 15 sec.
Sleep Monitoring and
offline signal classification
Chaudhary, U. & Birbaumer, N. submitted

27. Katrin,W. 23y., Juvenile ALS. Completely Locked-In. With her and family‘s permission
Questions with known answers plus feedback of NIRS classification

28. Completely locked-in (CLIS)
Patient W.F.
Communication with NIRS-
Brain Machine-Interface (BMI):
Blue bars: questions with known
Answers
Orange bars: open questions
Black dots below last session-
Period: questions asked by
Unknown voice
Permission of legal guardian
(husband)
From Gallegos-Ayala et al,
Neurology (2014)

29. Fun lojter hofenung wer ich noch
meschuge.
Sono matto di speranza
I am mad with hope.
Estoy loco de esperanza
Vor lauter Hoffnung werd‘ ich noch verrückt.
Itxaropena izugarria daukat
Jiddish Saying

30. 30