This document summarizes various oral manifestations of systemic diseases. It discusses oral signs of gastrointestinal diseases like ulcers and glossitis in celiac disease. It also covers oral signs of liver diseases like bleeding tendency in alcoholic cirrhosis. Further, it outlines oral manifestations of hematological conditions like gingival hypertrophy in leukemia. The document also discusses oral signs of endocrine, pulmonary, renal and nutritional deficiencies. Finally, it examines various oral lesions like aphthous ulcers, changes in tongue coating, and disorders of the salivary glands.
AIDS is defined as a condition indicative of a defect in cell-mediated immunity occurring in a person with no known cause for immunodeficiency other than the presence of HIV.
CDC defined AIDS as
“The occurrence of one or more group of life-threatening opportunistic infections, malignancies, neurologic diseases and other specific illness in patients with HIV infection or with CD4 counts less than 200/cu mm”
AIDS is defined as a condition indicative of a defect in cell-mediated immunity occurring in a person with no known cause for immunodeficiency other than the presence of HIV.
CDC defined AIDS as
“The occurrence of one or more group of life-threatening opportunistic infections, malignancies, neurologic diseases and other specific illness in patients with HIV infection or with CD4 counts less than 200/cu mm”
Morphologically altered tissue in which cancer is more likely to occur than its apparently normal counter part.
-WHO(1978)
Definition
Leukoplakia is defined as ‘white patch’ or ‘plaque’ in the oral cavity, which cannot be scraped off or stripped off easily and more over which cannot be charectarized clinically or pathologically as any other disease. –WHO
Redefined as a “ predominantly white lesion of oral mucosa that cannot be characterized as any other definable lesion; some oral leukoplakia will transform into cancer” (Axell T, 1996)
Homogenous Leukoplakia
Non-Homogenous Leukoplakia
Granular or Nodular Leukoplakia
Speckled or Erythroleukoplakia
Verruciform Leukoplakia
Proliferative Verrucous Leukoplakia
Morphologically altered tissue in which cancer is more likely to occur than its apparently normal counter part.
-WHO(1978)
Definition
Leukoplakia is defined as ‘white patch’ or ‘plaque’ in the oral cavity, which cannot be scraped off or stripped off easily and more over which cannot be charectarized clinically or pathologically as any other disease. –WHO
Redefined as a “ predominantly white lesion of oral mucosa that cannot be characterized as any other definable lesion; some oral leukoplakia will transform into cancer” (Axell T, 1996)
Homogenous Leukoplakia
Non-Homogenous Leukoplakia
Granular or Nodular Leukoplakia
Speckled or Erythroleukoplakia
Verruciform Leukoplakia
Proliferative Verrucous Leukoplakia
Richard Frye, MD, PhD, FAAP, FAAN, CPI, will discuss:
*The enteric (gut) microbiome has an important influence on health and disease states in humans.
* The enteric microbiome influences the human host using chemical mediators, some of which can directly affect mitochondrial function
* Short chain fatty acids produced by gut bacteria not only modulate mitochondrial function and cellular regulatory pathways, but can also be used as mitochondrial fuels.
Science Cabaret by Dr. Rodney Dietert "How to train your super organism..via ...Kitty Gifford
Attendees (and their microbes) at this event enjoyed a lively discussion on how we might better interact with our environment to support a healthier life for ourselves and our children. Think with your microbes about why we have to suffer from ever-increasing numbers of debilitating chronic diseases (asthma, food allergies, diabetes, autoimmune conditions, obesity, heart disease and cancer).
with Dr. Rodney Dietert, Cornell University Professor, Department of Microbiology and Immunology
Dr. Rodney Dietert is an internationally-known author, lecturer, scientist, book series editor, and educator. He is the author of Strategies for Protecting Your Child’s Immune System, and Science Sifting: Tools for Innovation in Science and Technology.
Human nutrition, gut microbiome and immune system S'eclairer
Dr Zahida Chaudnary talks with the students about nutrition, gut microbiomes, and nutrition as we look at diseases and how your body reacts to what you eat.
Check out the slideshow by itself here.
Want an audio version? Subscribe to our Podcast on iTunes!
Want to join us for the live discussion? Check out our Social Media in the noon hour every Monday as we sit down on Google Hangout OnAir! Follow us on Twitter, Facebook, or Google+ to get updated with the link when we start!
Many systemic diseases are reflected in the oral mucosa, maxilla, and mandible.
Mucosal changes may include ulceration or mucosal bleeding.
Immunodeficiency can lead to opportunistic diseases such as infection and neoplasia.
Bone disease can affect the maxilla and mandible.
Systemic disease can cause dental and periodontal changes.
Drugs prescribed for a systemic disease can affect oral tissue.
Children have oral mucosal conditions and other head and neck medical problems which have both similarities and differences to those found in adults .
A wide variety of oral lesions and soft tissue anomalies are detected in children, but the low frequency at which many of these entities occur makes them challenging to clinically diagnose.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Best Ayurvedic medicine for Gas and IndigestionSwastikAyurveda
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
3. Background
- The mouth (buccal cavity)
is the reservoir for the
chewing and mixing of
food with saliva.
- It is the primary site of
digestion and respiration
as well as the primary
communication structure.
12. • Sjögren syndrome
– autoimmune disease
– men : women - 1 : 9, 50 years and older
Main signs
– sicca syndrome
– keratoconjuctivitis sicca
– xerostomia
Oral signs
– decrease in saliva
• xerostomia
– dry, red, wrinkled mucosa
• difficulty in swalloving and eating
• disturbance in taste and speech
• increased dental caries
• infections
• atrophy of the papilae
• candidiasis
Connective-tissue diseases
13. • Kawasaki disease
– vasculitis of medium and large arteries
Oral signs
– swelling of papilae on the surface of the
tongue (strawbery tongue)
– intense erythema of the mucosal
surfaces
– cracked, cherry red, swolen and
hemorrhagic lips
Connective-tissue diseases
14. • Scleroderma
– diffuse sclerosis of the skin, GIT,
heart muscle, lungs, kidney
Oral signs
– pursed lips – dificult to open the
mouth
– esophageal sclerosis
gastroesophageal reflux – damage
of enamel
– pale, rigid mucosa
– teleangiectasias
– decreased mobility of tongue
– salivary hypofunction
Connective-tissue diseases
Limited mouth opening and decreased
tongue mobility
Gingival retraction
21. • Cushing´s syndrome
– osteoporosis pathological
fractures of the mandible,
maxilla or alveolar bone
– delayed healing of fractures
and soft tissue injuries
• Addison´s disease
– oral mucosal melanosis –
buccal mucosa, tongue
Endocrine diseases
moon face
hyperpigmentation
22. • Uremic stomatitis
– in undiagnosed and untreated chronic renal
failure
– irritation and chemical injury of mucosa by
ammonia or ammonium compounds
Signs
– painful plagues and crusts – bucal mucosa,
the floor or dosrum of the tongue, floor of the
mouth
– Type I
• generalized or localized erythema
• exudate
• pain, burning, xerostomia, halitosis,
gingival bleeding, candidiosis
– Type II
• ulceration
• secondary infection
• anemia
Renal diseases
24. Nutritional Deficiencies
• Thiamine (Vitamin B1) and Niacin/nicotinic acid
(Vitamin B3) are also reported to cause some glossitis
and cheilitis.
• Folate deficiency leads to a megaloblastic anemia that
demonstrates many of the same oral characteristics of
pernicious anemia.
• Scurvy caused by vitamin C deficiency may cause
petechiae to ecchymoses in the submucosa.
• Mucous membrane changes may lead to gingival
hypertrophy and erosive, bleeding gums.
25. Disorders of Teeth
DISORDER FINDINGS
Bulimia Erosion of enamel and loss of dentin
Congenital
cytomegalovirus
Yellow dentin and hypoplastic pitted
enamel
Congenital
porphyria
Erythrodontia of canine teeth and molars
and brown discoloration of incisors
Congenital
syphilis
Hutchinson teeth, mulberry molars
Gardner
syndrome
Supernumerary teeth
Dr. TAREK SHETA, M.D
26. Disorders of Teeth
Lepromatous leprosy Reddening of upper teeth (pink spots)
Primary biliary
cirrhosis
Green pigment deposits
Sjogren syndrome Caries, increased plaque accumulation, poor
oral hygiene
GERD Erosion of enamel due to repeated exposure to
gastric acid
Tetracycline staining Permanent gray discoloration
Tuberous sclerosis Pitted enamel of the permanent teeth
Dr. TAREK SHETA, M.D
27. Periodontitis
Definition -chronic infection of connective tissue, periodontal
ligament and alveolar bone
Aetiology: diabetes, heart disease, stroke and preterm birth
birth control pills , steroids, Down syndrome, Langerhans cell
histiocytosis, HIV
29. Aphthous ulceration
• Acute, recurrent,
painful ulcers on
nonkeratinized
mucosa
• Most common
cause of oral
ulcerations
• Effect up to 30 %
of the population
Dr. TAREK SHETA, M.D
30. Aphthous ulceration
Minor aphthae
(90 -95 %)
Major aphthae
(5-10%)
Herpetiform
ulcers
(1-5%)
Age of onset Childhood or
adolescence
Childhood or
adolescence
Young adult
Ulcer size 2–4 mm 10 mm or larger Initially tiny, but
ulcers coalesce
Number of ulcers Up to about 6 Up to about 6 10–100
Sites Mainly vestibule,
labial, buccal
mucosa &
floor of mouth
Any site Any site but often
on ventrum of
tongue
Duration of each
ulcer
Up to 10 days Up to 1 month Up to 1 month
39. Normal tongue coating is formed of:
1- Tongue papillae.
2- Food debris.
3- Bacteria.
4- Desquamated epithelium.
Dr. TAREK SHETA, M.D
40. The tongue coating
varies in different individuals.
Varies in the same individual during the day
It is continuously formed
it is marked in the morning and is removed by:
1-Mechanical factors: speaking and chewing food.
2-Salivary flow
Dr. TAREK SHETA, M.D
41. Tongue coating is in a continuous
process of removal and formation.
- If removal exceeds formation
atrophy
- If formation exceeds removal
increased tongue coating.
Dr. TAREK SHETA, M.D
43. 1- Deficient or impaired utilization of
nutrients
1-Iron deficiency anemia.
3-Vitamin B deficiency especially (vitamin B2,
B6, B12, folic acid and nicotinic acid).
Pernicious anemia.
4-Anemia associated with parasitic infection as
ascaris and bilhariziasis.
5-Malnutrition, malabsorption.
6-Chronic alcoholism.
Etiology
Dr. TAREK SHETA, M.D
45. 3- Drugs
-Drugs that:
• Interfere with the growth and maturation
of the epithelium e.g cyclosporine.
• Induce candidosis e.g. antibiotic, steroid.
• Induce xerostomia e.g anticholinergic
drugs, radiotherapy.
Dr. TAREK SHETA, M.D
46. 4- Miscellaneous
1- Frictional irritation: atrophy at tip &
lateral borders of tongue.
2- Atrophic lichen planus.
3- Epidermolysis bullosa: ulceration
healed by scar.
4- Long standing xerostomia.
5- Diabetes and chronic candidiasis may
produce a lesion called central papillary
atrophy.
Dr. TAREK SHETA, M.D
48. White hairy tongue
• hypertrophy of filiform papillae resembling hair-
like projections
• Aetiology:- heavy tobacco use, mouth breathing,
antibiotic therapy, poor oral hygiene, general
debilitation, radiation therapy, chronic use of
bismuth containing antacids, lack of dietary
roughage, Febrile illness.
• White, yellow green, brown, or black color is due
to chromogenic bacteria or staining from
exogenous sources
52. Geographic tongue
• benign inflammatory condition,
due to Loss of filiform papillae
• Erythematous plaques with well
demarcated white border
• Etiology- diabetes mellitus,
anemia, hormonal disturbances,
psoriasis, Reiter syndrome,
atopic dermatitis,, Down
syndrome, lithium therapy
53. Fissured tongue (furrowed tongue,
scrotal tongue, grooved tongue)
• normal variant in 5-
11% individuals
• Also seen in :
psoriasis, Down
syndrome,
acromegaly, Sjogren
syndrome
57. Macroglossia
• CP: Difficult mastication
and speech and accidental
tongue biting
• CAUSES:
– Down syndrome,
– hypothyroidism,
– neurofibromatosis,
– infection by mycobacteria,
– amyloidosis
58. The stratified squamous epith. if chronically irritated by:
Chemical: spices.
Thermal: smoking.
Infection: syphilis.
Mechanical: dental irritation.
Formed by thickening and hyperkeratinization with the
formation of white patches.
Precancerous: biopsy
Leukoplakia of the tongue
Dr. TAREK SHETA, M.D
59. Oral hairy leukoplakia
• caused by Epstein-Barr
virus, presents as
asymptomatic,
corrugated, white plaques
with accentuation of
vertical folds along the
lateral borders of tongue
• Mainly seen in HIV
infection, organ transplant
recipients and patients on
chemotherapy
Dr. TAREK SHETA, M.D