Пероральні матриксні таблетки – лікарська форма для пролонгації вивільнення активного фармацевтичного інгредієнта (Валентин Могилюк)

•

0 recomendaciones•322 vistas

Пероральные матричные таблетки - лекарственная форма для пролонгации высвобождения активного фармацевтического ингредиента

Salud y medicina

Пероральні матриксні таблетки – лікарська форма для пролонгації вивільнення активного фармацевтичного інгредієнта (Валентин Могилюк)

Más contenido relacionado

Más de Valentyn Mohylyuk

PATVIS APA: visual inspection system for automated particle analysis

Valentyn Mohylyuk

NETZSCH Nevio Instrument Series for THERMAL ANALYSIS

Valentyn Mohylyuk

Purpose Fluid-bed coating of microparticles using aqueous polymer dispersions is a challenge due to particle agglomeration. Agglomeration is an undesirable phenomenon especially for modified release products resulting in inconsistent and unreliable coating thickness and drug release profile. Due to the small particle size and relatively high coating level, the determination of agglomerated particles is complicated and cannot be performed by common methods such as sieve analysis and observation under light microscope. The objective of this study was to investigate appropriate methods to determine the internal structure of coated microparticles to support decision making in the formulation and coating process development.

2018.10.05. aaps. particles investigation

Valentyn Mohylyuk

Purpose Most oral dosage forms such as tablets and capsules are not suitable for older people with swallowing difficulties. Capsules opening and tablet crushing are commonly used to overcome this problem. In addition to safety and legal concerns, this approach cannot be applied to sustained release products because of the loss of their functionality, consequently causing dose dumping and, undesirable side effects and even toxicity. The number of appropriate medicines for older patients with swallowing difficulties is limited because of the absence of appropriate oral dosage forms. One of the most appropriate forms of medicines for patients with swallowing difficulties are liquid formulations. To overcome the described issues in older patients with dysphagia, the present study aimed at the development of film-coated sustained release microparticles for use in redispersible multi-dose oral suspensions to ensure facilitated swallowing and acceptable shelf life.

2018.10.03. aaps sr supension

Valentyn Mohylyuk

The present study was aimed at the development of a redispersible multi-dose suspension based on coated microparticles to ensure easy swallowing and sustained release of metoprolol succinate. To provide sustained release of metoprolol succinate, the microparticles were prepared by drug loading and Eudragit NM coating in a fluid-bed coater. Compositions of the liquid suspension vehicle were selected to reduce solubility of metoprolol succinate. The effect of vehicle composition and suspension storage time at RT on drug leaching into the suspension vehicle and on the drug release profile were investigated. The approach allowed a redispersible multi-dose suspension of metoprolol microparticles which, after one month storage, displayed negligible drug leaching into the suspension vehicle and a sustained release profile comparable to the profile before storage.

2018.09.07. APS@FIP poster "Development of multi-dose oral sustained release ...

Valentyn Mohylyuk

The present study was aimed at the development of a re-dispersible multi-dose suspension based on coated microparticles to ensure easy swallowing and sustained release of metoprolol succinate. To provide sustained release of metoprolol succinate, the microparticles were prepared by drug loading and Eudragit® NM coating in a fluid-bed coater. Compositions of the liquid suspension vehicle were selected to reduce solubility of metoprolol succinate. The effect of vehicle composition and suspension storage time at RT on drug leaching into the suspension vehicle and on the drug release profile were investigated. The approach allowed a re-dispersible multi-dose suspension of metoprolol microparticles which, after one month’s storage, displayed negligible drug leaching into the suspension vehicle and a sustained release profile comparable to the profile before storage.

2018.09.07. Development of multi-dose oral sustained release suspensions for ...

Valentyn Mohylyuk

2017.10.18. Обзор мероприятия: Индустрия 4.0: Тенденции в области фармацевтич...

Valentyn Mohylyuk

2017.11.07-08. Medicines for older adults:

Valentyn Mohylyuk

2017.06.13 14. 3rd tech seminar from shin etsu (bradford england)

Valentyn Mohylyuk

ANNOTATION Mohylyuk V.V. Scientific and practical substantiation of formulation and technology of sustained release matrix tablets. Case study: Trimetazidine dihydrochloride. – Manuscript. A thesis for the Candidate of Pharmacy Degree in specialty 15.00.01. – Technology of drugs, organization of pharmaceutical business and forensic pharmacy. – Shupyk National Medical Academy of Postgraduate Education, Kyiv, 2016. Dissertation is dedicated to the study of factors affecting the release kinetics of freely soluble active pharmaceutical ingredient trimetazidine dihydrochloride (TMZ•2HCl) in vitro from matrix tablets produced using direct compression method. Effect of soluble matrix formers on TMZ•2HCl release profile from matrix tablets was conducted. It was experimentally established that matrix former release prolongation possibility increased with increasing of possibility to form viscous solutions in water: Klucel HXF > Methocel K15M > Polyox WSR-301 > Kollidon K-90 for different polymers and Methocel K100M > K15M > K100LV for same polymers with different molecular weight. Slowdown of release in the release medium with pH 6.8 was due to the interaction of TMZ•2HCl and Carbopol 71G with rubber-like layer formation. It was experimentally established that effect of insoluble matrix formers on TMZ•2HCl release profile from matrix tablets was in sequence: Ethocel 10 > Precirol ATO 5 ≈ Kollidon SR > Eudragit RSPO. Swelling of Kollidon SR matrix was due to elastic recovery of spherical shape of polymer particles and polyvinyl acetate swelling upon hydration. Diluents type effect on TMZ•2HCl dissolution profile was investigated. Soluble (sorbitol), insoluble (calcium hydrogen phosphate dihydrate), insoluble and swellable (cellulose microcrystalline) diluents were used. Faster TMZ•2HCl release from Ethocel 10, Kollidon SR and Methocel K4M matrix tablets with sorbitol than Emcompress and Avicel PH-101 was established. During determination of Emcompress and Avicel PH-101 effect on release kinetics from matrix tablets with different matrix formers were established that release was faster using: Avicel PH-101 in insoluble unswellable matrix of Ethocel 10; Emcompress in insoluble swellable matrix of Kollidon SR; Avicel PH-101 in soluble swellable matrix of Methocel K4М. It was established that TMZ•2HCl release kinetics from matrix tablets with Ethocel 10, Kollidon SR and Methocel K4M and Emcompress diluent was higher in pH 1 medium than in pH 6.8 which is consistent with pH-dependent Emcompress solubility. Soluble diluents particle size effect on TMZ•2HCl dissolution profile was also investigated. Decreasing of TMZ•2HCl dissolution kinetics from Ethocel 10 matrix tablets with lactose and sorbitol particle size increasing was established. The dissolution kinetics from Kollidon

2016.02.17. Extract from PhD Dissertation (Mohylyuk Valentyn)

Valentyn Mohylyuk

11 International Controlled Release Seminar

Valentyn Mohylyuk

2017. Micropellets coated with Kollicoat Smartseal 30 D (Full version)

Valentyn Mohylyuk

«Тенденции в области фармацевтического производства и технологий в контексте развития украинского фармрынка» Панельная дискуссия Конференция началась с панельной дискуссии с участием двух экспертов, работающих в украинских фармацевтических компаниях, – андрея гоя, руководителя департамента исследований и разработок ПАО «Фармак», и валентина могилюка, менеджера по стратегическому развитию ООО «Юнифарма».

2016.10.19. конференция

Valentyn Mohylyuk

2016. Dosage Form Optimization: Technology to Advance the Patient-Centric Dru...

Valentyn Mohylyuk

2014.09.30. Bioavailability Enhancement Webinar Series: Optimizing Technology Choice to Enhance Bioavailability Capsugel (Bend Research) Abstract: An increasing number of active compounds in pipelines today have properties that require functional formulation to enable exposure and efficacy. Despite many new technology choices, it is often difficult to match the right drug-delivery technology to a given molecule and problem statement. This problem is exacerbated by the need to save time and valuable drug in early development. This webinar describes an efficient strategy for mating enabling drug-delivery technologies with problem statements based on challenging compound properties and product concepts, building on an understanding of gut physiology, key molecule physicochemical properties, and the target product profile. Company Summary: Capsugel Dosage Form Solutions designs, develops and manufactures innovative dosage forms addressing bioavailability and other pressing product development challenges, including bioavailability enhancement, modified release, abuse deterrence, biotherapeutic processing, and inhalation formulation. Speakers Bio: Dr. David Vodak Vice President Bend Research Moderator Dr. Vodak's areas of expertise are research and development of novel pharmaceutical drug-delivery systems. Dr. Vodak holds a PhD in materials chemistry from the University of Michigan and a B.A. in chemistry from Willamette University. Dr. David Lyon Senior Vice President Bend Research Dr. Lyon is the Senior Vice President at Bend Research. He leads development activities for new technologies, oversees the development of predictive biomodels, and provides technical leadership to the research groups for new and applied technologies.

2014.09.30. Bioavailability Enhancement Webinar Series: Optimizing Technology...

Valentyn Mohylyuk

e-book optimizing topical semi solid drug formulation and performance (basf)

Valentyn Mohylyuk

2007 Требования к лекарственным средствам из растительного сырья

Valentyn Mohylyuk

Spray coatings of ethylcellulose for sustained drug release on multi-particulate dosage forms is common in the pharmaceutical industry, but can be disadvantageous because of long process times, need for organic solvent capabilities, and particulate agglomeration. Using a rotor process technology, ethylcellulose can be applied to drug layered beads as a dry powder; enabling the user to achieve high levels of weight gain in a short period of time while still demonstrating sustained release. Information will be presented comparing performance and productivity to traditional solvent-based Wurster coating and aqueous-based Wurster coating.

2016.08.15. rotor powder coating using ethocel ph (dow colorcon)

Valentyn Mohylyuk

2016.04. Инвестиционная пауза

Valentyn Mohylyuk

Свойства полимеров, а также полимеров в комбинации с пластификатором и пигментом, пропорции этих ингредиентов, метод нанесения пленочных покрытий и технологические параметры нанесения определяют физико-хи-мические свойства конечной оболочки. На мировом фармацевтическом рынке большинство декоративных покрытий твердых лекарственных форм содержат в своем составе полимер гидроксипропилметилцеллюлозу (ГПМЦ), номенклатура используемых полимеров в функциональных оболочках более разнообразна. На рынке вспомогательных веществ, предназначенных для нанесения функциональных пленочных покрытий, предлагаются как отдель-ные компоненты (полимеры, пластификаторы, пигменты), готовые смеси полимера, пластификатора и пигмента для приготовления суспензии, так и готовые дисперсии (табл. 1). Функциональные покрытия используют для решения фармакологических, технологических и маркетинговых задач.

Функциональные пленочные покрытия и практические аспекты их применения (2016....

Valentyn Mohylyuk

Más de Valentyn Mohylyuk (20)

PATVIS APA: visual inspection system for automated particle analysis

NETZSCH Nevio Instrument Series for THERMAL ANALYSIS

2018.10.05. aaps. particles investigation

2018.10.03. aaps sr supension

2018.09.07. APS@FIP poster "Development of multi-dose oral sustained release ...

2018.09.07. Development of multi-dose oral sustained release suspensions for ...

2017.10.18. Обзор мероприятия: Индустрия 4.0: Тенденции в области фармацевтич...

2017.11.07-08. Medicines for older adults:

2017.06.13 14. 3rd tech seminar from shin etsu (bradford england)

2016.02.17. Extract from PhD Dissertation (Mohylyuk Valentyn)

11 International Controlled Release Seminar

2017. Micropellets coated with Kollicoat Smartseal 30 D (Full version)

2016.10.19. конференция

2016. Dosage Form Optimization: Technology to Advance the Patient-Centric Dru...

2014.09.30. Bioavailability Enhancement Webinar Series: Optimizing Technology...

e-book optimizing topical semi solid drug formulation and performance (basf)

2007 Требования к лекарственным средствам из растительного сырья

2016.08.15. rotor powder coating using ethocel ph (dow colorcon)

2016.04. Инвестиционная пауза

Функциональные пленочные покрытия и практические аспекты их применения (2016....

Пероральні матриксні таблетки – лікарська форма для пролонгації вивільнення активного фармацевтичного інгредієнта (Валентин Могилюк)

Recomendados

Recomendados

Más contenido relacionado

Más de Valentyn Mohylyuk

Más de Valentyn Mohylyuk (20)