1. REDUCING CRBSI BY USING PREFILLED NORMAL
SALINE SOLUTION SYRINGES WHEN FLUSHING AND
LOCKING PORT DEVICES IN ADULT CANCER
PATIENTS; A SINGLE INSTITUTION PRELIMINARY
STUDY

2. Disclosure
• No
disclosures
related
to
this
study
• This
research
was
funded
solely
with
Ins6tu6onal
grants

3. ANALYSIS OF PORT FAILURES
IST GENOVA 1990-2008
INFECTION MECHANICAL FAILURE OTHERS
14
12.5
12
FAILURES %
10 10.3
8
7.1
6.6
6
4 4,3 3.9
3,4 3.1
2
0 0,6 0,5 0,4
90-95 95-00 00-05 05-08

4. PREFILLED SALINE SYRINGES RATIONALE
• SIMPLICITY OF USE
• REDUCTION OF MANIPULATION / CONTAMINATION
• SPARING NURSING TIME
• INCREASE PATIENT/NURSES SAFETY
• POSSIBLE REDUCTION OF CRBSI
• POSSIBLE SUBSTANTIAL SAVINGS

5. RETROSPECTIVE SINGLE INSTITUTION COHORT STUDY OF
801 IMPLANTED PORTS WITH TWO
DIFFERENT MEANS OF FLUSHING AND LOCKING DEVICES
MANUALLY FILLED
VS
PREFILLED NORMAL SALINE SYRINGES

6. 801 UNSELECTED CONSECUTIVE
IMPLANTED PORTS
( September 2009 – august 2011 )
SALINE LOCK EVERY
30-DAYS OR AFTER
EVERY ACCES
10 ml normal slaine 10 ml normal slaine
Manually Filled Syringes Prefilled Filled Syringes
MFS Group (303 patients) PFS Group ( 498 patients)
MINIMUM FOLLOW-UP : 6 MONTHS

7. MANUALLY FILLLED vs PREFILLED
SALYNE SYRINGES
PRIMARY STUDY OUTCOME
CRBS infection incidence requiring port
removal

8. MANUALLY FILLLED vs PREFILLED SALINE
SYRINGES
SECONDARY STUDY OUTCOMES *
• AGE
• GENDER
• PATHOLOGY
• STAGE DISEASE
• ACCES SITE
• BODY SIDE
* Multivariate analysis

9. MANUALLY FILLED vs PREFILLEDSALINE SYRINGES

10. Port removal according to the use of MFS or PFS

11. Port removal for CRBSI - Multivariate analysis

12. Port removal for any reason – Multivariate analysis

13. Pathogenic microorganisms responsible for catheter related
bloodstream infection according to the use of MFS and PFS

14. MANUALLY FILLED vs PREFILLED SALINE SYRINGES
CONCLUSIONS
Our study provides support that
switching from MFS to PFS use during
port flushing and locking procedures is
a usefull procedure to significantly
reduce the incidence rate of CRBSI.

15. MANUALLY FILLED vs PREFILLED SALINE SYRINGES
CONCLUSIONS
Further controlled studies are advisable to
confirm this result and to eventually assess
other potential attractive advantages, such
as improving nursing work flow, reducing
time to prepare flushing syringes.

16. THANK YOU VERY MUCH FOR
YOUR ATTENTION